Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

NFATC3 (nuclear factor of activated T cells 3)

Identity

Alias (NCBI)NF-AT4c
NFAT4
NFATX
HGNC (Hugo) NFATC3
HGNC Alias symbNFAT4
NFATX
HGNC Previous namenuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
 nuclear factor of activated T-cells 3
LocusID (NCBI) 4775
Atlas_Id 47574
Location 16q22.1  [Link to chromosome band 16q22]
Location_base_pair Starts at 68085370 and ends at 68229259 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
BCL2L2-PABPN1 (14q11.2) / NFATC3 (16q22.1)CLCN3 (4q33) / NFATC3 (16q22.1)NFATC3 (16q22.1) / EDC4 (16q22.1)
NFATC3 (16q22.1) / NDUFA1 (Xq24)NFATC3 (16q22.1) / NFATC3 (16q22.1)NFATC3 (16q22.1) / PLA2G15 (16q22.1)
PRMT7 (16q22.1) / NFATC3 (16q22.1)SLC7A6 (16q22.1) / NFATC3 (16q22.1)PRMT7 16q22.1 / NFATC3 16q22.1
SLC7A6 16q22.1 / NFATC3 16q22.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(16;16)(q22;q22) NFATC3/PLA2G15


External links

 

Nomenclature
HGNC (Hugo)NFATC3   7777
Cards
Entrez_Gene (NCBI)NFATC3    nuclear factor of activated T cells 3
AliasesNF-AT4c; NFAT4; NFATX
GeneCards (Weizmann)NFATC3
Ensembl hg19 (Hinxton)ENSG00000072736 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000072736 [Gene_View]  ENSG00000072736 [Sequence]  chr16:68085370-68229259 [Contig_View]  NFATC3 [Vega]
ICGC DataPortalENSG00000072736
TCGA cBioPortalNFATC3
AceView (NCBI)NFATC3
Genatlas (Paris)NFATC3
SOURCE (Princeton)NFATC3
Genetics Home Reference (NIH)NFATC3
Genomic and cartography
GoldenPath hg38 (UCSC)NFATC3  -     chr16:68085370-68229259 +  16q22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NFATC3  -     16q22.1   [Description]    (hg19-Feb_2009)
GoldenPathNFATC3 - 16q22.1 [CytoView hg19]  NFATC3 - 16q22.1 [CytoView hg38]
ImmunoBaseENSG00000072736
Genome Data Viewer NCBINFATC3 [Mapview hg19]  
OMIM602698   
Gene and transcription
Genbank (Entrez)AB209824 AK057574 AK290370 BC001050 BE350846
RefSeq transcript (Entrez)NM_004555 NM_173163 NM_173164 NM_173165
Consensus coding sequences : CCDS (NCBI)NFATC3
Gene ExpressionNFATC3 [ NCBI-GEO ]   NFATC3 [ EBI - ARRAY_EXPRESS ]   NFATC3 [ SEEK ]   NFATC3 [ MEM ]
Gene Expression Viewer (FireBrowse)NFATC3 [ Firebrowse - Broad ]
GenevisibleExpression of NFATC3 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4775
GTEX Portal (Tissue expression)NFATC3
Human Protein AtlasENSG00000072736-NFATC3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ12968   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ12968  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ12968
PhosPhoSitePlusQ12968
Domaine pattern : Prosite (Expaxy)REL_2 (PS50254)   
Domains : Interpro (EBI)Ig-like_fold    Ig_E-set    IPT_dom    NFAT    p53-like_TF_DNA-bd    RHD_dimer    RHD_DNA_bind_dom    RHD_DNA_bind_dom_sf   
Domain families : Pfam (Sanger)RHD_dimer (PF16179)    RHD_DNA_bind (PF00554)   
Domain families : Pfam (NCBI)pfam16179    pfam00554   
Domain families : Smart (EMBL)IPT (SM00429)  
Conserved Domain (NCBI)NFATC3
PDB (RSDB)2XRW    2XS0   
PDB Europe2XRW    2XS0   
PDB (PDBSum)2XRW    2XS0   
PDB (IMB)2XRW    2XS0   
Structural Biology KnowledgeBase2XRW    2XS0   
SCOP (Structural Classification of Proteins)2XRW    2XS0   
CATH (Classification of proteins structures)2XRW    2XS0   
SuperfamilyQ12968
AlphaFold pdb e-kbQ12968   
Human Protein Atlas [tissue]ENSG00000072736-NFATC3 [tissue]
HPRD04077
Protein Interaction databases
DIP (DOE-UCLA)Q12968
IntAct (EBI)Q12968
BioGRIDNFATC3
STRING (EMBL)NFATC3
ZODIACNFATC3
Ontologies - Pathways
QuickGOQ12968
Ontology : AmiGOchromatin  RNA polymerase II cis-regulatory region sequence-specific DNA binding  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription repressor activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  cytokine production  protein binding  nucleus  nucleoplasm  nucleoplasm  transcription regulator complex  cytoplasm  cytosol  cytosol  regulation of transcription by RNA polymerase II  inflammatory response  multicellular organism development  transcription factor binding  calcineurin-NFAT signaling cascade  Fc-epsilon receptor signaling pathway  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  negative regulation of pri-miRNA transcription by RNA polymerase II  negative regulation of vascular associated smooth muscle cell differentiation  sequence-specific double-stranded DNA binding  
Ontology : EGO-EBIchromatin  RNA polymerase II cis-regulatory region sequence-specific DNA binding  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription repressor activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  cytokine production  protein binding  nucleus  nucleoplasm  nucleoplasm  transcription regulator complex  cytoplasm  cytosol  cytosol  regulation of transcription by RNA polymerase II  inflammatory response  multicellular organism development  transcription factor binding  calcineurin-NFAT signaling cascade  Fc-epsilon receptor signaling pathway  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  negative regulation of pri-miRNA transcription by RNA polymerase II  negative regulation of vascular associated smooth muscle cell differentiation  sequence-specific double-stranded DNA binding  
Pathways : BIOCARTAfMLP induced chemokine gene expression in HMC-1 cells [Genes]    Effects of calcineurin in Keratinocyte Differentiation [Genes]    Signaling Pathway from G-Protein Families [Genes]    T Cell Receptor Signaling Pathway [Genes]    Fc Epsilon Receptor I Signaling in Mast Cells [Genes]    BCR Signaling Pathway [Genes]    NFAT and Hypertrophy of the heart (Transcription in the broken heart) [Genes]   
Pathways : KEGGMAPK signaling pathway    Wnt signaling pathway    Axon guidance    T cell receptor signaling pathway    B cell receptor signaling pathway    Hepatitis B    HTLV-I infection   
NDEx NetworkNFATC3
Atlas of Cancer Signalling NetworkNFATC3
Wikipedia pathwaysNFATC3
Orthology - Evolution
OrthoDB4775
GeneTree (enSembl)ENSG00000072736
Phylogenetic Trees/Animal Genes : TreeFamNFATC3
Homologs : HomoloGeneNFATC3
Homology/Alignments : Family Browser (UCSC)NFATC3
Gene fusions - Rearrangements
Fusion : MitelmanNFATC3/PLA2G15 [16q22.1/16q22.1]  
Fusion : MitelmanPRMT7/NFATC3 [16q22.1/16q22.1]  
Fusion : MitelmanSLC7A6/NFATC3 [16q22.1/16q22.1]  
Fusion : QuiverNFATC3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNFATC3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NFATC3
dbVarNFATC3
ClinVarNFATC3
MonarchNFATC3
1000_GenomesNFATC3 
Exome Variant ServerNFATC3
GNOMAD BrowserENSG00000072736
Varsome BrowserNFATC3
ACMGNFATC3 variants
VarityQ12968
Genomic Variants (DGV)NFATC3 [DGVbeta]
DECIPHERNFATC3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNFATC3 
Mutations
ICGC Data PortalNFATC3 
TCGA Data PortalNFATC3 
Broad Tumor PortalNFATC3
OASIS PortalNFATC3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNFATC3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DNFATC3
Mutations and Diseases : HGMDNFATC3
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaNFATC3
DgiDB (Drug Gene Interaction Database)NFATC3
DoCM (Curated mutations)NFATC3
CIViC (Clinical Interpretations of Variants in Cancer)NFATC3
Cancer3DNFATC3
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602698   
Orphanet
DisGeNETNFATC3
MedgenNFATC3
Genetic Testing Registry NFATC3
NextProtQ12968 [Medical]
GENETestsNFATC3
Target ValidationNFATC3
Huge Navigator NFATC3 [HugePedia]
ClinGenNFATC3
Clinical trials, drugs, therapy
MyCancerGenomeNFATC3
Protein Interactions : CTDNFATC3
Pharm GKB GenePA247
PharosQ12968
Clinical trialNFATC3
Miscellaneous
canSAR (ICR)NFATC3
HarmonizomeNFATC3
DataMed IndexNFATC3
Probes
Litterature
PubMed83 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXNFATC3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:22:38 CEST 2021

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.