NEO1 (neogenin 1)

2003-02-01  

Identity

HGNC
NEO1
LOCATION
15q24.1
LOCUSID
4756
ALIAS
IGDCC2,NGN,NTN1R2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4756
MIM: 601907
HGNC: 7754
Ensembl: ENSG00000067141

Variants:

dbSNP: 4756
ClinVar: 4756
TCGA: ENSG00000067141
COSMIC: NEO1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000067141ENST00000261908Q92859
ENSG00000067141ENST00000339362Q92859
ENSG00000067141ENST00000558964Q92859
ENSG00000067141ENST00000560262Q92859
ENSG00000067141ENST00000560328Q59FP8

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cell adhesion molecules (CAMs)KEGGko04514
Cell adhesion molecules (CAMs)KEGGhsa04514
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
Netrin-1 signalingREACTOMER-HSA-373752
MyogenesisREACTOMER-HSA-525793
CDO in myogenesisREACTOMER-HSA-375170

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
183268172008Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin.86
195643372009Hemojuvelin-neogenin interaction is required for bone morphogenic protein-4-induced hepcidin expression.34
211494532011Neogenin, a receptor for bone morphogenetic proteins.31
228937052012Neogenin interacts with matriptase-2 to facilitate hemojuvelin cleavage.28
182873312008Selective binding of RGMc/hemojuvelin, a key protein in systemic iron metabolism, to BMP-2 and neogenin.27
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
259386612015Repulsive guidance molecule is a structural bridge between neogenin and bone morphogenetic protein.27
237447772013Structure of the repulsive guidance molecule (RGM)-neogenin signaling hub.25
249304992014Up-regulation of neogenin-1 increases cell proliferation and motility in gastric cancer.22
183910162008The neogenin intracellular domain regulates gene transcription via nuclear translocation.20

Citation

Dessen P

NEO1 (neogenin 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41525/neo1