NEDD9 (neural precursor cell expressed, developmentally down-regulated 9)

2007-04-01  

Identity

HGNC
LOCATION
6p24.2
LOCUSID
ALIAS
CAS-L,CAS2,CASL,CASS2,HEF1
FUSION GENES

Other Information

Locus ID:

NCBI: 4739
MIM: 602265
HGNC: 7733
Ensembl: ENSG00000111859

Variants:

dbSNP: 4739
ClinVar: 4739
TCGA: ENSG00000111859
COSMIC: NEDD9

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000111859ENST00000379433Q14511
ENSG00000111859ENST00000379446Q14511
ENSG00000111859ENST00000397378D6RBQ2
ENSG00000111859ENST00000448183D6RDV1
ENSG00000111859ENST00000504387Q14511
ENSG00000111859ENST00000504387A0A024QZV9
ENSG00000111859ENST00000508546D6REP7
ENSG00000111859ENST00000513989D6RGD7
ENSG00000111859ENST00000620854A0A087WUD2

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
176047232007HEF1-dependent Aurora A activation induces disassembly of the primary cilium.336
205347412010Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals.108
161841682005The focal adhesion scaffolding protein HEF1 regulates activation of the Aurora-A and Nek2 kinases at the centrosome.100
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
179089962007A new central scaffold for metastasis: parsing HEF1/Cas-L/NEDD9.60
177030682007Molecular basis for HEF1/NEDD9/Cas-L action as a multifunctional co-ordinator of invasion, apoptosis and cell cycle.49
233554202013HEF1 promotes epithelial mesenchymal transition and bone invasion in prostate cancer under the regulation of microRNA-145.49
204986432010Regulation of invasive behavior by vascular endothelial growth factor is HEF1-dependent.38
213179292011HEF1, a novel target of Wnt signaling, promotes colonic cell migration and cancer progression.35
228690512012NEDD9, a novel target of miR-145, increases the invasiveness of glioblastoma.35

Citation

Dessen P

NEDD9 (neural precursor cell expressed, developmentally down-regulated 9)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46983/nedd9