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NELFE (negative elongation factor complex member E)

Identity

Alias_namesRDBP
RD RNA-binding protein
RD RNA binding protein
Alias_symbol (synonym)RD
D6S45
NELF-E
RDP
Other alias
HGNC (Hugo) NELFE
LocusID (NCBI) 7936
Atlas_Id 54077
Location 6p21.33  [Link to chromosome band 6p21]
Location_base_pair Starts at 31952087 and ends at 31959087 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NELFE   13974
Cards
Entrez_Gene (NCBI)NELFE  7936  negative elongation factor complex member E
AliasesD6S45; NELF-E; RD; RDBP; 
RDP
GeneCards (Weizmann)NELFE
Ensembl hg19 (Hinxton)ENSG00000204356 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000204356 [Gene_View]  chr6:31952087-31959087 [Contig_View]  NELFE [Vega]
ICGC DataPortalENSG00000204356
TCGA cBioPortalNELFE
AceView (NCBI)NELFE
Genatlas (Paris)NELFE
WikiGenes7936
SOURCE (Princeton)NELFE
Genetics Home Reference (NIH)NELFE
Genomic and cartography
GoldenPath hg38 (UCSC)NELFE  -     chr6:31952087-31959087 -  6p21.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NELFE  -     6p21.33   [Description]    (hg19-Feb_2009)
EnsemblNELFE - 6p21.33 [CytoView hg19]  NELFE - 6p21.33 [CytoView hg38]
Mapping of homologs : NCBINELFE [Mapview hg19]  NELFE [Mapview hg38]
OMIM154040   
Gene and transcription
Genbank (Entrez)AK300717 AK300898 AK302652 AK303152 BC025235
RefSeq transcript (Entrez)NM_002904
RefSeq genomic (Entrez)NC_000006 NC_018917 NT_113891 NT_167245 NT_167247 NT_167248 NT_167249
Consensus coding sequences : CCDS (NCBI)NELFE
Cluster EST : UnigeneHs.423935 [ NCBI ]
CGAP (NCI)Hs.423935
Alternative Splicing GalleryENSG00000204356
Gene ExpressionNELFE [ NCBI-GEO ]   NELFE [ EBI - ARRAY_EXPRESS ]   NELFE [ SEEK ]   NELFE [ MEM ]
Gene Expression Viewer (FireBrowse)NELFE [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7936
GTEX Portal (Tissue expression)NELFE
Protein : pattern, domain, 3D structure
UniProt/SwissProtP18615   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP18615  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP18615
Splice isoforms : SwissVarP18615
PhosPhoSitePlusP18615
Domaine pattern : Prosite (Expaxy)RRM (PS50102)   
Domains : Interpro (EBI)NELFE    Nucleotide-bd_a/b_plait    RRM_dom   
Domain families : Pfam (Sanger)RRM_1 (PF00076)   
Domain families : Pfam (NCBI)pfam00076   
Domain families : Smart (EMBL)RRM (SM00360)  
Conserved Domain (NCBI)NELFE
DMDM Disease mutations7936
Blocks (Seattle)NELFE
PDB (SRS)1X5P    2BZ2    2JX2   
PDB (PDBSum)1X5P    2BZ2    2JX2   
PDB (IMB)1X5P    2BZ2    2JX2   
PDB (RSDB)1X5P    2BZ2    2JX2   
Structural Biology KnowledgeBase1X5P    2BZ2    2JX2   
SCOP (Structural Classification of Proteins)1X5P    2BZ2    2JX2   
CATH (Classification of proteins structures)1X5P    2BZ2    2JX2   
SuperfamilyP18615
Human Protein AtlasENSG00000204356
Peptide AtlasP18615
HPRD01096
IPIIPI00941607   IPI00922214   IPI01009325   IPI00941723   IPI00642023   IPI00946182   IPI00921016   IPI00000858   IPI00946750   IPI01014919   IPI00947078   
Protein Interaction databases
DIP (DOE-UCLA)P18615
IntAct (EBI)P18615
FunCoupENSG00000204356
BioGRIDNELFE
STRING (EMBL)NELFE
ZODIACNELFE
Ontologies - Pathways
QuickGOP18615
Ontology : AmiGOchromatin binding  RNA binding  RNA binding  protein binding  nucleus  nucleoplasm  nucleoplasm  plasma membrane  transcription from RNA polymerase II promoter  transcription elongation from RNA polymerase II promoter  biological_process  nuclear body  NELF complex  negative regulation of transcription elongation from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  positive regulation of viral transcription  positive regulation of histone H3-K4 methylation  positive regulation of ERK1 and ERK2 cascade  negative regulation of mRNA polyadenylation  
Ontology : EGO-EBIchromatin binding  RNA binding  RNA binding  protein binding  nucleus  nucleoplasm  nucleoplasm  plasma membrane  transcription from RNA polymerase II promoter  transcription elongation from RNA polymerase II promoter  biological_process  nuclear body  NELF complex  negative regulation of transcription elongation from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  positive regulation of viral transcription  positive regulation of histone H3-K4 methylation  positive regulation of ERK1 and ERK2 cascade  negative regulation of mRNA polyadenylation  
NDEx NetworkNELFE
Atlas of Cancer Signalling NetworkNELFE
Wikipedia pathwaysNELFE
Orthology - Evolution
OrthoDB7936
GeneTree (enSembl)ENSG00000204356
Phylogenetic Trees/Animal Genes : TreeFamNELFE
HOVERGENP18615
HOGENOMP18615
Homologs : HomoloGeneNELFE
Homology/Alignments : Family Browser (UCSC)NELFE
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNELFE [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NELFE
dbVarNELFE
ClinVarNELFE
1000_GenomesNELFE 
Exome Variant ServerNELFE
ExAC (Exome Aggregation Consortium)NELFE (select the gene name)
Genetic variants : HAPMAP7936
Genomic Variants (DGV)NELFE [DGVbeta]
DECIPHERNELFE [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNELFE 
Mutations
ICGC Data PortalNELFE 
TCGA Data PortalNELFE 
Broad Tumor PortalNELFE
OASIS PortalNELFE [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDNELFE
BioMutasearch NELFE
DgiDB (Drug Gene Interaction Database)NELFE
DoCM (Curated mutations)NELFE (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NELFE (select a term)
intoGenNELFE
Cancer3DNELFE(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM154040   
Orphanet
MedgenNELFE
Genetic Testing Registry NELFE
NextProtP18615 [Medical]
TSGene7936
GENETestsNELFE
Target ValidationNELFE
Huge Navigator NELFE [HugePedia]
snp3D : Map Gene to Disease7936
BioCentury BCIQNELFE
ClinGenNELFE
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7936
Chemical/Pharm GKB GenePA134974984
Clinical trialNELFE
Miscellaneous
canSAR (ICR)NELFE (select the gene name)
Probes
Litterature
PubMed60 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNELFE
EVEXNELFE
GoPubMedNELFE
iHOPNELFE
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:21:57 CEST 2017

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