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NEK7 (NIMA related kinase 7)

Identity

Alias_namesNIMA (never in mitosis gene a)-related kinase 7
Other alias-
HGNC (Hugo) NEK7
LocusID (NCBI) 140609
Atlas_Id 43375
Location 1q31.3  [Link to chromosome band 1q31]
Location_base_pair Starts at 198156978 and ends at 198322418 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
DICER1 (14q32.13) / NEK7 (1q31.3)NEK7 (1q31.3) / ATP2B4 (1q32.1)NEK7 (1q31.3) / CD1C (1q23.1)
NEK7 (1q31.3) / CRB1 (1q31.3)NEK7 (1q31.3) / INTS7 (1q32.3)NEK7 (1q31.3) / MALT1 (18q21.32)
RPL34 (4q25) / NEK7 (1q31.3)NEK7 1q31.3 / ATP2B4 1q32.1NEK7 1q31.3 / CD1C 1q23.1
NEK7 1q31.3 / CRB1 1q31.3NEK7 1q31.3 / INTS7 1q32.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NEK7   13386
Cards
Entrez_Gene (NCBI)NEK7  140609  NIMA related kinase 7
Aliases
GeneCards (Weizmann)NEK7
Ensembl hg19 (Hinxton)ENSG00000151414 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000151414 [Gene_View]  chr1:198156978-198322418 [Contig_View]  NEK7 [Vega]
ICGC DataPortalENSG00000151414
TCGA cBioPortalNEK7
AceView (NCBI)NEK7
Genatlas (Paris)NEK7
WikiGenes140609
SOURCE (Princeton)NEK7
Genetics Home Reference (NIH)NEK7
Genomic and cartography
GoldenPath hg38 (UCSC)NEK7  -     chr1:198156978-198322418 +  1q31.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NEK7  -     1q31.3   [Description]    (hg19-Feb_2009)
EnsemblNEK7 - 1q31.3 [CytoView hg19]  NEK7 - 1q31.3 [CytoView hg38]
Mapping of homologs : NCBINEK7 [Mapview hg19]  NEK7 [Mapview hg38]
OMIM606848   
Gene and transcription
Genbank (Entrez)AB062450 AK313411 AL080111 BC043003 BC152872
RefSeq transcript (Entrez)NM_133494
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NEK7
Cluster EST : UnigeneHs.745083 [ NCBI ]
CGAP (NCI)Hs.745083
Alternative Splicing GalleryENSG00000151414
Gene ExpressionNEK7 [ NCBI-GEO ]   NEK7 [ EBI - ARRAY_EXPRESS ]   NEK7 [ SEEK ]   NEK7 [ MEM ]
Gene Expression Viewer (FireBrowse)NEK7 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)140609
GTEX Portal (Tissue expression)NEK7
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8TDX7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8TDX7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8TDX7
Splice isoforms : SwissVarQ8TDX7
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusQ8TDX7
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser-Thr/Tyr_kinase_cat_dom    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)NEK7
DMDM Disease mutations140609
Blocks (Seattle)NEK7
PDB (SRS)2WQM    2WQN    5DE2   
PDB (PDBSum)2WQM    2WQN    5DE2   
PDB (IMB)2WQM    2WQN    5DE2   
PDB (RSDB)2WQM    2WQN    5DE2   
Structural Biology KnowledgeBase2WQM    2WQN    5DE2   
SCOP (Structural Classification of Proteins)2WQM    2WQN    5DE2   
CATH (Classification of proteins structures)2WQM    2WQN    5DE2   
SuperfamilyQ8TDX7
Human Protein AtlasENSG00000151414
Peptide AtlasQ8TDX7
HPRD06027
IPIIPI00152658   IPI00643850   IPI00646684   IPI01014491   IPI01014966   
Protein Interaction databases
DIP (DOE-UCLA)Q8TDX7
IntAct (EBI)Q8TDX7
FunCoupENSG00000151414
BioGRIDNEK7
STRING (EMBL)NEK7
ZODIACNEK7
Ontologies - Pathways
QuickGOQ8TDX7
Ontology : AmiGOcytokinesis  spindle pole  protein serine/threonine kinase activity  ATP binding  nucleoplasm  cytoplasm  microtubule organizing center  microtubule  protein phosphorylation  regulation of mitotic cell cycle  positive regulation of telomere maintenance via telomerase  metal ion binding  spindle assembly  positive regulation of telomerase activity  positive regulation of telomere capping  
Ontology : EGO-EBIcytokinesis  spindle pole  protein serine/threonine kinase activity  ATP binding  nucleoplasm  cytoplasm  microtubule organizing center  microtubule  protein phosphorylation  regulation of mitotic cell cycle  positive regulation of telomere maintenance via telomerase  metal ion binding  spindle assembly  positive regulation of telomerase activity  positive regulation of telomere capping  
NDEx NetworkNEK7
Atlas of Cancer Signalling NetworkNEK7
Wikipedia pathwaysNEK7
Orthology - Evolution
OrthoDB140609
GeneTree (enSembl)ENSG00000151414
Phylogenetic Trees/Animal Genes : TreeFamNEK7
HOVERGENQ8TDX7
HOGENOMQ8TDX7
Homologs : HomoloGeneNEK7
Homology/Alignments : Family Browser (UCSC)NEK7
Gene fusions - Rearrangements
Fusion : MitelmanNEK7/ATP2B4 [1q31.3/1q32.1]  
Fusion : MitelmanNEK7/CD1C [1q31.3/1q23.1]  [t(1;1)(q23;q31)]  
Fusion : MitelmanNEK7/CRB1 [1q31.3/1q31.3]  [t(1;1)(q31;q31)]  
Fusion : MitelmanNEK7/INTS7 [1q31.3/1q32.3]  [t(1;1)(q31;q32)]  
Fusion: TCGANEK7 1q31.3 ATP2B4 1q32.1 LUSC
Fusion: TCGANEK7 1q31.3 CD1C 1q23.1 PRAD
Fusion: TCGANEK7 1q31.3 CRB1 1q31.3 BRCA
Fusion: TCGANEK7 1q31.3 INTS7 1q32.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNEK7 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NEK7
dbVarNEK7
ClinVarNEK7
1000_GenomesNEK7 
Exome Variant ServerNEK7
ExAC (Exome Aggregation Consortium)NEK7 (select the gene name)
Genetic variants : HAPMAP140609
Genomic Variants (DGV)NEK7 [DGVbeta]
DECIPHERNEK7 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNEK7 
Mutations
ICGC Data PortalNEK7 
TCGA Data PortalNEK7 
Broad Tumor PortalNEK7
OASIS PortalNEK7 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNEK7  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNEK7
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NEK7
DgiDB (Drug Gene Interaction Database)NEK7
DoCM (Curated mutations)NEK7 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NEK7 (select a term)
intoGenNEK7
Cancer3DNEK7(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606848   
Orphanet
MedgenNEK7
Genetic Testing Registry NEK7
NextProtQ8TDX7 [Medical]
TSGene140609
GENETestsNEK7
Target ValidationNEK7
Huge Navigator NEK7 [HugePedia]
snp3D : Map Gene to Disease140609
BioCentury BCIQNEK7
ClinGenNEK7
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD140609
Chemical/Pharm GKB GenePA31551
Clinical trialNEK7
Miscellaneous
canSAR (ICR)NEK7 (select the gene name)
Probes
Litterature
PubMed29 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNEK7
EVEXNEK7
GoPubMedNEK7
iHOPNEK7
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 17:08:57 CEST 2017

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