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NEK2 (NIMA related kinase 2)

Identity

Alias_namesNIMA (never in mitosis gene a)-related kinase 2
Alias_symbol (synonym)NLK1
NEK2A
RP67
PPP1R111
Other aliasHsPK21
HGNC (Hugo) NEK2
LocusID (NCBI) 4751
Atlas_Id 43372
Location 1q32.3  [Link to chromosome band 1q32]
Location_base_pair Starts at 211658257 and ends at 211675630 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
NVL (1q42.11) / NEK2 (1q32.3)NVL 1q42.11 / NEK2 1q32.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NEK2   7745
Cards
Entrez_Gene (NCBI)NEK2  4751  NIMA related kinase 2
AliasesHsPK21; NEK2A; NLK1; PPP1R111; 
RP67
GeneCards (Weizmann)NEK2
Ensembl hg19 (Hinxton)ENSG00000117650 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000117650 [Gene_View]  chr1:211658257-211675630 [Contig_View]  NEK2 [Vega]
ICGC DataPortalENSG00000117650
TCGA cBioPortalNEK2
AceView (NCBI)NEK2
Genatlas (Paris)NEK2
WikiGenes4751
SOURCE (Princeton)NEK2
Genetics Home Reference (NIH)NEK2
Genomic and cartography
GoldenPath hg38 (UCSC)NEK2  -     chr1:211658257-211675630 -  1q32.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NEK2  -     1q32.3   [Description]    (hg19-Feb_2009)
EnsemblNEK2 - 1q32.3 [CytoView hg19]  NEK2 - 1q32.3 [CytoView hg38]
Mapping of homologs : NCBINEK2 [Mapview hg19]  NEK2 [Mapview hg38]
OMIM604043   615565   
Gene and transcription
Genbank (Entrez)AK223353 AK225522 AK303092 AY045701 AY863109
RefSeq transcript (Entrez)NM_001204182 NM_001204183 NM_002497
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NEK2
Cluster EST : UnigeneHs.153704 [ NCBI ]
CGAP (NCI)Hs.153704
Alternative Splicing GalleryENSG00000117650
Gene ExpressionNEK2 [ NCBI-GEO ]   NEK2 [ EBI - ARRAY_EXPRESS ]   NEK2 [ SEEK ]   NEK2 [ MEM ]
Gene Expression Viewer (FireBrowse)NEK2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4751
GTEX Portal (Tissue expression)NEK2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP51955   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP51955  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP51955
Splice isoforms : SwissVarP51955
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusP51955
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)NEK2
DMDM Disease mutations4751
Blocks (Seattle)NEK2
PDB (SRS)2JAV    2W5A    2W5B    2W5H    2WQO    2XK3    2XK4    2XK6    2XK7    2XK8    2XKC    2XKD    2XKE    2XKF    2XNM    2XNN    2XNO    2XNP    4A4X    4AFE    5M51    5M53    5M55    5M57   
PDB (PDBSum)2JAV    2W5A    2W5B    2W5H    2WQO    2XK3    2XK4    2XK6    2XK7    2XK8    2XKC    2XKD    2XKE    2XKF    2XNM    2XNN    2XNO    2XNP    4A4X    4AFE    5M51    5M53    5M55    5M57   
PDB (IMB)2JAV    2W5A    2W5B    2W5H    2WQO    2XK3    2XK4    2XK6    2XK7    2XK8    2XKC    2XKD    2XKE    2XKF    2XNM    2XNN    2XNO    2XNP    4A4X    4AFE    5M51    5M53    5M55    5M57   
PDB (RSDB)2JAV    2W5A    2W5B    2W5H    2WQO    2XK3    2XK4    2XK6    2XK7    2XK8    2XKC    2XKD    2XKE    2XKF    2XNM    2XNN    2XNO    2XNP    4A4X    4AFE    5M51    5M53    5M55    5M57   
Structural Biology KnowledgeBase2JAV    2W5A    2W5B    2W5H    2WQO    2XK3    2XK4    2XK6    2XK7    2XK8    2XKC    2XKD    2XKE    2XKF    2XNM    2XNN    2XNO    2XNP    4A4X    4AFE    5M51    5M53    5M55    5M57   
SCOP (Structural Classification of Proteins)2JAV    2W5A    2W5B    2W5H    2WQO    2XK3    2XK4    2XK6    2XK7    2XK8    2XKC    2XKD    2XKE    2XKF    2XNM    2XNN    2XNO    2XNP    4A4X    4AFE    5M51    5M53    5M55    5M57   
CATH (Classification of proteins structures)2JAV    2W5A    2W5B    2W5H    2WQO    2XK3    2XK4    2XK6    2XK7    2XK8    2XKC    2XKD    2XKE    2XKF    2XNM    2XNN    2XNO    2XNP    4A4X    4AFE    5M51    5M53    5M55    5M57   
SuperfamilyP51955
Human Protein AtlasENSG00000117650
Peptide AtlasP51955
HPRD04953
IPIIPI00021331   IPI00647904   IPI00641713   IPI01025730   IPI01014791   IPI00977760   
Protein Interaction databases
DIP (DOE-UCLA)P51955
IntAct (EBI)P51955
FunCoupENSG00000117650
BioGRIDNEK2
STRING (EMBL)NEK2
ZODIACNEK2
Ontologies - Pathways
QuickGOP51955
Ontology : AmiGOmitotic sister chromatid segregation  G2/M transition of mitotic cell cycle  mitotic cell cycle  kinetochore  kinetochore  condensed chromosome kinetochore  condensed nuclear chromosome  spindle pole  blastocyst development  protein kinase activity  protein kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  nucleoplasm  nucleolus  centrosome  cytosol  microtubule  protein phosphorylation  protein phosphorylation  chromosome segregation  regulation of mitotic nuclear division  protein phosphatase binding  midbody  positive regulation of telomere maintenance via telomerase  protein complex  negative regulation of DNA binding  regulation of mitotic centrosome separation  regulation of mitotic centrosome separation  protein autophosphorylation  protein autophosphorylation  metal ion binding  spindle assembly  centrosome separation  cell division  meiotic cell cycle  positive regulation of telomerase activity  regulation of attachment of spindle microtubules to kinetochore  mitotic spindle assembly  ciliary basal body docking  negative regulation of centriole-centriole cohesion  positive regulation of telomere capping  
Ontology : EGO-EBImitotic sister chromatid segregation  G2/M transition of mitotic cell cycle  mitotic cell cycle  kinetochore  kinetochore  condensed chromosome kinetochore  condensed nuclear chromosome  spindle pole  blastocyst development  protein kinase activity  protein kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  nucleoplasm  nucleolus  centrosome  cytosol  microtubule  protein phosphorylation  protein phosphorylation  chromosome segregation  regulation of mitotic nuclear division  protein phosphatase binding  midbody  positive regulation of telomere maintenance via telomerase  protein complex  negative regulation of DNA binding  regulation of mitotic centrosome separation  regulation of mitotic centrosome separation  protein autophosphorylation  protein autophosphorylation  metal ion binding  spindle assembly  centrosome separation  cell division  meiotic cell cycle  positive regulation of telomerase activity  regulation of attachment of spindle microtubules to kinetochore  mitotic spindle assembly  ciliary basal body docking  negative regulation of centriole-centriole cohesion  positive regulation of telomere capping  
NDEx NetworkNEK2
Atlas of Cancer Signalling NetworkNEK2
Wikipedia pathwaysNEK2
Orthology - Evolution
OrthoDB4751
GeneTree (enSembl)ENSG00000117650
Phylogenetic Trees/Animal Genes : TreeFamNEK2
HOVERGENP51955
HOGENOMP51955
Homologs : HomoloGeneNEK2
Homology/Alignments : Family Browser (UCSC)NEK2
Gene fusions - Rearrangements
Fusion : MitelmanNVL/NEK2 [1q42.11/1q32.3]  [t(1;1)(q32;q42)]  
Fusion: TCGANVL 1q42.11 NEK2 1q32.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNEK2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NEK2
dbVarNEK2
ClinVarNEK2
1000_GenomesNEK2 
Exome Variant ServerNEK2
ExAC (Exome Aggregation Consortium)NEK2 (select the gene name)
Genetic variants : HAPMAP4751
Genomic Variants (DGV)NEK2 [DGVbeta]
DECIPHERNEK2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNEK2 
Mutations
ICGC Data PortalNEK2 
TCGA Data PortalNEK2 
Broad Tumor PortalNEK2
OASIS PortalNEK2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNEK2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNEK2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NEK2
DgiDB (Drug Gene Interaction Database)NEK2
DoCM (Curated mutations)NEK2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NEK2 (select a term)
intoGenNEK2
Cancer3DNEK2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604043    615565   
Orphanet659   
MedgenNEK2
Genetic Testing Registry NEK2
NextProtP51955 [Medical]
TSGene4751
GENETestsNEK2
Target ValidationNEK2
Huge Navigator NEK2 [HugePedia]
snp3D : Map Gene to Disease4751
BioCentury BCIQNEK2
ClinGenNEK2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4751
Chemical/Pharm GKB GenePA31546
Clinical trialNEK2
Miscellaneous
canSAR (ICR)NEK2 (select the gene name)
Probes
Litterature
PubMed117 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNEK2
EVEXNEK2
GoPubMedNEK2
iHOPNEK2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:46:36 CEST 2017

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