NETO2 (neuropilin and tolloid like 2)

2016-08-01  

Identity

HGNC
NETO2
LOCATION
16q12.1
LOCUSID
81831
ALIAS
BTCL2,NEOT2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 81831
MIM: 607974
HGNC: 14644
Ensembl: ENSG00000171208

Variants:

dbSNP: 81831
ClinVar: 81831
TCGA: ENSG00000171208
COSMIC: NETO2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000171208ENST00000303155Q8NC67
ENSG00000171208ENST00000562435Q8NC67
ENSG00000171208ENST00000562559H3BM37
ENSG00000171208ENST00000563078H3BSR0
ENSG00000171208ENST00000564667H3BTE1

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
192173762009A transmembrane accessory subunit that modulates kainate-type glutamate receptors.103
153401612004Signal peptide prediction based on analysis of experimentally verified cleavage sites.32
266995442015Upregulation of NETO2 expression correlates with tumor progression and poor prognosis in colorectal carcinoma.8
262773402015The auxiliary subunits Neto1 and Neto2 have distinct, subunit-dependent effects at recombinant GluK1- and GluK2-containing kainate receptors.6
292973842017Upregulation of NETO2 gene in colorectal cancer.5
307707912019NETO2 promotes invasion and metastasis of gastric cancer cells via activation of PI3K/Akt/NF-κB/Snail axis and predicts outcome of the patients.5
299895762018[Transcription Factor SAP30 Is Involved in the Activation of NETO2 Gene Expression in Clear Cell Renal Cell Carcinoma].1
309754692019Reducing NETO2 expression prevents human nasopharyngeal carcinoma (NPC) progression by suppressing metastasis and inducing apoptosis.0

Citation

Dessen P

NETO2 (neuropilin and tolloid like 2)

Atlas Genet Cytogenet Oncol Haematol. 2016-08-01

Online version: http://atlasgeneticsoncology.org/gene/55913/neto2