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NEDD4 (NEDD4 E3 ubiquitin protein ligase)

Identity

Alias (NCBI)NEDD4-1
RPF1
HGNC (Hugo) NEDD4
HGNC Alias symbKIAA0093
MGC176705
NEDD4-1
RPF1
HGNC Alias namereceptor-potentiating factor 1
HGNC Previous nameneural precursor cell expressed, developmentally down-regulated 4
 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
LocusID (NCBI) 4734
Atlas_Id 45752
Location 15q21.3  [Link to chromosome band 15q21]
Location_base_pair Starts at 55826919 and ends at 55917131 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
NEDD4 (15q21.3) / ADAMTSL3 (15q25.2)NEDD4 (15q21.3) / ARMCX3 (Xq22.1)NEDD4 (15q21.3) / GABRA5 (15q12)
NEDD4 (15q21.3) / NEDD4 (15q21.3)NEDD4 (15q21.3) / RDH10 (8q21.11)NEDD4 (15q21.3) / RFX7 (15q21.3)
RAB27A (15q21.3) / NEDD4 (15q21.3)RDH10 (8q21.11) / NEDD4 (15q21.3)NEDD4 15q21.3 / ADAMTSL3 15q25.2
NEDD4 15q21.3 / GABRA5 15q12NEDD4 15q21.3 / RFX7 15q21.3RAB27A 15q21.3 / NEDD4 15q21.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)NEDD4   7727
Cards
Entrez_Gene (NCBI)NEDD4    NEDD4 E3 ubiquitin protein ligase
AliasesNEDD4-1; RPF1
GeneCards (Weizmann)NEDD4
Ensembl hg19 (Hinxton)ENSG00000069869 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000069869 [Gene_View]  ENSG00000069869 [Sequence]  chr15:55826919-55917131 [Contig_View]  NEDD4 [Vega]
ICGC DataPortalENSG00000069869
TCGA cBioPortalNEDD4
AceView (NCBI)NEDD4
Genatlas (Paris)NEDD4
SOURCE (Princeton)NEDD4
Genetics Home Reference (NIH)NEDD4
Genomic and cartography
GoldenPath hg38 (UCSC)NEDD4  -     chr15:55826919-55917131 -  15q21.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NEDD4  -     15q21.3   [Description]    (hg19-Feb_2009)
GoldenPathNEDD4 - 15q21.3 [CytoView hg19]  NEDD4 - 15q21.3 [CytoView hg38]
ImmunoBaseENSG00000069869
Genome Data Viewer NCBINEDD4 [Mapview hg19]  
OMIM602278   
Gene and transcription
Genbank (Entrez)AK304394 AK307541 AL832063 AL832359 AL833293
RefSeq transcript (Entrez)NM_001284338 NM_001284339 NM_001284340 NM_001329212 NM_006154 NM_198400
Consensus coding sequences : CCDS (NCBI)NEDD4
Gene ExpressionNEDD4 [ NCBI-GEO ]   NEDD4 [ EBI - ARRAY_EXPRESS ]   NEDD4 [ SEEK ]   NEDD4 [ MEM ]
Gene Expression Viewer (FireBrowse)NEDD4 [ Firebrowse - Broad ]
GenevisibleExpression of NEDD4 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4734
GTEX Portal (Tissue expression)NEDD4
Human Protein AtlasENSG00000069869-NEDD4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP46934   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP46934  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP46934
PhosPhoSitePlusP46934
Domaine pattern : Prosite (Expaxy)HECT (PS50237)    WW_DOMAIN_1 (PS01159)    WW_DOMAIN_2 (PS50020)   
Domains : Interpro (EBI)C2_domain_sf    HECT_dom    Hect_E3_ubiquitin_ligase    WW_dom    WW_dom_sf   
Domain families : Pfam (Sanger)HECT (PF00632)    WW (PF00397)   
Domain families : Pfam (NCBI)pfam00632    pfam00397   
Domain families : Smart (EMBL)HECTc (SM00119)  WW (SM00456)  
Conserved Domain (NCBI)NEDD4
PDB (RSDB)2KPZ    2KQ0    2M3O    2XBB    2XBF    3B7Y    4BBN    4BE8    4N7F    4N7H    5AHT    5C7J    5C91   
PDB Europe2KPZ    2KQ0    2M3O    2XBB    2XBF    3B7Y    4BBN    4BE8    4N7F    4N7H    5AHT    5C7J    5C91   
PDB (PDBSum)2KPZ    2KQ0    2M3O    2XBB    2XBF    3B7Y    4BBN    4BE8    4N7F    4N7H    5AHT    5C7J    5C91   
PDB (IMB)2KPZ    2KQ0    2M3O    2XBB    2XBF    3B7Y    4BBN    4BE8    4N7F    4N7H    5AHT    5C7J    5C91   
Structural Biology KnowledgeBase2KPZ    2KQ0    2M3O    2XBB    2XBF    3B7Y    4BBN    4BE8    4N7F    4N7H    5AHT    5C7J    5C91   
SCOP (Structural Classification of Proteins)2KPZ    2KQ0    2M3O    2XBB    2XBF    3B7Y    4BBN    4BE8    4N7F    4N7H    5AHT    5C7J    5C91   
CATH (Classification of proteins structures)2KPZ    2KQ0    2M3O    2XBB    2XBF    3B7Y    4BBN    4BE8    4N7F    4N7H    5AHT    5C7J    5C91   
SuperfamilyP46934
AlphaFold pdb e-kbP46934   
Human Protein Atlas [tissue]ENSG00000069869-NEDD4 [tissue]
HPRD03786
Protein Interaction databases
DIP (DOE-UCLA)P46934
IntAct (EBI)P46934
BioGRIDNEDD4
STRING (EMBL)NEDD4
ZODIACNEDD4
Ontologies - Pathways
QuickGOP46934
Ontology : AmiGOubiquitin ligase complex  protein polyubiquitination  chromatin  protein binding  cytoplasm  cytoplasm  Golgi apparatus  cytosol  cytosol  plasma membrane  plasma membrane  cell cortex  ubiquitin-dependent protein catabolic process  ubiquitin-dependent protein catabolic process  protein targeting to lysosome  lysosomal transport  neuromuscular junction development  negative regulation of sodium ion transport  negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage  positive regulation of phosphatidylinositol 3-kinase signaling  regulation of macroautophagy  apicolateral plasma membrane  protein ubiquitination  protein ubiquitination  protein ubiquitination  sodium channel inhibitor activity  sodium channel inhibitor activity  enzyme binding  protein domain specific binding  negative regulation of vascular endothelial growth factor receptor signaling pathway  neuron projection development  neuron projection development  receptor internalization  receptor internalization  beta-2 adrenergic receptor binding  receptor catabolic process  receptor catabolic process  protein-containing complex  cellular response to UV  regulation of ion transmembrane transport  regulation of membrane potential  glucocorticoid receptor signaling pathway  ubiquitin binding  proteasome-mediated ubiquitin-dependent protein catabolic process  ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway  dendritic spine  formation of structure involved in a symbiotic process  positive regulation of protein catabolic process  positive regulation of protein catabolic process  viral budding  positive regulation of nucleocytoplasmic transport  perinuclear region of cytoplasm  regulation of dendrite morphogenesis  regulation of dendrite morphogenesis  regulation of synapse organization  phosphoserine residue binding  phosphothreonine residue binding  progesterone receptor signaling pathway  response to calcium ion  ubiquitin protein ligase activity  ubiquitin protein ligase activity  extracellular exosome  RNA polymerase binding  proline-rich region binding  proline-rich region binding  protein K63-linked ubiquitination  regulation of potassium ion transmembrane transporter activity  negative regulation of sodium ion transmembrane transporter activity  negative regulation of sodium ion transmembrane transporter activity  
Ontology : EGO-EBIubiquitin ligase complex  protein polyubiquitination  chromatin  protein binding  cytoplasm  cytoplasm  Golgi apparatus  cytosol  cytosol  plasma membrane  plasma membrane  cell cortex  ubiquitin-dependent protein catabolic process  ubiquitin-dependent protein catabolic process  protein targeting to lysosome  lysosomal transport  neuromuscular junction development  negative regulation of sodium ion transport  negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage  positive regulation of phosphatidylinositol 3-kinase signaling  regulation of macroautophagy  apicolateral plasma membrane  protein ubiquitination  protein ubiquitination  protein ubiquitination  sodium channel inhibitor activity  sodium channel inhibitor activity  enzyme binding  protein domain specific binding  negative regulation of vascular endothelial growth factor receptor signaling pathway  neuron projection development  neuron projection development  receptor internalization  receptor internalization  beta-2 adrenergic receptor binding  receptor catabolic process  receptor catabolic process  protein-containing complex  cellular response to UV  regulation of ion transmembrane transport  regulation of membrane potential  glucocorticoid receptor signaling pathway  ubiquitin binding  proteasome-mediated ubiquitin-dependent protein catabolic process  ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway  dendritic spine  formation of structure involved in a symbiotic process  positive regulation of protein catabolic process  positive regulation of protein catabolic process  viral budding  positive regulation of nucleocytoplasmic transport  perinuclear region of cytoplasm  regulation of dendrite morphogenesis  regulation of dendrite morphogenesis  regulation of synapse organization  phosphoserine residue binding  phosphothreonine residue binding  progesterone receptor signaling pathway  response to calcium ion  ubiquitin protein ligase activity  ubiquitin protein ligase activity  extracellular exosome  RNA polymerase binding  proline-rich region binding  proline-rich region binding  protein K63-linked ubiquitination  regulation of potassium ion transmembrane transporter activity  negative regulation of sodium ion transmembrane transporter activity  negative regulation of sodium ion transmembrane transporter activity  
Pathways : KEGGUbiquitin mediated proteolysis    Endocytosis    Epstein-Barr virus infection   
NDEx NetworkNEDD4
Atlas of Cancer Signalling NetworkNEDD4
Wikipedia pathwaysNEDD4
Orthology - Evolution
OrthoDB4734
GeneTree (enSembl)ENSG00000069869
Phylogenetic Trees/Animal Genes : TreeFamNEDD4
Homologs : HomoloGeneNEDD4
Homology/Alignments : Family Browser (UCSC)NEDD4
Gene fusions - Rearrangements
Fusion : MitelmanNEDD4/ADAMTSL3 [15q21.3/15q25.2]  
Fusion : MitelmanNEDD4/GABRA5 [15q21.3/15q12]  
Fusion : MitelmanNEDD4/RDH10 [15q21.3/8q21.11]  
Fusion : MitelmanNEDD4/RFX7 [15q21.3/15q21.3]  
Fusion : MitelmanRAB27A/NEDD4 [15q21.3/15q21.3]  
Fusion : MitelmanRDH10/NEDD4 [8q21.11/15q21.3]  
Fusion : QuiverNEDD4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNEDD4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NEDD4
dbVarNEDD4
ClinVarNEDD4
MonarchNEDD4
1000_GenomesNEDD4 
Exome Variant ServerNEDD4
GNOMAD BrowserENSG00000069869
Varsome BrowserNEDD4
ACMGNEDD4 variants
VarityP46934
Genomic Variants (DGV)NEDD4 [DGVbeta]
DECIPHERNEDD4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNEDD4 
Mutations
ICGC Data PortalNEDD4 
TCGA Data PortalNEDD4 
Broad Tumor PortalNEDD4
OASIS PortalNEDD4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNEDD4  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DNEDD4
Mutations and Diseases : HGMDNEDD4
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaNEDD4
DgiDB (Drug Gene Interaction Database)NEDD4
DoCM (Curated mutations)NEDD4
CIViC (Clinical Interpretations of Variants in Cancer)NEDD4
Cancer3DNEDD4
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602278   
Orphanet
DisGeNETNEDD4
MedgenNEDD4
Genetic Testing Registry NEDD4
NextProtP46934 [Medical]
GENETestsNEDD4
Target ValidationNEDD4
Huge Navigator NEDD4 [HugePedia]
ClinGenNEDD4
Clinical trials, drugs, therapy
MyCancerGenomeNEDD4
Protein Interactions : CTDNEDD4
Pharm GKB GenePA31533
PharosP46934
Clinical trialNEDD4
Miscellaneous
canSAR (ICR)NEDD4
HarmonizomeNEDD4
DataMed IndexNEDD4
Probes
Litterature
PubMed357 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXNEDD4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:22:28 CEST 2021

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