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NEK1 (NIMA-related kinase 1)

Identity

Other namesNY-REN-55
SRPS2
SRPS2A
HGNC (Hugo) NEK1
LocusID (NCBI) 4750
Location 4q33
Location_base_pair Starts at 170314421 and ends at 170533778 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)NEK1   7744
Entrez_Gene (NCBI)NEK1  4750  NIMA-related kinase 1
Cards
GeneCards (Weizmann)NEK1
Ensembl (Hinxton)ENSG00000137601 [Gene_View]  chr4:170314421-170533778 [Contig_View]  NEK1 [Vega]
AceView (NCBI)NEK1
Genatlas (Paris)NEK1
SOURCE (Stanford)NM_001199397 NM_001199398 NM_001199399 NM_001199400 NM_012224
Genomic and cartography
GoldenPath (UCSC)NEK1  -  4q33   chr4:170314421-170533778 -  4q33   [Description]    (hg19-Feb_2009)
EnsemblNEK1 - 4q33 [CytoView]
Mapping of homologs : NCBINEK1 [Mapview]
OMIM253520   263520   604588   
Gene and transcription
Genbank (Entrez)AB067488 AF155113 AI984346 AK025658 AK027580
RefSeq transcript (SRS)NM_001199397 NM_001199398 NM_001199399 NM_001199400 NM_012224
RefSeq transcript (Entrez)NM_001199397 NM_001199398 NM_001199399 NM_001199400 NM_012224
RefSeq genomic (SRS)AC_000136 NC_000004 NC_018915 NG_027982 NT_016354 NW_001838921 NW_004078021
RefSeq genomic (Entrez)AC_000136 NC_000004 NC_018915 NG_027982 NT_016354 NW_001838921 NW_004078021
Consensus coding sequences : CCDS (NCBI)NEK1
Cluster EST : UnigeneHs.481181 [ SRS ] Hs.481181 [ NCBI ]
CGAP (NCI)Hs.481181
Alternative Splicing : Fast-db (Paris)GSHG0023636
Alternative Splicing GalleryENSG00000137601
Gene ExpressionNEK1 [ NCBI-GEO ]   NEK1 [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96PY6 (SRS) Q96PY6 (Uniprot)
NextProtQ96PY6
With graphics : InterProQ96PY6
Splice isoforms : SwissVarQ96PY6(Swissvar)
Domaine pattern : Prosite (SRS)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (SRS)Kinase-like_dom    Prot_kinase_cat_dom    Protein_kinase_ATP_BS    Ser/Thr_dual-sp_kinase_dom    Ser/Thr_kinase_AS   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_cat_dom    Protein_kinase_ATP_BS    Ser/Thr_dual-sp_kinase_dom    Ser/Thr_kinase_AS   
Related proteins : CluSTrQ96PY6
Domain families : Pfam (SRS)Pkinase (PF00069)   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
DMDM4750
Blocks (Seattle)Q96PY6
PDB (SRS)4APC    4B9D   
PDB (PDBSum)4APC    4B9D   
PDB (IMB)4APC    4B9D   
PDB (RSDB)4APC    4B9D   
Human Protein AtlasENSG00000137601
HPRD06847
IPIIPI00044749   IPI00219958   IPI00747017   IPI00909179   IPI00909379   IPI00783100   IPI00968167   IPI00967891   
Protein Interaction databases
DIP (DOE-UCLA)Q96PY6
IntAct (EBI)Q96PY6
FunCoupENSG00000137601
REACTOMENEK1
Protein Interaction Database4750
BioGRIDNEK1
InParanoidQ96PY6
Interologous Interaction database Q96PY6
IntegromeDBNEK1
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)NEK1
SNP (GeneSNP Utah)NEK1
SNP : HGBaseNEK1
Genetic variants : HAPMAPNEK1
Somatic Mutations in Cancer : COSMICNEK1 
CONAN: Copy Number AnalysisNEK1 
Mutations and Diseases : HGMDNEK1
OMIM253520    263520    604588   
GENETests253520    263520    604588   
Disease Genetic AssociationNEK1
Huge Navigator NEK1 [HugePedia]  NEK1 [HugeCancerGEM]
Genomic VariantsNEK1  NEK1 [DGVbeta]
ClinVarNEK1
snp3D : Map Gene to Disease4750
General knowledge
Homologs : HomoloGeneNEK1
Homology/Alignments : Family Browser (UCSC)NEK1
Phylogenetic Trees/Animal Genes : TreeFamNEK1
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.1 [ Enzyme-SRS ]   2.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
Chemical/Protein Interactions : CTD4750
Chemical/Pharm GKB GenePA31545
Clinical trialNEK1
Cancer Resource (Charite)ENSG00000137601
Ontology : AmiGOpericentriolar material  protein kinase activity  protein serine/threonine kinase activity  protein tyrosine kinase activity  protein binding  ATP binding  nucleus  nucleolus  cytoplasm  centrosome  response to DNA damage stimulus  mitosis  response to ionizing radiation  nuclear membrane  cilium assembly  metal ion binding  cell division  
Ontology : EGO-EBIpericentriolar material  protein kinase activity  protein serine/threonine kinase activity  protein tyrosine kinase activity  protein binding  ATP binding  nucleus  nucleolus  cytoplasm  centrosome  response to DNA damage stimulus  mitosis  response to ionizing radiation  nuclear membrane  cilium assembly  metal ion binding  cell division  
Other databases
Probes
Litterature
PubMed24 Pubmed reference(s) in Entrez
PubGeneNEK1
iHOPNEK1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jun 14 17:37:33 CEST 2013
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