NEXN (nexilin F-actin binding protein)

2011-03-01  

Identity

HGNC
NEXN
LOCATION
1p31.1
LOCUSID
91624
ALIAS
CMH20,NELIN
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 91624
MIM: 613121
HGNC: 29557
Ensembl: ENSG00000162614

Variants:

dbSNP: 91624
ClinVar: 91624
TCGA: ENSG00000162614
COSMIC: NEXN

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000162614ENST00000330010Q0ZGT2
ENSG00000162614ENST00000334785Q0ZGT2
ENSG00000162614ENST00000342754H7BXY5
ENSG00000162614ENST00000401035E7ETM8
ENSG00000162614ENST00000440324E7EUA0

Expression (GTEx)

0
50
100
150
200
250
300
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
198814922009Nexilin mutations destabilize cardiac Z-disks and lead to dilated cardiomyopathy.64
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
209701042010Mutations in NEXN, a Z-disc gene, are associated with hypertrophic cardiomyopathy.21
158235602005NELIN, a new F-actin associated protein, stimulates HeLa cell migration and adhesion.13
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
305894152019Long noncoding RNA NEXN-AS1 mitigates atherosclerosis by regulating the actin-binding protein NEXN.10
243492012013NEXN is a novel susceptibility gene for coronary artery disease in Han Chinese.6
248663832014NEXN inhibits GATA4 and leads to atrial septal defects in mice and humans.4
264589852015Regulatory mechanism of human vascular smooth muscle cell phenotypic transformation induced by NELIN.4

Citation

Dessen P

NEXN (nexilin F-actin binding protein)

Atlas Genet Cytogenet Oncol Haematol. 2011-03-01

Online version: http://atlasgeneticsoncology.org/gene/52154/nexn