NEDD1 (NEDD1 gamma-tubulin ring complex targeting factor)

2013-07-01  

Identity

HGNC
NEDD1
LOCATION
12q23.1
LOCUSID
121441
ALIAS
GCP-WD,TUBGCP7
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 121441
MIM: 600372
HGNC: 7723
Ensembl: ENSG00000139350

Variants:

dbSNP: 121441
ClinVar: 121441
TCGA: ENSG00000139350
COSMIC: NEDD1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000139350ENST00000266742Q8NHV4
ENSG00000139350ENST00000266742A0A024RBE5
ENSG00000139350ENST00000411739Q8NHV4
ENSG00000139350ENST00000429527Q8NHV4
ENSG00000139350ENST00000429527A0A024RBE5
ENSG00000139350ENST00000457368Q8NHV4
ENSG00000139350ENST00000553609G3V4I9
ENSG00000139350ENST00000554226G3V2V3
ENSG00000139350ENST00000555806G3V2S2
ENSG00000139350ENST00000557092G3V2M9
ENSG00000139350ENST00000557478G3V4L2
ENSG00000139350ENST00000557644Q8NHV4

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Cilium AssemblyREACTOMER-HSA-5617833
Anchoring of the basal body to the plasma membraneREACTOMER-HSA-5620912
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G2-G2/M phasesREACTOMER-HSA-453274
G2/M TransitionREACTOMER-HSA-69275
Regulation of PLK1 Activity at G2/M TransitionREACTOMER-HSA-2565942
Centrosome maturationREACTOMER-HSA-380287
Recruitment of mitotic centrosome proteins and complexesREACTOMER-HSA-380270
Recruitment of NuMA to mitotic centrosomesREACTOMER-HSA-380320
Loss of proteins required for interphase microtubule organization from the centrosomeREACTOMER-HSA-380284
Loss of Nlp from mitotic centrosomesREACTOMER-HSA-380259
AURKA Activation by TPX2REACTOMER-HSA-8854518

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
163780992006GCP-WD is a gamma-tubulin targeting factor required for centrosomal and chromatin-mediated microtubule nucleation.124
164613622006NEDD1-dependent recruitment of the gamma-tubulin ring complex to the centrosome is necessary for centriole duplication and spindle assembly.104
190293372008FAM29A promotes microtubule amplification via recruitment of the NEDD1-gamma-tubulin complex to the mitotic spindle.45
195090602009Sequential phosphorylation of Nedd1 by Cdk1 and Plk1 is required for targeting of the gammaTuRC to the centrosome.34
228189142012Nek9 phosphorylation of NEDD1/GCP-WD contributes to Plk1 control of γ-tubulin recruitment to the mitotic centrosome.28
232738982013The role of NEDD1 phosphorylation by Aurora A in chromosomal microtubule nucleation and spindle function.17
225955252012Novel NEDD1 phosphorylation sites regulate γ-tubulin binding and mitotic spindle assembly.14
202247772010A direct interaction with NEDD1 regulates gamma-tubulin recruitment to the centrosome.13
192435932009The centrosome protein NEDD1 as a potential pharmacological target to induce cell cycle arrest.8
231067872013Intraperitoneal delivery of a small interfering RNA targeting NEDD1 prolongs the survival of scirrhous gastric cancer model mice.6

Citation

Dessen P

NEDD1 (NEDD1 gamma-tubulin ring complex targeting factor)

Atlas Genet Cytogenet Oncol Haematol. 2013-07-01

Online version: http://atlasgeneticsoncology.org/gene/53473/nedd1