NEK11 (NIMA related kinase 11)

2006-10-01  

Identity

HGNC
LOCATION
3q22.1
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 79858
MIM: 609779
HGNC: 18593
Ensembl: ENSG00000114670

Variants:

dbSNP: 79858
ClinVar: 79858
TCGA: ENSG00000114670
COSMIC: NEK11

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000114670ENST00000356918Q8NG66
ENSG00000114670ENST00000383366Q8NG66
ENSG00000114670ENST00000507910Q8NG66
ENSG00000114670ENST00000508196Q8NG66
ENSG00000114670ENST00000510474D6RGV6
ENSG00000114670ENST00000510688Q8NG66
ENSG00000114670ENST00000510769E9PHI8
ENSG00000114670ENST00000511262Q8NG66
ENSG00000114670ENST00000514915D6RJF7
ENSG00000114670ENST00000602792A0A075B7B3

Expression (GTEx)

0
5
10
15
20
25

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
185198262008Molecular genetics of successful smoking cessation: convergent genome-wide association study results.130
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
197348892009NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint.57
121540882002Nek11, a new member of the NIMA family of kinases, involved in DNA replication and genotoxic stress responses.29
200904222010NEK11: linking CHK1 and CDC25A in DNA damage checkpoint signaling.17
151619102004Nucleolar Nek11 is a novel target of Nek2A in G1/S-arrested cells.14
265013532015Loss of Nek11 Prevents G2/M Arrest and Promotes Cell Death in HCT116 Colorectal Cancer Cells Exposed to Therapeutic DNA Damaging Agents.8
249693182014Downregulation of NEK11 is associated with drug resistance in ovarian cancer.6

Citation

Dessen P

NEK11 (NIMA related kinase 11)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43371/nek11