| BCL2L2-PABPN1 (14q11.2) / NFATC3 (16q22.1) | CLCN3 (4q33) / NFATC3 (16q22.1) | NFATC3 (16q22.1) / EDC4 (16q22.1) |
|
NFATC3 (16q22.1) / NDUFA1 (Xq24) | NFATC3 (16q22.1) / NFATC3 (16q22.1) | NFATC3 (16q22.1) / PLA2G15 (16q22.1) |
|
PRMT7 (16q22.1) / NFATC3 (16q22.1) | SLC7A6 (16q22.1) / NFATC3 (16q22.1) | PRMT7 16q22.1 / NFATC3 16q22.1 |
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SLC7A6 16q22.1 / NFATC3 16q22.1 |
| Nomenclature |
HGNC (Hugo) | NFATC3 7777 |
| Cards |
Entrez_Gene (NCBI) | NFATC3 4775 nuclear factor of activated T cells 3 |
Aliases | NFAT4; NFATX |
GeneCards (Weizmann) | NFATC3 |
Ensembl hg19 (Hinxton) | ENSG00000072736 [Gene_View] |
Ensembl hg38 (Hinxton) | ENSG00000072736 [Gene_View]  ENSG00000072736 [Sequence] chr16:68085366-68229259 [Contig_View] NFATC3 [Vega] |
ICGC DataPortal | ENSG00000072736 |
TCGA cBioPortal | NFATC3 |
AceView (NCBI) | NFATC3 |
Genatlas (Paris) | NFATC3 |
WikiGenes | 4775 |
SOURCE (Princeton) | NFATC3 |
Genetics Home Reference (NIH) | NFATC3 |
| Genomic and cartography |
GoldenPath hg38 (UCSC) | NFATC3 - chr16:68085366-68229259 + 16q22.1 [Description] (hg38-Dec_2013) |
GoldenPath hg19 (UCSC) | NFATC3 - 16q22.1 [Description] (hg19-Feb_2009) |
Ensembl | NFATC3 - 16q22.1 [CytoView hg19] NFATC3 - 16q22.1 [CytoView hg38] |
Mapping of homologs : NCBI | NFATC3 [Mapview hg19] NFATC3 [Mapview hg38] |
OMIM | 602698 |
| Gene and transcription |
Genbank (Entrez) | AB209824 AK057574 AK290370 BC001050 BE350846 |
RefSeq transcript (Entrez) | NM_004555 NM_173163 NM_173164 NM_173165 |
RefSeq genomic (Entrez) | |
Consensus coding sequences : CCDS (NCBI) | NFATC3 |
Cluster EST : Unigene | Hs.436585 [ NCBI ] |
CGAP (NCI) | Hs.436585 |
Alternative Splicing Gallery | ENSG00000072736 |
Gene Expression | NFATC3 [ NCBI-GEO ] NFATC3 [ EBI - ARRAY_EXPRESS ]
NFATC3 [ SEEK ] NFATC3 [ MEM ] |
Gene Expression Viewer (FireBrowse) | NFATC3 [ Firebrowse - Broad ] |
SOURCE (Princeton) | Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60] |
Genevestigator | Expression in : [tissues]  [cell-lines]  [cancer]  [perturbations]   |
BioGPS (Tissue expression) | 4775 |
GTEX Portal (Tissue expression) | NFATC3 |
Human Protein Atlas | ENSG00000072736-NFATC3 [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
UniProt/SwissProt | Q12968 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
NextProt | Q12968 [Sequence] [Exons] [Medical] [Publications] |
With graphics : InterPro | Q12968 |
Splice isoforms : SwissVar | Q12968 |
PhosPhoSitePlus | Q12968 |
Domaine pattern : Prosite (Expaxy) | REL_2 (PS50254) |
Domains : Interpro (EBI) | Ig-like_fold Ig_E-set IPT_dom NFAT p53-like_TF_DNA-bd RHD_dimer RHD_DNA_bind_dom RHD_DNA_bind_dom_sf |
Domain families : Pfam (Sanger) | RHD_dimer (PF16179) RHD_DNA_bind (PF00554) |
Domain families : Pfam (NCBI) | pfam16179 pfam00554 |
Domain families : Smart (EMBL) | IPT (SM00429) |
Conserved Domain (NCBI) | NFATC3 |
DMDM Disease mutations | 4775 |
Blocks (Seattle) | NFATC3 |
PDB (RSDB) | 2XRW 2XS0 |
PDB Europe | 2XRW 2XS0 |
PDB (PDBSum) | 2XRW 2XS0 |
PDB (IMB) | 2XRW 2XS0 |
Structural Biology KnowledgeBase | 2XRW 2XS0 |
SCOP (Structural Classification of Proteins) | 2XRW 2XS0 |
CATH (Classification of proteins structures) | 2XRW 2XS0 |
Superfamily | Q12968 |
Human Protein Atlas [tissue] | ENSG00000072736-NFATC3 [tissue] |
Peptide Atlas | Q12968 |
HPRD | 04077 |
IPI | IPI00030369 IPI00005240 IPI00215624 IPI00215625 IPI00215626 IPI00215627 IPI01012926 IPI01013707 |
| Protein Interaction databases |
DIP (DOE-UCLA) | Q12968 |
IntAct (EBI) | Q12968 |
FunCoup | ENSG00000072736 |
BioGRID | NFATC3 |
STRING (EMBL) | NFATC3 |
ZODIAC | NFATC3 |
| Ontologies - Pathways |
QuickGO | Q12968 |
Ontology : AmiGO | RNA polymerase II proximal promoter sequence-specific DNA binding RNA polymerase II proximal promoter sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific cytokine production chromatin binding DNA-binding transcription factor activity protein binding nucleus nucleus nucleoplasm nucleoplasm transcription factor complex cytoplasm cytosol cytosol cytosol regulation of transcription by RNA polymerase II transcription by RNA polymerase II inflammatory response transcription factor binding calcineurin-NFAT signaling cascade Fc-epsilon receptor signaling pathway nuclear transcription factor complex positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II negative regulation of pri-miRNA transcription by RNA polymerase II negative regulation of vascular smooth muscle cell differentiation |
Ontology : EGO-EBI | RNA polymerase II proximal promoter sequence-specific DNA binding RNA polymerase II proximal promoter sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific cytokine production chromatin binding DNA-binding transcription factor activity protein binding nucleus nucleus nucleoplasm nucleoplasm transcription factor complex cytoplasm cytosol cytosol cytosol regulation of transcription by RNA polymerase II transcription by RNA polymerase II inflammatory response transcription factor binding calcineurin-NFAT signaling cascade Fc-epsilon receptor signaling pathway nuclear transcription factor complex positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II negative regulation of pri-miRNA transcription by RNA polymerase II negative regulation of vascular smooth muscle cell differentiation |
Pathways : KEGG | MAPK signaling pathway Wnt signaling pathway Axon guidance T cell receptor signaling pathway B cell receptor signaling pathway Hepatitis B HTLV-I infection |
NDEx Network | NFATC3 |
Atlas of Cancer Signalling Network | NFATC3 |
Wikipedia pathways | NFATC3 |
| Orthology - Evolution |
OrthoDB | 4775 |
GeneTree (enSembl) | ENSG00000072736 |
Phylogenetic Trees/Animal Genes : TreeFam | NFATC3 |
HOGENOM | Q12968 |
Homologs : HomoloGene | NFATC3 |
Homology/Alignments : Family Browser (UCSC) | NFATC3 |
| Gene fusions - Rearrangements |
Fusion : Mitelman | NFATC3/PLA2G15 [16q22.1/16q22.1]   |
Fusion : Mitelman | PRMT7/NFATC3 [16q22.1/16q22.1]  [t(16;16)(q22;q22)] |
Fusion : Mitelman | SLC7A6/NFATC3 [16q22.1/16q22.1]  [t(16;16)(q22;q22)] |
Fusion Portal | PRMT7 16q22.1 NFATC3 16q22.1 BRCA |
Fusion Portal | SLC7A6 16q22.1 NFATC3 16q22.1 LUAD |
Fusion : Quiver | NFATC3 |
| Polymorphisms : SNP and Copy number variants |
NCBI Variation Viewer | NFATC3 [hg38] |
dbSNP Single Nucleotide Polymorphism (NCBI) | NFATC3 |
dbVar | NFATC3 |
ClinVar | NFATC3 |
1000_Genomes | NFATC3 |
Exome Variant Server | NFATC3 |
ExAC (Exome Aggregation Consortium) | ENSG00000072736 |
GNOMAD Browser | ENSG00000072736 |
Varsome Browser | NFATC3 |
Genetic variants : HAPMAP | 4775 |
Genomic Variants (DGV) | NFATC3 [DGVbeta] |
DECIPHER | NFATC3 [patients] [syndromes] [variants] [genes] |
CONAN: Copy Number Analysis | NFATC3 |
| Mutations |
ICGC Data Portal | NFATC3 |
TCGA Data Portal | NFATC3 |
Broad Tumor Portal | NFATC3 |
OASIS Portal | NFATC3 [ Somatic mutations - Copy number] |
Somatic Mutations in Cancer : COSMIC | NFATC3 [overview] [genome browser] [tissue] [distribution] |
Mutations and Diseases : HGMD | NFATC3 |
LOVD (Leiden Open Variation Database) | Whole genome datasets |
LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
BioMuta | search NFATC3 |
DgiDB (Drug Gene Interaction Database) | NFATC3 |
DoCM (Curated mutations) | NFATC3 (select the gene name) |
CIViC (Clinical Interpretations of Variants in Cancer) | NFATC3 (select a term) |
intoGen | NFATC3 |
Cancer3D | NFATC3(select the gene name) |
Impact of mutations | [PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
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OMIM | 602698 |
Orphanet | |
DisGeNET | NFATC3 |
Medgen | NFATC3 |
Genetic Testing Registry | NFATC3
|
NextProt | Q12968 [Medical] |
TSGene | 4775 |
GENETests | NFATC3 |
Target Validation | NFATC3 |
Huge Navigator |
NFATC3 [HugePedia] |
snp3D : Map Gene to Disease | 4775 |
BioCentury BCIQ | NFATC3 |
ClinGen | NFATC3 |
| Clinical trials, drugs, therapy |
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Chemical/Protein Interactions : CTD | 4775 |
Chemical/Pharm GKB Gene | PA247 |
Clinical trial | NFATC3 |
| Miscellaneous |
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canSAR (ICR) | NFATC3 (select the gene name) |
DataMed Index | NFATC3 |
| Probes |
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| Litterature |
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PubMed | 75 Pubmed reference(s) in Entrez |
GeneRIFs | Gene References Into Functions (Entrez) |
CoreMine | NFATC3 |
EVEX | NFATC3 |
GoPubMed | NFATC3 |
iHOP | NFATC3 |