NFATC4 (nuclear factor of activated T cells 4)

2007-02-01  

Identity

HGNC
LOCATION
14q12
LOCUSID
ALIAS
NF-AT3,NF-ATC4,NFAT3

Other Information

Locus ID:

NCBI: 4776
MIM: 602699
HGNC: 7778
Ensembl: ENSG00000100968

Variants:

dbSNP: 4776
ClinVar: 4776
TCGA: ENSG00000100968
COSMIC: NFATC4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100968ENST00000250373Q14934
ENSG00000100968ENST00000413692Q14934
ENSG00000100968ENST00000422617Q14934
ENSG00000100968ENST00000424781Q14934
ENSG00000100968ENST00000539237Q14934
ENSG00000100968ENST00000553469Q14934
ENSG00000100968ENST00000553708Q14934
ENSG00000100968ENST00000553879Q14934
ENSG00000100968ENST00000554050Q14934
ENSG00000100968ENST00000554344Q14934
ENSG00000100968ENST00000554473Q14934
ENSG00000100968ENST00000554591Q14934
ENSG00000100968ENST00000554661Q14934
ENSG00000100968ENST00000554779G3V4U6
ENSG00000100968ENST00000554903G3V4K1
ENSG00000100968ENST00000554966Q14934
ENSG00000100968ENST00000555167Q14934
ENSG00000100968ENST00000555393Q14934
ENSG00000100968ENST00000555453Q14934
ENSG00000100968ENST00000555590Q14934
ENSG00000100968ENST00000555802Q14934
ENSG00000100968ENST00000556169Q14934
ENSG00000100968ENST00000556279Q14934
ENSG00000100968ENST00000556759Q14934
ENSG00000100968ENST00000557451Q14934
ENSG00000100968ENST00000557674G3V5H0
ENSG00000100968ENST00000557767Q14934

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Wnt signaling pathwayKEGGko04310
Axon guidanceKEGGko04360
Wnt signaling pathwayKEGGhsa04310
Axon guidanceKEGGhsa04360
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
Hepatitis BKEGGhsa05161
Oxytocin signaling pathwayKEGGhsa04921
Oxytocin signaling pathwayKEGGko04921
cGMP-PKG signaling pathwayKEGGhsa04022
cGMP-PKG signaling pathwayKEGGko04022

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA33678PPP3CAGenePathwayassociated23922006
PA33679PPP3CBGenePathwayassociated23922006
PA33680PPP3CCGenePathwayassociated23922006
PA33681PPP3R1GenePathwayassociated23922006
PA33682PPP3R2GenePathwayassociated23922006

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
223788902012Inhibition of the NFAT pathway alleviates amyloid β neurotoxicity in a mouse model of Alzheimer's disease.40
172132022007RSK2 mediates muscle cell differentiation through regulation of NFAT3.29
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
221642652011Syndecan-4 is essential for development of concentric myocardial hypertrophy via stretch-induced activation of the calcineurin-NFAT pathway.24
164891192006Essential role of ROS-mediated NFAT activation in TNF-alpha induction by crystalline silica exposure.22
196530052009The combined impact of metabolic gene polymorphisms on elite endurance athlete status and related phenotypes.22
162197652005Stimulatory cross-talk between NFAT3 and estrogen receptor in breast cancer cells.21
242574152013NFAT3 and TGF-β/SMAD3 regulate the expression of miR-140 in osteoarthritis.19
229772512012Distinct activation properties of the nuclear factor of activated T-cells (NFAT) isoforms NFATc3 and NFATc4 in neurons.18

Citation

Dessen P

NFATC4 (nuclear factor of activated T cells 4)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43963/nfatc4