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NELFE (negative elongation factor complex member E)

Identity

Alias (NCBI)D6S45
NELF-E
RD
RDBP
RDP
HGNC (Hugo) NELFE
HGNC Alias symbRD
D6S45
NELF-E
RDP
HGNC Previous nameRDBP
HGNC Previous nameRD RNA-binding protein
 RD RNA binding protein
LocusID (NCBI) 7936
Atlas_Id 54077
Location 6p21.33  [Link to chromosome band 6p21]
Location_base_pair Starts at 31952087 and ends at 31958971 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)NELFE   13974
Cards
Entrez_Gene (NCBI)NELFE    negative elongation factor complex member E
AliasesD6S45; NELF-E; RD; RDBP; 
RDP
GeneCards (Weizmann)NELFE
Ensembl hg19 (Hinxton)ENSG00000204356 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000204356 [Gene_View]  ENSG00000204356 [Sequence]  chr6:31952087-31958971 [Contig_View]  NELFE [Vega]
ICGC DataPortalENSG00000204356
TCGA cBioPortalNELFE
AceView (NCBI)NELFE
Genatlas (Paris)NELFE
SOURCE (Princeton)NELFE
Genetics Home Reference (NIH)NELFE
Genomic and cartography
GoldenPath hg38 (UCSC)NELFE  -     chr6:31952087-31958971 -  6p21.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NELFE  -     6p21.33   [Description]    (hg19-Feb_2009)
GoldenPathNELFE - 6p21.33 [CytoView hg19]  NELFE - 6p21.33 [CytoView hg38]
ImmunoBaseENSG00000204356
Genome Data Viewer NCBINELFE [Mapview hg19]  
OMIM154040   
Gene and transcription
Genbank (Entrez)AK300717 AK300898 AK302652 AK303152 BC025235
RefSeq transcript (Entrez)NM_002904
Consensus coding sequences : CCDS (NCBI)NELFE
Gene ExpressionNELFE [ NCBI-GEO ]   NELFE [ EBI - ARRAY_EXPRESS ]   NELFE [ SEEK ]   NELFE [ MEM ]
Gene Expression Viewer (FireBrowse)NELFE [ Firebrowse - Broad ]
GenevisibleExpression of NELFE in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7936
GTEX Portal (Tissue expression)NELFE
Human Protein AtlasENSG00000204356-NELFE [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP18615   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP18615  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP18615
PhosPhoSitePlusP18615
Domaine pattern : Prosite (Expaxy)RRM (PS50102)   
Domains : Interpro (EBI)NELFE    NELFE_RRM    Nucleotide-bd_a/b_plait_sf    RBD_domain_sf    RRM_dom   
Domain families : Pfam (Sanger)RRM_1 (PF00076)   
Domain families : Pfam (NCBI)pfam00076   
Domain families : Smart (EMBL)RRM (SM00360)  
Conserved Domain (NCBI)NELFE
PDB (RSDB)1X5P    2BZ2    2JX2    5OOB    6GML   
PDB Europe1X5P    2BZ2    2JX2    5OOB    6GML   
PDB (PDBSum)1X5P    2BZ2    2JX2    5OOB    6GML   
PDB (IMB)1X5P    2BZ2    2JX2    5OOB    6GML   
Structural Biology KnowledgeBase1X5P    2BZ2    2JX2    5OOB    6GML   
SCOP (Structural Classification of Proteins)1X5P    2BZ2    2JX2    5OOB    6GML   
CATH (Classification of proteins structures)1X5P    2BZ2    2JX2    5OOB    6GML   
SuperfamilyP18615
AlphaFold pdb e-kbP18615   
Human Protein Atlas [tissue]ENSG00000204356-NELFE [tissue]
HPRD01096
Protein Interaction databases
DIP (DOE-UCLA)P18615
IntAct (EBI)P18615
BioGRIDNELFE
STRING (EMBL)NELFE
ZODIACNELFE
Ontologies - Pathways
QuickGOP18615
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  chromatin binding  RNA binding  RNA binding  protein binding  nucleus  nucleoplasm  nucleoplasm  plasma membrane  transcription by RNA polymerase II  transcription elongation from RNA polymerase II promoter  nuclear body  NELF complex  NELF complex  negative regulation of transcription elongation from RNA polymerase II promoter  positive regulation of transcription by RNA polymerase II  positive regulation of viral transcription  positive regulation of histone H3-K4 methylation  positive regulation of ERK1 and ERK2 cascade  negative regulation of mRNA polyadenylation  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  chromatin binding  RNA binding  RNA binding  protein binding  nucleus  nucleoplasm  nucleoplasm  plasma membrane  transcription by RNA polymerase II  transcription elongation from RNA polymerase II promoter  nuclear body  NELF complex  NELF complex  negative regulation of transcription elongation from RNA polymerase II promoter  positive regulation of transcription by RNA polymerase II  positive regulation of viral transcription  positive regulation of histone H3-K4 methylation  positive regulation of ERK1 and ERK2 cascade  negative regulation of mRNA polyadenylation  
NDEx NetworkNELFE
Atlas of Cancer Signalling NetworkNELFE
Wikipedia pathwaysNELFE
Orthology - Evolution
OrthoDB7936
GeneTree (enSembl)ENSG00000204356
Phylogenetic Trees/Animal Genes : TreeFamNELFE
Homologs : HomoloGeneNELFE
Homology/Alignments : Family Browser (UCSC)NELFE
Gene fusions - Rearrangements
Fusion : QuiverNELFE
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNELFE [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NELFE
dbVarNELFE
ClinVarNELFE
MonarchNELFE
1000_GenomesNELFE 
Exome Variant ServerNELFE
GNOMAD BrowserENSG00000204356
Varsome BrowserNELFE
ACMGNELFE variants
VarityP18615
Genomic Variants (DGV)NELFE [DGVbeta]
DECIPHERNELFE [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNELFE 
Mutations
ICGC Data PortalNELFE 
TCGA Data PortalNELFE 
Broad Tumor PortalNELFE
OASIS PortalNELFE [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNELFE  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DNELFE
Mutations and Diseases : HGMDNELFE
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaNELFE
DgiDB (Drug Gene Interaction Database)NELFE
DoCM (Curated mutations)NELFE
CIViC (Clinical Interpretations of Variants in Cancer)NELFE
Cancer3DNELFE
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM154040   
Orphanet
DisGeNETNELFE
MedgenNELFE
Genetic Testing Registry NELFE
NextProtP18615 [Medical]
GENETestsNELFE
Target ValidationNELFE
Huge Navigator NELFE [HugePedia]
ClinGenNELFE
Clinical trials, drugs, therapy
MyCancerGenomeNELFE
Protein Interactions : CTDNELFE
Pharm GKB GenePA134974984
PharosP18615
Clinical trialNELFE
Miscellaneous
canSAR (ICR)NELFE
HarmonizomeNELFE
DataMed IndexNELFE
Probes
Litterature
PubMed81 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXNELFE
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:22:33 CEST 2021

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