| CCND1 (11q13.3) / NFAT5 (16q22.1) | NFAT5 (16q22.1) / FHOD1 (16q22.1) | NFAT5 (16q22.1) / HHAT (1q32.2) |
|
NFAT5 (16q22.1) / NFAT5 (16q22.1) | NFAT5 (16q22.1) / SNTB2 (16q22.1) | NFAT5 (16q22.1) / VPS4A (16q22.1) |
|
NFAT5 (16q22.1) / WWP2 (16q22.1) | USP24 (1p32.3) / NFAT5 (16q22.1) | NFAT5 16q22.1 / FHOD1 16q22.1 |
|
NFAT5 16q22.1 / HHAT 1q32.2 |
| Nomenclature |
HGNC (Hugo) | NFAT5 7774 |
| Cards |
Entrez_Gene (NCBI) | NFAT5 10725 nuclear factor of activated T cells 5 |
Aliases | NF-AT5; NFATL1; NFATZ; OREBP; |
| TONEBP |
GeneCards (Weizmann) | NFAT5 |
Ensembl hg19 (Hinxton) | ENSG00000102908 [Gene_View] |
Ensembl hg38 (Hinxton) | ENSG00000102908 [Gene_View]  ENSG00000102908 [Sequence] chr16:69565966-69695688 [Contig_View] NFAT5 [Vega] |
ICGC DataPortal | ENSG00000102908 |
TCGA cBioPortal | NFAT5 |
AceView (NCBI) | NFAT5 |
Genatlas (Paris) | NFAT5 |
WikiGenes | 10725 |
SOURCE (Princeton) | NFAT5 |
Genetics Home Reference (NIH) | NFAT5 |
| Genomic and cartography |
GoldenPath hg38 (UCSC) | NFAT5 - chr16:69565966-69695688 + 16q22.1 [Description] (hg38-Dec_2013) |
GoldenPath hg19 (UCSC) | NFAT5 - 16q22.1 [Description] (hg19-Feb_2009) |
GoldenPath | NFAT5 - 16q22.1 [CytoView hg19] NFAT5 - 16q22.1 [CytoView hg38] |
ImmunoBase | ENSG00000102908 |
Mapping of homologs : NCBI | NFAT5 [Mapview hg19] NFAT5 [Mapview hg38] |
OMIM | 604708 |
| Gene and transcription |
Genbank (Entrez) | AA291524 AA321843 AB020634 AF089824 AF134870 |
RefSeq transcript (Entrez) | NM_001113178 NM_001367709 NM_006599 NM_138713 NM_138714 NM_173214 NM_173215 |
RefSeq genomic (Entrez) | |
Consensus coding sequences : CCDS (NCBI) | NFAT5 |
Cluster EST : Unigene | Hs.371987 [ NCBI ] |
CGAP (NCI) | Hs.371987 |
Alternative Splicing Gallery | ENSG00000102908 |
Gene Expression | NFAT5 [ NCBI-GEO ] NFAT5 [ EBI - ARRAY_EXPRESS ]
NFAT5 [ SEEK ] NFAT5 [ MEM ] |
Gene Expression Viewer (FireBrowse) | NFAT5 [ Firebrowse - Broad ] |
SOURCE (Princeton) | Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60] |
Genevestigator | Expression in : [tissues]  [cell-lines]  [cancer]  [perturbations]   |
BioGPS (Tissue expression) | 10725 |
GTEX Portal (Tissue expression) | NFAT5 |
Human Protein Atlas | ENSG00000102908-NFAT5 [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
UniProt/SwissProt | O94916 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
NextProt | O94916 [Sequence] [Exons] [Medical] [Publications] |
With graphics : InterPro | O94916 |
Splice isoforms : SwissVar | O94916 |
PhosPhoSitePlus | O94916 |
Domaine pattern : Prosite (Expaxy) | REL_2 (PS50254) |
Domains : Interpro (EBI) | Ig-like_fold Ig_E-set IPT_dom NFAT NFAT5 p53-like_TF_DNA-bd RHD_dimer RHD_DNA_bind_dom RHD_DNA_bind_dom_sf |
Domain families : Pfam (Sanger) | RHD_dimer (PF16179) RHD_DNA_bind (PF00554) |
Domain families : Pfam (NCBI) | pfam16179 pfam00554 |
Domain families : Smart (EMBL) | IPT (SM00429) |
Conserved Domain (NCBI) | NFAT5 |
DMDM Disease mutations | 10725 |
Blocks (Seattle) | NFAT5 |
PDB (RSDB) | 1IMH |
PDB Europe | 1IMH |
PDB (PDBSum) | 1IMH |
PDB (IMB) | 1IMH |
Structural Biology KnowledgeBase | 1IMH |
SCOP (Structural Classification of Proteins) | 1IMH |
CATH (Classification of proteins structures) | 1IMH |
Superfamily | O94916 |
Human Protein Atlas [tissue] | ENSG00000102908-NFAT5 [tissue] |
Peptide Atlas | O94916 |
HPRD | 05272 |
IPI | IPI00217710 IPI00218771 IPI00218772 IPI00877627 IPI00514115 |
| Protein Interaction databases |
DIP (DOE-UCLA) | O94916 |
IntAct (EBI) | O94916 |
FunCoup | ENSG00000102908 |
BioGRID | NFAT5 |
STRING (EMBL) | NFAT5 |
ZODIAC | NFAT5 |
| Ontologies - Pathways |
QuickGO | O94916 |
Ontology : AmiGO | RNA polymerase II proximal promoter sequence-specific DNA binding RNA polymerase II proximal promoter sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific cytokine production chromatin binding DNA-binding transcription factor activity protein binding nucleus nucleus nucleoplasm transcription factor complex cytosol cytosol transcription by RNA polymerase II response to osmotic stress signal transduction excretion transcription factor binding calcineurin-NFAT signaling cascade nuclear transcription factor complex positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II regulation of calcineurin-NFAT signaling cascade cellular response to cytokine stimulus positive regulation of NIK/NF-kappaB signaling positive regulation of leukocyte adhesion to vascular endothelial cell |
Ontology : EGO-EBI | RNA polymerase II proximal promoter sequence-specific DNA binding RNA polymerase II proximal promoter sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific cytokine production chromatin binding DNA-binding transcription factor activity protein binding nucleus nucleus nucleoplasm transcription factor complex cytosol cytosol transcription by RNA polymerase II response to osmotic stress signal transduction excretion transcription factor binding calcineurin-NFAT signaling cascade nuclear transcription factor complex positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II regulation of calcineurin-NFAT signaling cascade cellular response to cytokine stimulus positive regulation of NIK/NF-kappaB signaling positive regulation of leukocyte adhesion to vascular endothelial cell |
NDEx Network | NFAT5 |
Atlas of Cancer Signalling Network | NFAT5 |
Wikipedia pathways | NFAT5 |
| Orthology - Evolution |
OrthoDB | 10725 |
GeneTree (enSembl) | ENSG00000102908 |
Phylogenetic Trees/Animal Genes : TreeFam | NFAT5 |
HOGENOM | O94916 |
Homologs : HomoloGene | NFAT5 |
Homology/Alignments : Family Browser (UCSC) | NFAT5 |
| Gene fusions - Rearrangements |
Fusion : Mitelman | NFAT5/FHOD1 [16q22.1/16q22.1]   |
Fusion : Mitelman | NFAT5/HHAT [16q22.1/1q32.2]  [t(1;16)(q32;q22)] |
Fusion : Mitelman | NFAT5/SNTB2 [16q22.1/16q22.1]  [dup(16)(q22q22)] |
Fusion Portal | NFAT5 16q22.1 FHOD1 16q22.1 LUAD |
Fusion Portal | NFAT5 16q22.1 HHAT 1q32.2 LUAD |
Fusion : Quiver | NFAT5 |
| Polymorphisms : SNP and Copy number variants |
NCBI Variation Viewer | NFAT5 [hg38] |
dbSNP Single Nucleotide Polymorphism (NCBI) | NFAT5 |
dbVar | NFAT5 |
ClinVar | NFAT5 |
1000_Genomes | NFAT5 |
Exome Variant Server | NFAT5 |
ExAC (Exome Aggregation Consortium) | ENSG00000102908 |
GNOMAD Browser | ENSG00000102908 |
Varsome Browser | NFAT5 |
Genetic variants : HAPMAP | 10725 |
Genomic Variants (DGV) | NFAT5 [DGVbeta] |
DECIPHER | NFAT5 [patients] [syndromes] [variants] [genes] |
CONAN: Copy Number Analysis | NFAT5 |
| Mutations |
ICGC Data Portal | NFAT5 |
TCGA Data Portal | NFAT5 |
Broad Tumor Portal | NFAT5 |
OASIS Portal | NFAT5 [ Somatic mutations - Copy number] |
Somatic Mutations in Cancer : COSMIC | NFAT5 [overview] [genome browser] [tissue] [distribution] |
Somatic Mutations in Cancer : COSMIC3D | NFAT5 |
Mutations and Diseases : HGMD | NFAT5 |
LOVD (Leiden Open Variation Database) | Whole genome datasets |
LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
BioMuta | search NFAT5 |
DgiDB (Drug Gene Interaction Database) | NFAT5 |
DoCM (Curated mutations) | NFAT5 (select the gene name) |
CIViC (Clinical Interpretations of Variants in Cancer) | NFAT5 (select a term) |
intoGen | NFAT5 |
Cancer3D | NFAT5(select the gene name) |
Impact of mutations | [PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
---|
OMIM | 604708 |
Orphanet | |
DisGeNET | NFAT5 |
Medgen | NFAT5 |
Genetic Testing Registry | NFAT5
|
NextProt | O94916 [Medical] |
TSGene | 10725 |
GENETests | NFAT5 |
Target Validation | NFAT5 |
Huge Navigator |
NFAT5 [HugePedia] |
snp3D : Map Gene to Disease | 10725 |
BioCentury BCIQ | NFAT5 |
ClinGen | NFAT5 |
| Clinical trials, drugs, therapy |
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Chemical/Protein Interactions : CTD | 10725 |
Chemical/Pharm GKB Gene | PA31581 |
Clinical trial | NFAT5 |
| Miscellaneous |
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canSAR (ICR) | NFAT5 (select the gene name) |
DataMed Index | NFAT5 |
| Probes |
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| Litterature |
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PubMed | 112 Pubmed reference(s) in Entrez |
GeneRIFs | Gene References Into Functions (Entrez) |
CoreMine | NFAT5 |
EVEX | NFAT5 |
GoPubMed | NFAT5 |
iHOP | NFAT5 |