NEIL3 (nei like DNA glycosylase 3)

2005-02-01 Affiliation

Identity

HGNC

NEIL3

LOCATION

4q34.3

LOCUSID

55247

ALIAS

FGP2,FPG2,NEI3,ZGRF3,hFPG2,hNEI3

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 55247
MIM: 608934
HGNC: 24573
Ensembl: ENSG00000109674

Variants:

dbSNP: 55247
ClinVar: 55247
TCGA: ENSG00000109674
COSMIC: NEIL3

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000109674	ENST00000264596	Q8TAT5
ENSG00000109674	ENST00000513321	D6RAV1

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Base excision repair	KEGG	ko03410
Base excision repair	KEGG	hsa03410

References

Pubmed ID	Year	Title	Citations
12433996	2002	Human DNA glycosylases of the bacterial Fpg/MutM superfamily: an alternative pathway for the repair of 8-oxoguanine and other oxidation products in DNA.	95
23926102	2013	Neil3 and NEIL1 DNA glycosylases remove oxidative damages from quadruplex DNA and exhibit preferences for lesions in the telomeric sequence context.	43
23755964	2013	Human NEIL3 is mainly a monofunctional DNA glycosylase removing spiroimindiohydantoin and guanidinohydantoin.	37
27760045	2016	Deficiency of base excision repair enzyme NEIL3 drives increased predisposition to autoimmunity.	23
18270339	2008	Comprehensive analysis of DNA repair gene variants and risk of meningioma.	22
22365498	2012	Release from quiescence stimulates the expression of human NEIL3 under the control of the Ras dependent ERK-MAP kinase pathway.	21
19170771	2009	Human Nei-like protein NEIL3 has AP lyase activity specific for single-stranded DNA and confers oxidative stress resistance in Escherichia coli mutant.	20
22569481	2012	Expression and purification of active mouse and human NEIL3 proteins.	20
18515411	2008	Inherited predisposition to colorectal adenomas caused by multiple rare alleles of MUTYH but not OGG1, NUDT1, NTH1 or NEIL 1, 2 or 3.	16
27042257	2016	Abnormal Expressions of DNA Glycosylase Genes NEIL1, NEIL2, and NEIL3 Are Associated with Somatic Mutation Loads in Human Cancer.	11

Citation

Dessen P

NEIL3 (nei like DNA glycosylase 3)

Atlas Genet Cytogenet Oncol Haematol. 2005-02-01

Online version: http://atlasgeneticsoncology.org/gene/43003/neil3