Atlas of Genetics and Cytogenetics in Oncology and Haematology

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NEU1 (neuraminidase 1)

Identity

Alias (NCBI)NANH
NEU
SIAL1
HGNC (Hugo) NEU1
HGNC Previous nameNEU
HGNC Previous namesialidase 1 (lysosomal sialidase)
 neuraminidase 1 (lysosomal sialidase)
LocusID (NCBI) 4758
Atlas_Id 50393
Location 6p21.33  [Link to chromosome band 6p21]
Location_base_pair Starts at 31857659 and ends at 31862821 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
FGA (4q31.3) / NEU1 (6p21.33)NEU1 (6p21.33) / NEU1 (6p21.33)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)NEU1   7758
Cards
Entrez_Gene (NCBI)NEU1  4758  neuraminidase 1
AliasesNANH; NEU; SIAL1
GeneCards (Weizmann)NEU1
Ensembl hg19 (Hinxton)ENSG00000204386 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000204386 [Gene_View]  ENSG00000204386 [Sequence]  chr6:31857659-31862821 [Contig_View]  NEU1 [Vega]
ICGC DataPortalENSG00000204386
TCGA cBioPortalNEU1
AceView (NCBI)NEU1
Genatlas (Paris)NEU1
WikiGenes4758
SOURCE (Princeton)NEU1
Genetics Home Reference (NIH)NEU1
Genomic and cartography
GoldenPath hg38 (UCSC)NEU1  -     chr6:31857659-31862821 -  6p21.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NEU1  -     6p21.33   [Description]    (hg19-Feb_2009)
GoldenPathNEU1 - 6p21.33 [CytoView hg19]  NEU1 - 6p21.33 [CytoView hg38]
ImmunoBaseENSG00000204386
genome Data Viewer NCBINEU1 [Mapview hg19]  
OMIM256550   608272   
Gene and transcription
Genbank (Entrez)AB209011 AF040958 AK290966 AK313006 BC000722
RefSeq transcript (Entrez)NM_000434
RefSeq genomic (Entrez)NC_000006 NG_008201 NT_113891 NT_167244 NT_167245 NT_167246 NT_167247 NT_167248 NT_167249
Consensus coding sequences : CCDS (NCBI)NEU1
Alternative Splicing GalleryENSG00000204386
Gene ExpressionNEU1 [ NCBI-GEO ]   NEU1 [ EBI - ARRAY_EXPRESS ]   NEU1 [ SEEK ]   NEU1 [ MEM ]
Gene Expression Viewer (FireBrowse)NEU1 [ Firebrowse - Broad ]
GenevisibleExpression of NEU1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4758
GTEX Portal (Tissue expression)NEU1
Human Protein AtlasENSG00000204386-NEU1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ99519   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ99519  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ99519
Splice isoforms : SwissVarQ99519
Catalytic activity : Enzyme3.2.1.18 [ Enzyme-Expasy ]   3.2.1.183.2.1.18 [ IntEnz-EBI ]   3.2.1.18 [ BRENDA ]   3.2.1.18 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ99519
Domains : Interpro (EBI)Sialidase    Sialidase_fam    Sialidase_sf   
Domain families : Pfam (Sanger)BNR_2 (PF13088)   
Domain families : Pfam (NCBI)pfam13088   
Conserved Domain (NCBI)NEU1
DMDM Disease mutations4758
Blocks (Seattle)NEU1
SuperfamilyQ99519
Human Protein Atlas [tissue]ENSG00000204386-NEU1 [tissue]
Peptide AtlasQ99519
HPRD09751
IPIIPI00029817   IPI00980596   IPI00978251   
Protein Interaction databases
DIP (DOE-UCLA)Q99519
IntAct (EBI)Q99519
FunCoupENSG00000204386
BioGRIDNEU1
STRING (EMBL)NEU1
ZODIACNEU1
Ontologies - Pathways
QuickGOQ99519
Ontology : AmiGOexo-alpha-sialidase activity  exo-alpha-sialidase activity  exo-alpha-sialidase activity  protein binding  extracellular region  cytoplasm  lysosome  lysosome  lysosomal membrane  plasma membrane  glycosphingolipid metabolic process  ganglioside catabolic process  oligosaccharide catabolic process  oligosaccharide catabolic process  membrane  alpha-sialidase activity  cell junction  specific granule lumen  lysosomal lumen  intracellular membrane-bounded organelle  intracellular membrane-bounded organelle  neutrophil degranulation  exo-alpha-(2->3)-sialidase activity  exo-alpha-(2->6)-sialidase activity  exo-alpha-(2->8)-sialidase activity  extracellular exosome  
Ontology : EGO-EBIexo-alpha-sialidase activity  exo-alpha-sialidase activity  exo-alpha-sialidase activity  protein binding  extracellular region  cytoplasm  lysosome  lysosome  lysosomal membrane  plasma membrane  glycosphingolipid metabolic process  ganglioside catabolic process  oligosaccharide catabolic process  oligosaccharide catabolic process  membrane  alpha-sialidase activity  cell junction  specific granule lumen  lysosomal lumen  intracellular membrane-bounded organelle  intracellular membrane-bounded organelle  neutrophil degranulation  exo-alpha-(2->3)-sialidase activity  exo-alpha-(2->6)-sialidase activity  exo-alpha-(2->8)-sialidase activity  extracellular exosome  
Pathways : KEGGOther glycan degradation    Sphingolipid metabolism    Lysosome   
NDEx NetworkNEU1
Atlas of Cancer Signalling NetworkNEU1
Wikipedia pathwaysNEU1
Orthology - Evolution
OrthoDB4758
GeneTree (enSembl)ENSG00000204386
Phylogenetic Trees/Animal Genes : TreeFamNEU1
HOGENOMQ99519
Homologs : HomoloGeneNEU1
Homology/Alignments : Family Browser (UCSC)NEU1
Gene fusions - Rearrangements
Fusion : QuiverNEU1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNEU1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NEU1
dbVarNEU1
ClinVarNEU1
MonarchNEU1
1000_GenomesNEU1 
Exome Variant ServerNEU1
GNOMAD BrowserENSG00000204386
Varsome BrowserNEU1
Genetic variants : HAPMAP4758
Genomic Variants (DGV)NEU1 [DGVbeta]
DECIPHERNEU1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNEU1 
Mutations
ICGC Data PortalNEU1 
TCGA Data PortalNEU1 
Broad Tumor PortalNEU1
OASIS PortalNEU1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNEU1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DNEU1
Mutations and Diseases : HGMDNEU1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NEU1
DgiDB (Drug Gene Interaction Database)NEU1
DoCM (Curated mutations)NEU1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NEU1 (select a term)
intoGenNEU1
Cancer3DNEU1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM256550    608272   
Orphanet26    12321    12322   
DisGeNETNEU1
MedgenNEU1
Genetic Testing Registry NEU1
NextProtQ99519 [Medical]
TSGene4758
GENETestsNEU1
Target ValidationNEU1
Huge Navigator NEU1 [HugePedia]
snp3D : Map Gene to Disease4758
BioCentury BCIQNEU1
ClinGenNEU1
Clinical trials, drugs, therapy
Protein Interactions : CTD4758
Pharm GKB GenePA31560
Clinical trialNEU1
Miscellaneous
canSAR (ICR)NEU1 (select the gene name)
HarmonizomeNEU1
DataMed IndexNEU1
Probes
Litterature
PubMed111 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNEU1
EVEXNEU1
GoPubMedNEU1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 14 14:24:06 CEST 2020
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