Atlas of Genetics and Cytogenetics in Oncology and Haematology


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NEUROD2 (neuronal differentiation 2)

Identity

Alias_namesneurogenic differentiation 2
Alias_symbol (synonym)NDRF
bHLHa1
Other alias
HGNC (Hugo) NEUROD2
LocusID (NCBI) 4761
Atlas_Id 54498
Location 17q12  [Link to chromosome band 17q12]
Location_base_pair Starts at 37760021 and ends at 37764175 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CDC42EP4 (17q25.1) / NEUROD2 (17q12)LRRC59 (17q21.33) / NEUROD2 (17q12)NEUROD2 (17q12) / IRF2BP2 (1q42.3)
NEUROD2 (17q12) / NLRP14 (11p15.4)NEUROD2 (17q12) / SFTPB (2p11.2)CDC42EP4 17q25.1 / NEUROD2 17q12

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NEUROD2   7763
Cards
Entrez_Gene (NCBI)NEUROD2  4761  neuronal differentiation 2
AliasesNDRF; bHLHa1
GeneCards (Weizmann)NEUROD2
Ensembl hg19 (Hinxton)ENSG00000171532 [Gene_View]  chr17:37760021-37764175 [Contig_View]  NEUROD2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000171532 [Gene_View]  chr17:37760021-37764175 [Contig_View]  NEUROD2 [Vega]
ICGC DataPortalENSG00000171532
TCGA cBioPortalNEUROD2
AceView (NCBI)NEUROD2
Genatlas (Paris)NEUROD2
WikiGenes4761
SOURCE (Princeton)NEUROD2
Genetics Home Reference (NIH)NEUROD2
Genomic and cartography
GoldenPath hg19 (UCSC)NEUROD2  -     chr17:37760021-37764175 -  17q12   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)NEUROD2  -     17q12   [Description]    (hg38-Dec_2013)
EnsemblNEUROD2 - 17q12 [CytoView hg19]  NEUROD2 - 17q12 [CytoView hg38]
Mapping of homologs : NCBINEUROD2 [Mapview hg19]  NEUROD2 [Mapview hg38]
OMIM601725   
Gene and transcription
Genbank (Entrez)AB021742 AW134767 BC022481 BT019365
RefSeq transcript (Entrez)NM_006160
RefSeq genomic (Entrez)NC_000017 NC_018928 NT_010783 NW_004929407
Consensus coding sequences : CCDS (NCBI)NEUROD2
Cluster EST : UnigeneHs.322431 [ NCBI ]
CGAP (NCI)Hs.322431
Alternative Splicing GalleryENSG00000171532
Gene ExpressionNEUROD2 [ NCBI-GEO ]   NEUROD2 [ EBI - ARRAY_EXPRESS ]   NEUROD2 [ SEEK ]   NEUROD2 [ MEM ]
Gene Expression Viewer (FireBrowse)NEUROD2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4761
GTEX Portal (Tissue expression)NEUROD2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15784   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ15784  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ15784
Splice isoforms : SwissVarQ15784
PhosPhoSitePlusQ15784
Domaine pattern : Prosite (Expaxy)BHLH (PS50888)   
Domains : Interpro (EBI)bHLH_dom    Neurod2    Neurogenic_DUF    TF_bHLH_NeuroD   
Domain families : Pfam (Sanger)HLH (PF00010)    Neuro_bHLH (PF12533)   
Domain families : Pfam (NCBI)pfam00010    pfam12533   
Domain families : Smart (EMBL)HLH (SM00353)  
Conserved Domain (NCBI)NEUROD2
DMDM Disease mutations4761
Blocks (Seattle)NEUROD2
SuperfamilyQ15784
Human Protein AtlasENSG00000171532
Peptide AtlasQ15784
HPRD03429
IPIIPI00302045   
Protein Interaction databases
DIP (DOE-UCLA)Q15784
IntAct (EBI)Q15784
FunCoupENSG00000171532
BioGRIDNEUROD2
STRING (EMBL)NEUROD2
ZODIACNEUROD2
Ontologies - Pathways
QuickGOQ15784
Ontology : AmiGORNA polymerase II regulatory region sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding  behavioral fear response  transcription factor activity, sequence-specific DNA binding  transcription corepressor activity  nucleus  regulation of transcription from RNA polymerase II promoter  transcription from RNA polymerase II promoter  nervous system development  associative learning  protein ubiquitination  cerebellar cortex development  positive regulation of synaptic plasticity  positive regulation of neuron differentiation  positive regulation of transcription from RNA polymerase II promoter  protein heterodimerization activity  neuron development  positive regulation of calcium-mediated signaling  positive regulation of sequence-specific DNA binding transcription factor activity  E-box binding  cellular response to electrical stimulus  cellular response to calcium ion  positive regulation of synapse maturation  negative regulation of nucleic acid-templated transcription  negative regulation of synapse maturation  
Ontology : EGO-EBIRNA polymerase II regulatory region sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding  behavioral fear response  transcription factor activity, sequence-specific DNA binding  transcription corepressor activity  nucleus  regulation of transcription from RNA polymerase II promoter  transcription from RNA polymerase II promoter  nervous system development  associative learning  protein ubiquitination  cerebellar cortex development  positive regulation of synaptic plasticity  positive regulation of neuron differentiation  positive regulation of transcription from RNA polymerase II promoter  protein heterodimerization activity  neuron development  positive regulation of calcium-mediated signaling  positive regulation of sequence-specific DNA binding transcription factor activity  E-box binding  cellular response to electrical stimulus  cellular response to calcium ion  positive regulation of synapse maturation  negative regulation of nucleic acid-templated transcription  negative regulation of synapse maturation  
NDEx NetworkNEUROD2
Atlas of Cancer Signalling NetworkNEUROD2
Wikipedia pathwaysNEUROD2
Orthology - Evolution
OrthoDB4761
GeneTree (enSembl)ENSG00000171532
Phylogenetic Trees/Animal Genes : TreeFamNEUROD2
HOVERGENQ15784
HOGENOMQ15784
Homologs : HomoloGeneNEUROD2
Homology/Alignments : Family Browser (UCSC)NEUROD2
Gene fusions - Rearrangements
Fusion : MitelmanCDC42EP4/NEUROD2 [17q25.1/17q12]  [t(17;17)(q12;q25)]  
Fusion : MitelmanLRRC59/NEUROD2 [17q21.33/17q12]  [t(17;17)(q12;q21)]  
Fusion: TCGACDC42EP4 17q25.1 NEUROD2 17q12 BRCA
Fusion Cancer (Beijing)NEUROD2 [17q12]  -  SFTPB [2p11.2]  [FUSC003644]  [FUSC003644]
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNEUROD2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NEUROD2
dbVarNEUROD2
ClinVarNEUROD2
1000_GenomesNEUROD2 
Exome Variant ServerNEUROD2
ExAC (Exome Aggregation Consortium)NEUROD2 (select the gene name)
Genetic variants : HAPMAP4761
Genomic Variants (DGV)NEUROD2 [DGVbeta]
DECIPHER (Syndromes)17:37760021-37764175  ENSG00000171532
CONAN: Copy Number AnalysisNEUROD2 
Mutations
ICGC Data PortalNEUROD2 
TCGA Data PortalNEUROD2 
Broad Tumor PortalNEUROD2
OASIS PortalNEUROD2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNEUROD2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNEUROD2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NEUROD2
DgiDB (Drug Gene Interaction Database)NEUROD2
DoCM (Curated mutations)NEUROD2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NEUROD2 (select a term)
intoGenNEUROD2
Cancer3DNEUROD2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601725   
Orphanet
MedgenNEUROD2
Genetic Testing Registry NEUROD2
NextProtQ15784 [Medical]
TSGene4761
GENETestsNEUROD2
Huge Navigator NEUROD2 [HugePedia]
snp3D : Map Gene to Disease4761
BioCentury BCIQNEUROD2
ClinGenNEUROD2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4761
Chemical/Pharm GKB GenePA31565
Clinical trialNEUROD2
Miscellaneous
canSAR (ICR)NEUROD2 (select the gene name)
Probes
Litterature
PubMed19 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNEUROD2
EVEXNEUROD2
GoPubMedNEUROD2
iHOPNEUROD2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:18:41 CET 2017

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