NELFCD (negative elongation factor complex member C/D)

2010-10-01  

Identity

HGNC
LOCATION
20q13.32
LOCUSID
ALIAS
HSPC130,NELF-C,NELF-D,TH1,TH1L

Other Information

Locus ID:

NCBI: 51497
MIM: 605297
HGNC: 15934
Ensembl: ENSG00000101158

Variants:

dbSNP: 51497
ClinVar: 51497
TCGA: ENSG00000101158
COSMIC: NELFCD

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000101158ENST00000460601X6RLT1
ENSG00000101158ENST00000602795H0UI80
ENSG00000101158ENST00000652272Q8IXH7

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
DiseaseREACTOMER-HSA-1643685
Infectious diseaseREACTOMER-HSA-5663205
HIV InfectionREACTOMER-HSA-162906
HIV Life CycleREACTOMER-HSA-162587
Late Phase of HIV Life CycleREACTOMER-HSA-162599
Transcription of the HIV genomeREACTOMER-HSA-167172
HIV Transcription ElongationREACTOMER-HSA-167169
Formation of the HIV-1 Early Elongation ComplexREACTOMER-HSA-167158
Tat-mediated elongation of the HIV-1 transcriptREACTOMER-HSA-167246
Formation of HIV-1 elongation complex containing HIV-1 TatREACTOMER-HSA-167200
Abortive elongation of HIV-1 transcript in the absence of TatREACTOMER-HSA-167242
HIV elongation arrest and recoveryREACTOMER-HSA-167287
Formation of HIV elongation complex in the absence of HIV TatREACTOMER-HSA-167152
Pausing and recovery of HIV elongationREACTOMER-HSA-167290
Tat-mediated HIV elongation arrest and recoveryREACTOMER-HSA-167243
Pausing and recovery of Tat-mediated HIV elongationREACTOMER-HSA-167238
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
RNA Polymerase II TranscriptionREACTOMER-HSA-73857
RNA Polymerase II Pre-transcription EventsREACTOMER-HSA-674695
RNA Polymerase II Transcription ElongationREACTOMER-HSA-75955
Formation of the Early Elongation ComplexREACTOMER-HSA-113418
Formation of RNA Pol II elongation complexREACTOMER-HSA-112382
TP53 Regulates Transcription of DNA Repair GenesREACTOMER-HSA-6796648

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA151249535diureticsChemicalClinicalAnnotationassociatedPD
PA164713347Thiazides, plainChemicalClinicalAnnotationassociatedPD
PA444552HypertensionDiseaseClinicalAnnotationassociatedPD
PA449899hydrochlorothiazideChemicalClinicalAnnotationassociatedPD

References

Pubmed IDYearTitleCitations
174990422007NELF interacts with CBC and participates in 3' end processing of replication-dependent histone mRNAs.100
126120622003Human transcription elongation factor NELF: identification of novel subunits and reconstitution of the functionally active complex.86
200289842010Human negative elongation factor activates transcription and regulates alternative transcription initiation.25
191365542009Trihydrophobin 1 Interacts with PAK1 and Regulates ERK/MAPK Activation and Cell Migration.16
272823912016Architecture and RNA binding of the human negative elongation factor.15
196730362009Association of tagging single nucleotide polymorphisms on 8 candidate genes in dopaminergic pathway with schizophrenia in Croatian population.10
146847502004Trihydrophobin 1 is a new negative regulator of A-Raf kinase.4
207354312010Negative role of trihydrophobin 1 in breast cancer growth and migration.4
171313882007Ubiquitin-dependent proteolysis of trihydrophobin 1 (TH1) by the human papilloma virus E6-associated protein (E6-AP).3
192458072009Cellular dynamics of the negative transcription elongation factor NELF.3

Citation

Dessen P

NELFCD (negative elongation factor complex member C/D)

Atlas Genet Cytogenet Oncol Haematol. 2010-10-01

Online version: http://atlasgeneticsoncology.org/gene/51720/nelfcd