Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

NFATC4 (nuclear factor of activated T cells 4)

Identity

Alias_namesnuclear factor of activated T-cells
Alias_symbol (synonym)NFAT3
Other aliasNF-AT3
NF-ATC4
HGNC (Hugo) NFATC4
LocusID (NCBI) 4776
Atlas_Id 43963
Location 14q12  [Link to chromosome band 14q12]
Location_base_pair Starts at 24368020 and ends at 24379606 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NFATC4   7778
Cards
Entrez_Gene (NCBI)NFATC4  4776  nuclear factor of activated T cells 4
AliasesNF-AT3; NF-ATC4; NFAT3
GeneCards (Weizmann)NFATC4
Ensembl hg19 (Hinxton)ENSG00000100968 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000100968 [Gene_View]  ENSG00000100968 [Sequence]  chr14:24368020-24379606 [Contig_View]  NFATC4 [Vega]
ICGC DataPortalENSG00000100968
TCGA cBioPortalNFATC4
AceView (NCBI)NFATC4
Genatlas (Paris)NFATC4
WikiGenes4776
SOURCE (Princeton)NFATC4
Genetics Home Reference (NIH)NFATC4
Genomic and cartography
GoldenPath hg38 (UCSC)NFATC4  -     chr14:24368020-24379606 +  14q12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NFATC4  -     14q12   [Description]    (hg19-Feb_2009)
EnsemblNFATC4 - 14q12 [CytoView hg19]  NFATC4 - 14q12 [CytoView hg38]
Mapping of homologs : NCBINFATC4 [Mapview hg19]  NFATC4 [Mapview hg38]
OMIM602699   
Gene and transcription
Genbank (Entrez)AK293185 AK293873 AK300450 AK302271 AK309339
RefSeq transcript (Entrez)NM_001136022 NM_001198965 NM_001198966 NM_001198967 NM_001288802 NM_001320043 NM_004554
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NFATC4
Cluster EST : UnigeneHs.77810 [ NCBI ]
CGAP (NCI)Hs.77810
Alternative Splicing GalleryENSG00000100968
Gene ExpressionNFATC4 [ NCBI-GEO ]   NFATC4 [ EBI - ARRAY_EXPRESS ]   NFATC4 [ SEEK ]   NFATC4 [ MEM ]
Gene Expression Viewer (FireBrowse)NFATC4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4776
GTEX Portal (Tissue expression)NFATC4
Human Protein AtlasENSG00000100968-NFATC4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14934   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ14934  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ14934
Splice isoforms : SwissVarQ14934
PhosPhoSitePlusQ14934
Domaine pattern : Prosite (Expaxy)REL_2 (PS50254)   
Domains : Interpro (EBI)Ig-like_fold    Ig_E-set    IPT    NFAT    p53-like_TF_DNA-bd    RHD_dimer    RHD_DNA_bind_dom   
Domain families : Pfam (Sanger)RHD_dimer (PF16179)    RHD_DNA_bind (PF00554)   
Domain families : Pfam (NCBI)pfam16179    pfam00554   
Domain families : Smart (EMBL)IPT (SM00429)  
Conserved Domain (NCBI)NFATC4
DMDM Disease mutations4776
Blocks (Seattle)NFATC4
PDB (SRS)2YRP   
PDB (PDBSum)2YRP   
PDB (IMB)2YRP   
PDB (RSDB)2YRP   
Structural Biology KnowledgeBase2YRP   
SCOP (Structural Classification of Proteins)2YRP   
CATH (Classification of proteins structures)2YRP   
SuperfamilyQ14934
Human Protein Atlas [tissue]ENSG00000100968-NFATC4 [tissue]
Peptide AtlasQ14934
HPRD09096
IPI###############################################################################################################################################################################################################################################################   
Protein Interaction databases
DIP (DOE-UCLA)Q14934
IntAct (EBI)Q14934
FunCoupENSG00000100968
BioGRIDNFATC4
STRING (EMBL)NFATC4
ZODIACNFATC4
Ontologies - Pathways
QuickGOQ14934
Ontology : AmiGORNA polymerase II proximal promoter sequence-specific DNA binding  transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding  transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding  branching involved in blood vessel morphogenesis  transcription coactivator activity  protein binding  nucleus  transcription factor complex  cytosol  transcription by RNA polymerase II  inflammatory response  heart development  transcription factor binding  intrinsic apoptotic signaling pathway in response to DNA damage  nuclear speck  negative regulation of Wnt signaling pathway  negative regulation of protein binding  positive regulation of tumor necrosis factor production  calcineurin-NFAT signaling cascade  cellular response to UV  negative regulation of chromatin binding  peroxisome proliferator activated receptor binding  cellular respiration  positive regulation of transcription by RNA polymerase II  regulation of synaptic plasticity  negative regulation of dendrite morphogenesis  smooth muscle cell differentiation  muscle cell development  cellular response to lithium ion  negative regulation of pri-miRNA transcription by RNA polymerase II  cellular response to ionomycin  negative regulation of synapse maturation  positive regulation of apoptotic signaling pathway  
Ontology : EGO-EBIRNA polymerase II proximal promoter sequence-specific DNA binding  transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding  transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding  branching involved in blood vessel morphogenesis  transcription coactivator activity  protein binding  nucleus  transcription factor complex  cytosol  transcription by RNA polymerase II  inflammatory response  heart development  transcription factor binding  intrinsic apoptotic signaling pathway in response to DNA damage  nuclear speck  negative regulation of Wnt signaling pathway  negative regulation of protein binding  positive regulation of tumor necrosis factor production  calcineurin-NFAT signaling cascade  cellular response to UV  negative regulation of chromatin binding  peroxisome proliferator activated receptor binding  cellular respiration  positive regulation of transcription by RNA polymerase II  regulation of synaptic plasticity  negative regulation of dendrite morphogenesis  smooth muscle cell differentiation  muscle cell development  cellular response to lithium ion  negative regulation of pri-miRNA transcription by RNA polymerase II  cellular response to ionomycin  negative regulation of synapse maturation  positive regulation of apoptotic signaling pathway  
Pathways : BIOCARTAFc Epsilon Receptor I Signaling in Mast Cells [Genes]    NFAT and Hypertrophy of the heart (Transcription in the broken heart) [Genes]    Effects of calcineurin in Keratinocyte Differentiation [Genes]    Signaling Pathway from G-Protein Families [Genes]    fMLP induced chemokine gene expression in HMC-1 cells [Genes]    BCR Signaling Pathway [Genes]    T Cell Receptor Signaling Pathway [Genes]   
Pathways : KEGGMAPK signaling pathway    Natural killer cell mediated cytotoxicity    T cell receptor signaling pathway    VEGF signaling pathway    Axon guidance    Wnt signaling pathway    B cell receptor signaling pathway   
NDEx NetworkNFATC4
Atlas of Cancer Signalling NetworkNFATC4
Wikipedia pathwaysNFATC4
Orthology - Evolution
OrthoDB4776
GeneTree (enSembl)ENSG00000100968
Phylogenetic Trees/Animal Genes : TreeFamNFATC4
HOVERGENQ14934
HOGENOMQ14934
Homologs : HomoloGeneNFATC4
Homology/Alignments : Family Browser (UCSC)NFATC4
Gene fusions - Rearrangements
Fusion : QuiverNFATC4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNFATC4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NFATC4
dbVarNFATC4
ClinVarNFATC4
1000_GenomesNFATC4 
Exome Variant ServerNFATC4
ExAC (Exome Aggregation Consortium)ENSG00000100968
GNOMAD BrowserENSG00000100968
Genetic variants : HAPMAP4776
Genomic Variants (DGV)NFATC4 [DGVbeta]
DECIPHERNFATC4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNFATC4 
Mutations
ICGC Data PortalNFATC4 
TCGA Data PortalNFATC4 
Broad Tumor PortalNFATC4
OASIS PortalNFATC4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNFATC4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNFATC4
intOGen PortalNFATC4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NFATC4
DgiDB (Drug Gene Interaction Database)NFATC4
DoCM (Curated mutations)NFATC4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NFATC4 (select a term)
intoGenNFATC4
Cancer3DNFATC4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602699   
Orphanet
DisGeNETNFATC4
MedgenNFATC4
Genetic Testing Registry NFATC4
NextProtQ14934 [Medical]
TSGene4776
GENETestsNFATC4
Target ValidationNFATC4
Huge Navigator NFATC4 [HugePedia]
snp3D : Map Gene to Disease4776
BioCentury BCIQNFATC4
ClinGenNFATC4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4776
Chemical/Pharm GKB GenePA31584
Clinical trialNFATC4
Miscellaneous
canSAR (ICR)NFATC4 (select the gene name)
Probes
Litterature
PubMed72 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNFATC4
EVEXNFATC4
GoPubMedNFATC4
iHOPNFATC4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jun 22 16:40:04 CEST 2018

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.