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NEK6 (NIMA related kinase 6)

Identity

Alias_namesNIMA (never in mitosis gene a)-related kinase 6
Alias_symbol (synonym)SID6-1512
Other alias
HGNC (Hugo) NEK6
LocusID (NCBI) 10783
Atlas_Id 43374
Location 9q33.3  [Link to chromosome band 9q33]
Location_base_pair Starts at 127020196 and ends at 127114719 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
C12orf73 (12q23.3) / NEK6 (9q33.3)NEK6 (9q33.3) / TPM4 (19p13.12)PPP2R4 (9q34.11) / NEK6 (9q33.3)
PPP2R4 9q34.11 / NEK6 9q33.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NEK6   7749
Cards
Entrez_Gene (NCBI)NEK6  10783  NIMA related kinase 6
AliasesSID6-1512
GeneCards (Weizmann)NEK6
Ensembl hg19 (Hinxton)ENSG00000119408 [Gene_View]  chr9:127020196-127114719 [Contig_View]  NEK6 [Vega]
Ensembl hg38 (Hinxton)ENSG00000119408 [Gene_View]  chr9:127020196-127114719 [Contig_View]  NEK6 [Vega]
ICGC DataPortalENSG00000119408
TCGA cBioPortalNEK6
AceView (NCBI)NEK6
Genatlas (Paris)NEK6
WikiGenes10783
SOURCE (Princeton)NEK6
Genetics Home Reference (NIH)NEK6
Genomic and cartography
GoldenPath hg19 (UCSC)NEK6  -     chr9:127020196-127114719 +  9q33.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)NEK6  -     9q33.3   [Description]    (hg38-Dec_2013)
EnsemblNEK6 - 9q33.3 [CytoView hg19]  NEK6 - 9q33.3 [CytoView hg38]
Mapping of homologs : NCBINEK6 [Mapview hg19]  NEK6 [Mapview hg38]
OMIM604884   
Gene and transcription
Genbank (Entrez)AB026289 AF087909 AJ420460 AK294614 AK313071
RefSeq transcript (Entrez)NM_001145001 NM_001166167 NM_001166168 NM_001166169 NM_001166170 NM_001166171 NM_014397
RefSeq genomic (Entrez)NC_000009 NC_018920 NT_008470 NW_004929366
Consensus coding sequences : CCDS (NCBI)NEK6
Cluster EST : UnigeneHs.197071 [ NCBI ]
CGAP (NCI)Hs.197071
Alternative Splicing GalleryENSG00000119408
Gene ExpressionNEK6 [ NCBI-GEO ]   NEK6 [ EBI - ARRAY_EXPRESS ]   NEK6 [ SEEK ]   NEK6 [ MEM ]
Gene Expression Viewer (FireBrowse)NEK6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10783
GTEX Portal (Tissue expression)NEK6
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9HC98   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9HC98  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9HC98
Splice isoforms : SwissVarQ9HC98
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusQ9HC98
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser-Thr/Tyr_kinase_cat_dom    Ser/Thr_dual-sp_kinase    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)NEK6
DMDM Disease mutations10783
Blocks (Seattle)NEK6
SuperfamilyQ9HC98
Human Protein AtlasENSG00000119408
Peptide AtlasQ9HC98
HPRD05348
IPIIPI00550738   IPI00396662   IPI00946980   IPI00946494   IPI00479896   IPI00645296   IPI00647464   IPI00642169   IPI00642737   IPI00640945   IPI00641516   
Protein Interaction databases
DIP (DOE-UCLA)Q9HC98
IntAct (EBI)Q9HC98
FunCoupENSG00000119408
BioGRIDNEK6
STRING (EMBL)NEK6
ZODIACNEK6
Ontologies - Pathways
QuickGOQ9HC98
Ontology : AmiGOmagnesium ion binding  cytokinesis  spindle pole  protein serine/threonine kinase activity  protein serine/threonine kinase activity  signal transducer activity  protein binding  ATP binding  nucleus  nucleoplasm  cytoplasm  microtubule organizing center  cytosol  microtubule  protein phosphorylation  apoptotic process  chromosome segregation  mitotic nuclear division  mitotic nuclear envelope disassembly  signal transduction  regulation of mitotic cell cycle  nuclear speck  peptidyl-serine phosphorylation  kinesin binding  protein kinase binding  regulation of mitotic metaphase/anaphase transition  G2 DNA damage checkpoint  positive regulation of I-kappaB kinase/NF-kappaB signaling  intracellular membrane-bounded organelle  protein autophosphorylation  spindle assembly  regulation of cellular senescence  
Ontology : EGO-EBImagnesium ion binding  cytokinesis  spindle pole  protein serine/threonine kinase activity  protein serine/threonine kinase activity  signal transducer activity  protein binding  ATP binding  nucleus  nucleoplasm  cytoplasm  microtubule organizing center  cytosol  microtubule  protein phosphorylation  apoptotic process  chromosome segregation  mitotic nuclear division  mitotic nuclear envelope disassembly  signal transduction  regulation of mitotic cell cycle  nuclear speck  peptidyl-serine phosphorylation  kinesin binding  protein kinase binding  regulation of mitotic metaphase/anaphase transition  G2 DNA damage checkpoint  positive regulation of I-kappaB kinase/NF-kappaB signaling  intracellular membrane-bounded organelle  protein autophosphorylation  spindle assembly  regulation of cellular senescence  
NDEx NetworkNEK6
Atlas of Cancer Signalling NetworkNEK6
Wikipedia pathwaysNEK6
Orthology - Evolution
OrthoDB10783
GeneTree (enSembl)ENSG00000119408
Phylogenetic Trees/Animal Genes : TreeFamNEK6
HOVERGENQ9HC98
HOGENOMQ9HC98
Homologs : HomoloGeneNEK6
Homology/Alignments : Family Browser (UCSC)NEK6
Gene fusions - Rearrangements
Fusion : MitelmanPPP2R4/NEK6 [9q34.11/9q33.3]  [t(9;9)(q33;q34)]  
Fusion: TCGAPPP2R4 9q34.11 NEK6 9q33.3 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNEK6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NEK6
dbVarNEK6
ClinVarNEK6
1000_GenomesNEK6 
Exome Variant ServerNEK6
ExAC (Exome Aggregation Consortium)NEK6 (select the gene name)
Genetic variants : HAPMAP10783
Genomic Variants (DGV)NEK6 [DGVbeta]
DECIPHER (Syndromes)9:127020196-127114719  ENSG00000119408
CONAN: Copy Number AnalysisNEK6 
Mutations
ICGC Data PortalNEK6 
TCGA Data PortalNEK6 
Broad Tumor PortalNEK6
OASIS PortalNEK6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNEK6  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNEK6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NEK6
DgiDB (Drug Gene Interaction Database)NEK6
DoCM (Curated mutations)NEK6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NEK6 (select a term)
intoGenNEK6
Cancer3DNEK6(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604884   
Orphanet
MedgenNEK6
Genetic Testing Registry NEK6
NextProtQ9HC98 [Medical]
TSGene10783
GENETestsNEK6
Huge Navigator NEK6 [HugePedia]
snp3D : Map Gene to Disease10783
BioCentury BCIQNEK6
ClinGenNEK6
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10783
Chemical/Pharm GKB GenePA31550
Clinical trialNEK6
Miscellaneous
canSAR (ICR)NEK6 (select the gene name)
Probes
Litterature
PubMed44 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNEK6
EVEXNEK6
GoPubMedNEK6
iHOPNEK6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:12:04 CEST 2017

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