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NEURL1 (neuralized E3 ubiquitin protein ligase 1)

Identity

Alias (NCBI)NEUR1
NEURL
RNF67
bA416N2.1
neu
neu-1
HGNC (Hugo) NEURL1
HGNC Alias symbh-neu
RNF67
neu-1
HGNC Previous nameNEURL
HGNC Previous nameneuralized (Drosophila)-like
 neuralized-like (Drosophila)
 neuralized homolog (Drosophila)
LocusID (NCBI) 9148
Atlas_Id 41527
Location 10q24.33  [Link to chromosome band 10q24]
Location_base_pair Starts at 103493705 and ends at 103592546 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
NEURL1 (10q24.33) / PDCD11 (10q24.33)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)NEURL1   7761
Cards
Entrez_Gene (NCBI)NEURL1    neuralized E3 ubiquitin protein ligase 1
AliasesNEUR1; NEURL; RNF67; bA416N2.1; 
neu; neu-1
GeneCards (Weizmann)NEURL1
Ensembl hg19 (Hinxton)ENSG00000107954 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000107954 [Gene_View]  ENSG00000107954 [Sequence]  chr10:103493705-103592546 [Contig_View]  NEURL1 [Vega]
ICGC DataPortalENSG00000107954
TCGA cBioPortalNEURL1
AceView (NCBI)NEURL1
Genatlas (Paris)NEURL1
SOURCE (Princeton)NEURL1
Genetics Home Reference (NIH)NEURL1
Genomic and cartography
GoldenPath hg38 (UCSC)NEURL1  -     chr10:103493705-103592546 +  10q24.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NEURL1  -     10q24.33   [Description]    (hg19-Feb_2009)
GoldenPathNEURL1 - 10q24.33 [CytoView hg19]  NEURL1 - 10q24.33 [CytoView hg38]
ImmunoBaseENSG00000107954
Genome Data Viewer NCBINEURL1 [Mapview hg19]  
OMIM603804   
Gene and transcription
Genbank (Entrez)AF029729 AK299620 BC026336 U87864
RefSeq transcript (Entrez)NM_004210
Consensus coding sequences : CCDS (NCBI)NEURL1
Gene ExpressionNEURL1 [ NCBI-GEO ]   NEURL1 [ EBI - ARRAY_EXPRESS ]   NEURL1 [ SEEK ]   NEURL1 [ MEM ]
Gene Expression Viewer (FireBrowse)NEURL1 [ Firebrowse - Broad ]
GenevisibleExpression of NEURL1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9148
GTEX Portal (Tissue expression)NEURL1
Human Protein AtlasENSG00000107954-NEURL1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO76050   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO76050  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO76050
Catalytic activity : Enzyme2.3.2.27 [ Enzyme-Expasy ]   2.3.2.272.3.2.27 [ IntEnz-EBI ]   2.3.2.27 [ BRENDA ]   2.3.2.27 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusO76050
Domaine pattern : Prosite (Expaxy)NHR (PS51065)    ZF_RING_2 (PS50089)   
Domains : Interpro (EBI)B30.2/SPRY_sf    Neuralized    NHR_dom    Znf_RING    Znf_RING/FYVE/PHD   
Domain families : Pfam (Sanger)Neuralized (PF07177)   
Domain families : Pfam (NCBI)pfam07177   
Domain families : Smart (EMBL)NEUZ (SM00588)  
Conserved Domain (NCBI)NEURL1
SuperfamilyO76050
AlphaFold pdb e-kbO76050   
Human Protein Atlas [tissue]ENSG00000107954-NEURL1 [tissue]
HPRD04815
Protein Interaction databases
DIP (DOE-UCLA)O76050
IntAct (EBI)O76050
BioGRIDNEURL1
STRING (EMBL)NEURL1
ZODIACNEURL1
Ontologies - Pathways
QuickGOO76050
Ontology : AmiGOubiquitin-protein transferase activity  plasma membrane  plasma membrane  regulation of translation  protein monoubiquitination  Notch signaling pathway  sperm axoneme assembly  nervous system development  brain development  skeletal muscle tissue development  lactation  negative regulation of cell population proliferation  postsynaptic density  postsynaptic density  positive regulation of apoptotic process  dendritic spine  perikaryon  translation factor activity, non-nucleic acid binding  positive regulation of epidermal growth factor-activated receptor activity  negative regulation of Notch signaling pathway  negative regulation of Notch signaling pathway  metal ion binding  positive regulation of long-term neuronal synaptic plasticity  perinuclear region of cytoplasm  positive regulation of filopodium assembly  positive regulation of dendritic spine development  ubiquitin protein ligase activity  cellular response to amino acid stimulus  positive regulation of synapse maturation  apical dendrite  
Ontology : EGO-EBIubiquitin-protein transferase activity  plasma membrane  plasma membrane  regulation of translation  protein monoubiquitination  Notch signaling pathway  sperm axoneme assembly  nervous system development  brain development  skeletal muscle tissue development  lactation  negative regulation of cell population proliferation  postsynaptic density  postsynaptic density  positive regulation of apoptotic process  dendritic spine  perikaryon  translation factor activity, non-nucleic acid binding  positive regulation of epidermal growth factor-activated receptor activity  negative regulation of Notch signaling pathway  negative regulation of Notch signaling pathway  metal ion binding  positive regulation of long-term neuronal synaptic plasticity  perinuclear region of cytoplasm  positive regulation of filopodium assembly  positive regulation of dendritic spine development  ubiquitin protein ligase activity  cellular response to amino acid stimulus  positive regulation of synapse maturation  apical dendrite  
NDEx NetworkNEURL1
Atlas of Cancer Signalling NetworkNEURL1
Wikipedia pathwaysNEURL1
Orthology - Evolution
OrthoDB9148
GeneTree (enSembl)ENSG00000107954
Phylogenetic Trees/Animal Genes : TreeFamNEURL1
Homologs : HomoloGeneNEURL1
Homology/Alignments : Family Browser (UCSC)NEURL1
Gene fusions - Rearrangements
Fusion : MitelmanNEURL1/PDCD11 [10q24.33/10q24.33]  
Fusion : QuiverNEURL1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNEURL1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NEURL1
dbVarNEURL1
ClinVarNEURL1
MonarchNEURL1
1000_GenomesNEURL1 
Exome Variant ServerNEURL1
GNOMAD BrowserENSG00000107954
Varsome BrowserNEURL1
ACMGNEURL1 variants
VarityO76050
Genomic Variants (DGV)NEURL1 [DGVbeta]
DECIPHERNEURL1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNEURL1 
Mutations
ICGC Data PortalNEURL1 
TCGA Data PortalNEURL1 
Broad Tumor PortalNEURL1
OASIS PortalNEURL1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNEURL1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DNEURL1
Mutations and Diseases : HGMDNEURL1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaNEURL1
DgiDB (Drug Gene Interaction Database)NEURL1
DoCM (Curated mutations)NEURL1
CIViC (Clinical Interpretations of Variants in Cancer)NEURL1
Cancer3DNEURL1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603804   
Orphanet
DisGeNETNEURL1
MedgenNEURL1
Genetic Testing Registry NEURL1
NextProtO76050 [Medical]
GENETestsNEURL1
Target ValidationNEURL1
Huge Navigator NEURL1 [HugePedia]
ClinGenNEURL1
Clinical trials, drugs, therapy
MyCancerGenomeNEURL1
Protein Interactions : CTDNEURL1
Pharm GKB GenePA31563
PharosO76050
Clinical trialNEURL1
Miscellaneous
canSAR (ICR)NEURL1
HarmonizomeNEURL1
DataMed IndexNEURL1
Probes
Litterature
PubMed26 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXNEURL1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:22:35 CEST 2021

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