Atlas of Genetics and Cytogenetics in Oncology and Haematology

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NFATC3 (nuclear factor of activated T cells 3)

Identity

Alias_namesnuclear factor of activated T-cells
Alias_symbol (synonym)NFAT4
NFATX
Other alias
HGNC (Hugo) NFATC3
LocusID (NCBI) 4775
Atlas_Id 47574
Location 16q22.1  [Link to chromosome band 16q22]
Location_base_pair Starts at 68085366 and ends at 68229259 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
BCL2L2-PABPN1 (14q11.2) / NFATC3 (16q22.1)CLCN3 (4q33) / NFATC3 (16q22.1)NFATC3 (16q22.1) / EDC4 (16q22.1)
NFATC3 (16q22.1) / NDUFA1 (Xq24)NFATC3 (16q22.1) / NFATC3 (16q22.1)NFATC3 (16q22.1) / PLA2G15 (16q22.1)
PRMT7 (16q22.1) / NFATC3 (16q22.1)SLC7A6 (16q22.1) / NFATC3 (16q22.1)PRMT7 16q22.1 / NFATC3 16q22.1
SLC7A6 16q22.1 / NFATC3 16q22.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(16;16)(q22;q22) NFATC3/PLA2G15

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 3 ]
  NFATC3/PLA2G15 (16q22)
PRMT7/NFATC3 (16q22)
SLC7A6/NFATC3 (16q22)

External links

Nomenclature
HGNC (Hugo)NFATC3   7777
Cards
Entrez_Gene (NCBI)NFATC3  4775  nuclear factor of activated T cells 3
AliasesNFAT4; NFATX
GeneCards (Weizmann)NFATC3
Ensembl hg19 (Hinxton)ENSG00000072736 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000072736 [Gene_View]  ENSG00000072736 [Sequence]  chr16:68085366-68229259 [Contig_View]  NFATC3 [Vega]
ICGC DataPortalENSG00000072736
TCGA cBioPortalNFATC3
AceView (NCBI)NFATC3
Genatlas (Paris)NFATC3
WikiGenes4775
SOURCE (Princeton)NFATC3
Genetics Home Reference (NIH)NFATC3
Genomic and cartography
GoldenPath hg38 (UCSC)NFATC3  -     chr16:68085366-68229259 +  16q22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NFATC3  -     16q22.1   [Description]    (hg19-Feb_2009)
EnsemblNFATC3 - 16q22.1 [CytoView hg19]  NFATC3 - 16q22.1 [CytoView hg38]
Mapping of homologs : NCBINFATC3 [Mapview hg19]  NFATC3 [Mapview hg38]
OMIM602698   
Gene and transcription
Genbank (Entrez)AB209824 AK057574 AK290370 BC001050 BE350846
RefSeq transcript (Entrez)NM_004555 NM_173163 NM_173164 NM_173165
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NFATC3
Cluster EST : UnigeneHs.436585 [ NCBI ]
CGAP (NCI)Hs.436585
Alternative Splicing GalleryENSG00000072736
Gene ExpressionNFATC3 [ NCBI-GEO ]   NFATC3 [ EBI - ARRAY_EXPRESS ]   NFATC3 [ SEEK ]   NFATC3 [ MEM ]
Gene Expression Viewer (FireBrowse)NFATC3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4775
GTEX Portal (Tissue expression)NFATC3
Human Protein AtlasENSG00000072736-NFATC3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ12968   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ12968  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ12968
Splice isoforms : SwissVarQ12968
PhosPhoSitePlusQ12968
Domaine pattern : Prosite (Expaxy)REL_2 (PS50254)   
Domains : Interpro (EBI)Ig-like_fold    Ig_E-set    IPT_dom    NFAT    p53-like_TF_DNA-bd    RHD_dimer    RHD_DNA_bind_dom    RHD_DNA_bind_dom_sf   
Domain families : Pfam (Sanger)RHD_dimer (PF16179)    RHD_DNA_bind (PF00554)   
Domain families : Pfam (NCBI)pfam16179    pfam00554   
Domain families : Smart (EMBL)IPT (SM00429)  
Conserved Domain (NCBI)NFATC3
DMDM Disease mutations4775
Blocks (Seattle)NFATC3
PDB (SRS)2XRW    2XS0   
PDB (PDBSum)2XRW    2XS0   
PDB (IMB)2XRW    2XS0   
PDB (RSDB)2XRW    2XS0   
Structural Biology KnowledgeBase2XRW    2XS0   
SCOP (Structural Classification of Proteins)2XRW    2XS0   
CATH (Classification of proteins structures)2XRW    2XS0   
SuperfamilyQ12968
Human Protein Atlas [tissue]ENSG00000072736-NFATC3 [tissue]
Peptide AtlasQ12968
HPRD04077
IPIIPI00030369   IPI00005240   IPI00215624   IPI00215625   IPI00215626   IPI00215627   IPI01012926   IPI01013707   
Protein Interaction databases
DIP (DOE-UCLA)Q12968
IntAct (EBI)Q12968
FunCoupENSG00000072736
BioGRIDNFATC3
STRING (EMBL)NFATC3
ZODIACNFATC3
Ontologies - Pathways
QuickGOQ12968
Ontology : AmiGORNA polymerase II proximal promoter sequence-specific DNA binding  RNA polymerase II proximal promoter sequence-specific DNA binding  RNA polymerase II transcription factor activity, sequence-specific DNA binding  RNA polymerase II transcription factor activity, sequence-specific DNA binding  RNA polymerase II transcription factor activity, sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding  transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding  cytokine production  chromatin binding  DNA-binding transcription factor activity  protein binding  nucleus  nucleus  nucleoplasm  nucleoplasm  transcription factor complex  cytoplasm  cytosol  cytosol  cytosol  regulation of transcription by RNA polymerase II  transcription by RNA polymerase II  transcription by RNA polymerase II  inflammatory response  transcription factor binding  calcineurin-NFAT signaling cascade  Fc-epsilon receptor signaling pathway  nuclear transcription factor complex  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  negative regulation of pri-miRNA transcription by RNA polymerase II  negative regulation of vascular smooth muscle cell differentiation  
Ontology : EGO-EBIRNA polymerase II proximal promoter sequence-specific DNA binding  RNA polymerase II proximal promoter sequence-specific DNA binding  RNA polymerase II transcription factor activity, sequence-specific DNA binding  RNA polymerase II transcription factor activity, sequence-specific DNA binding  RNA polymerase II transcription factor activity, sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding  transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding  cytokine production  chromatin binding  DNA-binding transcription factor activity  protein binding  nucleus  nucleus  nucleoplasm  nucleoplasm  transcription factor complex  cytoplasm  cytosol  cytosol  cytosol  regulation of transcription by RNA polymerase II  transcription by RNA polymerase II  transcription by RNA polymerase II  inflammatory response  transcription factor binding  calcineurin-NFAT signaling cascade  Fc-epsilon receptor signaling pathway  nuclear transcription factor complex  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  negative regulation of pri-miRNA transcription by RNA polymerase II  negative regulation of vascular smooth muscle cell differentiation  
Pathways : KEGGMAPK signaling pathway    Wnt signaling pathway    Axon guidance    T cell receptor signaling pathway    B cell receptor signaling pathway    Hepatitis B    HTLV-I infection   
NDEx NetworkNFATC3
Atlas of Cancer Signalling NetworkNFATC3
Wikipedia pathwaysNFATC3
Orthology - Evolution
OrthoDB4775
GeneTree (enSembl)ENSG00000072736
Phylogenetic Trees/Animal Genes : TreeFamNFATC3
HOVERGENQ12968
HOGENOMQ12968
Homologs : HomoloGeneNFATC3
Homology/Alignments : Family Browser (UCSC)NFATC3
Gene fusions - Rearrangements
Fusion : MitelmanNFATC3/PLA2G15 [16q22.1/16q22.1]  
Fusion : MitelmanPRMT7/NFATC3 [16q22.1/16q22.1]  [t(16;16)(q22;q22)]  
Fusion : MitelmanSLC7A6/NFATC3 [16q22.1/16q22.1]  [t(16;16)(q22;q22)]  
Fusion PortalPRMT7 16q22.1 NFATC3 16q22.1 BRCA
Fusion PortalSLC7A6 16q22.1 NFATC3 16q22.1 LUAD
Fusion : QuiverNFATC3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNFATC3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NFATC3
dbVarNFATC3
ClinVarNFATC3
1000_GenomesNFATC3 
Exome Variant ServerNFATC3
ExAC (Exome Aggregation Consortium)ENSG00000072736
GNOMAD BrowserENSG00000072736
Varsome BrowserNFATC3
Genetic variants : HAPMAP4775
Genomic Variants (DGV)NFATC3 [DGVbeta]
DECIPHERNFATC3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNFATC3 
Mutations
ICGC Data PortalNFATC3 
TCGA Data PortalNFATC3 
Broad Tumor PortalNFATC3
OASIS PortalNFATC3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNFATC3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNFATC3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NFATC3
DgiDB (Drug Gene Interaction Database)NFATC3
DoCM (Curated mutations)NFATC3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NFATC3 (select a term)
intoGenNFATC3
Cancer3DNFATC3(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602698   
Orphanet
DisGeNETNFATC3
MedgenNFATC3
Genetic Testing Registry NFATC3
NextProtQ12968 [Medical]
TSGene4775
GENETestsNFATC3
Target ValidationNFATC3
Huge Navigator NFATC3 [HugePedia]
snp3D : Map Gene to Disease4775
BioCentury BCIQNFATC3
ClinGenNFATC3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4775
Chemical/Pharm GKB GenePA247
Clinical trialNFATC3
Miscellaneous
canSAR (ICR)NFATC3 (select the gene name)
Probes
Litterature
PubMed73 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNFATC3
EVEXNFATC3
GoPubMedNFATC3
iHOPNFATC3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Aug 27 11:40:34 CEST 2018
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