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NEDD4 (neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase)

Identity

Alias_namesneural precursor cell expressed
Alias_symbol (synonym)KIAA0093
MGC176705
NEDD4-1
RPF1
Other alias
HGNC (Hugo) NEDD4
LocusID (NCBI) 4734
Atlas_Id 45752
Location 15q21.3  [Link to chromosome band 15q21]
Location_base_pair Starts at 55826919 and ends at 55917131 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
NEDD4 (15q21.3) / ADAMTSL3 (15q25.2)NEDD4 (15q21.3) / ARMCX3 (Xq22.1)NEDD4 (15q21.3) / GABRA5 (15q12)
NEDD4 (15q21.3) / NEDD4 (15q21.3)NEDD4 (15q21.3) / RDH10 (8q21.11)NEDD4 (15q21.3) / RFX7 (15q21.3)
RAB27A (15q21.3) / NEDD4 (15q21.3)RDH10 (8q21.11) / NEDD4 (15q21.3)NEDD4 15q21.3 / ADAMTSL3 15q25.2
NEDD4 15q21.3 / GABRA5 15q12NEDD4 15q21.3 / RFX7 15q21.3RAB27A 15q21.3 / NEDD4 15q21.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Squamous Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)NEDD4   7727
Cards
Entrez_Gene (NCBI)NEDD4  4734  neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
AliasesNEDD4-1; RPF1
GeneCards (Weizmann)NEDD4
Ensembl hg19 (Hinxton)ENSG00000069869 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000069869 [Gene_View]  chr15:55826919-55917131 [Contig_View]  NEDD4 [Vega]
ICGC DataPortalENSG00000069869
TCGA cBioPortalNEDD4
AceView (NCBI)NEDD4
Genatlas (Paris)NEDD4
WikiGenes4734
SOURCE (Princeton)NEDD4
Genetics Home Reference (NIH)NEDD4
Genomic and cartography
GoldenPath hg38 (UCSC)NEDD4  -     chr15:55826919-55917131 -  15q21.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NEDD4  -     15q21.3   [Description]    (hg19-Feb_2009)
EnsemblNEDD4 - 15q21.3 [CytoView hg19]  NEDD4 - 15q21.3 [CytoView hg38]
Mapping of homologs : NCBINEDD4 [Mapview hg19]  NEDD4 [Mapview hg38]
OMIM602278   
Gene and transcription
Genbank (Entrez)AK304394 AK307541 AL832063 AL832359 AL833293
RefSeq transcript (Entrez)NM_001284338 NM_001284339 NM_001284340 NM_001329212 NM_006154 NM_198400
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NEDD4
Cluster EST : UnigeneHs.1565 [ NCBI ]
CGAP (NCI)Hs.1565
Alternative Splicing GalleryENSG00000069869
Gene ExpressionNEDD4 [ NCBI-GEO ]   NEDD4 [ EBI - ARRAY_EXPRESS ]   NEDD4 [ SEEK ]   NEDD4 [ MEM ]
Gene Expression Viewer (FireBrowse)NEDD4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4734
GTEX Portal (Tissue expression)NEDD4
Protein : pattern, domain, 3D structure
UniProt/SwissProtP46934   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP46934  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP46934
Splice isoforms : SwissVarP46934
PhosPhoSitePlusP46934
Domaine pattern : Prosite (Expaxy)HECT (PS50237)    WW_DOMAIN_1 (PS01159)    WW_DOMAIN_2 (PS50020)   
Domains : Interpro (EBI)C2_dom    HECT_dom    WW_dom   
Domain families : Pfam (Sanger)HECT (PF00632)    WW (PF00397)   
Domain families : Pfam (NCBI)pfam00632    pfam00397   
Domain families : Smart (EMBL)HECTc (SM00119)  WW (SM00456)  
Conserved Domain (NCBI)NEDD4
DMDM Disease mutations4734
Blocks (Seattle)NEDD4
PDB (SRS)2KPZ    2KQ0    2M3O    2XBB    2XBF    3B7Y    4BBN    4BE8    4N7F    4N7H    5AHT    5C7J    5C91   
PDB (PDBSum)2KPZ    2KQ0    2M3O    2XBB    2XBF    3B7Y    4BBN    4BE8    4N7F    4N7H    5AHT    5C7J    5C91   
PDB (IMB)2KPZ    2KQ0    2M3O    2XBB    2XBF    3B7Y    4BBN    4BE8    4N7F    4N7H    5AHT    5C7J    5C91   
PDB (RSDB)2KPZ    2KQ0    2M3O    2XBB    2XBF    3B7Y    4BBN    4BE8    4N7F    4N7H    5AHT    5C7J    5C91   
Structural Biology KnowledgeBase2KPZ    2KQ0    2M3O    2XBB    2XBF    3B7Y    4BBN    4BE8    4N7F    4N7H    5AHT    5C7J    5C91   
SCOP (Structural Classification of Proteins)2KPZ    2KQ0    2M3O    2XBB    2XBF    3B7Y    4BBN    4BE8    4N7F    4N7H    5AHT    5C7J    5C91   
CATH (Classification of proteins structures)2KPZ    2KQ0    2M3O    2XBB    2XBF    3B7Y    4BBN    4BE8    4N7F    4N7H    5AHT    5C7J    5C91   
SuperfamilyP46934
Human Protein AtlasENSG00000069869
Peptide AtlasP46934
HPRD03786
IPIIPI00945379   IPI00969091   IPI00384495   IPI00940829   IPI00964065   IPI01011003   IPI00964317   IPI00967965   
Protein Interaction databases
DIP (DOE-UCLA)P46934
IntAct (EBI)P46934
FunCoupENSG00000069869
BioGRIDNEDD4
STRING (EMBL)NEDD4
ZODIACNEDD4
Ontologies - Pathways
QuickGOP46934
Ontology : AmiGOubiquitin ligase complex  chromatin  adaptive immune response  outflow tract morphogenesis  endocardial cushion development  protein binding  cytoplasm  Golgi apparatus  cytosol  cytosol  plasma membrane  plasma membrane  cell cortex  protein monoubiquitination  protein targeting to lysosome  lysosomal transport  neuromuscular junction development  negative regulation of sodium ion transport  negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage  positive regulation of phosphatidylinositol 3-kinase signaling  regulation of macroautophagy  apicolateral plasma membrane  protein ubiquitination  transmission of virus  sodium channel inhibitor activity  protein domain specific binding  negative regulation of vascular endothelial growth factor receptor signaling pathway  neuron projection development  receptor internalization  beta-2 adrenergic receptor binding  receptor catabolic process  cellular response to UV  regulation of ion transmembrane transport  ionotropic glutamate receptor binding  T cell activation  regulation of membrane potential  protein ubiquitination involved in ubiquitin-dependent protein catabolic process  protein ubiquitination involved in ubiquitin-dependent protein catabolic process  glucocorticoid receptor signaling pathway  ubiquitin binding  ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway  dendritic spine  development involved in symbiotic interaction  positive regulation of protein catabolic process  positive regulation of nucleocytoplasmic transport  perinuclear region of cytoplasm  blood vessel morphogenesis  regulation of dendrite morphogenesis  regulation of synapse organization  phosphoserine binding  phosphothreonine binding  progesterone receptor signaling pathway  response to calcium ion  ubiquitin protein ligase activity  extracellular exosome  RNA polymerase binding  proline-rich region binding  proline-rich region binding  protein K63-linked ubiquitination  regulation of potassium ion transmembrane transporter activity  negative regulation of sodium ion transmembrane transporter activity  
Ontology : EGO-EBIubiquitin ligase complex  chromatin  adaptive immune response  outflow tract morphogenesis  endocardial cushion development  protein binding  cytoplasm  Golgi apparatus  cytosol  cytosol  plasma membrane  plasma membrane  cell cortex  protein monoubiquitination  protein targeting to lysosome  lysosomal transport  neuromuscular junction development  negative regulation of sodium ion transport  negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage  positive regulation of phosphatidylinositol 3-kinase signaling  regulation of macroautophagy  apicolateral plasma membrane  protein ubiquitination  transmission of virus  sodium channel inhibitor activity  protein domain specific binding  negative regulation of vascular endothelial growth factor receptor signaling pathway  neuron projection development  receptor internalization  beta-2 adrenergic receptor binding  receptor catabolic process  cellular response to UV  regulation of ion transmembrane transport  ionotropic glutamate receptor binding  T cell activation  regulation of membrane potential  protein ubiquitination involved in ubiquitin-dependent protein catabolic process  protein ubiquitination involved in ubiquitin-dependent protein catabolic process  glucocorticoid receptor signaling pathway  ubiquitin binding  ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway  dendritic spine  development involved in symbiotic interaction  positive regulation of protein catabolic process  positive regulation of nucleocytoplasmic transport  perinuclear region of cytoplasm  blood vessel morphogenesis  regulation of dendrite morphogenesis  regulation of synapse organization  phosphoserine binding  phosphothreonine binding  progesterone receptor signaling pathway  response to calcium ion  ubiquitin protein ligase activity  extracellular exosome  RNA polymerase binding  proline-rich region binding  proline-rich region binding  protein K63-linked ubiquitination  regulation of potassium ion transmembrane transporter activity  negative regulation of sodium ion transmembrane transporter activity  
Pathways : KEGGUbiquitin mediated proteolysis    Endocytosis    Epstein-Barr virus infection   
NDEx NetworkNEDD4
Atlas of Cancer Signalling NetworkNEDD4
Wikipedia pathwaysNEDD4
Orthology - Evolution
OrthoDB4734
GeneTree (enSembl)ENSG00000069869
Phylogenetic Trees/Animal Genes : TreeFamNEDD4
HOVERGENP46934
HOGENOMP46934
Homologs : HomoloGeneNEDD4
Homology/Alignments : Family Browser (UCSC)NEDD4
Gene fusions - Rearrangements
Fusion : MitelmanNEDD4/ADAMTSL3 [15q21.3/15q25.2]  
Fusion : MitelmanNEDD4/GABRA5 [15q21.3/15q12]  [t(15;15)(q12;q21)]  
Fusion : MitelmanNEDD4/RDH10 [15q21.3/8q21.11]  [t(8;15)(q21;q21)]  
Fusion : MitelmanNEDD4/RFX7 [15q21.3/15q21.3]  [t(15;15)(q21;q21)]  
Fusion : MitelmanRAB27A/NEDD4 [15q21.3/15q21.3]  [t(15;15)(q21;q21)]  
Fusion : MitelmanRDH10/NEDD4 [8q21.11/15q21.3]  [t(8;15)(q21;q21)]  
Fusion: TCGANEDD4 15q21.3 ADAMTSL3 15q25.2 BRCA
Fusion: TCGANEDD4 15q21.3 GABRA5 15q12 BLCA
Fusion: TCGANEDD4 15q21.3 RFX7 15q21.3 BRCA
Fusion: TCGARAB27A 15q21.3 NEDD4 15q21.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNEDD4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NEDD4
dbVarNEDD4
ClinVarNEDD4
1000_GenomesNEDD4 
Exome Variant ServerNEDD4
ExAC (Exome Aggregation Consortium)NEDD4 (select the gene name)
Genetic variants : HAPMAP4734
Genomic Variants (DGV)NEDD4 [DGVbeta]
DECIPHERNEDD4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNEDD4 
Mutations
ICGC Data PortalNEDD4 
TCGA Data PortalNEDD4 
Broad Tumor PortalNEDD4
OASIS PortalNEDD4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNEDD4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNEDD4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NEDD4
DgiDB (Drug Gene Interaction Database)NEDD4
DoCM (Curated mutations)NEDD4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NEDD4 (select a term)
intoGenNEDD4
Cancer3DNEDD4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602278   
Orphanet
MedgenNEDD4
Genetic Testing Registry NEDD4
NextProtP46934 [Medical]
TSGene4734
GENETestsNEDD4
Target ValidationNEDD4
Huge Navigator NEDD4 [HugePedia]
snp3D : Map Gene to Disease4734
BioCentury BCIQNEDD4
ClinGenNEDD4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4734
Chemical/Pharm GKB GenePA31533
Clinical trialNEDD4
Miscellaneous
canSAR (ICR)NEDD4 (select the gene name)
Probes
Litterature
PubMed257 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNEDD4
EVEXNEDD4
GoPubMedNEDD4
iHOPNEDD4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:46:33 CEST 2017

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