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NEK1 (NIMA related kinase 1)

Identity

Alias_namesNIMA (never in mitosis gene a)-related kinase 1
Alias_symbol (synonym)NY-REN-55
KIAA1901
Other aliasSRPS2
SRPS2A
SRTD6
HGNC (Hugo) NEK1
LocusID (NCBI) 4750
Atlas_Id 43369
Location 4q33  [Link to chromosome band 4q33]
Location_base_pair Starts at 169393270 and ends at 169612627 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
NEK1 (4q33) / APPL1 (3p14.3)NEK1 (4q33) / RPS6KC1 (1q32.3)NKAIN2 (6q22.31) / NEK1 (4q33)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NEK1   7744
Cards
Entrez_Gene (NCBI)NEK1  4750  NIMA related kinase 1
AliasesNY-REN-55; SRPS2; SRPS2A; SRTD6
GeneCards (Weizmann)NEK1
Ensembl hg19 (Hinxton)ENSG00000137601 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000137601 [Gene_View]  chr4:169393270-169612627 [Contig_View]  NEK1 [Vega]
ICGC DataPortalENSG00000137601
TCGA cBioPortalNEK1
AceView (NCBI)NEK1
Genatlas (Paris)NEK1
WikiGenes4750
SOURCE (Princeton)NEK1
Genetics Home Reference (NIH)NEK1
Genomic and cartography
GoldenPath hg38 (UCSC)NEK1  -     chr4:169393270-169612627 -  4q33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NEK1  -     4q33   [Description]    (hg19-Feb_2009)
EnsemblNEK1 - 4q33 [CytoView hg19]  NEK1 - 4q33 [CytoView hg38]
Mapping of homologs : NCBINEK1 [Mapview hg19]  NEK1 [Mapview hg38]
OMIM263520   604588   
Gene and transcription
Genbank (Entrez)AB067488 AF155113 AI984346 AK025658 AK027580
RefSeq transcript (Entrez)NM_001199397 NM_001199398 NM_001199399 NM_001199400 NM_012224
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NEK1
Cluster EST : UnigeneHs.481181 [ NCBI ]
CGAP (NCI)Hs.481181
Alternative Splicing GalleryENSG00000137601
Gene ExpressionNEK1 [ NCBI-GEO ]   NEK1 [ EBI - ARRAY_EXPRESS ]   NEK1 [ SEEK ]   NEK1 [ MEM ]
Gene Expression Viewer (FireBrowse)NEK1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4750
GTEX Portal (Tissue expression)NEK1
Human Protein AtlasENSG00000137601-NEK1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96PY6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96PY6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96PY6
Splice isoforms : SwissVarQ96PY6
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusQ96PY6
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)NEK1
DMDM Disease mutations4750
Blocks (Seattle)NEK1
PDB (SRS)4APC    4B9D   
PDB (PDBSum)4APC    4B9D   
PDB (IMB)4APC    4B9D   
PDB (RSDB)4APC    4B9D   
Structural Biology KnowledgeBase4APC    4B9D   
SCOP (Structural Classification of Proteins)4APC    4B9D   
CATH (Classification of proteins structures)4APC    4B9D   
SuperfamilyQ96PY6
Human Protein Atlas [tissue]ENSG00000137601-NEK1 [tissue]
Peptide AtlasQ96PY6
HPRD06847
IPIIPI00044749   IPI00219958   IPI00747017   IPI00909179   IPI00909379   IPI00783100   IPI00968167   IPI00967891   
Protein Interaction databases
DIP (DOE-UCLA)Q96PY6
IntAct (EBI)Q96PY6
FunCoupENSG00000137601
BioGRIDNEK1
STRING (EMBL)NEK1
ZODIACNEK1
Ontologies - Pathways
QuickGOQ96PY6
Ontology : AmiGOpericentriolar material  protein kinase activity  signal transducer, downstream of receptor, with serine/threonine kinase activity  protein tyrosine kinase activity  protein binding  ATP binding  nucleus  cytoplasm  centrosome  protein phosphorylation  cell cycle  kinase activity  peptidyl-tyrosine phosphorylation  signal transduction by protein phosphorylation  metal ion binding  cell division  cilium assembly  
Ontology : EGO-EBIpericentriolar material  protein kinase activity  signal transducer, downstream of receptor, with serine/threonine kinase activity  protein tyrosine kinase activity  protein binding  ATP binding  nucleus  cytoplasm  centrosome  protein phosphorylation  cell cycle  kinase activity  peptidyl-tyrosine phosphorylation  signal transduction by protein phosphorylation  metal ion binding  cell division  cilium assembly  
NDEx NetworkNEK1
Atlas of Cancer Signalling NetworkNEK1
Wikipedia pathwaysNEK1
Orthology - Evolution
OrthoDB4750
GeneTree (enSembl)ENSG00000137601
Phylogenetic Trees/Animal Genes : TreeFamNEK1
HOVERGENQ96PY6
HOGENOMQ96PY6
Homologs : HomoloGeneNEK1
Homology/Alignments : Family Browser (UCSC)NEK1
Gene fusions - Rearrangements
Fusion: Tumor Portal NEK1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNEK1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NEK1
dbVarNEK1
ClinVarNEK1
1000_GenomesNEK1 
Exome Variant ServerNEK1
ExAC (Exome Aggregation Consortium)ENSG00000137601
GNOMAD BrowserENSG00000137601
Genetic variants : HAPMAP4750
Genomic Variants (DGV)NEK1 [DGVbeta]
DECIPHERNEK1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNEK1 
Mutations
ICGC Data PortalNEK1 
TCGA Data PortalNEK1 
Broad Tumor PortalNEK1
OASIS PortalNEK1 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDNEK1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NEK1
DgiDB (Drug Gene Interaction Database)NEK1
DoCM (Curated mutations)NEK1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NEK1 (select a term)
intoGenNEK1
Cancer3DNEK1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM263520    604588   
Orphanet12212   
MedgenNEK1
Genetic Testing Registry NEK1
NextProtQ96PY6 [Medical]
TSGene4750
GENETestsNEK1
Target ValidationNEK1
Huge Navigator NEK1 [HugePedia]
snp3D : Map Gene to Disease4750
BioCentury BCIQNEK1
ClinGenNEK1 (curated)
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4750
Chemical/Pharm GKB GenePA31545
Clinical trialNEK1
Miscellaneous
canSAR (ICR)NEK1 (select the gene name)
Probes
Litterature
PubMed39 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNEK1
EVEXNEK1
GoPubMedNEK1
iHOPNEK1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Nov 9 13:02:25 CET 2017

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