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NFATC2IP (nuclear factor of activated T cells 2 interacting protein)

Identity

Alias (NCBI)ESC2
NIP45
RAD60
HGNC (Hugo) NFATC2IP
HGNC Alias symbFLJ14639
NIP45
RAD60
ESC2
HGNC Previous namenuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein
LocusID (NCBI) 84901
Atlas_Id 70812
Location 16p11.2  [Link to chromosome band 16p11]
Location_base_pair Starts at 28950997 and ends at 28966446 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ABCC1 (16p13.11) / NFATC2IP (16p11.2)NFATC2IP (16p11.2) / HS3ST4 (16p12.1)NFATC2IP (16p11.2) / LRRC8A (9q34.11)
NFATC2IP (16p11.2) / SPNS1 (16p11.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)NFATC2IP   25906
Cards
Entrez_Gene (NCBI)NFATC2IP    nuclear factor of activated T cells 2 interacting protein
AliasesESC2; NIP45; RAD60
GeneCards (Weizmann)NFATC2IP
Ensembl hg19 (Hinxton)ENSG00000176953 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000176953 [Gene_View]  ENSG00000176953 [Sequence]  chr16:28950997-28966446 [Contig_View]  NFATC2IP [Vega]
ICGC DataPortalENSG00000176953
TCGA cBioPortalNFATC2IP
AceView (NCBI)NFATC2IP
Genatlas (Paris)NFATC2IP
SOURCE (Princeton)NFATC2IP
Genetics Home Reference (NIH)NFATC2IP
Genomic and cartography
GoldenPath hg38 (UCSC)NFATC2IP  -     chr16:28950997-28966446 +  16p11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NFATC2IP  -     16p11.2   [Description]    (hg19-Feb_2009)
GoldenPathNFATC2IP - 16p11.2 [CytoView hg19]  NFATC2IP - 16p11.2 [CytoView hg38]
ImmunoBaseENSG00000176953
Genome Data Viewer NCBINFATC2IP [Mapview hg19]  
OMIM614525   
Gene and transcription
Genbank (Entrez)AF458593 AK027545 AK074761 AK094764 AK297333
RefSeq transcript (Entrez)NM_001394784 NM_001394785 NM_001394786 NM_032815
Consensus coding sequences : CCDS (NCBI)NFATC2IP
Gene ExpressionNFATC2IP [ NCBI-GEO ]   NFATC2IP [ EBI - ARRAY_EXPRESS ]   NFATC2IP [ SEEK ]   NFATC2IP [ MEM ]
Gene Expression Viewer (FireBrowse)NFATC2IP [ Firebrowse - Broad ]
GenevisibleExpression of NFATC2IP in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)84901
GTEX Portal (Tissue expression)NFATC2IP
Human Protein AtlasENSG00000176953-NFATC2IP [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8NCF5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8NCF5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8NCF5
PhosPhoSitePlusQ8NCF5
Domaine pattern : Prosite (Expaxy)UBIQUITIN_2 (PS50053)   
Domains : Interpro (EBI)Rad60/SUMO-like_dom    Ubiquitin-like_dom    Ubiquitin-like_domsf   
Domain families : Pfam (Sanger)Rad60-SLD (PF11976)   
Domain families : Pfam (NCBI)pfam11976   
Domain families : Smart (EMBL)UBQ (SM00213)  
Conserved Domain (NCBI)NFATC2IP
PDB (RSDB)2JXX    2L76    3RD2   
PDB Europe2JXX    2L76    3RD2   
PDB (PDBSum)2JXX    2L76    3RD2   
PDB (IMB)2JXX    2L76    3RD2   
Structural Biology KnowledgeBase2JXX    2L76    3RD2   
SCOP (Structural Classification of Proteins)2JXX    2L76    3RD2   
CATH (Classification of proteins structures)2JXX    2L76    3RD2   
SuperfamilyQ8NCF5
AlphaFold pdb e-kbQ8NCF5   
Human Protein Atlas [tissue]ENSG00000176953-NFATC2IP [tissue]
HPRD10971
Protein Interaction databases
DIP (DOE-UCLA)Q8NCF5
IntAct (EBI)Q8NCF5
BioGRIDNFATC2IP
STRING (EMBL)NFATC2IP
ZODIACNFATC2IP
Ontologies - Pathways
QuickGOQ8NCF5
Ontology : AmiGOcytokine production  nucleus  cytoplasm  positive regulation of transcription by RNA polymerase II  
Ontology : EGO-EBIcytokine production  nucleus  cytoplasm  positive regulation of transcription by RNA polymerase II  
NDEx NetworkNFATC2IP
Atlas of Cancer Signalling NetworkNFATC2IP
Wikipedia pathwaysNFATC2IP
Orthology - Evolution
OrthoDB84901
GeneTree (enSembl)ENSG00000176953
Phylogenetic Trees/Animal Genes : TreeFamNFATC2IP
Homologs : HomoloGeneNFATC2IP
Homology/Alignments : Family Browser (UCSC)NFATC2IP
Gene fusions - Rearrangements
Fusion : QuiverNFATC2IP
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNFATC2IP [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NFATC2IP
dbVarNFATC2IP
ClinVarNFATC2IP
MonarchNFATC2IP
1000_GenomesNFATC2IP 
Exome Variant ServerNFATC2IP
GNOMAD BrowserENSG00000176953
Varsome BrowserNFATC2IP
ACMGNFATC2IP variants
VarityQ8NCF5
Genomic Variants (DGV)NFATC2IP [DGVbeta]
DECIPHERNFATC2IP [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNFATC2IP 
Mutations
ICGC Data PortalNFATC2IP 
TCGA Data PortalNFATC2IP 
Broad Tumor PortalNFATC2IP
OASIS PortalNFATC2IP [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNFATC2IP  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DNFATC2IP
Mutations and Diseases : HGMDNFATC2IP
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaNFATC2IP
DgiDB (Drug Gene Interaction Database)NFATC2IP
DoCM (Curated mutations)NFATC2IP
CIViC (Clinical Interpretations of Variants in Cancer)NFATC2IP
Cancer3DNFATC2IP
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM614525   
Orphanet
DisGeNETNFATC2IP
MedgenNFATC2IP
Genetic Testing Registry NFATC2IP
NextProtQ8NCF5 [Medical]
GENETestsNFATC2IP
Target ValidationNFATC2IP
Huge Navigator NFATC2IP [HugePedia]
ClinGenNFATC2IP
Clinical trials, drugs, therapy
MyCancerGenomeNFATC2IP
Protein Interactions : CTDNFATC2IP
Pharm GKB GenePA134887712
PharosQ8NCF5
Clinical trialNFATC2IP
Miscellaneous
canSAR (ICR)NFATC2IP
HarmonizomeNFATC2IP
DataMed IndexNFATC2IP
Probes
Litterature
PubMed24 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXNFATC2IP
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 16:12:40 CEST 2021

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