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NECTIN2 (nectin cell adhesion molecule 2)

Identity

Alias (NCBI)CD112
HVEB
PRR2
PVRL2
PVRR2
HGNC (Hugo) NECTIN2
HGNC Alias symbPVRR2
PRR2
CD112
HGNC Previous nameHVEB
 PVRL2
HGNC Previous namepoliovirus receptor-related 2 (herpesvirus entry mediator B)
LocusID (NCBI) 5819
Atlas_Id 55629
Location 19q13.32  [Link to chromosome band 19q13]
Location_base_pair Starts at 44846297 and ends at 44878938 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
NECTIN2 (19q13.32) / ADAMTS12 (5p13.3)NECTIN2 (19q13.32) / RAD51B (14q24.1)NECTIN2 (19q13.32) / TRBV20OR9-2 ()
NECTIN2 (19q13.32) / ZMAT2 (5q31.3)POLR2A (17p13.1) / NECTIN2 (19q13.32)TRA () / NECTIN2 (19q13.32)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(14;19)(q11;q13) TRA/NECTIN2
t(14;19)(q32;q13) IGH/Various Partners


External links

 

Nomenclature
HGNC (Hugo)NECTIN2   9707
Cards
Entrez_Gene (NCBI)NECTIN2    nectin cell adhesion molecule 2
AliasesCD112; HVEB; PRR2; PVRL2; 
PVRR2
GeneCards (Weizmann)NECTIN2
Ensembl hg19 (Hinxton)ENSG00000130202 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000130202 [Gene_View]  ENSG00000130202 [Sequence]  chr19:44846297-44878938 [Contig_View]  NECTIN2 [Vega]
ICGC DataPortalENSG00000130202
TCGA cBioPortalNECTIN2
AceView (NCBI)NECTIN2
Genatlas (Paris)NECTIN2
SOURCE (Princeton)NECTIN2
Genetics Home Reference (NIH)NECTIN2
Genomic and cartography
GoldenPath hg38 (UCSC)NECTIN2  -     chr19:44846297-44878938 +  19q13.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NECTIN2  -     19q13.32   [Description]    (hg19-Feb_2009)
GoldenPathNECTIN2 - 19q13.32 [CytoView hg19]  NECTIN2 - 19q13.32 [CytoView hg38]
ImmunoBaseENSG00000130202
Genome Data Viewer NCBINECTIN2 [Mapview hg19]  
OMIM600798   
Gene and transcription
Genbank (Entrez)AF058448 AJ708439 AK291330 BC003091 BQ549399
RefSeq transcript (Entrez)NM_001042724 NM_002856
Consensus coding sequences : CCDS (NCBI)NECTIN2
Gene ExpressionNECTIN2 [ NCBI-GEO ]   NECTIN2 [ EBI - ARRAY_EXPRESS ]   NECTIN2 [ SEEK ]   NECTIN2 [ MEM ]
Gene Expression Viewer (FireBrowse)NECTIN2 [ Firebrowse - Broad ]
GenevisibleExpression of NECTIN2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5819
GTEX Portal (Tissue expression)NECTIN2
Human Protein AtlasENSG00000130202-NECTIN2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ92692   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ92692  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ92692
PhosPhoSitePlusQ92692
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)   
Domains : Interpro (EBI)CD80_C2-set    Ig-like_dom    Ig-like_dom_sf    Ig-like_fold    Ig_sub    Ig_V-set    Nectin-2   
Domain families : Pfam (Sanger)C2-set_2 (PF08205)    V-set (PF07686)   
Domain families : Pfam (NCBI)pfam08205    pfam07686   
Domain families : Smart (EMBL)IG (SM00409)  IGv (SM00406)  
Conserved Domain (NCBI)NECTIN2
PDB (RSDB)3R0N    4DFH    4DFI    4HZA    5V52   
PDB Europe3R0N    4DFH    4DFI    4HZA    5V52   
PDB (PDBSum)3R0N    4DFH    4DFI    4HZA    5V52   
PDB (IMB)3R0N    4DFH    4DFI    4HZA    5V52   
Structural Biology KnowledgeBase3R0N    4DFH    4DFI    4HZA    5V52   
SCOP (Structural Classification of Proteins)3R0N    4DFH    4DFI    4HZA    5V52   
CATH (Classification of proteins structures)3R0N    4DFH    4DFI    4HZA    5V52   
SuperfamilyQ92692
AlphaFold pdb e-kbQ92692   
Human Protein Atlas [tissue]ENSG00000130202-NECTIN2 [tissue]
HPRD02879
Protein Interaction databases
DIP (DOE-UCLA)Q92692
IntAct (EBI)Q92692
BioGRIDNECTIN2
STRING (EMBL)NECTIN2
ZODIACNECTIN2
Ontologies - Pathways
QuickGOQ92692
Ontology : AmiGOvirus receptor activity  acrosome assembly  positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target  positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target  positive regulation of immunoglobulin mediated immune response  positive regulation of immunoglobulin mediated immune response  protein binding  plasma membrane  plasma membrane  cell-cell junction  zonula adherens  focal adhesion  cytoskeleton organization  homophilic cell adhesion via plasma membrane adhesion molecules  homophilic cell adhesion via plasma membrane adhesion molecules  spermatid development  spermatid nucleus differentiation  fertilization  cell surface  coreceptor activity  integral component of membrane  integral component of membrane  fusion of virus membrane with host plasma membrane  fusion of virus membrane with host plasma membrane  sperm mitochondrion organization  cell part morphogenesis  positive regulation of mast cell activation  positive regulation of mast cell activation  adherens junction organization  susceptibility to natural killer cell mediated cytotoxicity  susceptibility to natural killer cell mediated cytotoxicity  identical protein binding  protein homodimerization activity  apical junction complex  cell-cell contact zone  adhesion of symbiont to host  cilium organization  positive regulation of natural killer cell mediated cytotoxicity  regulation of viral entry into host cell  regulation of viral entry into host cell  coreceptor-mediated virion attachment to host cell  coreceptor-mediated virion attachment to host cell  regulation of immune response  cell adhesion molecule binding  cell adhesion molecule binding  positive regulation of T cell receptor signaling pathway  positive regulation of T cell receptor signaling pathway  establishment of mitochondrion localization  susceptibility to T cell mediated cytotoxicity  susceptibility to T cell mediated cytotoxicity  extracellular exosome  
Ontology : EGO-EBIvirus receptor activity  acrosome assembly  positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target  positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target  positive regulation of immunoglobulin mediated immune response  positive regulation of immunoglobulin mediated immune response  protein binding  plasma membrane  plasma membrane  cell-cell junction  zonula adherens  focal adhesion  cytoskeleton organization  homophilic cell adhesion via plasma membrane adhesion molecules  homophilic cell adhesion via plasma membrane adhesion molecules  spermatid development  spermatid nucleus differentiation  fertilization  cell surface  coreceptor activity  integral component of membrane  integral component of membrane  fusion of virus membrane with host plasma membrane  fusion of virus membrane with host plasma membrane  sperm mitochondrion organization  cell part morphogenesis  positive regulation of mast cell activation  positive regulation of mast cell activation  adherens junction organization  susceptibility to natural killer cell mediated cytotoxicity  susceptibility to natural killer cell mediated cytotoxicity  identical protein binding  protein homodimerization activity  apical junction complex  cell-cell contact zone  adhesion of symbiont to host  cilium organization  positive regulation of natural killer cell mediated cytotoxicity  regulation of viral entry into host cell  regulation of viral entry into host cell  coreceptor-mediated virion attachment to host cell  coreceptor-mediated virion attachment to host cell  regulation of immune response  cell adhesion molecule binding  cell adhesion molecule binding  positive regulation of T cell receptor signaling pathway  positive regulation of T cell receptor signaling pathway  establishment of mitochondrion localization  susceptibility to T cell mediated cytotoxicity  susceptibility to T cell mediated cytotoxicity  extracellular exosome  
NDEx NetworkNECTIN2
Atlas of Cancer Signalling NetworkNECTIN2
Wikipedia pathwaysNECTIN2
Orthology - Evolution
OrthoDB5819
GeneTree (enSembl)ENSG00000130202
Phylogenetic Trees/Animal Genes : TreeFamNECTIN2
Homologs : HomoloGeneNECTIN2
Homology/Alignments : Family Browser (UCSC)NECTIN2
Gene fusions - Rearrangements
Fusion : QuiverNECTIN2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNECTIN2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NECTIN2
dbVarNECTIN2
ClinVarNECTIN2
MonarchNECTIN2
1000_GenomesNECTIN2 
Exome Variant ServerNECTIN2
GNOMAD BrowserENSG00000130202
Varsome BrowserNECTIN2
ACMGNECTIN2 variants
VarityQ92692
Genomic Variants (DGV)NECTIN2 [DGVbeta]
DECIPHERNECTIN2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNECTIN2 
Mutations
ICGC Data PortalNECTIN2 
TCGA Data PortalNECTIN2 
Broad Tumor PortalNECTIN2
OASIS PortalNECTIN2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNECTIN2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DNECTIN2
Mutations and Diseases : HGMDNECTIN2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaNECTIN2
DgiDB (Drug Gene Interaction Database)NECTIN2
DoCM (Curated mutations)NECTIN2
CIViC (Clinical Interpretations of Variants in Cancer)NECTIN2
Cancer3DNECTIN2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600798   
Orphanet
DisGeNETNECTIN2
MedgenNECTIN2
Genetic Testing Registry NECTIN2
NextProtQ92692 [Medical]
GENETestsNECTIN2
Target ValidationNECTIN2
Huge Navigator NECTIN2 [HugePedia]
ClinGenNECTIN2
Clinical trials, drugs, therapy
MyCancerGenomeNECTIN2
Protein Interactions : CTDNECTIN2
Pharm GKB GenePA34052
PharosQ92692
Clinical trialNECTIN2
Miscellaneous
canSAR (ICR)NECTIN2
HarmonizomeNECTIN2
DataMed IndexNECTIN2
Probes
Litterature
PubMed107 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXNECTIN2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:22:27 CEST 2021

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