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NEK5 (NIMA related kinase 5)

Identity

Alias_namesNIMA (never in mitosis gene a)-related kinase 5
Other alias-
HGNC (Hugo) NEK5
LocusID (NCBI) 341676
Atlas_Id 43373
Location 13q14.3  [Link to chromosome band 13q14]
Location_base_pair Starts at 52638900 and ends at 52703228 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NEK5   7748
Cards
Entrez_Gene (NCBI)NEK5  341676  NIMA related kinase 5
Aliases
GeneCards (Weizmann)NEK5
Ensembl hg19 (Hinxton)ENSG00000197168 [Gene_View]  chr13:52638900-52703228 [Contig_View]  NEK5 [Vega]
Ensembl hg38 (Hinxton)ENSG00000197168 [Gene_View]  chr13:52638900-52703228 [Contig_View]  NEK5 [Vega]
ICGC DataPortalENSG00000197168
TCGA cBioPortalNEK5
AceView (NCBI)NEK5
Genatlas (Paris)NEK5
WikiGenes341676
SOURCE (Princeton)NEK5
Genetics Home Reference (NIH)NEK5
Genomic and cartography
GoldenPath hg19 (UCSC)NEK5  -     chr13:52638900-52703228 -  13q14.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)NEK5  -     13q14.3   [Description]    (hg38-Dec_2013)
EnsemblNEK5 - 13q14.3 [CytoView hg19]  NEK5 - 13q14.3 [CytoView hg38]
Mapping of homologs : NCBINEK5 [Mapview hg19]  NEK5 [Mapview hg38]
OMIM616731   
Gene and transcription
Genbank (Entrez)AK126330 BC063885 HY018243
RefSeq transcript (Entrez)NM_199289
RefSeq genomic (Entrez)NC_000013 NC_018924 NT_024524 NW_004929388
Consensus coding sequences : CCDS (NCBI)NEK5
Cluster EST : UnigeneHs.672144 [ NCBI ]
CGAP (NCI)Hs.672144
Alternative Splicing GalleryENSG00000197168
Gene ExpressionNEK5 [ NCBI-GEO ]   NEK5 [ EBI - ARRAY_EXPRESS ]   NEK5 [ SEEK ]   NEK5 [ MEM ]
Gene Expression Viewer (FireBrowse)NEK5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)341676
GTEX Portal (Tissue expression)NEK5
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6P3R8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6P3R8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6P3R8
Splice isoforms : SwissVarQ6P3R8
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusQ6P3R8
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_dual-sp_kinase    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)NEK5
DMDM Disease mutations341676
Blocks (Seattle)NEK5
SuperfamilyQ6P3R8
Human Protein AtlasENSG00000197168
Peptide AtlasQ6P3R8
IPIIPI00243995   IPI00977768   
Protein Interaction databases
DIP (DOE-UCLA)Q6P3R8
IntAct (EBI)Q6P3R8
FunCoupENSG00000197168
BioGRIDNEK5
STRING (EMBL)NEK5
ZODIACNEK5
Ontologies - Pathways
QuickGOQ6P3R8
Ontology : AmiGOprotein serine/threonine kinase activity  ATP binding  protein phosphorylation  metal ion binding  positive regulation of striated muscle cell differentiation  positive regulation of cysteine-type endopeptidase activity  
Ontology : EGO-EBIprotein serine/threonine kinase activity  ATP binding  protein phosphorylation  metal ion binding  positive regulation of striated muscle cell differentiation  positive regulation of cysteine-type endopeptidase activity  
NDEx NetworkNEK5
Atlas of Cancer Signalling NetworkNEK5
Wikipedia pathwaysNEK5
Orthology - Evolution
OrthoDB341676
GeneTree (enSembl)ENSG00000197168
Phylogenetic Trees/Animal Genes : TreeFamNEK5
HOVERGENQ6P3R8
HOGENOMQ6P3R8
Homologs : HomoloGeneNEK5
Homology/Alignments : Family Browser (UCSC)NEK5
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNEK5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NEK5
dbVarNEK5
ClinVarNEK5
1000_GenomesNEK5 
Exome Variant ServerNEK5
ExAC (Exome Aggregation Consortium)NEK5 (select the gene name)
Genetic variants : HAPMAP341676
Genomic Variants (DGV)NEK5 [DGVbeta]
DECIPHER (Syndromes)13:52638900-52703228  ENSG00000197168
CONAN: Copy Number AnalysisNEK5 
Mutations
ICGC Data PortalNEK5 
TCGA Data PortalNEK5 
Broad Tumor PortalNEK5
OASIS PortalNEK5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNEK5  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNEK5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NEK5
DgiDB (Drug Gene Interaction Database)NEK5
DoCM (Curated mutations)NEK5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NEK5 (select a term)
intoGenNEK5
Cancer3DNEK5(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM616731   
Orphanet
MedgenNEK5
Genetic Testing Registry NEK5
NextProtQ6P3R8 [Medical]
TSGene341676
GENETestsNEK5
Huge Navigator NEK5 [HugePedia]
snp3D : Map Gene to Disease341676
BioCentury BCIQNEK5
ClinGenNEK5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD341676
Chemical/Pharm GKB GenePA31549
Clinical trialNEK5
Miscellaneous
canSAR (ICR)NEK5 (select the gene name)
Probes
Litterature
PubMed6 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNEK5
EVEXNEK5
GoPubMedNEK5
iHOPNEK5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:18:36 CET 2017

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