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NEK11 (NIMA related kinase 11)

Identity

Alias_namesNIMA (never in mitosis gene a)- related kinase 11
Alias_symbol (synonym)FLJ23495
Other alias-
HGNC (Hugo) NEK11
LocusID (NCBI) 79858
Atlas_Id 43371
Location 3q22.1  [Link to chromosome band 3q22]
Location_base_pair Starts at 130745694 and ends at 131069309 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CAST (5q15) / NEK11 (3q22.1)NEK11 (3q22.1) / ATP2C1 (3q22.1)NEK11 (3q22.1) / BDH1 (3q29)
NEK11 (3q22.1) / DBNL (7p13)TOPBP1 (3q22.1) / NEK11 (3q22.1)NEK11 3q22.1 / ATP2C1 3q22.1
NEK11 3q22.1 / BDH1 3q29TOPBP1 3q22.1 / NEK11 3q22.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NEK11   18593
Cards
Entrez_Gene (NCBI)NEK11  79858  NIMA related kinase 11
Aliases
GeneCards (Weizmann)NEK11
Ensembl hg19 (Hinxton)ENSG00000114670 [Gene_View]  chr3:130745694-131069309 [Contig_View]  NEK11 [Vega]
Ensembl hg38 (Hinxton)ENSG00000114670 [Gene_View]  chr3:130745694-131069309 [Contig_View]  NEK11 [Vega]
ICGC DataPortalENSG00000114670
TCGA cBioPortalNEK11
AceView (NCBI)NEK11
Genatlas (Paris)NEK11
WikiGenes79858
SOURCE (Princeton)NEK11
Genetics Home Reference (NIH)NEK11
Genomic and cartography
GoldenPath hg19 (UCSC)NEK11  -     chr3:130745694-131069309 +  3q22.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)NEK11  -     3q22.1   [Description]    (hg38-Dec_2013)
EnsemblNEK11 - 3q22.1 [CytoView hg19]  NEK11 - 3q22.1 [CytoView hg38]
Mapping of homologs : NCBINEK11 [Mapview hg19]  NEK11 [Mapview hg38]
OMIM609779   
Gene and transcription
Genbank (Entrez)AB071996 AB071997 AK027148 AK123021 AK293261
RefSeq transcript (Entrez)NM_001146003 NM_001321220 NM_001321221 NM_001321222 NM_001321223 NM_001321224 NM_024800 NM_145910
RefSeq genomic (Entrez)NC_000003 NC_018914 NG_029225 NT_005612 NW_004929311
Consensus coding sequences : CCDS (NCBI)NEK11
Cluster EST : UnigeneHs.657336 [ NCBI ]
CGAP (NCI)Hs.657336
Alternative Splicing GalleryENSG00000114670
Gene ExpressionNEK11 [ NCBI-GEO ]   NEK11 [ EBI - ARRAY_EXPRESS ]   NEK11 [ SEEK ]   NEK11 [ MEM ]
Gene Expression Viewer (FireBrowse)NEK11 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)79858
GTEX Portal (Tissue expression)NEK11
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8NG66   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8NG66  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8NG66
Splice isoforms : SwissVarQ8NG66
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusQ8NG66
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Ser/Thr_dual-sp_kinase    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)NEK11
DMDM Disease mutations79858
Blocks (Seattle)NEK11
SuperfamilyQ8NG66
Human Protein AtlasENSG00000114670
Peptide AtlasQ8NG66
HPRD14821
IPIIPI00745916   IPI00745302   IPI00398836   IPI00789673   IPI00788917   IPI00909435   IPI00965297   IPI00966497   
Protein Interaction databases
DIP (DOE-UCLA)Q8NG66
IntAct (EBI)Q8NG66
FunCoupENSG00000114670
BioGRIDNEK11
STRING (EMBL)NEK11
ZODIACNEK11
Ontologies - Pathways
QuickGOQ8NG66
Ontology : AmiGOprotein serine/threonine kinase activity  protein binding  ATP binding  nucleoplasm  nucleolus  protein phosphorylation  histone phosphorylation  G2 DNA damage checkpoint  intra-S DNA damage checkpoint  intracellular signal transduction  mitotic cell cycle phase transition  metal ion binding  regulation of mitotic cell cycle phase transition  
Ontology : EGO-EBIprotein serine/threonine kinase activity  protein binding  ATP binding  nucleoplasm  nucleolus  protein phosphorylation  histone phosphorylation  G2 DNA damage checkpoint  intra-S DNA damage checkpoint  intracellular signal transduction  mitotic cell cycle phase transition  metal ion binding  regulation of mitotic cell cycle phase transition  
NDEx NetworkNEK11
Atlas of Cancer Signalling NetworkNEK11
Wikipedia pathwaysNEK11
Orthology - Evolution
OrthoDB79858
GeneTree (enSembl)ENSG00000114670
Phylogenetic Trees/Animal Genes : TreeFamNEK11
HOVERGENQ8NG66
HOGENOMQ8NG66
Homologs : HomoloGeneNEK11
Homology/Alignments : Family Browser (UCSC)NEK11
Gene fusions - Rearrangements
Fusion : MitelmanNEK11/ATP2C1 [3q22.1/3q22.1]  
Fusion : MitelmanNEK11/BDH1 [3q22.1/3q29]  [t(3;3)(q22;q29)]  
Fusion : MitelmanTOPBP1/NEK11 [3q22.1/3q22.1]  [t(3;3)(q22;q22)]  
Fusion: TCGANEK11 3q22.1 ATP2C1 3q22.1 BRCA
Fusion: TCGANEK11 3q22.1 BDH1 3q29 LGG
Fusion: TCGATOPBP1 3q22.1 NEK11 3q22.1 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNEK11 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NEK11
dbVarNEK11
ClinVarNEK11
1000_GenomesNEK11 
Exome Variant ServerNEK11
ExAC (Exome Aggregation Consortium)NEK11 (select the gene name)
Genetic variants : HAPMAP79858
Genomic Variants (DGV)NEK11 [DGVbeta]
DECIPHER (Syndromes)3:130745694-131069309  ENSG00000114670
CONAN: Copy Number AnalysisNEK11 
Mutations
ICGC Data PortalNEK11 
TCGA Data PortalNEK11 
Broad Tumor PortalNEK11
OASIS PortalNEK11 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNEK11  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNEK11
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NEK11
DgiDB (Drug Gene Interaction Database)NEK11
DoCM (Curated mutations)NEK11 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NEK11 (select a term)
intoGenNEK11
Cancer3DNEK11(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609779   
Orphanet
MedgenNEK11
Genetic Testing Registry NEK11
NextProtQ8NG66 [Medical]
TSGene79858
GENETestsNEK11
Huge Navigator NEK11 [HugePedia]
snp3D : Map Gene to Disease79858
BioCentury BCIQNEK11
ClinGenNEK11
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD79858
Chemical/Pharm GKB GenePA38595
Clinical trialNEK11
Miscellaneous
canSAR (ICR)NEK11 (select the gene name)
Probes
Litterature
PubMed19 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNEK11
EVEXNEK11
GoPubMedNEK11
iHOPNEK11
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:12:03 CEST 2017

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