NEK4 (NIMA related kinase 4)

2003-11-01  

Identity

HGNC
LOCATION
3p21.1
LOCUSID
ALIAS
NRK2,STK2,pp12301
FUSION GENES

Other Information

Locus ID:

NCBI: 6787
MIM: 601959
HGNC: 11399
Ensembl: ENSG00000114904

Variants:

dbSNP: 6787
ClinVar: 6787
TCGA: ENSG00000114904
COSMIC: NEK4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000114904ENST00000233027P51957
ENSG00000114904ENST00000383721P51957
ENSG00000114904ENST00000461689E7EX48
ENSG00000114904ENST00000487068H7C5M0
ENSG00000114904ENST00000496822F8WAX1
ENSG00000114904ENST00000535191P51957

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
194169212009Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry.114
207340642010A large-scale candidate gene association study of age at menarche and age at natural menopause.38
216852042011The ciliopathy-associated protein homologs RPGRIP1 and RPGRIP1L are linked to cilium integrity through interaction with Nek4 serine/threonine kinase.31
228516942012Nek4 regulates entry into replicative senescence and the response to DNA damage in human fibroblasts.21
201036362010Nek4 status differentially alters sensitivity to distinct microtubule poisons.16
208006032010Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.12
302478002018NEK4 kinase regulates EMT to promote lung cancer metastasis.5
276027542016Inhibition of never in mitosis A (NIMA)-related kinase-4 reduces survivin expression and sensitizes cancer cells to TRAIL-induced cell death.4

Citation

Dessen P

NEK4 (NIMA related kinase 4)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/41522/nek4