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NFE2 (nuclear factor, erythroid 2)

Identity

Alias (NCBI)NF-E2
p45
HGNC (Hugo) NFE2
HGNC Alias symbNF-E2
HGNC Previous namenuclear factor (erythroid-derived 2), 45kD
 nuclear factor (erythroid-derived 2), 45kDa
LocusID (NCBI) 4778
Atlas_Id 41529
Location 12q13.13  [Link to chromosome band 12q13]
Location_base_pair Starts at 54292107 and ends at 54295779 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CBX5 (12q13.13)::NFE2 (12q13.13)NFE2 (12q13.13)::STARD7 (2q11.2)R3HDM2 (12q13.3)::NFE2 (12q13.13)
CBX5 12q13.13::NFE2 12q13.13NFE2 12q13.13::STARD7 2q11.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)NFE2   7780
Cards
Entrez_Gene (NCBI)NFE2    nuclear factor, erythroid 2
AliasesNF-E2; p45
GeneCards (Weizmann)NFE2
Ensembl hg19 (Hinxton)ENSG00000123405 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000123405 [Gene_View]  ENSG00000123405 [Sequence]  chr12:54292107-54295779 [Contig_View]  NFE2 [Vega]
ICGC DataPortalENSG00000123405
TCGA cBioPortalNFE2
AceView (NCBI)NFE2
Genatlas (Paris)NFE2
SOURCE (Princeton)NFE2
Genetics Home Reference (NIH)NFE2
Genomic and cartography
GoldenPath hg38 (UCSC)NFE2  -     chr12:54292107-54295779 -  12q13.13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NFE2  -     12q13.13   [Description]    (hg19-Feb_2009)
GoldenPathNFE2 - 12q13.13 [CytoView hg19]  NFE2 - 12q13.13 [CytoView hg38]
ImmunoBaseENSG00000123405
Genome Data Viewer NCBINFE2 [Mapview hg19]  
OMIM601490   
Gene and transcription
Genbank (Entrez)AK290555 AK290564 AK313207 BC005044 BE243330
RefSeq transcript (Entrez)NM_001136023 NM_001261461 NM_006163
Consensus coding sequences : CCDS (NCBI)NFE2
Gene ExpressionNFE2 [ NCBI-GEO ]   NFE2 [ EBI - ARRAY_EXPRESS ]   NFE2 [ SEEK ]   NFE2 [ MEM ]
Gene Expression Viewer (FireBrowse)NFE2 [ Firebrowse - Broad ]
GenevisibleExpression of NFE2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4778
GTEX Portal (Tissue expression)NFE2
Human Protein AtlasENSG00000123405-NFE2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ16621   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ16621  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ16621
PhosPhoSitePlusQ16621
Domaine pattern : Prosite (Expaxy)BZIP (PS50217)    BZIP_BASIC (PS00036)   
Domains : Interpro (EBI)bZIP    bZIP_Maf    NF-E2_p45    TF_DNA-bd_sf   
Domain families : Pfam (Sanger)bZIP_Maf (PF03131)   
Domain families : Pfam (NCBI)pfam03131   
Domain families : Smart (EMBL)BRLZ (SM00338)  
Conserved Domain (NCBI)NFE2
PDB (RSDB)1LVX    2KZ5   
PDB Europe1LVX    2KZ5   
PDB (PDBSum)1LVX    2KZ5   
PDB (IMB)1LVX    2KZ5   
Structural Biology KnowledgeBase1LVX    2KZ5   
SCOP (Structural Classification of Proteins)1LVX    2KZ5   
CATH (Classification of proteins structures)1LVX    2KZ5   
SuperfamilyQ16621
AlphaFold pdb e-kbQ16621   
Human Protein Atlas [tissue]ENSG00000123405-NFE2 [tissue]
HPRD09030
Protein Interaction databases
DIP (DOE-UCLA)Q16621
IntAct (EBI)Q16621
BioGRIDNFE2
STRING (EMBL)NFE2
ZODIACNFE2
Ontologies - Pathways
QuickGOQ16621
Ontology : AmiGOchromatin  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  cis-regulatory region sequence-specific DNA binding  DNA binding  DNA-binding transcription factor activity  protein binding  nucleus  nucleoplasm  cytoplasm  nucleosome disassembly  regulation of transcription by RNA polymerase II  multicellular organism development  hemostasis  PML body  protein-DNA complex  identical protein binding  sequence-specific DNA binding  positive regulation of transcription, DNA-templated  protein N-terminus binding  WW domain binding  WW domain binding  RNA polymerase II transcription regulator complex  sequence-specific double-stranded DNA binding  
Ontology : EGO-EBIchromatin  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  cis-regulatory region sequence-specific DNA binding  DNA binding  DNA-binding transcription factor activity  protein binding  nucleus  nucleoplasm  cytoplasm  nucleosome disassembly  regulation of transcription by RNA polymerase II  multicellular organism development  hemostasis  PML body  protein-DNA complex  identical protein binding  sequence-specific DNA binding  positive regulation of transcription, DNA-templated  protein N-terminus binding  WW domain binding  WW domain binding  RNA polymerase II transcription regulator complex  sequence-specific double-stranded DNA binding  
NDEx NetworkNFE2
Atlas of Cancer Signalling NetworkNFE2
Wikipedia pathwaysNFE2
Orthology - Evolution
OrthoDB4778
GeneTree (enSembl)ENSG00000123405
Phylogenetic Trees/Animal Genes : TreeFamNFE2
Homologs : HomoloGeneNFE2
Homology/Alignments : Family Browser (UCSC)NFE2
Gene fusions - Rearrangements
Fusion : MitelmanCBX5::NFE2 [12q13.13/12q13.13]  
Fusion : MitelmanNFE2::STARD7 [12q13.13/2q11.2]  
Fusion : MitelmanR3HDM2::NFE2 [12q13.3/12q13.13]  
Fusion : QuiverNFE2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNFE2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NFE2
dbVarNFE2
ClinVarNFE2
MonarchNFE2
1000_GenomesNFE2 
Exome Variant ServerNFE2
GNOMAD BrowserENSG00000123405
Varsome BrowserNFE2
ACMGNFE2 variants
VarityQ16621
Genomic Variants (DGV)NFE2 [DGVbeta]
DECIPHERNFE2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNFE2 
Mutations
ICGC Data PortalNFE2 
TCGA Data PortalNFE2 
Broad Tumor PortalNFE2
OASIS PortalNFE2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNFE2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DNFE2
Mutations and Diseases : HGMDNFE2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaNFE2
DgiDB (Drug Gene Interaction Database)NFE2
DoCM (Curated mutations)NFE2
CIViC (Clinical Interpretations of Variants in Cancer)NFE2
Cancer3DNFE2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601490   
Orphanet
DisGeNETNFE2
MedgenNFE2
Genetic Testing Registry NFE2
NextProtQ16621 [Medical]
GENETestsNFE2
Target ValidationNFE2
Huge Navigator NFE2 [HugePedia]
ClinGenNFE2
Clinical trials, drugs, therapy
MyCancerGenomeNFE2
Protein Interactions : CTDNFE2
Pharm GKB GenePA31586
PharosQ16621
Clinical trialNFE2
Miscellaneous
canSAR (ICR)NFE2
HarmonizomeNFE2
ARCHS4NFE2
DataMed IndexNFE2
Probes
Litterature
PubMed79 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXNFE2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Thu Jan 20 12:49:17 CET 2022

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