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NEGR1 (neuronal growth regulator 1)

Identity

Alias (NCBI)DMML2433
IGLON4
KILON
Ntra
HGNC (Hugo) NEGR1
HGNC Alias symbKILON
MGC46680
Ntra
IGLON4
HGNC Alias namea kindred of IgLON
 neurotractin
 IgLON family member 4
LocusID (NCBI) 257194
Atlas_Id 51177
Location 1p31.1  [Link to chromosome band 1p31]
Location_base_pair Starts at 71395943 and ends at 72282539 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
C1orf112 (1q24.2)::NEGR1 (1p31.1)CLU (8p21.1)::NEGR1 (1p31.1)ETS1 (11q24.3)::NEGR1 (1p31.1)
MYO6 (6q14.1)::NEGR1 (1p31.1)NEGR1 (1p31.1)::ASXL2 (2p23.3)NEGR1 (1p31.1)::ERICH3 (1p31.1)
NEGR1 (1p31.1)::ETS1 (11q24.3)NEGR1 (1p31.1)::RBM3 (Xp11.23)NEGR1 (1p31.1)::SRSF11 (1p31.1)
NEGR1 (1p31.1)::ZRANB2 (1p31.1)RMST (12q23.1)::NEGR1 (1p31.1)RNF122 (8p12)::NEGR1 (1p31.1)
WHSC1L1 (8p11.23)::NEGR1 (1p31.1)MYO6 6q14.1::NEGR1 1p31.1NEGR1 1p31.1 C1orf173
NEGR1 1p31.1::ZRANB2 1p31.1RNF122 8p12::NEGR1 1p31.1WHSC1L1 8p11.23::NEGR1 1p31.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)NEGR1   17302
Cards
Entrez_Gene (NCBI)NEGR1    neuronal growth regulator 1
AliasesDMML2433; IGLON4; KILON; Ntra
GeneCards (Weizmann)NEGR1
Ensembl hg19 (Hinxton)ENSG00000172260 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000172260 [Gene_View]  ENSG00000172260 [Sequence]  chr1:71395943-72282539 [Contig_View]  NEGR1 [Vega]
ICGC DataPortalENSG00000172260
TCGA cBioPortalNEGR1
AceView (NCBI)NEGR1
Genatlas (Paris)NEGR1
SOURCE (Princeton)NEGR1
Genetics Home Reference (NIH)NEGR1
Genomic and cartography
GoldenPath hg38 (UCSC)NEGR1  -     chr1:71395943-72282539 -  1p31.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NEGR1  -     1p31.1   [Description]    (hg19-Feb_2009)
GoldenPathNEGR1 - 1p31.1 [CytoView hg19]  NEGR1 - 1p31.1 [CytoView hg38]
ImmunoBaseENSG00000172260
Genome Data Viewer NCBINEGR1 [Mapview hg19]  
OMIM613173   
Gene and transcription
Genbank (Entrez)AK092307 AK295481 BC036771 BX538014 BX648027
RefSeq transcript (Entrez)NM_173808
Consensus coding sequences : CCDS (NCBI)NEGR1
Gene ExpressionNEGR1 [ NCBI-GEO ]   NEGR1 [ EBI - ARRAY_EXPRESS ]   NEGR1 [ SEEK ]   NEGR1 [ MEM ]
Gene Expression Viewer (FireBrowse)NEGR1 [ Firebrowse - Broad ]
GenevisibleExpression of NEGR1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)257194
GTEX Portal (Tissue expression)NEGR1
Human Protein AtlasENSG00000172260-NEGR1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ7Z3B1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ7Z3B1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ7Z3B1
PhosPhoSitePlusQ7Z3B1
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)   
Domains : Interpro (EBI)Ig-like_dom    Ig-like_dom_sf    Ig-like_fold    Ig_I-set    Ig_sub    Ig_sub2   
Domain families : Pfam (Sanger)I-set (PF07679)   
Domain families : Pfam (NCBI)pfam07679   
Domain families : Smart (EMBL)IG (SM00409)  IGc2 (SM00408)  
Conserved Domain (NCBI)NEGR1
PDB (RSDB)6DLD    6U6T   
PDB Europe6DLD    6U6T   
PDB (PDBSum)6DLD    6U6T   
PDB (IMB)6DLD    6U6T   
Structural Biology KnowledgeBase6DLD    6U6T   
SCOP (Structural Classification of Proteins)6DLD    6U6T   
CATH (Classification of proteins structures)6DLD    6U6T   
SuperfamilyQ7Z3B1
AlphaFold pdb e-kbQ7Z3B1   
Human Protein Atlas [tissue]ENSG00000172260-NEGR1 [tissue]
HPRD14820
Protein Interaction databases
DIP (DOE-UCLA)Q7Z3B1
IntAct (EBI)Q7Z3B1
BioGRIDNEGR1
STRING (EMBL)NEGR1
ZODIACNEGR1
Ontologies - Pathways
QuickGOQ7Z3B1
Ontology : AmiGOprotein binding  extracellular region  plasma membrane  locomotory behavior  feeding behavior  positive regulation of neuron projection development  anchored component of membrane  cell-cell adhesion  
Ontology : EGO-EBIprotein binding  extracellular region  plasma membrane  locomotory behavior  feeding behavior  positive regulation of neuron projection development  anchored component of membrane  cell-cell adhesion  
Pathways : KEGGCell adhesion molecules (CAMs)   
NDEx NetworkNEGR1
Atlas of Cancer Signalling NetworkNEGR1
Wikipedia pathwaysNEGR1
Orthology - Evolution
OrthoDB257194
GeneTree (enSembl)ENSG00000172260
Phylogenetic Trees/Animal Genes : TreeFamNEGR1
Homologs : HomoloGeneNEGR1
Homology/Alignments : Family Browser (UCSC)NEGR1
Gene fusions - Rearrangements
Fusion : MitelmanETS1::NEGR1 [11q24.3/1p31.1]  
Fusion : MitelmanMYO6::NEGR1 [6q14.1/1p31.1]  
Fusion : MitelmanNEGR1::ERICH3 [1p31.1/1p31.1]  
Fusion : MitelmanNEGR1::ETS1 [1p31.1/11q24.3]  
Fusion : MitelmanNEGR1::ZRANB2 [1p31.1/1p31.1]  
Fusion : MitelmanRNF122::NEGR1 [8p12/1p31.1]  
Fusion : MitelmanWHSC1L1::NEGR1 [8p11.23/1p31.1]  
Fusion : QuiverNEGR1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNEGR1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NEGR1
dbVarNEGR1
ClinVarNEGR1
MonarchNEGR1
1000_GenomesNEGR1 
Exome Variant ServerNEGR1
GNOMAD BrowserENSG00000172260
Varsome BrowserNEGR1
ACMGNEGR1 variants
VarityQ7Z3B1
Genomic Variants (DGV)NEGR1 [DGVbeta]
DECIPHERNEGR1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNEGR1 
Mutations
ICGC Data PortalNEGR1 
TCGA Data PortalNEGR1 
Broad Tumor PortalNEGR1
OASIS PortalNEGR1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNEGR1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DNEGR1
Mutations and Diseases : HGMDNEGR1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaNEGR1
DgiDB (Drug Gene Interaction Database)NEGR1
DoCM (Curated mutations)NEGR1
CIViC (Clinical Interpretations of Variants in Cancer)NEGR1
Cancer3DNEGR1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM613173   
Orphanet
DisGeNETNEGR1
MedgenNEGR1
Genetic Testing Registry NEGR1
NextProtQ7Z3B1 [Medical]
GENETestsNEGR1
Target ValidationNEGR1
Huge Navigator NEGR1 [HugePedia]
ClinGenNEGR1
Clinical trials, drugs, therapy
MyCancerGenomeNEGR1
Protein Interactions : CTDNEGR1
Pharm GKB GenePA134862452
PharosQ7Z3B1
Clinical trialNEGR1
Miscellaneous
canSAR (ICR)NEGR1
HarmonizomeNEGR1
ARCHS4NEGR1
DataMed IndexNEGR1
Probes
Litterature
PubMed62 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXNEGR1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sun Jan 16 18:24:31 CET 2022

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