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NECTIN2 (nectin cell adhesion molecule 2)

Identity

Alias_namesHVEB
PVRL2
poliovirus receptor-related 2 (herpesvirus entry mediator B)
Alias_symbol (synonym)PVRR2
PRR2
CD112
Other alias
HGNC (Hugo) NECTIN2
LocusID (NCBI) 5819
Atlas_Id 55629
Location 19q13.32  [Link to chromosome band 19q13]
Location_base_pair Starts at 44846136 and ends at 44889228 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
NECTIN2 (19q13.32) / ADAMTS12 (5p13.3)NECTIN2 (19q13.32) / RAD51B (14q24.1)NECTIN2 (19q13.32) / TRBV20OR9-2 ()
NECTIN2 (19q13.32) / ZMAT2 (5q31.3)POLR2A (17p13.1) / NECTIN2 (19q13.32)TRA () / NECTIN2 (19q13.32)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NECTIN2   9707
Cards
Entrez_Gene (NCBI)NECTIN2  5819  nectin cell adhesion molecule 2
AliasesCD112; HVEB; PRR2; PVRL2; 
PVRR2
GeneCards (Weizmann)NECTIN2
Ensembl hg19 (Hinxton)ENSG00000130202 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000130202 [Gene_View]  chr19:44846136-44889228 [Contig_View]  NECTIN2 [Vega]
ICGC DataPortalENSG00000130202
TCGA cBioPortalNECTIN2
AceView (NCBI)NECTIN2
Genatlas (Paris)NECTIN2
WikiGenes5819
SOURCE (Princeton)NECTIN2
Genetics Home Reference (NIH)NECTIN2
Genomic and cartography
GoldenPath hg38 (UCSC)NECTIN2  -     chr19:44846136-44889228 +  19q13.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NECTIN2  -     19q13.32   [Description]    (hg19-Feb_2009)
EnsemblNECTIN2 - 19q13.32 [CytoView hg19]  NECTIN2 - 19q13.32 [CytoView hg38]
Mapping of homologs : NCBINECTIN2 [Mapview hg19]  NECTIN2 [Mapview hg38]
OMIM600798   
Gene and transcription
Genbank (Entrez)AF058448 AJ708439 AK291330 BC003091 BQ549399
RefSeq transcript (Entrez)NM_001042724 NM_002856
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NECTIN2
Cluster EST : UnigeneHs.655455 [ NCBI ]
CGAP (NCI)Hs.655455
Alternative Splicing GalleryENSG00000130202
Gene ExpressionNECTIN2 [ NCBI-GEO ]   NECTIN2 [ EBI - ARRAY_EXPRESS ]   NECTIN2 [ SEEK ]   NECTIN2 [ MEM ]
Gene Expression Viewer (FireBrowse)NECTIN2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5819
GTEX Portal (Tissue expression)NECTIN2
Human Protein AtlasENSG00000130202-NECTIN2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ92692   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ92692  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ92692
Splice isoforms : SwissVarQ92692
PhosPhoSitePlusQ92692
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)   
Domains : Interpro (EBI)CD80_C2-set    Ig-like_dom    Ig-like_fold    Ig_sub    Ig_V-set    Nectin-2   
Domain families : Pfam (Sanger)C2-set_2 (PF08205)    V-set (PF07686)   
Domain families : Pfam (NCBI)pfam08205    pfam07686   
Domain families : Smart (EMBL)IG (SM00409)  IGv (SM00406)  
Conserved Domain (NCBI)NECTIN2
DMDM Disease mutations5819
Blocks (Seattle)NECTIN2
PDB (SRS)3R0N    4DFH    4DFI    4HZA   
PDB (PDBSum)3R0N    4DFH    4DFI    4HZA   
PDB (IMB)3R0N    4DFH    4DFI    4HZA   
PDB (RSDB)3R0N    4DFH    4DFI    4HZA   
Structural Biology KnowledgeBase3R0N    4DFH    4DFI    4HZA   
SCOP (Structural Classification of Proteins)3R0N    4DFH    4DFI    4HZA   
CATH (Classification of proteins structures)3R0N    4DFH    4DFI    4HZA   
SuperfamilyQ92692
Human Protein Atlas [tissue]ENSG00000130202-NECTIN2 [tissue]
Peptide AtlasQ92692
HPRD02879
IPIIPI00022661   IPI00215980   
Protein Interaction databases
DIP (DOE-UCLA)Q92692
IntAct (EBI)Q92692
FunCoupENSG00000130202
BioGRIDNECTIN2
STRING (EMBL)NECTIN2
ZODIACNECTIN2
Ontologies - Pathways
QuickGOQ92692
Ontology : AmiGOvirus receptor activity  acrosome assembly  positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target  positive regulation of immunoglobulin mediated immune response  receptor binding  protein binding  plasma membrane  integral component of plasma membrane  cell-cell junction  cell-cell adherens junction  zonula adherens  focal adhesion  cytoskeleton organization  homophilic cell adhesion via plasma membrane adhesion molecules  heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules  signal transduction  spermatid development  spermatid nucleus differentiation  cell recognition  fertilization  cell surface  coreceptor activity  integral component of membrane  fusion of virus membrane with host plasma membrane  sperm mitochondrion organization  cell part morphogenesis  positive regulation of mast cell activation  adherens junction organization  susceptibility to natural killer cell mediated cytotoxicity  identical protein binding  protein homodimerization activity  cell-cell contact zone  adhesion of symbiont to host  cilium organization  positive regulation of natural killer cell mediated cytotoxicity  regulation of viral entry into host cell  coreceptor-mediated virion attachment to host cell  protein heterodimerization activity  regulation of immune response  cell adhesion molecule binding  establishment of mitochondrion localization  susceptibility to T cell mediated cytotoxicity  extracellular exosome  
Ontology : EGO-EBIvirus receptor activity  acrosome assembly  positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target  positive regulation of immunoglobulin mediated immune response  receptor binding  protein binding  plasma membrane  integral component of plasma membrane  cell-cell junction  cell-cell adherens junction  zonula adherens  focal adhesion  cytoskeleton organization  homophilic cell adhesion via plasma membrane adhesion molecules  heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules  signal transduction  spermatid development  spermatid nucleus differentiation  cell recognition  fertilization  cell surface  coreceptor activity  integral component of membrane  fusion of virus membrane with host plasma membrane  sperm mitochondrion organization  cell part morphogenesis  positive regulation of mast cell activation  adherens junction organization  susceptibility to natural killer cell mediated cytotoxicity  identical protein binding  protein homodimerization activity  cell-cell contact zone  adhesion of symbiont to host  cilium organization  positive regulation of natural killer cell mediated cytotoxicity  regulation of viral entry into host cell  coreceptor-mediated virion attachment to host cell  protein heterodimerization activity  regulation of immune response  cell adhesion molecule binding  establishment of mitochondrion localization  susceptibility to T cell mediated cytotoxicity  extracellular exosome  
NDEx NetworkNECTIN2
Atlas of Cancer Signalling NetworkNECTIN2
Wikipedia pathwaysNECTIN2
Orthology - Evolution
OrthoDB5819
GeneTree (enSembl)ENSG00000130202
Phylogenetic Trees/Animal Genes : TreeFamNECTIN2
HOVERGENQ92692
HOGENOMQ92692
Homologs : HomoloGeneNECTIN2
Homology/Alignments : Family Browser (UCSC)NECTIN2
Gene fusions - Rearrangements
Tumor Fusion PortalNECTIN2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNECTIN2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NECTIN2
dbVarNECTIN2
ClinVarNECTIN2
1000_GenomesNECTIN2 
Exome Variant ServerNECTIN2
ExAC (Exome Aggregation Consortium)ENSG00000130202
GNOMAD BrowserENSG00000130202
Genetic variants : HAPMAP5819
Genomic Variants (DGV)NECTIN2 [DGVbeta]
DECIPHERNECTIN2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNECTIN2 
Mutations
ICGC Data PortalNECTIN2 
TCGA Data PortalNECTIN2 
Broad Tumor PortalNECTIN2
OASIS PortalNECTIN2 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDNECTIN2
BioMutasearch NECTIN2
DgiDB (Drug Gene Interaction Database)NECTIN2
DoCM (Curated mutations)NECTIN2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NECTIN2 (select a term)
intoGenNECTIN2
Cancer3DNECTIN2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600798   
Orphanet
DisGeNETNECTIN2
MedgenNECTIN2
Genetic Testing Registry NECTIN2
NextProtQ92692 [Medical]
TSGene5819
GENETestsNECTIN2
Target ValidationNECTIN2
Huge Navigator NECTIN2 [HugePedia]
snp3D : Map Gene to Disease5819
BioCentury BCIQNECTIN2
ClinGenNECTIN2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5819
Chemical/Pharm GKB GenePA34052
Clinical trialNECTIN2
Miscellaneous
canSAR (ICR)NECTIN2 (select the gene name)
Probes
Litterature
PubMed77 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNECTIN2
EVEXNECTIN2
GoPubMedNECTIN2
iHOPNECTIN2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:25:57 CET 2017

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