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NECAB2 (N-terminal EF-hand calcium binding protein 2)

Identity

Alias (NCBI)EFCBP2
stip-2
HGNC (Hugo) NECAB2
HGNC Previous nameEFCBP2
HGNC Previous nameEF-hand calcium binding protein 2
LocusID (NCBI) 54550
Atlas_Id 70793
Location 16q23.3  [Link to chromosome band 16q23]
Location_base_pair Starts at 83968632 and ends at 84002774 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
KIAA0556 (16p12.1) / NECAB2 (16q23.3)TOM1L2 (17p11.2) / NECAB2 (16q23.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(16;16)(p12;q23) KIAA0556/NECAB2

External links

Nomenclature
HGNC (Hugo)NECAB2   23746
Cards
Entrez_Gene (NCBI)NECAB2    N-terminal EF-hand calcium binding protein 2
AliasesEFCBP2; stip-2
GeneCards (Weizmann)NECAB2
Ensembl hg19 (Hinxton)ENSG00000103154 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000103154 [Gene_View]  ENSG00000103154 [Sequence]  chr16:83968632-84002774 [Contig_View]  NECAB2 [Vega]
ICGC DataPortalENSG00000103154
TCGA cBioPortalNECAB2
AceView (NCBI)NECAB2
Genatlas (Paris)NECAB2
SOURCE (Princeton)NECAB2
Genetics Home Reference (NIH)NECAB2
Genomic and cartography
GoldenPath hg38 (UCSC)NECAB2  -     chr16:83968632-84002774 +  16q23.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NECAB2  -     16q23.3   [Description]    (hg19-Feb_2009)
GoldenPathNECAB2 - 16q23.3 [CytoView hg19]  NECAB2 - 16q23.3 [CytoView hg38]
ImmunoBaseENSG00000103154
genome Data Viewer NCBINECAB2 [Mapview hg19]  
OMIM618130   
Gene and transcription
Genbank (Entrez)AF070637 AF193758 AK127376 AY299331 BC016979
RefSeq transcript (Entrez)NM_001329748 NM_001329749 NM_019065
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NECAB2
Alternative Splicing GalleryENSG00000103154
Gene ExpressionNECAB2 [ NCBI-GEO ]   NECAB2 [ EBI - ARRAY_EXPRESS ]   NECAB2 [ SEEK ]   NECAB2 [ MEM ]
Gene Expression Viewer (FireBrowse)NECAB2 [ Firebrowse - Broad ]
GenevisibleExpression of NECAB2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)54550
GTEX Portal (Tissue expression)NECAB2
Human Protein AtlasENSG00000103154-NECAB2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ7Z6G3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ7Z6G3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ7Z6G3
Splice isoforms : SwissVarQ7Z6G3
PhosPhoSitePlusQ7Z6G3
Domaine pattern : Prosite (Expaxy)ABM (PS51725)    EF_HAND_1 (PS00018)    EF_HAND_2 (PS50222)   
Domains : Interpro (EBI)ABM_dom    Dimeric_a/b-barrel    EF-hand-dom_pair    EF_Hand_1_Ca_BS    EF_hand_dom    NECAB1/2/3   
Domain families : Pfam (Sanger)ABM (PF03992)   
Domain families : Pfam (NCBI)pfam03992   
Domain families : Smart (EMBL)EFh (SM00054)  
Conserved Domain (NCBI)NECAB2
Blocks (Seattle)NECAB2
SuperfamilyQ7Z6G3
Human Protein Atlas [tissue]ENSG00000103154-NECAB2 [tissue]
Peptide AtlasQ7Z6G3
HPRD13263
IPIIPI00641920   
Protein Interaction databases
DIP (DOE-UCLA)Q7Z6G3
IntAct (EBI)Q7Z6G3
BioGRIDNECAB2
STRING (EMBL)NECAB2
ZODIACNECAB2
Ontologies - Pathways
QuickGOQ7Z6G3
Ontology : AmiGOcalcium ion binding  protein binding  cytoplasm  plasma membrane  axon  dendrite  A2A adenosine receptor binding  type 5 metabotropic glutamate receptor binding  regulation of amyloid precursor protein biosynthetic process  positive regulation of adenosine receptor signaling pathway  positive regulation of ERK1 and ERK2 cascade  positive regulation of glutamate receptor signaling pathway  negative regulation of G protein-coupled receptor internalization  positive regulation of protein localization to membrane  
Ontology : EGO-EBIcalcium ion binding  protein binding  cytoplasm  plasma membrane  axon  dendrite  A2A adenosine receptor binding  type 5 metabotropic glutamate receptor binding  regulation of amyloid precursor protein biosynthetic process  positive regulation of adenosine receptor signaling pathway  positive regulation of ERK1 and ERK2 cascade  positive regulation of glutamate receptor signaling pathway  negative regulation of G protein-coupled receptor internalization  positive regulation of protein localization to membrane  
NDEx NetworkNECAB2
Atlas of Cancer Signalling NetworkNECAB2
Wikipedia pathwaysNECAB2
Orthology - Evolution
OrthoDB54550
GeneTree (enSembl)ENSG00000103154
Phylogenetic Trees/Animal Genes : TreeFamNECAB2
HOGENOMQ7Z6G3
Homologs : HomoloGeneNECAB2
Homology/Alignments : Family Browser (UCSC)NECAB2
Gene fusions - Rearrangements
Fusion : QuiverNECAB2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNECAB2 [hg38]
dbVarNECAB2
ClinVarNECAB2
MonarchNECAB2
1000_GenomesNECAB2 
Exome Variant ServerNECAB2
GNOMAD BrowserENSG00000103154
Varsome BrowserNECAB2
Genomic Variants (DGV)NECAB2 [DGVbeta]
DECIPHERNECAB2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNECAB2 
Mutations
ICGC Data PortalNECAB2 
TCGA Data PortalNECAB2 
Broad Tumor PortalNECAB2
OASIS PortalNECAB2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNECAB2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DNECAB2
Mutations and Diseases : HGMDNECAB2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NECAB2
DgiDB (Drug Gene Interaction Database)NECAB2
DoCM (Curated mutations)NECAB2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NECAB2 (select a term)
intoGenNECAB2
Cancer3DNECAB2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM618130   
Orphanet
DisGeNETNECAB2
MedgenNECAB2
Genetic Testing Registry NECAB2
NextProtQ7Z6G3 [Medical]
GENETestsNECAB2
Target ValidationNECAB2
Huge Navigator NECAB2 [HugePedia]
ClinGenNECAB2
Clinical trials, drugs, therapy
MyCancerGenomeNECAB2
Protein Interactions : CTD
Pharm GKB GenePA162397412
Clinical trialNECAB2
Miscellaneous
canSAR (ICR)NECAB2 (select the gene name)
HarmonizomeNECAB2
DataMed IndexNECAB2
Probes
Litterature
PubMed24 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNECAB2
EVEXNECAB2
GoPubMedNECAB2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat Dec 5 17:18:58 CET 2020
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