NFATC3 (nuclear factor of activated T cells 3)

2007-07-01  

Identity

HGNC
LOCATION
16q22.1
LOCUSID
ALIAS
NF-AT4c,NFAT4,NFATX
FUSION GENES

Other Information

Locus ID:

NCBI: 4775
MIM: 602698
HGNC: 7777
Ensembl: ENSG00000072736

Variants:

dbSNP: 4775
ClinVar: 4775
TCGA: ENSG00000072736
COSMIC: NFATC3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000072736ENST00000329524Q12968
ENSG00000072736ENST00000329524B5B2S0
ENSG00000072736ENST00000346183Q12968
ENSG00000072736ENST00000346183B5B2S1
ENSG00000072736ENST00000349223Q12968
ENSG00000072736ENST00000539828F8VPH9
ENSG00000072736ENST00000561714F8VPH9
ENSG00000072736ENST00000562171H3BRM3
ENSG00000072736ENST00000562926H3BR83
ENSG00000072736ENST00000565750H3BU30
ENSG00000072736ENST00000568466F8VPH9
ENSG00000072736ENST00000570212H3BRS1
ENSG00000072736ENST00000575270I3L3K7

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
Wnt signaling pathwayKEGGko04310
Axon guidanceKEGGko04360
T cell receptor signaling pathwayKEGGko04660
B cell receptor signaling pathwayKEGGko04662
MAPK signaling pathwayKEGGhsa04010
Wnt signaling pathwayKEGGhsa04310
Axon guidanceKEGGhsa04360
T cell receptor signaling pathwayKEGGhsa04660
B cell receptor signaling pathwayKEGGhsa04662
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
Hepatitis BKEGGhsa05161
Oxytocin signaling pathwayKEGGhsa04921
Oxytocin signaling pathwayKEGGko04921
cGMP-PKG signaling pathwayKEGGhsa04022
cGMP-PKG signaling pathwayKEGGko04022
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Fc epsilon receptor (FCERI) signalingREACTOMER-HSA-2454202
FCERI mediated Ca+2 mobilizationREACTOMER-HSA-2871809
C-type lectin receptors (CLRs)REACTOMER-HSA-5621481
CLEC7A (Dectin-1) signalingREACTOMER-HSA-5607764
CLEC7A (Dectin-1) induces NFAT activationREACTOMER-HSA-5607763
Th1 and Th2 cell differentiationKEGGko04658
Th1 and Th2 cell differentiationKEGGhsa04658
Th17 cell differentiationKEGGko04659
Th17 cell differentiationKEGGhsa04659

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
164459772006ATP autocrine/paracrine signaling induces calcium oscillations and NFAT activation in human mesenchymal stem cells.53
232195322013Dynamic response diversity of NFAT isoforms in individual living cells.45
162606082005The DnaJ-related factor Mrj interacts with nuclear factor of activated T cells c3 and mediates transcriptional repression through class II histone deacetylase recruitment.39
258186452015Distinct spatial Ca2+ signatures selectively activate different NFAT transcription factor isoforms.37
151731722004Nuclear factor of activated T cells regulates transcription of the surfactant protein D gene (Sftpd) via direct interaction with thyroid transcription factor-1 in lung epithelial cells.27
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
170353322006NFAT4 is required for JC virus infection of glial cells.25
186763762008Cooperative synergy between NFAT and MyoD regulates myogenin expression and myogenesis.24
239294332014miR-23a inhibits E-cadherin expression and is regulated by AP-1 and NFAT4 complex during Fas-induced EMT in gastrointestinal cancer.24

Citation

Dessen P

NFATC3 (nuclear factor of activated T cells 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-07-01

Online version: http://atlasgeneticsoncology.org/gene/47574/nfatc3