NFAM1 (NFAT activating protein with ITAM motif 1)

2014-11-01  

Identity

HGNC
LOCATION
22q13.2
LOCUSID
ALIAS
CNAIP

Other Information

Locus ID:

NCBI: 150372
MIM: 608740
HGNC: 29872
Ensembl: ENSG00000235568

Variants:

dbSNP: 150372
ClinVar: 150372
TCGA: ENSG00000235568
COSMIC: NFAM1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000235568ENST00000329021Q8NET5
ENSG00000235568ENST00000355469F8WE95

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
170793312007Novel blocker of NFAT activation inhibits IL-6 production in human myometrial arteries and reduces vascular smooth muscle cell proliferation.40
182955962008CD28 and Grb-2, relative to Gads or Grap, preferentially co-operate with Vav1 in the activation of NFAT/AP-1 transcription.8
126159192003Calcineurin/nuclear factors of activated T cells (NFAT)-activating and immunoreceptor tyrosine-based activation motif (ITAM)-containing protein (CNAIP), a novel ITAM-containing protein that activates the calcineurin/NFAT-signaling pathway.6
180317842008Nuclear factor of activated T-cells (NFAT) plays a role in SV40 infection.6

Citation

Dessen P

NFAM1 (NFAT activating protein with ITAM motif 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/70811/nfam1