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NELL2 (neural EGFL like 2)

Identity

Alias_namesnel (chicken)-like 2
NEL-like 2 (chicken)
Alias_symbol (synonym)NRP2
Other alias
HGNC (Hugo) NELL2
LocusID (NCBI) 4753
Atlas_Id 41524
Location 12q12  [Link to chromosome band 12q12]
Location_base_pair Starts at 44508275 and ends at 44876850 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ASB8 (12q13.11) / NELL2 (12q12)KCNA1 (12p13.32) / NELL2 (12q12)LOC100507412 (-) / NELL2 (12q12)
NELL2 (12q12) / ATF7 (12q13.13)NELL2 (12q12) / ATXN7L3B (12q21.1)NELL2 (12q12) / UBR7 (14q32.12)
ASB8 12q13.11 / NELL2 12q12NELL2 12q12 / ATF7 12q13.13

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NELL2   7751
Cards
Entrez_Gene (NCBI)NELL2  4753  neural EGFL like 2
AliasesNRP2
GeneCards (Weizmann)NELL2
Ensembl hg19 (Hinxton)ENSG00000184613 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000184613 [Gene_View]  chr12:44508275-44876850 [Contig_View]  NELL2 [Vega]
ICGC DataPortalENSG00000184613
TCGA cBioPortalNELL2
AceView (NCBI)NELL2
Genatlas (Paris)NELL2
WikiGenes4753
SOURCE (Princeton)NELL2
Genetics Home Reference (NIH)NELL2
Genomic and cartography
GoldenPath hg38 (UCSC)NELL2  -     chr12:44508275-44876850 -  12q12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NELL2  -     12q12   [Description]    (hg19-Feb_2009)
EnsemblNELL2 - 12q12 [CytoView hg19]  NELL2 - 12q12 [CytoView hg38]
Mapping of homologs : NCBINELL2 [Mapview hg19]  NELL2 [Mapview hg38]
OMIM602320   
Gene and transcription
Genbank (Entrez)AK055385 AK056082 AK095637 AK295125 AK297521
RefSeq transcript (Entrez)NM_001145107 NM_001145108 NM_001145109 NM_001145110 NM_006159
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NELL2
Cluster EST : UnigeneHs.505326 [ NCBI ]
CGAP (NCI)Hs.505326
Alternative Splicing GalleryENSG00000184613
Gene ExpressionNELL2 [ NCBI-GEO ]   NELL2 [ EBI - ARRAY_EXPRESS ]   NELL2 [ SEEK ]   NELL2 [ MEM ]
Gene Expression Viewer (FireBrowse)NELL2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4753
GTEX Portal (Tissue expression)NELL2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ99435   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ99435  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ99435
Splice isoforms : SwissVarQ99435
PhosPhoSitePlusQ99435
Domaine pattern : Prosite (Expaxy)ASX_HYDROXYL (PS00010)    EGF_1 (PS00022)    EGF_2 (PS01186)    EGF_3 (PS50026)    EGF_CA (PS01187)    VWFC_1 (PS01208)    VWFC_2 (PS50184)   
Domains : Interpro (EBI)ConA-like_dom    EGF-like_Ca-bd_dom    EGF-like_CS    EGF-like_dom    EGF-type_Asp/Asn_hydroxyl_site    EGF_Ca-bd_CS    Growth_fac_rcpt_    Laminin_G    VWF_dom   
Domain families : Pfam (Sanger)EGF_CA (PF07645)    Laminin_G_2 (PF02210)    VWC (PF00093)   
Domain families : Pfam (NCBI)pfam07645    pfam02210    pfam00093   
Domain families : Smart (EMBL)EGF (SM00181)  EGF_CA (SM00179)  LamG (SM00282)  TSPN (SM00210)  VWC (SM00214)  VWC_out (SM00215)  
Conserved Domain (NCBI)NELL2
DMDM Disease mutations4753
Blocks (Seattle)NELL2
SuperfamilyQ99435
Human Protein AtlasENSG00000184613
Peptide AtlasQ99435
HPRD11891
IPIIPI00015260   IPI00797539   IPI00795624   IPI01020825   IPI01021571   IPI01021725   IPI01021510   IPI01022247   IPI01022397   IPI01022003   IPI01022142   IPI01022907   IPI00922434   IPI00921881   
Protein Interaction databases
DIP (DOE-UCLA)Q99435
IntAct (EBI)Q99435
FunCoupENSG00000184613
BioGRIDNELL2
STRING (EMBL)NELL2
ZODIACNELL2
Ontologies - Pathways
QuickGOQ99435
Ontology : AmiGOcalcium ion binding  protein binding  extracellular region  cell  neuron cellular homeostasis  
Ontology : EGO-EBIcalcium ion binding  protein binding  extracellular region  cell  neuron cellular homeostasis  
NDEx NetworkNELL2
Atlas of Cancer Signalling NetworkNELL2
Wikipedia pathwaysNELL2
Orthology - Evolution
OrthoDB4753
GeneTree (enSembl)ENSG00000184613
Phylogenetic Trees/Animal Genes : TreeFamNELL2
HOVERGENQ99435
HOGENOMQ99435
Homologs : HomoloGeneNELL2
Homology/Alignments : Family Browser (UCSC)NELL2
Gene fusions - Rearrangements
Fusion : MitelmanASB8/NELL2 [12q13.11/12q12]  [t(12;12)(q12;q13)]  
Fusion : MitelmanNELL2/ATF7 [12q12/12q13.13]  [t(12;12)(q12;q13)]  
Fusion : MitelmanNELL2/ATXN7L3B [12q12/12q21.1]  [del(12)(q12q21)]  
Fusion: TCGAASB8 12q13.11 NELL2 12q12 LUAD
Fusion: TCGANELL2 12q12 ATF7 12q13.13 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNELL2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NELL2
dbVarNELL2
ClinVarNELL2
1000_GenomesNELL2 
Exome Variant ServerNELL2
ExAC (Exome Aggregation Consortium)NELL2 (select the gene name)
Genetic variants : HAPMAP4753
Genomic Variants (DGV)NELL2 [DGVbeta]
DECIPHERNELL2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNELL2 
Mutations
ICGC Data PortalNELL2 
TCGA Data PortalNELL2 
Broad Tumor PortalNELL2
OASIS PortalNELL2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNELL2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNELL2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NELL2
DgiDB (Drug Gene Interaction Database)NELL2
DoCM (Curated mutations)NELL2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NELL2 (select a term)
intoGenNELL2
Cancer3DNELL2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602320   
Orphanet
MedgenNELL2
Genetic Testing Registry NELL2
NextProtQ99435 [Medical]
TSGene4753
GENETestsNELL2
Target ValidationNELL2
Huge Navigator NELL2 [HugePedia]
snp3D : Map Gene to Disease4753
BioCentury BCIQNELL2
ClinGenNELL2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4753
Chemical/Pharm GKB GenePA31553
Clinical trialNELL2
Miscellaneous
canSAR (ICR)NELL2 (select the gene name)
Probes
Litterature
PubMed19 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNELL2
EVEXNELL2
GoPubMedNELL2
iHOPNELL2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:21:57 CEST 2017

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