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NEK4 (NIMA related kinase 4)

Identity

Alias_namesSTK2
serine/threonine kinase 2
NIMA (never in mitosis gene a)-related kinase 4
Alias_symbol (synonym)NRK2
pp12301
Other alias
HGNC (Hugo) NEK4
LocusID (NCBI) 6787
Atlas_Id 41522
Location 3p21.1  [Link to chromosome band 3p21]
Location_base_pair Starts at 52708449 and ends at 52770949 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
NEK4 (3p21.1) / CD3EAP (19q13.32)NEK4 (3p21.1) / SEPSECS (4p15.2)NEK4 (3p21.1) / SETD2 (3p21.31)
NEK4 (3p21.1) / SFMBT1 (3p21.1)PBRM1 (3p21.1) / NEK4 (3p21.1)NEK4 3p21.1 / SETD2 3p21.31
PBRM1 3p21.1 / NEK4 3p21.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Small Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)NEK4   11399
Cards
Entrez_Gene (NCBI)NEK4  6787  NIMA related kinase 4
AliasesNRK2; STK2; pp12301
GeneCards (Weizmann)NEK4
Ensembl hg19 (Hinxton)ENSG00000114904 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000114904 [Gene_View]  chr3:52708449-52770949 [Contig_View]  NEK4 [Vega]
ICGC DataPortalENSG00000114904
TCGA cBioPortalNEK4
AceView (NCBI)NEK4
Genatlas (Paris)NEK4
WikiGenes6787
SOURCE (Princeton)NEK4
Genetics Home Reference (NIH)NEK4
Genomic and cartography
GoldenPath hg38 (UCSC)NEK4  -     chr3:52708449-52770949 -  3p21.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NEK4  -     3p21.1   [Description]    (hg19-Feb_2009)
EnsemblNEK4 - 3p21.1 [CytoView hg19]  NEK4 - 3p21.1 [CytoView hg38]
Mapping of homologs : NCBINEK4 [Mapview hg19]  NEK4 [Mapview hg38]
OMIM601959   
Gene and transcription
Genbank (Entrez)AI860526 AK294165 AK312420 BC015515 BC063044
RefSeq transcript (Entrez)NM_001193533 NM_001348412 NM_001348413 NM_001348414 NM_003157
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NEK4
Cluster EST : UnigeneHs.631921 [ NCBI ]
CGAP (NCI)Hs.631921
Alternative Splicing GalleryENSG00000114904
Gene ExpressionNEK4 [ NCBI-GEO ]   NEK4 [ EBI - ARRAY_EXPRESS ]   NEK4 [ SEEK ]   NEK4 [ MEM ]
Gene Expression Viewer (FireBrowse)NEK4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6787
GTEX Portal (Tissue expression)NEK4
Human Protein AtlasENSG00000114904-NEK4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP51957   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP51957  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP51957
Splice isoforms : SwissVarP51957
PhosPhoSitePlusP51957
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)NEK4
DMDM Disease mutations6787
Blocks (Seattle)NEK4
SuperfamilyP51957
Human Protein Atlas [tissue]ENSG00000114904-NEK4 [tissue]
Peptide AtlasP51957
HPRD11880
IPIIPI00021333   IPI00440811   IPI00946811   IPI00946620   IPI00946789   
Protein Interaction databases
DIP (DOE-UCLA)P51957
IntAct (EBI)P51957
FunCoupENSG00000114904
BioGRIDNEK4
STRING (EMBL)NEK4
ZODIACNEK4
Ontologies - Pathways
QuickGOP51957
Ontology : AmiGOmitotic cell cycle  protein serine/threonine kinase activity  signal transducer, downstream of receptor, with serine/threonine kinase activity  ATP binding  cytoplasm  cytoplasm  cilium  protein phosphorylation  cellular response to DNA damage stimulus  signal transduction by protein phosphorylation  manganese ion binding  positive regulation of transcription, DNA-templated  cell division  regulation of replicative cell aging  regulation of cellular senescence  regulation of response to DNA damage stimulus  
Ontology : EGO-EBImitotic cell cycle  protein serine/threonine kinase activity  signal transducer, downstream of receptor, with serine/threonine kinase activity  ATP binding  cytoplasm  cytoplasm  cilium  protein phosphorylation  cellular response to DNA damage stimulus  signal transduction by protein phosphorylation  manganese ion binding  positive regulation of transcription, DNA-templated  cell division  regulation of replicative cell aging  regulation of cellular senescence  regulation of response to DNA damage stimulus  
NDEx NetworkNEK4
Atlas of Cancer Signalling NetworkNEK4
Wikipedia pathwaysNEK4
Orthology - Evolution
OrthoDB6787
GeneTree (enSembl)ENSG00000114904
Phylogenetic Trees/Animal Genes : TreeFamNEK4
HOVERGENP51957
HOGENOMP51957
Homologs : HomoloGeneNEK4
Homology/Alignments : Family Browser (UCSC)NEK4
Gene fusions - Rearrangements
Fusion : MitelmanNEK4/SETD2 [3p21.1/3p21.31]  
Fusion : MitelmanNEK4/SFMBT1 [3p21.1/3p21.1]  [t(3;3)(p21;p21)]  
Fusion : MitelmanPBRM1/NEK4 [3p21.1/3p21.1]  [t(3;3)(p21;p21)]  
Fusion: TCGA_MDACCNEK4 3p21.1 SETD2 3p21.31 BLCA
Fusion: TCGA_MDACCPBRM1 3p21.1 NEK4 3p21.1 SKCM
Tumor Fusion PortalNEK4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNEK4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NEK4
dbVarNEK4
ClinVarNEK4
1000_GenomesNEK4 
Exome Variant ServerNEK4
ExAC (Exome Aggregation Consortium)ENSG00000114904
GNOMAD BrowserENSG00000114904
Genetic variants : HAPMAP6787
Genomic Variants (DGV)NEK4 [DGVbeta]
DECIPHERNEK4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNEK4 
Mutations
ICGC Data PortalNEK4 
TCGA Data PortalNEK4 
Broad Tumor PortalNEK4
OASIS PortalNEK4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNEK4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNEK4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NEK4
DgiDB (Drug Gene Interaction Database)NEK4
DoCM (Curated mutations)NEK4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NEK4 (select a term)
intoGenNEK4
Cancer3DNEK4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601959   
Orphanet
DisGeNETNEK4
MedgenNEK4
Genetic Testing Registry NEK4
NextProtP51957 [Medical]
TSGene6787
GENETestsNEK4
Target ValidationNEK4
Huge Navigator NEK4 [HugePedia]
snp3D : Map Gene to Disease6787
BioCentury BCIQNEK4
ClinGenNEK4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6787
Chemical/Pharm GKB GenePA31548
Clinical trialNEK4
Miscellaneous
canSAR (ICR)NEK4 (select the gene name)
Probes
Litterature
PubMed22 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNEK4
EVEXNEK4
GoPubMedNEK4
iHOPNEK4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:26:00 CET 2017

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