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NEIL2 (nei like DNA glycosylase 2)

Identity

Alias_namesnei like 2 (E. coli)
nei endonuclease VIII-like 2 (E. coli)
Alias_symbol (synonym)NEH2
FLJ31644
MGC2832
MGC4505
Other aliasNEI2
HGNC (Hugo) NEIL2
LocusID (NCBI) 252969
Atlas_Id 41520
Location 8p23.1  [Link to chromosome band 8p23]
Location_base_pair Starts at 11627172 and ends at 11644854 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
FDFT1 (8p23.1) / NEIL2 (8p23.1)FDFT1 8p23.1 / NEIL2 8p23.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NEIL2   18956
Cards
Entrez_Gene (NCBI)NEIL2  252969  nei like DNA glycosylase 2
AliasesNEH2; NEI2
GeneCards (Weizmann)NEIL2
Ensembl hg19 (Hinxton)ENSG00000154328 [Gene_View]  chr8:11627172-11644854 [Contig_View]  NEIL2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000154328 [Gene_View]  chr8:11627172-11644854 [Contig_View]  NEIL2 [Vega]
ICGC DataPortalENSG00000154328
TCGA cBioPortalNEIL2
AceView (NCBI)NEIL2
Genatlas (Paris)NEIL2
WikiGenes252969
SOURCE (Princeton)NEIL2
Genetics Home Reference (NIH)NEIL2
Genomic and cartography
GoldenPath hg19 (UCSC)NEIL2  -     chr8:11627172-11644854 +  8p23.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)NEIL2  -     8p23.1   [Description]    (hg38-Dec_2013)
EnsemblNEIL2 - 8p23.1 [CytoView hg19]  NEIL2 - 8p23.1 [CytoView hg38]
Mapping of homologs : NCBINEIL2 [Mapview hg19]  NEIL2 [Mapview hg38]
OMIM608933   
Gene and transcription
Genbank (Entrez)AB079070 AK056206 AK097389 AK225837 AK294224
RefSeq transcript (Entrez)NM_001135746 NM_001135747 NM_001135748 NM_145043
RefSeq genomic (Entrez)NC_000008 NC_018919 NT_077531 NW_004929336
Consensus coding sequences : CCDS (NCBI)NEIL2
Cluster EST : UnigeneHs.293818 [ NCBI ]
CGAP (NCI)Hs.293818
Alternative Splicing GalleryENSG00000154328
Gene ExpressionNEIL2 [ NCBI-GEO ]   NEIL2 [ EBI - ARRAY_EXPRESS ]   NEIL2 [ SEEK ]   NEIL2 [ MEM ]
Gene Expression Viewer (FireBrowse)NEIL2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)252969
GTEX Portal (Tissue expression)NEIL2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ969S2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ969S2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ969S2
Splice isoforms : SwissVarQ969S2
Catalytic activity : Enzyme3.2.2.- [ Enzyme-Expasy ]   3.2.2.-3.2.2.- [ IntEnz-EBI ]   3.2.2.- [ BRENDA ]   3.2.2.- [ KEGG ]   
PhosPhoSitePlusQ969S2
Domaine pattern : Prosite (Expaxy)FPG_CAT (PS51068)    ZF_FPG_2 (PS51066)   
Domains : Interpro (EBI)DNA_glyclase/AP_lyase_DNA-bd    FPG_cat    Ribosomal_S13-like_H2TH    Znf_DNA_glyclase/AP_lyase   
Domain families : Pfam (Sanger)H2TH (PF06831)   
Domain families : Pfam (NCBI)pfam06831   
Conserved Domain (NCBI)NEIL2
DMDM Disease mutations252969
Blocks (Seattle)NEIL2
PDB (SRS)1VZP   
PDB (PDBSum)1VZP   
PDB (IMB)1VZP   
PDB (RSDB)1VZP   
Structural Biology KnowledgeBase1VZP   
SCOP (Structural Classification of Proteins)1VZP   
CATH (Classification of proteins structures)1VZP   
SuperfamilyQ969S2
Human Protein AtlasENSG00000154328
Peptide AtlasQ969S2
HPRD16406
IPIIPI00410616   IPI00478031   IPI00478436   IPI00902701   IPI00984002   IPI00983488   
Protein Interaction databases
DIP (DOE-UCLA)Q969S2
IntAct (EBI)Q969S2
FunCoupENSG00000154328
BioGRIDNEIL2
STRING (EMBL)NEIL2
ZODIACNEIL2
Ontologies - Pathways
QuickGOQ969S2
Ontology : AmiGOdamaged DNA binding  DNA-(apurinic or apyrimidinic site) lyase activity  protein binding  nucleoplasm  cytoplasm  spindle microtubule  nucleotide-excision repair  microtubule binding  zinc ion binding  DNA N-glycosylase activity  depyrimidination  
Ontology : EGO-EBIdamaged DNA binding  DNA-(apurinic or apyrimidinic site) lyase activity  protein binding  nucleoplasm  cytoplasm  spindle microtubule  nucleotide-excision repair  microtubule binding  zinc ion binding  DNA N-glycosylase activity  depyrimidination  
Pathways : KEGGBase excision repair   
NDEx NetworkNEIL2
Atlas of Cancer Signalling NetworkNEIL2
Wikipedia pathwaysNEIL2
Orthology - Evolution
OrthoDB252969
GeneTree (enSembl)ENSG00000154328
Phylogenetic Trees/Animal Genes : TreeFamNEIL2
HOVERGENQ969S2
HOGENOMQ969S2
Homologs : HomoloGeneNEIL2
Homology/Alignments : Family Browser (UCSC)NEIL2
Gene fusions - Rearrangements
Fusion : MitelmanFDFT1/NEIL2 [8p23.1/8p23.1]  [t(8;8)(p23;p23)]  
Fusion: TCGAFDFT1 8p23.1 NEIL2 8p23.1 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNEIL2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NEIL2
dbVarNEIL2
ClinVarNEIL2
1000_GenomesNEIL2 
Exome Variant ServerNEIL2
ExAC (Exome Aggregation Consortium)NEIL2 (select the gene name)
Genetic variants : HAPMAP252969
Genomic Variants (DGV)NEIL2 [DGVbeta]
DECIPHER (Syndromes)8:11627172-11644854  ENSG00000154328
CONAN: Copy Number AnalysisNEIL2 
Mutations
ICGC Data PortalNEIL2 
TCGA Data PortalNEIL2 
Broad Tumor PortalNEIL2
OASIS PortalNEIL2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNEIL2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNEIL2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NEIL2
DgiDB (Drug Gene Interaction Database)NEIL2
DoCM (Curated mutations)NEIL2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NEIL2 (select a term)
intoGenNEIL2
Cancer3DNEIL2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608933   
Orphanet
MedgenNEIL2
Genetic Testing Registry NEIL2
NextProtQ969S2 [Medical]
TSGene252969
GENETestsNEIL2
Huge Navigator NEIL2 [HugePedia]
snp3D : Map Gene to Disease252969
BioCentury BCIQNEIL2
ClinGenNEIL2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD252969
Chemical/Pharm GKB GenePA38769
Clinical trialNEIL2
Miscellaneous
canSAR (ICR)NEIL2 (select the gene name)
Probes
Litterature
PubMed40 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNEIL2
EVEXNEIL2
GoPubMedNEIL2
iHOPNEIL2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:12:02 CEST 2017

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