NFAT5 (nuclear factor of activated T cells 5)

2007-02-01  

Identity

HGNC
LOCATION
16q22.1
LOCUSID
ALIAS
NF-AT5,NFATL1,NFATZ,OREBP,TONEBP
FUSION GENES

Other Information

Locus ID:

NCBI: 10725
MIM: 604708
HGNC: 7774
Ensembl: ENSG00000102908

Variants:

dbSNP: 10725
ClinVar: 10725
TCGA: ENSG00000102908
COSMIC: NFAT5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000102908ENST00000349945O94916
ENSG00000102908ENST00000354436O94916
ENSG00000102908ENST00000393742A0A499FIS8
ENSG00000102908ENST00000426654O94916
ENSG00000102908ENST00000563474J3KRL6
ENSG00000102908ENST00000565301J3QKS5
ENSG00000102908ENST00000566899A0A499FJX5
ENSG00000102908ENST00000567239O94916
ENSG00000102908ENST00000567990H3BP21
ENSG00000102908ENST00000627621A0A494C020
ENSG00000102908ENST00000650987A0A494C020

Expression (GTEx)

0
5
10
15
20
25

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA444552HypertensionDiseaseLiterature, MultilinkAnnotationassociated24560520

References

Pubmed IDYearTitleCitations
120803492002The role of NFAT transcription factors in integrin-mediated carcinoma invasion.165
118774542002NFAT: ubiquitous regulator of cell differentiation and adaptation.100
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
110460132000The NFAT-related protein NFATL1 (TonEBP/NFAT5) is induced upon T cell activation in a calcineurin-dependent manner.54
117928702002Activity of the TonEBP/OREBP transactivation domain varies directly with extracellular NaCl concentration.49
123597212002Fyn and p38 signaling are both required for maximal hypertonic activation of the osmotic response element-binding protein/tonicity-responsive enhancer-binding protein (OREBP/TonEBP).49
206859652010Osmoprotective transcription factor NFAT5/TonEBP modulates nuclear factor-kappaB activity.48
151735732004ATM, a DNA damage-inducible kinase, contributes to activation by high NaCl of the transcription factor TonEBP/OREBP.42
117801472002Structure of a TonEBP-DNA complex reveals DNA encircled by a transcription factor.41
124829472002cAMP-independent role of PKA in tonicity-induced transactivation of tonicity-responsive enhancer/ osmotic response element-binding protein.38

Citation

Dessen P

NFAT5 (nuclear factor of activated T cells 5)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43657/nfat5