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NEDD8 (neural precursor cell expressed, developmentally down-regulated 8)

Identity

Alias_symbol (synonym)Nedd-8
Other aliasNEDD-8
HGNC (Hugo) NEDD8
LocusID (NCBI) 4738
Atlas_Id 41518
Location 14q12  [Link to chromosome band 14q12]
Location_base_pair Starts at 24686057 and ends at 24701576 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
BAG4 (8p11.23) / NEDD8 (14q12)BAG4 8p11.23 / NEDD8 14q12

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NEDD8   7732
Cards
Entrez_Gene (NCBI)NEDD8  4738  neural precursor cell expressed, developmentally down-regulated 8
AliasesNEDD-8
GeneCards (Weizmann)NEDD8
Ensembl hg19 (Hinxton)ENSG00000129559 [Gene_View]  chr14:24686057-24701576 [Contig_View]  NEDD8 [Vega]
Ensembl hg38 (Hinxton)ENSG00000129559 [Gene_View]  chr14:24686057-24701576 [Contig_View]  NEDD8 [Vega]
ICGC DataPortalENSG00000129559
TCGA cBioPortalNEDD8
AceView (NCBI)NEDD8
Genatlas (Paris)NEDD8
WikiGenes4738
SOURCE (Princeton)NEDD8
Genetics Home Reference (NIH)NEDD8
Genomic and cartography
GoldenPath hg19 (UCSC)NEDD8  -     chr14:24686057-24701576 -  14q12   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)NEDD8  -     14q12   [Description]    (hg38-Dec_2013)
EnsemblNEDD8 - 14q12 [CytoView hg19]  NEDD8 - 14q12 [CytoView hg38]
Mapping of homologs : NCBINEDD8 [Mapview hg19]  NEDD8 [Mapview hg38]
OMIM603171   
Gene and transcription
Genbank (Entrez)AK125214 BC038290 BC064899 BC104200 BC104201
RefSeq transcript (Entrez)NM_006156
RefSeq genomic (Entrez)NC_000014 NC_018925 NT_026437 NW_004929393
Consensus coding sequences : CCDS (NCBI)NEDD8
Cluster EST : UnigeneHs.531064 [ NCBI ]
CGAP (NCI)Hs.531064
Alternative Splicing GalleryENSG00000129559
Gene ExpressionNEDD8 [ NCBI-GEO ]   NEDD8 [ EBI - ARRAY_EXPRESS ]   NEDD8 [ SEEK ]   NEDD8 [ MEM ]
Gene Expression Viewer (FireBrowse)NEDD8 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4738
GTEX Portal (Tissue expression)NEDD8
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15843   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ15843  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ15843
Splice isoforms : SwissVarQ15843
PhosPhoSitePlusQ15843
Domaine pattern : Prosite (Expaxy)UBIQUITIN_1 (PS00299)    UBIQUITIN_2 (PS50053)   
Domains : Interpro (EBI)Ubiquitin    Ubiquitin-rel_dom    Ubiquitin_CS    Ubiquitin_dom   
Domain families : Pfam (Sanger)ubiquitin (PF00240)   
Domain families : Pfam (NCBI)pfam00240   
Domain families : Smart (EMBL)UBQ (SM00213)  
Conserved Domain (NCBI)NEDD8
DMDM Disease mutations4738
Blocks (Seattle)NEDD8
PDB (SRS)1NDD    1R4M    1R4N    1XT9    2BKR    2KO3    2NVU    3DBH    3DBL    3DBR    3DQV    3GZN    4F8C    4FBJ    4HCP    4P5O   
PDB (PDBSum)1NDD    1R4M    1R4N    1XT9    2BKR    2KO3    2NVU    3DBH    3DBL    3DBR    3DQV    3GZN    4F8C    4FBJ    4HCP    4P5O   
PDB (IMB)1NDD    1R4M    1R4N    1XT9    2BKR    2KO3    2NVU    3DBH    3DBL    3DBR    3DQV    3GZN    4F8C    4FBJ    4HCP    4P5O   
PDB (RSDB)1NDD    1R4M    1R4N    1XT9    2BKR    2KO3    2NVU    3DBH    3DBL    3DBR    3DQV    3GZN    4F8C    4FBJ    4HCP    4P5O   
Structural Biology KnowledgeBase1NDD    1R4M    1R4N    1XT9    2BKR    2KO3    2NVU    3DBH    3DBL    3DBR    3DQV    3GZN    4F8C    4FBJ    4HCP    4P5O   
SCOP (Structural Classification of Proteins)1NDD    1R4M    1R4N    1XT9    2BKR    2KO3    2NVU    3DBH    3DBL    3DBR    3DQV    3GZN    4F8C    4FBJ    4HCP    4P5O   
CATH (Classification of proteins structures)1NDD    1R4M    1R4N    1XT9    2BKR    2KO3    2NVU    3DBH    3DBL    3DBR    3DQV    3GZN    4F8C    4FBJ    4HCP    4P5O   
SuperfamilyQ15843
Human Protein AtlasENSG00000129559
Peptide AtlasQ15843
HPRD04412
IPIIPI00020008   IPI00873768   
Protein Interaction databases
DIP (DOE-UCLA)Q15843
IntAct (EBI)Q15843
FunCoupENSG00000129559
BioGRIDNEDD8
STRING (EMBL)NEDD8
ZODIACNEDD8
Ontologies - Pathways
QuickGOQ15843
Ontology : AmiGOprotein binding  nucleus  cytosol  regulation of transcription from RNA polymerase II promoter  cellular protein modification process  proteolysis  ubiquitin-dependent protein catabolic process  transforming growth factor beta receptor signaling pathway  protein localization  anatomical structure morphogenesis  response to organic cyclic compound  ubiquitin protein ligase binding  protein neddylation  extracellular exosome  
Ontology : EGO-EBIprotein binding  nucleus  cytosol  regulation of transcription from RNA polymerase II promoter  cellular protein modification process  proteolysis  ubiquitin-dependent protein catabolic process  transforming growth factor beta receptor signaling pathway  protein localization  anatomical structure morphogenesis  response to organic cyclic compound  ubiquitin protein ligase binding  protein neddylation  extracellular exosome  
Pathways : BIOCARTARegulation of p27 Phosphorylation during Cell Cycle Progression [Genes]   
NDEx NetworkNEDD8
Atlas of Cancer Signalling NetworkNEDD8
Wikipedia pathwaysNEDD8
Orthology - Evolution
OrthoDB4738
GeneTree (enSembl)ENSG00000129559
Phylogenetic Trees/Animal Genes : TreeFamNEDD8
HOVERGENQ15843
HOGENOMQ15843
Homologs : HomoloGeneNEDD8
Homology/Alignments : Family Browser (UCSC)NEDD8
Gene fusions - Rearrangements
Fusion : MitelmanBAG4/NEDD8 [8p11.23/14q12]  [t(8;14)(p11;q12)]  
Fusion: TCGABAG4 8p11.23 NEDD8 14q12 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNEDD8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NEDD8
dbVarNEDD8
ClinVarNEDD8
1000_GenomesNEDD8 
Exome Variant ServerNEDD8
ExAC (Exome Aggregation Consortium)NEDD8 (select the gene name)
Genetic variants : HAPMAP4738
Genomic Variants (DGV)NEDD8 [DGVbeta]
DECIPHER (Syndromes)14:24686057-24701576  ENSG00000129559
CONAN: Copy Number AnalysisNEDD8 
Mutations
ICGC Data PortalNEDD8 
TCGA Data PortalNEDD8 
Broad Tumor PortalNEDD8
OASIS PortalNEDD8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNEDD8  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNEDD8
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NEDD8
DgiDB (Drug Gene Interaction Database)NEDD8
DoCM (Curated mutations)NEDD8 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NEDD8 (select a term)
intoGenNEDD8
Cancer3DNEDD8(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603171   
Orphanet
MedgenNEDD8
Genetic Testing Registry NEDD8
NextProtQ15843 [Medical]
TSGene4738
GENETestsNEDD8
Huge Navigator NEDD8 [HugePedia]
snp3D : Map Gene to Disease4738
BioCentury BCIQNEDD8
ClinGenNEDD8
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4738
Chemical/Pharm GKB GenePA31537
Clinical trialNEDD8
Miscellaneous
canSAR (ICR)NEDD8 (select the gene name)
Probes
Litterature
PubMed151 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNEDD8
EVEXNEDD8
GoPubMedNEDD8
iHOPNEDD8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:12:01 CEST 2017

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