NEDD4 (NEDD4 E3 ubiquitin protein ligase)

2007-02-01  

Identity

HGNC
LOCATION
15q21.3
LOCUSID
ALIAS
NEDD4-1,RPF1
FUSION GENES

Other Information

Locus ID:

NCBI: 4734
MIM: 602278
HGNC: 7727
Ensembl: ENSG00000069869

Variants:

dbSNP: 4734
ClinVar: 4734
TCGA: ENSG00000069869
COSMIC: NEDD4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000069869ENST00000338963P46934
ENSG00000069869ENST00000435532P46934
ENSG00000069869ENST00000502612H0Y9L1
ENSG00000069869ENST00000503468H0YA37
ENSG00000069869ENST00000506154P46934
ENSG00000069869ENST00000507063H0Y8H4
ENSG00000069869ENST00000508342P46934
ENSG00000069869ENST00000508871H0Y8X6
ENSG00000069869ENST00000648451A0A3B3IUC1

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
Ubiquitin mediated proteolysisKEGGko04120
Tight junctionKEGGko04530
Ubiquitin mediated proteolysisKEGGhsa04120
Tight junctionKEGGhsa04530
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
Epstein-Barr virus infectionKEGGhsa05169
Epstein-Barr virus infectionKEGGko05169
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Antiviral mechanism by IFN-stimulated genesREACTOMER-HSA-1169410
ISG15 antiviral mechanismREACTOMER-HSA-1169408
Signal TransductionREACTOMER-HSA-162582
Signaling by ERBB4REACTOMER-HSA-1236394
Downregulation of ERBB4 signalingREACTOMER-HSA-1253288

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA451906warfarinChemicalClinicalAnnotationassociatedPD27488176

References

Pubmed IDYearTitleCitations
172182602007NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN.253
183051672008ISG15 inhibits Ebola VP40 VLP budding in an L-domain-dependent manner by blocking Nedd4 ligase activity.120
168852332006RNA interference screen reveals an essential role of Nedd4-2 in dopamine transporter ubiquitination and endocytosis.94
185445332008Nedd4 mediates agonist-dependent ubiquitination, lysosomal targeting, and degradation of the beta2-adrenergic receptor.94
182870952008ISG15 inhibits Nedd4 ubiquitin E3 activity and enhances the innate antiviral response.86
179967032007Damage-induced ubiquitylation of human RNA polymerase II by the ubiquitin ligase Nedd4, but not Cockayne syndrome proteins or BRCA1.83
205593252010Arrestin domain-containing protein 3 recruits the NEDD4 E3 ligase to mediate ubiquitination of the beta2-adrenergic receptor.83
151266352004Nedd4.1-mediated ubiquitination and subsequent recruitment of Tsg101 ensure HTLV-1 Gag trafficking towards the multivesicular body pathway prior to virus budding.73
152179102004Cardiac voltage-gated sodium channel Nav1.5 is regulated by Nedd4-2 mediated ubiquitination.69
213383542011Nedd4-mediated AMPA receptor ubiquitination regulates receptor turnover and trafficking.68

Citation

Dessen P

NEDD4 (NEDD4 E3 ubiquitin protein ligase)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45752/nedd4