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NECAB3 (N-terminal EF-hand calcium binding protein 3)

Identity

Alias_namesSYTIP2
APBA2BP
amyloid beta (A4) precursor protein-binding, family A, member 2 binding protein
Alias_symbol (synonym)XB51
dJ63M2.4
NIP1
dJ63M2.5
EFCBP3
Other aliasSTIP3
HGNC (Hugo) NECAB3
LocusID (NCBI) 63941
Atlas_Id 70794
Location 20q11.22  [Link to chromosome band 20q11]
Location_base_pair Starts at 32244893 and ends at 32262264 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
AP2A1 (19q13.33) / NECAB3 (20q11.22)NECAB3 (20q11.22) / ARHGAP40 (20q11.23)NECAB3 (20q11.22) / DCN (12q21.33)
TADA2A (17q12) / NECAB3 (20q11.22)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NECAB3   15851
Cards
Entrez_Gene (NCBI)NECAB3  63941  N-terminal EF-hand calcium binding protein 3
AliasesAPBA2BP; EFCBP3; NIP1; STIP3; 
SYTIP2; XB51; dJ63M2.4; dJ63M2.5
GeneCards (Weizmann)NECAB3
Ensembl hg19 (Hinxton)ENSG00000125967 [Gene_View]  chr20:32244893-32262264 [Contig_View]  NECAB3 [Vega]
Ensembl hg38 (Hinxton)ENSG00000125967 [Gene_View]  chr20:32244893-32262264 [Contig_View]  NECAB3 [Vega]
ICGC DataPortalENSG00000125967
TCGA cBioPortalNECAB3
AceView (NCBI)NECAB3
Genatlas (Paris)NECAB3
WikiGenes63941
SOURCE (Princeton)NECAB3
Genetics Home Reference (NIH)NECAB3
Genomic and cartography
GoldenPath hg19 (UCSC)NECAB3  -     chr20:32244893-32262264 -  20q11.22   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)NECAB3  -     20q11.22   [Description]    (hg38-Dec_2013)
EnsemblNECAB3 - 20q11.22 [CytoView hg19]  NECAB3 - 20q11.22 [CytoView hg38]
Mapping of homologs : NCBINECAB3 [Mapview hg19]  NECAB3 [Mapview hg38]
OMIM612478   
Gene and transcription
Genbank (Entrez)AB039947 AF193759 AF409141 AK023706 AK124388
RefSeq transcript (Entrez)NM_031231 NM_031232
RefSeq genomic (Entrez)NC_000020 NC_018931 NT_011362 NW_004929418
Consensus coding sequences : CCDS (NCBI)NECAB3
Cluster EST : UnigeneHs.516986 [ NCBI ]
CGAP (NCI)Hs.516986
Alternative Splicing GalleryENSG00000125967
Gene ExpressionNECAB3 [ NCBI-GEO ]   NECAB3 [ EBI - ARRAY_EXPRESS ]   NECAB3 [ SEEK ]   NECAB3 [ MEM ]
Gene Expression Viewer (FireBrowse)NECAB3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)63941
GTEX Portal (Tissue expression)NECAB3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96P71   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96P71  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96P71
Splice isoforms : SwissVarQ96P71
PhosPhoSitePlusQ96P71
Domaine pattern : Prosite (Expaxy)ABM (PS51725)    EF_HAND_1 (PS00018)    EF_HAND_2 (PS50222)   
Domains : Interpro (EBI)ABM-like    Dimeric_a/b-barrel    EF-hand-dom_pair    EF_Hand_1_Ca_BS    EF_hand_dom   
Domain families : Pfam (Sanger)ABM (PF03992)    EF-hand_5 (PF13202)   
Domain families : Pfam (NCBI)pfam03992    pfam13202   
Conserved Domain (NCBI)NECAB3
DMDM Disease mutations63941
Blocks (Seattle)NECAB3
SuperfamilyQ96P71
Human Protein AtlasENSG00000125967
Peptide AtlasQ96P71
HPRD07168
IPIIPI00102440   IPI00295304   IPI00218453   IPI00643209   
Protein Interaction databases
DIP (DOE-UCLA)Q96P71
IntAct (EBI)Q96P71
FunCoupENSG00000125967
BioGRIDNECAB3
STRING (EMBL)NECAB3
ZODIACNECAB3
Ontologies - Pathways
QuickGOQ96P71
Ontology : AmiGOGolgi cis cisterna  calcium ion binding  protein binding  nucleus  cytoplasm  endoplasmic reticulum membrane  protein secretion  protein metabolic process  regulation of amyloid precursor protein biosynthetic process  
Ontology : EGO-EBIGolgi cis cisterna  calcium ion binding  protein binding  nucleus  cytoplasm  endoplasmic reticulum membrane  protein secretion  protein metabolic process  regulation of amyloid precursor protein biosynthetic process  
NDEx NetworkNECAB3
Atlas of Cancer Signalling NetworkNECAB3
Wikipedia pathwaysNECAB3
Orthology - Evolution
OrthoDB63941
GeneTree (enSembl)ENSG00000125967
Phylogenetic Trees/Animal Genes : TreeFamNECAB3
HOVERGENQ96P71
HOGENOMQ96P71
Homologs : HomoloGeneNECAB3
Homology/Alignments : Family Browser (UCSC)NECAB3
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNECAB3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NECAB3
dbVarNECAB3
ClinVarNECAB3
1000_GenomesNECAB3 
Exome Variant ServerNECAB3
ExAC (Exome Aggregation Consortium)NECAB3 (select the gene name)
Genetic variants : HAPMAP63941
Genomic Variants (DGV)NECAB3 [DGVbeta]
DECIPHER (Syndromes)20:32244893-32262264  ENSG00000125967
CONAN: Copy Number AnalysisNECAB3 
Mutations
ICGC Data PortalNECAB3 
TCGA Data PortalNECAB3 
Broad Tumor PortalNECAB3
OASIS PortalNECAB3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNECAB3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNECAB3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NECAB3
DgiDB (Drug Gene Interaction Database)NECAB3
DoCM (Curated mutations)NECAB3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NECAB3 (select a term)
intoGenNECAB3
Cancer3DNECAB3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612478   
Orphanet
MedgenNECAB3
Genetic Testing Registry NECAB3
NextProtQ96P71 [Medical]
TSGene63941
GENETestsNECAB3
Huge Navigator NECAB3 [HugePedia]
snp3D : Map Gene to Disease63941
BioCentury BCIQNECAB3
ClinGenNECAB3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD63941
Chemical/Pharm GKB GenePA24871
Clinical trialNECAB3
Miscellaneous
canSAR (ICR)NECAB3 (select the gene name)
Probes
Litterature
PubMed19 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNECAB3
EVEXNECAB3
GoPubMedNECAB3
iHOPNECAB3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 12:34:48 CET 2017

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