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NFATC2IP (nuclear factor of activated T-cells 2 interacting protein)

Identity

Alias_namesnuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein
Alias_symbol (synonym)FLJ14639
NIP45
RAD60
ESC2
Other alias
HGNC (Hugo) NFATC2IP
LocusID (NCBI) 84901
Atlas_Id 70812
Location 16p11.2  [Link to chromosome band 16p11]
Location_base_pair Starts at 28950997 and ends at 28966446 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ABCC1 (16p13.11) / NFATC2IP (16p11.2)NFATC2IP (16p11.2) / HS3ST4 (16p12.1)NFATC2IP (16p11.2) / LRRC8A (9q34.11)
NFATC2IP (16p11.2) / SPNS1 (16p11.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NFATC2IP   25906
Cards
Entrez_Gene (NCBI)NFATC2IP  84901  nuclear factor of activated T-cells 2 interacting protein
AliasesESC2; NIP45; RAD60
GeneCards (Weizmann)NFATC2IP
Ensembl hg19 (Hinxton)ENSG00000176953 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000176953 [Gene_View]  chr16:28950997-28966446 [Contig_View]  NFATC2IP [Vega]
ICGC DataPortalENSG00000176953
TCGA cBioPortalNFATC2IP
AceView (NCBI)NFATC2IP
Genatlas (Paris)NFATC2IP
WikiGenes84901
SOURCE (Princeton)NFATC2IP
Genetics Home Reference (NIH)NFATC2IP
Genomic and cartography
GoldenPath hg38 (UCSC)NFATC2IP  -     chr16:28950997-28966446 +  16p11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NFATC2IP  -     16p11.2   [Description]    (hg19-Feb_2009)
EnsemblNFATC2IP - 16p11.2 [CytoView hg19]  NFATC2IP - 16p11.2 [CytoView hg38]
Mapping of homologs : NCBINFATC2IP [Mapview hg19]  NFATC2IP [Mapview hg38]
OMIM614525   
Gene and transcription
Genbank (Entrez)AF458593 AK027545 AK074761 AK094764 AK297333
RefSeq transcript (Entrez)NM_032815
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NFATC2IP
Cluster EST : UnigeneHs.513470 [ NCBI ]
CGAP (NCI)Hs.513470
Alternative Splicing GalleryENSG00000176953
Gene ExpressionNFATC2IP [ NCBI-GEO ]   NFATC2IP [ EBI - ARRAY_EXPRESS ]   NFATC2IP [ SEEK ]   NFATC2IP [ MEM ]
Gene Expression Viewer (FireBrowse)NFATC2IP [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)84901
GTEX Portal (Tissue expression)NFATC2IP
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8NCF5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8NCF5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8NCF5
Splice isoforms : SwissVarQ8NCF5
PhosPhoSitePlusQ8NCF5
Domaine pattern : Prosite (Expaxy)UBIQUITIN_2 (PS50053)   
Domains : Interpro (EBI)Rad60/SUMO-like_dom    Ubiquitin-rel_dom    Ubiquitin_dom   
Domain families : Pfam (Sanger)Rad60-SLD (PF11976)   
Domain families : Pfam (NCBI)pfam11976   
Domain families : Smart (EMBL)UBQ (SM00213)  
Conserved Domain (NCBI)NFATC2IP
DMDM Disease mutations84901
Blocks (Seattle)NFATC2IP
PDB (SRS)2JXX    2L76    3RD2   
PDB (PDBSum)2JXX    2L76    3RD2   
PDB (IMB)2JXX    2L76    3RD2   
PDB (RSDB)2JXX    2L76    3RD2   
Structural Biology KnowledgeBase2JXX    2L76    3RD2   
SCOP (Structural Classification of Proteins)2JXX    2L76    3RD2   
CATH (Classification of proteins structures)2JXX    2L76    3RD2   
SuperfamilyQ8NCF5
Human Protein AtlasENSG00000176953
Peptide AtlasQ8NCF5
HPRD10971
IPIIPI00171475   IPI00830023   IPI00830040   
Protein Interaction databases
DIP (DOE-UCLA)Q8NCF5
IntAct (EBI)Q8NCF5
FunCoupENSG00000176953
BioGRIDNFATC2IP
STRING (EMBL)NFATC2IP
ZODIACNFATC2IP
Ontologies - Pathways
QuickGOQ8NCF5
Ontology : AmiGOcytokine production  nucleus  cytoplasm  protein sumoylation  protein tag  positive regulation of transcription from RNA polymerase II promoter  
Ontology : EGO-EBIcytokine production  nucleus  cytoplasm  protein sumoylation  protein tag  positive regulation of transcription from RNA polymerase II promoter  
NDEx NetworkNFATC2IP
Atlas of Cancer Signalling NetworkNFATC2IP
Wikipedia pathwaysNFATC2IP
Orthology - Evolution
OrthoDB84901
GeneTree (enSembl)ENSG00000176953
Phylogenetic Trees/Animal Genes : TreeFamNFATC2IP
HOVERGENQ8NCF5
HOGENOMQ8NCF5
Homologs : HomoloGeneNFATC2IP
Homology/Alignments : Family Browser (UCSC)NFATC2IP
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNFATC2IP [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NFATC2IP
dbVarNFATC2IP
ClinVarNFATC2IP
1000_GenomesNFATC2IP 
Exome Variant ServerNFATC2IP
ExAC (Exome Aggregation Consortium)NFATC2IP (select the gene name)
Genetic variants : HAPMAP84901
Genomic Variants (DGV)NFATC2IP [DGVbeta]
DECIPHERNFATC2IP [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNFATC2IP 
Mutations
ICGC Data PortalNFATC2IP 
TCGA Data PortalNFATC2IP 
Broad Tumor PortalNFATC2IP
OASIS PortalNFATC2IP [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNFATC2IP  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNFATC2IP
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NFATC2IP
DgiDB (Drug Gene Interaction Database)NFATC2IP
DoCM (Curated mutations)NFATC2IP (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NFATC2IP (select a term)
intoGenNFATC2IP
Cancer3DNFATC2IP(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM614525   
Orphanet
MedgenNFATC2IP
Genetic Testing Registry NFATC2IP
NextProtQ8NCF5 [Medical]
TSGene84901
GENETestsNFATC2IP
Target ValidationNFATC2IP
Huge Navigator NFATC2IP [HugePedia]
snp3D : Map Gene to Disease84901
BioCentury BCIQNFATC2IP
ClinGenNFATC2IP
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD84901
Chemical/Pharm GKB GenePA134887712
Clinical trialNFATC2IP
Miscellaneous
canSAR (ICR)NFATC2IP (select the gene name)
Probes
Litterature
PubMed16 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNFATC2IP
EVEXNFATC2IP
GoPubMedNFATC2IP
iHOPNFATC2IP
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed May 31 15:32:35 CEST 2017

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