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NEK10 (NIMA related kinase 10)

Identity

Alias_namesNIMA (never in mitosis gene a)- related kinase 10
Alias_symbol (synonym)FLJ32685
Other alias-
HGNC (Hugo) NEK10
LocusID (NCBI) 152110
Atlas_Id 43370
Location 3p24.1  [Link to chromosome band 3p24]
Location_base_pair Starts at 27110903 and ends at 27216523 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
NEK10 (3p24.1) / DCUN1D4 (4q12)NEK10 (3p24.1) / QKI (6q26)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NEK10   18592
Cards
Entrez_Gene (NCBI)NEK10  152110  NIMA related kinase 10
Aliases
GeneCards (Weizmann)NEK10
Ensembl hg19 (Hinxton)ENSG00000163491 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000163491 [Gene_View]  chr3:27110903-27216523 [Contig_View]  NEK10 [Vega]
ICGC DataPortalENSG00000163491
TCGA cBioPortalNEK10
AceView (NCBI)NEK10
Genatlas (Paris)NEK10
WikiGenes152110
SOURCE (Princeton)NEK10
Genetics Home Reference (NIH)NEK10
Genomic and cartography
GoldenPath hg38 (UCSC)NEK10  -     chr3:27110903-27216523 -  3p24.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NEK10  -     3p24.1   [Description]    (hg19-Feb_2009)
EnsemblNEK10 - 3p24.1 [CytoView hg19]  NEK10 - 3p24.1 [CytoView hg38]
Mapping of homologs : NCBINEK10 [Mapview hg19]  NEK10 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AK057247 AK098832 AK123061 AK128585 BC045758
RefSeq transcript (Entrez)NM_001031741 NM_001304384 NM_152534 NM_199347
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NEK10
Cluster EST : UnigeneHs.743887 [ NCBI ]
CGAP (NCI)Hs.743887
Alternative Splicing GalleryENSG00000163491
Gene ExpressionNEK10 [ NCBI-GEO ]   NEK10 [ EBI - ARRAY_EXPRESS ]   NEK10 [ SEEK ]   NEK10 [ MEM ]
Gene Expression Viewer (FireBrowse)NEK10 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)152110
GTEX Portal (Tissue expression)NEK10
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6ZWH5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6ZWH5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6ZWH5
Splice isoforms : SwissVarQ6ZWH5
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusQ6ZWH5
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_TYR (PS00109)   
Domains : Interpro (EBI)ARM-like    ARM-type_fold    Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Tyr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Conserved Domain (NCBI)NEK10
DMDM Disease mutations152110
Blocks (Seattle)NEK10
SuperfamilyQ6ZWH5
Human Protein AtlasENSG00000163491
Peptide AtlasQ6ZWH5
HPRD08135
IPIIPI00065454   IPI00807359   IPI00807338   IPI00419203   IPI00915026   IPI00743191   IPI00646668   IPI00941775   IPI01015790   IPI00927325   IPI00924531   IPI00925173   
Protein Interaction databases
DIP (DOE-UCLA)Q6ZWH5
IntAct (EBI)Q6ZWH5
FunCoupENSG00000163491
BioGRIDNEK10
STRING (EMBL)NEK10
ZODIACNEK10
Ontologies - Pathways
QuickGOQ6ZWH5
Ontology : AmiGOprotein kinase activity  protein serine/threonine kinase activity  ATP binding  protein phosphorylation  positive regulation of protein autophosphorylation  positive regulation of MAP kinase activity  metal ion binding  regulation of ERK1 and ERK2 cascade  regulation of cell cycle G2/M phase transition  protein kinase complex  
Ontology : EGO-EBIprotein kinase activity  protein serine/threonine kinase activity  ATP binding  protein phosphorylation  positive regulation of protein autophosphorylation  positive regulation of MAP kinase activity  metal ion binding  regulation of ERK1 and ERK2 cascade  regulation of cell cycle G2/M phase transition  protein kinase complex  
NDEx NetworkNEK10
Atlas of Cancer Signalling NetworkNEK10
Wikipedia pathwaysNEK10
Orthology - Evolution
OrthoDB152110
GeneTree (enSembl)ENSG00000163491
Phylogenetic Trees/Animal Genes : TreeFamNEK10
HOVERGENQ6ZWH5
HOGENOMQ6ZWH5
Homologs : HomoloGeneNEK10
Homology/Alignments : Family Browser (UCSC)NEK10
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNEK10 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NEK10
dbVarNEK10
ClinVarNEK10
1000_GenomesNEK10 
Exome Variant ServerNEK10
ExAC (Exome Aggregation Consortium)NEK10 (select the gene name)
Genetic variants : HAPMAP152110
Genomic Variants (DGV)NEK10 [DGVbeta]
DECIPHERNEK10 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNEK10 
Mutations
ICGC Data PortalNEK10 
TCGA Data PortalNEK10 
Broad Tumor PortalNEK10
OASIS PortalNEK10 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNEK10  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNEK10
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NEK10
DgiDB (Drug Gene Interaction Database)NEK10
DoCM (Curated mutations)NEK10 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NEK10 (select a term)
intoGenNEK10
Cancer3DNEK10(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
MedgenNEK10
Genetic Testing Registry NEK10
NextProtQ6ZWH5 [Medical]
TSGene152110
GENETestsNEK10
Target ValidationNEK10
Huge Navigator NEK10 [HugePedia]
snp3D : Map Gene to Disease152110
BioCentury BCIQNEK10
ClinGenNEK10
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD152110
Chemical/Pharm GKB GenePA38594
Clinical trialNEK10
Miscellaneous
canSAR (ICR)NEK10 (select the gene name)
Probes
Litterature
PubMed10 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNEK10
EVEXNEK10
GoPubMedNEK10
iHOPNEK10
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 17:08:56 CEST 2017

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