NEUROG3 (neurogenin 3)

2009-05-01  

Identity

HGNC
LOCATION
10q22.1
LOCUSID
ALIAS
Atoh5,Math4B,NGN-3,bHLHa7,ngn3

Other Information

Locus ID:

NCBI: 50674
MIM: 604882
HGNC: 13806
Ensembl: ENSG00000122859

Variants:

dbSNP: 50674
ClinVar: 50674
TCGA: ENSG00000122859
COSMIC: NEUROG3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000122859ENST00000242462Q9Y4Z2

Expression (GTEx)

0
1
2

Pathways

PathwaySourceExternal ID
Maturity onset diabetes of the youngKEGGko04950
Maturity onset diabetes of the youngKEGGhsa04950
Developmental BiologyREACTOMER-HSA-1266738
Regulation of beta-cell developmentREACTOMER-HSA-186712
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cellsREACTOMER-HSA-210744
Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cellsREACTOMER-HSA-210746

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
371171852023USP7 controls NGN3 stability and pancreatic endocrine lineage development.2
371171852023USP7 controls NGN3 stability and pancreatic endocrine lineage development.2
361498142022Novel Variants and Phenotypes in NEUROG3-Associated Syndrome.1
361498142022Novel Variants and Phenotypes in NEUROG3-Associated Syndrome.1
327411442021Recognition of maturity-onset diabetes of the young in China.9
338784312021Effect of NEUROG3 polymorphism rs144643855 on regional spontaneous brain activity in major depressive disorder.3
343524112021Extensive NEUROG3 occupancy in the human pancreatic endocrine gene regulatory network.12
345504972021Protein Production and Purification of a Codon-Optimized Human NGN3 Transcription Factor from E. coli.1
345668962021Gene Signatures of NEUROGENIN3+ Endocrine Progenitor Cells in the Human Pancreas.5
327411442021Recognition of maturity-onset diabetes of the young in China.9
338784312021Effect of NEUROG3 polymorphism rs144643855 on regional spontaneous brain activity in major depressive disorder.3
343524112021Extensive NEUROG3 occupancy in the human pancreatic endocrine gene regulatory network.12
345504972021Protein Production and Purification of a Codon-Optimized Human NGN3 Transcription Factor from E. coli.1
345668962021Gene Signatures of NEUROGENIN3+ Endocrine Progenitor Cells in the Human Pancreas.5
318050142020Null mutations of NEUROG3 are associated with delayed-onset diabetes mellitus.6

Citation

Dessen P

NEUROG3 (neurogenin 3)

Atlas Genet Cytogenet Oncol Haematol. 2009-05-01

Online version: http://atlasgeneticsoncology.org/gene/50918/neurog3