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NEK3 (NIMA related kinase 3)

Identity

Alias_namesNIMA (never in mitosis gene a)-related kinase 3
Alias_symbol (synonym)HSPK36
MGC29949
Other alias
HGNC (Hugo) NEK3
LocusID (NCBI) 4752
Atlas_Id 41521
Location 13q14.3  [Link to chromosome band 13q14]
Location_base_pair Starts at 52706779 and ends at 52733996 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
cytochrome_b () / NEK3 (13q14.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NEK3   7746
Cards
Entrez_Gene (NCBI)NEK3  4752  NIMA related kinase 3
AliasesHSPK36
GeneCards (Weizmann)NEK3
Ensembl hg19 (Hinxton)ENSG00000136098 [Gene_View]  chr13:52706779-52733996 [Contig_View]  NEK3 [Vega]
Ensembl hg38 (Hinxton)ENSG00000136098 [Gene_View]  chr13:52706779-52733996 [Contig_View]  NEK3 [Vega]
ICGC DataPortalENSG00000136098
TCGA cBioPortalNEK3
AceView (NCBI)NEK3
Genatlas (Paris)NEK3
WikiGenes4752
SOURCE (Princeton)NEK3
Genetics Home Reference (NIH)NEK3
Genomic and cartography
GoldenPath hg19 (UCSC)NEK3  -     chr13:52706779-52733996 -  13q14.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)NEK3  -     13q14.3   [Description]    (hg38-Dec_2013)
EnsemblNEK3 - 13q14.3 [CytoView hg19]  NEK3 - 13q14.3 [CytoView hg38]
Mapping of homologs : NCBINEK3 [Mapview hg19]  NEK3 [Mapview hg38]
OMIM604044   
Gene and transcription
Genbank (Entrez)AB072828 AI026881 AI209040 AK131359 AK290259
RefSeq transcript (Entrez)NM_001146099 NM_002498 NM_152720
RefSeq genomic (Entrez)NC_000013 NC_018924 NT_024524 NW_004929388
Consensus coding sequences : CCDS (NCBI)NEK3
Cluster EST : UnigeneHs.409989 [ NCBI ]
CGAP (NCI)Hs.409989
Alternative Splicing GalleryENSG00000136098
Gene ExpressionNEK3 [ NCBI-GEO ]   NEK3 [ EBI - ARRAY_EXPRESS ]   NEK3 [ SEEK ]   NEK3 [ MEM ]
Gene Expression Viewer (FireBrowse)NEK3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4752
GTEX Portal (Tissue expression)NEK3
Protein : pattern, domain, 3D structure
UniProt/SwissProtP51956   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP51956  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP51956
Splice isoforms : SwissVarP51956
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusP51956
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_dual-sp_kinase    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)NEK3
DMDM Disease mutations4752
Blocks (Seattle)NEK3
SuperfamilyP51956
Human Protein AtlasENSG00000136098
Peptide AtlasP51956
HPRD04954
IPIIPI00943072   IPI01020856   IPI00465101   IPI01022156   IPI01021046   IPI01022975   IPI01021549   
Protein Interaction databases
DIP (DOE-UCLA)P51956
IntAct (EBI)P51956
FunCoupENSG00000136098
BioGRIDNEK3
STRING (EMBL)NEK3
ZODIACNEK3
Ontologies - Pathways
QuickGOP51956
Ontology : AmiGOprotein serine/threonine kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  nucleus  nucleus  cytoplasm  centrosome  protein phosphorylation  protein phosphorylation  microtubule-based process  chromosome segregation  mitotic nuclear division  establishment of cell polarity  axon  metal ion binding  neuron projection morphogenesis  cell division  regulation of tubulin deacetylation  
Ontology : EGO-EBIprotein serine/threonine kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  nucleus  nucleus  cytoplasm  centrosome  protein phosphorylation  protein phosphorylation  microtubule-based process  chromosome segregation  mitotic nuclear division  establishment of cell polarity  axon  metal ion binding  neuron projection morphogenesis  cell division  regulation of tubulin deacetylation  
NDEx NetworkNEK3
Atlas of Cancer Signalling NetworkNEK3
Wikipedia pathwaysNEK3
Orthology - Evolution
OrthoDB4752
GeneTree (enSembl)ENSG00000136098
Phylogenetic Trees/Animal Genes : TreeFamNEK3
HOVERGENP51956
HOGENOMP51956
Homologs : HomoloGeneNEK3
Homology/Alignments : Family Browser (UCSC)NEK3
Gene fusions - Rearrangements
Fusion Cancer (Beijing)cytochrome_b [NEK3]  -  13q14.3 [FUSC000353]
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNEK3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NEK3
dbVarNEK3
ClinVarNEK3
1000_GenomesNEK3 
Exome Variant ServerNEK3
ExAC (Exome Aggregation Consortium)NEK3 (select the gene name)
Genetic variants : HAPMAP4752
Genomic Variants (DGV)NEK3 [DGVbeta]
DECIPHER (Syndromes)13:52706779-52733996  ENSG00000136098
CONAN: Copy Number AnalysisNEK3 
Mutations
ICGC Data PortalNEK3 
TCGA Data PortalNEK3 
Broad Tumor PortalNEK3
OASIS PortalNEK3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNEK3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNEK3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NEK3
DgiDB (Drug Gene Interaction Database)NEK3
DoCM (Curated mutations)NEK3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NEK3 (select a term)
intoGenNEK3
Cancer3DNEK3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604044   
Orphanet
MedgenNEK3
Genetic Testing Registry NEK3
NextProtP51956 [Medical]
TSGene4752
GENETestsNEK3
Huge Navigator NEK3 [HugePedia]
snp3D : Map Gene to Disease4752
BioCentury BCIQNEK3
ClinGenNEK3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4752
Chemical/Pharm GKB GenePA31547
Clinical trialNEK3
Miscellaneous
canSAR (ICR)NEK3 (select the gene name)
Probes
Litterature
PubMed17 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNEK3
EVEXNEK3
GoPubMedNEK3
iHOPNEK3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Tue Mar 14 13:18:36 CET 2017

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