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NELFB (negative elongation factor complex member B)

Identity

Alias_namesCOBRA1
cofactor of BRCA1
Alias_symbol (synonym)KIAA1182
NELF-B
Other alias
HGNC (Hugo) NELFB
LocusID (NCBI) 25920
Atlas_Id 46321
Location 9q34.3  [Link to chromosome band 9q34]
Location_base_pair Starts at 140149752 and ends at 140168000 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
OS9 (12q13.3) / NELFB (9q34.3)RASA2 (3q23) / NELFB (9q34.3)TUBB4B (9q34.3) / NELFB (9q34.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Adenocarcinoma


External links

Nomenclature
HGNC (Hugo)NELFB   24324
Cards
Entrez_Gene (NCBI)NELFB  25920  negative elongation factor complex member B
AliasesCOBRA1; NELF-B
GeneCards (Weizmann)NELFB
Ensembl hg19 (Hinxton)ENSG00000188986 [Gene_View]  chr9:140149752-140168000 [Contig_View]  NELFB [Vega]
Ensembl hg38 (Hinxton)ENSG00000188986 [Gene_View]  chr9:140149752-140168000 [Contig_View]  NELFB [Vega]
ICGC DataPortalENSG00000188986
TCGA cBioPortalNELFB
AceView (NCBI)NELFB
Genatlas (Paris)NELFB
WikiGenes25920
SOURCE (Princeton)NELFB
Genetics Home Reference (NIH)NELFB
Genomic and cartography
GoldenPath hg19 (UCSC)NELFB  -     chr9:140149752-140168000 +  9q34.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)NELFB  -     9q34.3   [Description]    (hg38-Dec_2013)
EnsemblNELFB - 9q34.3 [CytoView hg19]  NELFB - 9q34.3 [CytoView hg38]
Mapping of homologs : NCBINELFB [Mapview hg19]  NELFB [Mapview hg38]
OMIM611180   
Gene and transcription
Genbank (Entrez)AB033008 AF464935 AK022651 AK091056 AL050280
RefSeq transcript (Entrez)NM_015456
RefSeq genomic (Entrez)NC_000009 NC_018920 NT_008470 NW_004929369
Consensus coding sequences : CCDS (NCBI)NELFB
Cluster EST : UnigeneHs.521809 [ NCBI ]
CGAP (NCI)Hs.521809
Alternative Splicing GalleryENSG00000188986
Gene ExpressionNELFB [ NCBI-GEO ]   NELFB [ EBI - ARRAY_EXPRESS ]   NELFB [ SEEK ]   NELFB [ MEM ]
Gene Expression Viewer (FireBrowse)NELFB [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)25920
GTEX Portal (Tissue expression)NELFB
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8WX92   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8WX92  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8WX92
Splice isoforms : SwissVarQ8WX92
PhosPhoSitePlusQ8WX92
Domains : Interpro (EBI)COBRA1   
Domain families : Pfam (Sanger)COBRA1 (PF06209)   
Domain families : Pfam (NCBI)pfam06209   
Conserved Domain (NCBI)NELFB
DMDM Disease mutations25920
Blocks (Seattle)NELFB
SuperfamilyQ8WX92
Human Protein AtlasENSG00000188986
Peptide AtlasQ8WX92
HPRD10845
IPIIPI00103483   
Protein Interaction databases
DIP (DOE-UCLA)Q8WX92
IntAct (EBI)Q8WX92
FunCoupENSG00000188986
BioGRIDNELFB
STRING (EMBL)NELFB
ZODIACNELFB
Ontologies - Pathways
QuickGOQ8WX92
Ontology : AmiGOprotein binding  nucleoplasm  nucleoplasm  cytoplasm  transcription from RNA polymerase II promoter  transcription elongation from RNA polymerase II promoter  NELF complex  negative regulation of transcription elongation from RNA polymerase II promoter  positive regulation of viral transcription  
Ontology : EGO-EBIprotein binding  nucleoplasm  nucleoplasm  cytoplasm  transcription from RNA polymerase II promoter  transcription elongation from RNA polymerase II promoter  NELF complex  negative regulation of transcription elongation from RNA polymerase II promoter  positive regulation of viral transcription  
NDEx NetworkNELFB
Atlas of Cancer Signalling NetworkNELFB
Wikipedia pathwaysNELFB
Orthology - Evolution
OrthoDB25920
GeneTree (enSembl)ENSG00000188986
Phylogenetic Trees/Animal Genes : TreeFamNELFB
HOVERGENQ8WX92
HOGENOMQ8WX92
Homologs : HomoloGeneNELFB
Homology/Alignments : Family Browser (UCSC)NELFB
Gene fusions - Rearrangements
Fusion : MitelmanRASA2/NELFB [3q23/9q34.3]  [t(3;9)(q23;q34)]  
Fusion : MitelmanTUBB4B/NELFB [9q34.3/9q34.3]  [t(9;9)(q34;q34)]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNELFB [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NELFB
dbVarNELFB
ClinVarNELFB
1000_GenomesNELFB 
Exome Variant ServerNELFB
ExAC (Exome Aggregation Consortium)NELFB (select the gene name)
Genetic variants : HAPMAP25920
Genomic Variants (DGV)NELFB [DGVbeta]
DECIPHER (Syndromes)9:140149752-140168000  ENSG00000188986
CONAN: Copy Number AnalysisNELFB 
Mutations
ICGC Data PortalNELFB 
TCGA Data PortalNELFB 
Broad Tumor PortalNELFB
OASIS PortalNELFB [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDNELFB
BioMutasearch NELFB
DgiDB (Drug Gene Interaction Database)NELFB
DoCM (Curated mutations)NELFB (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NELFB (select a term)
intoGenNELFB
Cancer3DNELFB(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611180   
Orphanet
MedgenNELFB
Genetic Testing Registry NELFB
NextProtQ8WX92 [Medical]
TSGene25920
GENETestsNELFB
Huge Navigator NELFB [HugePedia]
snp3D : Map Gene to Disease25920
BioCentury BCIQNELFB
ClinGenNELFB
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD25920
Chemical/Pharm GKB GenePA162382703
Clinical trialNELFB
Miscellaneous
canSAR (ICR)NELFB (select the gene name)
Probes
Litterature
PubMed51 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNELFB
EVEXNELFB
GoPubMedNELFB
iHOPNELFB
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:12:05 CEST 2017

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