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NEURL1 (neuralized E3 ubiquitin protein ligase 1)

Identity

Alias_namesNEURL
neuralized (Drosophila)-like
neuralized-like (Drosophila)
neuralized homolog (Drosophila)
Alias_symbol (synonym)h-neu
RNF67
neu-1
Other aliasNEUR1
bA416N2.1
neu
HGNC (Hugo) NEURL1
LocusID (NCBI) 9148
Atlas_Id 41527
Location 10q24.33  [Link to chromosome band 10q24]
Location_base_pair Starts at 103493978 and ends at 103592552 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
NEURL1 (10q24.33) / PDCD11 (10q24.33)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NEURL1   7761
Cards
Entrez_Gene (NCBI)NEURL1  9148  neuralized E3 ubiquitin protein ligase 1
AliasesNEUR1; NEURL; RNF67; bA416N2.1; 
neu; neu-1
GeneCards (Weizmann)NEURL1
Ensembl hg19 (Hinxton)ENSG00000107954 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000107954 [Gene_View]  chr10:103493978-103592552 [Contig_View]  NEURL1 [Vega]
ICGC DataPortalENSG00000107954
TCGA cBioPortalNEURL1
AceView (NCBI)NEURL1
Genatlas (Paris)NEURL1
WikiGenes9148
SOURCE (Princeton)NEURL1
Genetics Home Reference (NIH)NEURL1
Genomic and cartography
GoldenPath hg38 (UCSC)NEURL1  -     chr10:103493978-103592552 +  10q24.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NEURL1  -     10q24.33   [Description]    (hg19-Feb_2009)
EnsemblNEURL1 - 10q24.33 [CytoView hg19]  NEURL1 - 10q24.33 [CytoView hg38]
Mapping of homologs : NCBINEURL1 [Mapview hg19]  NEURL1 [Mapview hg38]
OMIM603804   
Gene and transcription
Genbank (Entrez)AF029729 AK299620 BC026336 U87864
RefSeq transcript (Entrez)NM_004210
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NEURL1
Cluster EST : UnigeneHs.594708 [ NCBI ]
CGAP (NCI)Hs.594708
Alternative Splicing GalleryENSG00000107954
Gene ExpressionNEURL1 [ NCBI-GEO ]   NEURL1 [ EBI - ARRAY_EXPRESS ]   NEURL1 [ SEEK ]   NEURL1 [ MEM ]
Gene Expression Viewer (FireBrowse)NEURL1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9148
GTEX Portal (Tissue expression)NEURL1
Protein : pattern, domain, 3D structure
UniProt/SwissProtO76050   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO76050  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO76050
Splice isoforms : SwissVarO76050
Catalytic activity : Enzyme2.3.2.27 [ Enzyme-Expasy ]   2.3.2.272.3.2.27 [ IntEnz-EBI ]   2.3.2.27 [ BRENDA ]   2.3.2.27 [ KEGG ]   
PhosPhoSitePlusO76050
Domaine pattern : Prosite (Expaxy)NHR (PS51065)    ZF_RING_2 (PS50089)   
Domains : Interpro (EBI)NHR_dom    Znf_RING    Znf_RING/FYVE/PHD   
Domain families : Pfam (Sanger)Neuralized (PF07177)   
Domain families : Pfam (NCBI)pfam07177   
Domain families : Smart (EMBL)NEUZ (SM00588)  
Conserved Domain (NCBI)NEURL1
DMDM Disease mutations9148
Blocks (Seattle)NEURL1
SuperfamilyO76050
Human Protein AtlasENSG00000107954
Peptide AtlasO76050
HPRD04815
IPIIPI00003483   IPI00554624   IPI00647579   
Protein Interaction databases
DIP (DOE-UCLA)O76050
IntAct (EBI)O76050
FunCoupENSG00000107954
BioGRIDNEURL1
STRING (EMBL)NEURL1
ZODIACNEURL1
Ontologies - Pathways
QuickGOO76050
Ontology : AmiGOubiquitin-protein transferase activity  plasma membrane  regulation of translation  protein monoubiquitination  Notch signaling pathway  sperm axoneme assembly  nervous system development  brain development  skeletal muscle tissue development  lactation  zinc ion binding  negative regulation of cell proliferation  postsynaptic density  cell junction  positive regulation of apoptotic process  dendritic spine  perikaryon  translation factor activity, non-nucleic acid binding  postsynaptic membrane  positive regulation of epidermal growth factor-activated receptor activity  negative regulation of Notch signaling pathway  positive regulation of long-term neuronal synaptic plasticity  perinuclear region of cytoplasm  positive regulation of filopodium assembly  positive regulation of dendritic spine development  ubiquitin protein ligase activity  cellular response to amino acid stimulus  positive regulation of synapse maturation  apical dendrite  
Ontology : EGO-EBIubiquitin-protein transferase activity  plasma membrane  regulation of translation  protein monoubiquitination  Notch signaling pathway  sperm axoneme assembly  nervous system development  brain development  skeletal muscle tissue development  lactation  zinc ion binding  negative regulation of cell proliferation  postsynaptic density  cell junction  positive regulation of apoptotic process  dendritic spine  perikaryon  translation factor activity, non-nucleic acid binding  postsynaptic membrane  positive regulation of epidermal growth factor-activated receptor activity  negative regulation of Notch signaling pathway  positive regulation of long-term neuronal synaptic plasticity  perinuclear region of cytoplasm  positive regulation of filopodium assembly  positive regulation of dendritic spine development  ubiquitin protein ligase activity  cellular response to amino acid stimulus  positive regulation of synapse maturation  apical dendrite  
NDEx NetworkNEURL1
Atlas of Cancer Signalling NetworkNEURL1
Wikipedia pathwaysNEURL1
Orthology - Evolution
OrthoDB9148
GeneTree (enSembl)ENSG00000107954
Phylogenetic Trees/Animal Genes : TreeFamNEURL1
HOVERGENO76050
HOGENOMO76050
Homologs : HomoloGeneNEURL1
Homology/Alignments : Family Browser (UCSC)NEURL1
Gene fusions - Rearrangements
Fusion : MitelmanNEURL1/PDCD11 [10q24.33/10q24.33]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNEURL1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NEURL1
dbVarNEURL1
ClinVarNEURL1
1000_GenomesNEURL1 
Exome Variant ServerNEURL1
ExAC (Exome Aggregation Consortium)NEURL1 (select the gene name)
Genetic variants : HAPMAP9148
Genomic Variants (DGV)NEURL1 [DGVbeta]
DECIPHERNEURL1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNEURL1 
Mutations
ICGC Data PortalNEURL1 
TCGA Data PortalNEURL1 
Broad Tumor PortalNEURL1
OASIS PortalNEURL1 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDNEURL1
BioMutasearch NEURL1
DgiDB (Drug Gene Interaction Database)NEURL1
DoCM (Curated mutations)NEURL1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NEURL1 (select a term)
intoGenNEURL1
Cancer3DNEURL1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603804   
Orphanet
MedgenNEURL1
Genetic Testing Registry NEURL1
NextProtO76050 [Medical]
TSGene9148
GENETestsNEURL1
Target ValidationNEURL1
Huge Navigator NEURL1 [HugePedia]
snp3D : Map Gene to Disease9148
BioCentury BCIQNEURL1
ClinGenNEURL1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9148
Chemical/Pharm GKB GenePA31563
Clinical trialNEURL1
Miscellaneous
canSAR (ICR)NEURL1 (select the gene name)
Probes
Litterature
PubMed18 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNEURL1
EVEXNEURL1
GoPubMedNEURL1
iHOPNEURL1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:21:59 CEST 2017

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