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NEDD9 (neural precursor cell expressed, developmentally down-regulated 9)

Identity

Alias_symbol (synonym)HEF1
CAS-L
CASS2
Other aliasCAS2
CASL
HGNC (Hugo) NEDD9
LocusID (NCBI) 4739
Atlas_Id 46983
Location 6p24.2  [Link to chromosome band 6p24]
Location_base_pair Starts at 11183298 and ends at 11382348 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CLINT1 (5q33.3) / NEDD9 (6p24.2)NEDD9 (6p24.2) / CLINT1 (5q33.3)NEDD9 (6p24.2) / NEDD9 (6p24.2)
NUP153 (6p22.3) / NEDD9 (6p24.2)TMLHE (Xq28) / NEDD9 (6p24.2)WBP5 () / NEDD9 (6p24.2)
NUP153 6p22.3 / NEDD9 6p24.2TMLHE Xq28 / NEDD9 6p24.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NEDD9   7733
Cards
Entrez_Gene (NCBI)NEDD9  4739  neural precursor cell expressed, developmentally down-regulated 9
AliasesCAS-L; CAS2; CASL; CASS2; 
HEF1
GeneCards (Weizmann)NEDD9
Ensembl hg19 (Hinxton)ENSG00000111859 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000111859 [Gene_View]  chr6:11183298-11382348 [Contig_View]  NEDD9 [Vega]
ICGC DataPortalENSG00000111859
TCGA cBioPortalNEDD9
AceView (NCBI)NEDD9
Genatlas (Paris)NEDD9
WikiGenes4739
SOURCE (Princeton)NEDD9
Genetics Home Reference (NIH)NEDD9
Genomic and cartography
GoldenPath hg38 (UCSC)NEDD9  -     chr6:11183298-11382348 -  6p24.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NEDD9  -     6p24.2   [Description]    (hg19-Feb_2009)
EnsemblNEDD9 - 6p24.2 [CytoView hg19]  NEDD9 - 6p24.2 [CytoView hg38]
Mapping of homologs : NCBINEDD9 [Mapview hg19]  NEDD9 [Mapview hg38]
OMIM602265   
Gene and transcription
Genbank (Entrez)AA814628 AJ420493 AK292682 AW963532 BC020686
RefSeq transcript (Entrez)NM_001142393 NM_001271033 NM_006403 NM_182966
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NEDD9
Cluster EST : UnigeneHs.37982 [ NCBI ]
CGAP (NCI)Hs.37982
Alternative Splicing GalleryENSG00000111859
Gene ExpressionNEDD9 [ NCBI-GEO ]   NEDD9 [ EBI - ARRAY_EXPRESS ]   NEDD9 [ SEEK ]   NEDD9 [ MEM ]
Gene Expression Viewer (FireBrowse)NEDD9 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4739
GTEX Portal (Tissue expression)NEDD9
Human Protein AtlasENSG00000111859-NEDD9 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14511   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ14511  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ14511
Splice isoforms : SwissVarQ14511
PhosPhoSitePlusQ14511
Domaine pattern : Prosite (Expaxy)SH3 (PS50002)   
Domains : Interpro (EBI)CAS_DUF3513    Serine_rich    SH3_domain   
Domain families : Pfam (Sanger)DUF3513 (PF12026)    Serine_rich (PF08824)    SH3_9 (PF14604)   
Domain families : Pfam (NCBI)pfam12026    pfam08824    pfam14604   
Domain families : Smart (EMBL)SH3 (SM00326)  
Conserved Domain (NCBI)NEDD9
DMDM Disease mutations4739
Blocks (Seattle)NEDD9
PDB (SRS)2L81   
PDB (PDBSum)2L81   
PDB (IMB)2L81   
PDB (RSDB)2L81   
Structural Biology KnowledgeBase2L81   
SCOP (Structural Classification of Proteins)2L81   
CATH (Classification of proteins structures)2L81   
SuperfamilyQ14511
Human Protein Atlas [tissue]ENSG00000111859-NEDD9 [tissue]
Peptide AtlasQ14511
HPRD11888
IPIIPI00031407   IPI00965935   IPI00514103   IPI00966015   IPI00964938   IPI01014978   IPI00964315   
Protein Interaction databases
DIP (DOE-UCLA)Q14511
IntAct (EBI)Q14511
FunCoupENSG00000111859
BioGRIDNEDD9
STRING (EMBL)NEDD9
ZODIACNEDD9
Ontologies - Pathways
QuickGOQ14511
Ontology : AmiGOspindle pole  protein binding  nucleus  nucleoplasm  cytoplasm  Golgi apparatus  spindle  cytosol  plasma membrane  focal adhesion  cell cortex  cytoskeleton organization  cell cycle  cell adhesion  signal transduction  integrin-mediated signaling pathway  lamellipodium  regulation of growth  actin filament bundle assembly  cell division  
Ontology : EGO-EBIspindle pole  protein binding  nucleus  nucleoplasm  cytoplasm  Golgi apparatus  spindle  cytosol  plasma membrane  focal adhesion  cell cortex  cytoskeleton organization  cell cycle  cell adhesion  signal transduction  integrin-mediated signaling pathway  lamellipodium  regulation of growth  actin filament bundle assembly  cell division  
NDEx NetworkNEDD9
Atlas of Cancer Signalling NetworkNEDD9
Wikipedia pathwaysNEDD9
Orthology - Evolution
OrthoDB4739
GeneTree (enSembl)ENSG00000111859
Phylogenetic Trees/Animal Genes : TreeFamNEDD9
HOVERGENQ14511
HOGENOMQ14511
Homologs : HomoloGeneNEDD9
Homology/Alignments : Family Browser (UCSC)NEDD9
Gene fusions - Rearrangements
Fusion : MitelmanNUP153/NEDD9 [6p22.3/6p24.2]  [t(6;6)(p22;p24)]  
Fusion : MitelmanTMLHE/NEDD9 [Xq28/6p24.2]  [t(X;6)(q28;p24)]  
Fusion: TCGA_MDACCNUP153 6p22.3 NEDD9 6p24.2 BRCA
Fusion: TCGA_MDACCTMLHE Xq28 NEDD9 6p24.2 HNSC
Tumor Fusion PortalNEDD9
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNEDD9 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NEDD9
dbVarNEDD9
ClinVarNEDD9
1000_GenomesNEDD9 
Exome Variant ServerNEDD9
ExAC (Exome Aggregation Consortium)ENSG00000111859
GNOMAD BrowserENSG00000111859
Genetic variants : HAPMAP4739
Genomic Variants (DGV)NEDD9 [DGVbeta]
DECIPHERNEDD9 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNEDD9 
Mutations
ICGC Data PortalNEDD9 
TCGA Data PortalNEDD9 
Broad Tumor PortalNEDD9
OASIS PortalNEDD9 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNEDD9  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNEDD9
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NEDD9
DgiDB (Drug Gene Interaction Database)NEDD9
DoCM (Curated mutations)NEDD9 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NEDD9 (select a term)
intoGenNEDD9
Cancer3DNEDD9(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602265   
Orphanet
DisGeNETNEDD9
MedgenNEDD9
Genetic Testing Registry NEDD9
NextProtQ14511 [Medical]
TSGene4739
GENETestsNEDD9
Target ValidationNEDD9
Huge Navigator NEDD9 [HugePedia]
snp3D : Map Gene to Disease4739
BioCentury BCIQNEDD9
ClinGenNEDD9
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4739
Chemical/Pharm GKB GenePA31538
Clinical trialNEDD9
Miscellaneous
canSAR (ICR)NEDD9 (select the gene name)
Probes
Litterature
PubMed118 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNEDD9
EVEXNEDD9
GoPubMedNEDD9
iHOPNEDD9
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:25:58 CET 2017

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