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NEGR1 (neuronal growth regulator 1)

Identity

Alias_symbol (synonym)KILON
MGC46680
Ntra
IGLON4
Other aliasDMML2433
HGNC (Hugo) NEGR1
LocusID (NCBI) 257194
Atlas_Id 51177
Location 1p31.1  [Link to chromosome band 1p31]
Location_base_pair Starts at 71402942 and ends at 72282594 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
C1orf112 (1q24.2) / NEGR1 (1p31.1)CLU (8p21.1) / NEGR1 (1p31.1)ETS1 (11q24.3) / NEGR1 (1p31.1)
MYO6 (6q14.1) / NEGR1 (1p31.1)NEGR1 (1p31.1) / ASXL2 (2p23.3)NEGR1 (1p31.1) / ERICH3 (1p31.1)
NEGR1 (1p31.1) / ETS1 (11q24.3)NEGR1 (1p31.1) / RBM3 (Xp11.23)NEGR1 (1p31.1) / SRSF11 (1p31.1)
NEGR1 (1p31.1) / ZRANB2 (1p31.1)RMST (12q23.1) / NEGR1 (1p31.1)RNF122 (8p12) / NEGR1 (1p31.1)
WHSC1L1 (8p11.23) / NEGR1 (1p31.1)MYO6 6q14.1 / NEGR1 1p31.1NEGR1 1p31.1 C1orf173
NEGR1 1p31.1 / ZRANB2 1p31.1RNF122 8p12 / NEGR1 1p31.1WHSC1L1 8p11.23 / NEGR1 1p31.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Squamous Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)NEGR1   17302
Cards
Entrez_Gene (NCBI)NEGR1  257194  neuronal growth regulator 1
AliasesDMML2433; IGLON4; KILON; Ntra
GeneCards (Weizmann)NEGR1
Ensembl hg19 (Hinxton)ENSG00000172260 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000172260 [Gene_View]  chr1:71402942-72282594 [Contig_View]  NEGR1 [Vega]
ICGC DataPortalENSG00000172260
TCGA cBioPortalNEGR1
AceView (NCBI)NEGR1
Genatlas (Paris)NEGR1
WikiGenes257194
SOURCE (Princeton)NEGR1
Genetics Home Reference (NIH)NEGR1
Genomic and cartography
GoldenPath hg38 (UCSC)NEGR1  -     chr1:71402942-72282594 -  1p31.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NEGR1  -     1p31.1   [Description]    (hg19-Feb_2009)
EnsemblNEGR1 - 1p31.1 [CytoView hg19]  NEGR1 - 1p31.1 [CytoView hg38]
Mapping of homologs : NCBINEGR1 [Mapview hg19]  NEGR1 [Mapview hg38]
OMIM613173   
Gene and transcription
Genbank (Entrez)AK092307 AK295481 BC036771 BX538014 BX648027
RefSeq transcript (Entrez)NM_173808
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NEGR1
Cluster EST : UnigeneHs.146542 [ NCBI ]
CGAP (NCI)Hs.146542
Alternative Splicing GalleryENSG00000172260
Gene ExpressionNEGR1 [ NCBI-GEO ]   NEGR1 [ EBI - ARRAY_EXPRESS ]   NEGR1 [ SEEK ]   NEGR1 [ MEM ]
Gene Expression Viewer (FireBrowse)NEGR1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)257194
GTEX Portal (Tissue expression)NEGR1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ7Z3B1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ7Z3B1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ7Z3B1
Splice isoforms : SwissVarQ7Z3B1
PhosPhoSitePlusQ7Z3B1
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)   
Domains : Interpro (EBI)Ig-like_dom    Ig-like_fold    Ig_I-set    Ig_sub    Ig_sub2   
Domain families : Pfam (Sanger)I-set (PF07679)   
Domain families : Pfam (NCBI)pfam07679   
Domain families : Smart (EMBL)IG (SM00409)  IGc2 (SM00408)  
Conserved Domain (NCBI)NEGR1
DMDM Disease mutations257194
Blocks (Seattle)NEGR1
SuperfamilyQ7Z3B1
Human Protein AtlasENSG00000172260
Peptide AtlasQ7Z3B1
HPRD14820
IPIIPI00176221   IPI00645710   
Protein Interaction databases
DIP (DOE-UCLA)Q7Z3B1
IntAct (EBI)Q7Z3B1
FunCoupENSG00000172260
BioGRIDNEGR1
STRING (EMBL)NEGR1
ZODIACNEGR1
Ontologies - Pathways
QuickGOQ7Z3B1
Ontology : AmiGOprotein binding  extracellular region  plasma membrane  C-terminal protein lipidation  locomotory behavior  feeding behavior  positive regulation of neuron projection development  single organismal cell-cell adhesion  anchored component of membrane  extracellular exosome  
Ontology : EGO-EBIprotein binding  extracellular region  plasma membrane  C-terminal protein lipidation  locomotory behavior  feeding behavior  positive regulation of neuron projection development  single organismal cell-cell adhesion  anchored component of membrane  extracellular exosome  
Pathways : KEGGCell adhesion molecules (CAMs)   
NDEx NetworkNEGR1
Atlas of Cancer Signalling NetworkNEGR1
Wikipedia pathwaysNEGR1
Orthology - Evolution
OrthoDB257194
GeneTree (enSembl)ENSG00000172260
Phylogenetic Trees/Animal Genes : TreeFamNEGR1
HOVERGENQ7Z3B1
HOGENOMQ7Z3B1
Homologs : HomoloGeneNEGR1
Homology/Alignments : Family Browser (UCSC)NEGR1
Gene fusions - Rearrangements
Fusion : MitelmanETS1/NEGR1 [11q24.3/1p31.1]  [t(1;11)(p31;q24)]  
Fusion : MitelmanMYO6/NEGR1 [6q14.1/1p31.1]  [t(1;6)(p31;q14)]  
Fusion : MitelmanNEGR1/ERICH3 [1p31.1/1p31.1]  [t(1;1)(p31;p31)]  
Fusion : MitelmanNEGR1/ETS1 [1p31.1/11q24.3]  [t(1;11)(p31;q24)]  
Fusion : MitelmanNEGR1/ZRANB2 [1p31.1/1p31.1]  [t(1;1)(p31;p31)]  
Fusion : MitelmanRNF122/NEGR1 [8p12/1p31.1]  [t(1;8)(p31;p12)]  
Fusion : MitelmanWHSC1L1/NEGR1 [8p11.23/1p31.1]  [t(1;8)(p31;p12)]  
Fusion: TCGAMYO6 6q14.1 NEGR1 1p31.1 PRAD
Fusion: TCGANEGR1 1p31.1 C1orf173 BRCA
Fusion: TCGANEGR1 1p31.1 ZRANB2 1p31.1 GBM
Fusion: TCGARNF122 8p12 NEGR1 1p31.1 BRCA
Fusion: TCGAWHSC1L1 8p11.23 NEGR1 1p31.1 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNEGR1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NEGR1
dbVarNEGR1
ClinVarNEGR1
1000_GenomesNEGR1 
Exome Variant ServerNEGR1
ExAC (Exome Aggregation Consortium)NEGR1 (select the gene name)
Genetic variants : HAPMAP257194
Genomic Variants (DGV)NEGR1 [DGVbeta]
DECIPHERNEGR1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNEGR1 
Mutations
ICGC Data PortalNEGR1 
TCGA Data PortalNEGR1 
Broad Tumor PortalNEGR1
OASIS PortalNEGR1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNEGR1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNEGR1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NEGR1
DgiDB (Drug Gene Interaction Database)NEGR1
DoCM (Curated mutations)NEGR1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NEGR1 (select a term)
intoGenNEGR1
Cancer3DNEGR1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM613173   
Orphanet
MedgenNEGR1
Genetic Testing Registry NEGR1
NextProtQ7Z3B1 [Medical]
TSGene257194
GENETestsNEGR1
Target ValidationNEGR1
Huge Navigator NEGR1 [HugePedia]
snp3D : Map Gene to Disease257194
BioCentury BCIQNEGR1
ClinGenNEGR1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD257194
Chemical/Pharm GKB GenePA134862452
Clinical trialNEGR1
Miscellaneous
canSAR (ICR)NEGR1 (select the gene name)
Probes
Litterature
PubMed50 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNEGR1
EVEXNEGR1
GoPubMedNEGR1
iHOPNEGR1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 25 19:21:53 CEST 2017

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