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NEXN (nexilin F-actin binding protein)

Identity

Alias_namesnexilin (F actin binding protein)
Alias_symbol (synonym)nexilin
NELIN
HGNC (Hugo) NEXN
LocusID (NCBI) 91624
Atlas_Id 52154
Location 1p31.1  [Link to chromosome band 1p31]
Location_base_pair Starts at 78354200 and ends at 78409578 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
NEXN (1p31.1) / AK5 (1p31.1)NEXN (1p31.1) / NEXN (1p31.1)NEXN (1p31.1) / UBN2 (7q34)
NEXN 1p31.1 / AK5 1p31.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NEXN   29557
LRG (Locus Reference Genomic)LRG_442
Cards
Entrez_Gene (NCBI)NEXN  91624  nexilin F-actin binding protein
AliasesCMH20; NELIN
GeneCards (Weizmann)NEXN
Ensembl hg19 (Hinxton)ENSG00000162614 [Gene_View]  chr1:78354200-78409578 [Contig_View]  NEXN [Vega]
Ensembl hg38 (Hinxton)ENSG00000162614 [Gene_View]  chr1:78354200-78409578 [Contig_View]  NEXN [Vega]
ICGC DataPortalENSG00000162614
TCGA cBioPortalNEXN
AceView (NCBI)NEXN
Genatlas (Paris)NEXN
WikiGenes91624
SOURCE (Princeton)NEXN
Genetics Home Reference (NIH)NEXN
Genomic and cartography
GoldenPath hg19 (UCSC)NEXN  -     chr1:78354200-78409578 +  1p31.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)NEXN  -     1p31.1   [Description]    (hg38-Dec_2013)
EnsemblNEXN - 1p31.1 [CytoView hg19]  NEXN - 1p31.1 [CytoView hg38]
Mapping of homologs : NCBINEXN [Mapview hg19]  NEXN [Mapview hg38]
OMIM613121   613122   613876   
Gene and transcription
Genbank (Entrez)AA249326 AF114264 AF176780 AK057954 AK127535
RefSeq transcript (Entrez)NM_001172309 NM_144573
RefSeq genomic (Entrez)NC_000001 NC_018912 NG_016625 NT_032977 NW_004929290
Consensus coding sequences : CCDS (NCBI)NEXN
Cluster EST : UnigeneHs.612385 [ NCBI ]
CGAP (NCI)Hs.612385
Alternative Splicing GalleryENSG00000162614
Gene ExpressionNEXN [ NCBI-GEO ]   NEXN [ EBI - ARRAY_EXPRESS ]   NEXN [ SEEK ]   NEXN [ MEM ]
Gene Expression Viewer (FireBrowse)NEXN [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)91624
GTEX Portal (Tissue expression)NEXN
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ0ZGT2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ0ZGT2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ0ZGT2
Splice isoforms : SwissVarQ0ZGT2
PhosPhoSitePlusQ0ZGT2
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)   
Domains : Interpro (EBI)Ig-like_dom    Ig-like_fold    Ig_I-set    Ig_sub   
Domain families : Pfam (Sanger)I-set (PF07679)   
Domain families : Pfam (NCBI)pfam07679   
Domain families : Smart (EMBL)IG (SM00409)  
Conserved Domain (NCBI)NEXN
DMDM Disease mutations91624
Blocks (Seattle)NEXN
SuperfamilyQ0ZGT2
Human Protein AtlasENSG00000162614
Peptide AtlasQ0ZGT2
HPRD11388
IPIIPI00180404   IPI00514299   IPI00855737   IPI00554751   IPI00384447   IPI00873443   IPI00385083   
Protein Interaction databases
DIP (DOE-UCLA)Q0ZGT2
IntAct (EBI)Q0ZGT2
FunCoupENSG00000162614
BioGRIDNEXN
STRING (EMBL)NEXN
ZODIACNEXN
Ontologies - Pathways
QuickGOQ0ZGT2
Ontology : AmiGOcytoskeleton  focal adhesion  structural constituent of muscle  Z disc  Z disc  regulation of cell migration  cardiac muscle fiber development  actin filament binding  regulation of cytoskeleton organization  
Ontology : EGO-EBIcytoskeleton  focal adhesion  structural constituent of muscle  Z disc  Z disc  regulation of cell migration  cardiac muscle fiber development  actin filament binding  regulation of cytoskeleton organization  
NDEx NetworkNEXN
Atlas of Cancer Signalling NetworkNEXN
Wikipedia pathwaysNEXN
Orthology - Evolution
OrthoDB91624
GeneTree (enSembl)ENSG00000162614
Phylogenetic Trees/Animal Genes : TreeFamNEXN
HOVERGENQ0ZGT2
HOGENOMQ0ZGT2
Homologs : HomoloGeneNEXN
Homology/Alignments : Family Browser (UCSC)NEXN
Gene fusions - Rearrangements
Fusion : MitelmanNEXN/AK5 [1p31.1/1p31.1]  
Fusion: TCGANEXN 1p31.1 AK5 1p31.1 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNEXN [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NEXN
dbVarNEXN
ClinVarNEXN
1000_GenomesNEXN 
Exome Variant ServerNEXN
ExAC (Exome Aggregation Consortium)NEXN (select the gene name)
Genetic variants : HAPMAP91624
Genomic Variants (DGV)NEXN [DGVbeta]
DECIPHER (Syndromes)1:78354200-78409578  ENSG00000162614
CONAN: Copy Number AnalysisNEXN 
Mutations
ICGC Data PortalNEXN 
TCGA Data PortalNEXN 
Broad Tumor PortalNEXN
OASIS PortalNEXN [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNEXN  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNEXN
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch NEXN
DgiDB (Drug Gene Interaction Database)NEXN
DoCM (Curated mutations)NEXN (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NEXN (select a term)
intoGenNEXN
Cancer3DNEXN(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM613121    613122    613876   
Orphanet635   
MedgenNEXN
Genetic Testing Registry NEXN
NextProtQ0ZGT2 [Medical]
TSGene91624
GENETestsNEXN
Huge Navigator NEXN [HugePedia]
snp3D : Map Gene to Disease91624
BioCentury BCIQNEXN
ClinGenNEXN
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD91624
Chemical/Pharm GKB GenePA134974801
Clinical trialNEXN
Miscellaneous
canSAR (ICR)NEXN (select the gene name)
Probes
Litterature
PubMed25 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNEXN
EVEXNEXN
GoPubMedNEXN
iHOPNEXN
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Nov 18 19:45:46 CET 2016

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