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NFE2L1 (nuclear factor, erythroid 2 like 1)

Identity

Alias (NCBI)LCR-F1
NRF1
TCF11
HGNC (Hugo) NFE2L1
HGNC Alias symbNRF1
LCR-F1
FLJ00380
HGNC Previous nameTCF11
HGNC Previous namenuclear factor (erythroid-derived 2)-like 1
 nuclear factor, erythroid 2-like 1
LocusID (NCBI) 4779
Atlas_Id 53247
Location 17q21.32  [Link to chromosome band 17q21]
Location_base_pair Starts at 48048359 and ends at 48061545 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ATXN1 (6p22.3) / NFE2L1 (17q21.32)HBA2 (16p13.3) / NFE2L1 (17q21.32)MICB (6p21.33) / NFE2L1 (17q21.32)
NFE2L1 (17q21.32) / CCDC36 (3p21.31)NFE2L1 (17q21.32) / EFHD1 (2q37.1)NFE2L1 (17q21.32) / NFE2L1 (17q21.32)
NFE2L1 (17q21.32) / PRKCSH (19p13.2)NFE2L1 (17q21.32) / SKAP1 (17q21.32)NFE2L1 (17q21.32) / SLC39A11 (17q24.3)
NFE2L1 (17q21.32) / TSPAN11 (12p11.21)NOS1 (12q24.22) / NFE2L1 (17q21.32)NFE2L1 17q21.32 / SLC39A11 17q24.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)NFE2L1   7781
Cards
Entrez_Gene (NCBI)NFE2L1    nuclear factor, erythroid 2 like 1
AliasesLCR-F1; NRF1; TCF11
GeneCards (Weizmann)NFE2L1
Ensembl hg19 (Hinxton)ENSG00000082641 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000082641 [Gene_View]  ENSG00000082641 [Sequence]  chr17:48048359-48061545 [Contig_View]  NFE2L1 [Vega]
ICGC DataPortalENSG00000082641
TCGA cBioPortalNFE2L1
AceView (NCBI)NFE2L1
Genatlas (Paris)NFE2L1
SOURCE (Princeton)NFE2L1
Genetics Home Reference (NIH)NFE2L1
Genomic and cartography
GoldenPath hg38 (UCSC)NFE2L1  -     chr17:48048359-48061545 +  17q21.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NFE2L1  -     17q21.32   [Description]    (hg19-Feb_2009)
GoldenPathNFE2L1 - 17q21.32 [CytoView hg19]  NFE2L1 - 17q21.32 [CytoView hg38]
ImmunoBaseENSG00000082641
Genome Data Viewer NCBINFE2L1 [Mapview hg19]  
OMIM163260   
Gene and transcription
Genbank (Entrez)AK090459 AK294553 AK302387 AL530578 AL833530
RefSeq transcript (Entrez)NM_001330261 NM_001330262 NM_003204
Consensus coding sequences : CCDS (NCBI)NFE2L1
Gene ExpressionNFE2L1 [ NCBI-GEO ]   NFE2L1 [ EBI - ARRAY_EXPRESS ]   NFE2L1 [ SEEK ]   NFE2L1 [ MEM ]
Gene Expression Viewer (FireBrowse)NFE2L1 [ Firebrowse - Broad ]
GenevisibleExpression of NFE2L1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4779
GTEX Portal (Tissue expression)NFE2L1
Human Protein AtlasENSG00000082641-NFE2L1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14494   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ14494  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ14494
PhosPhoSitePlusQ14494
Domaine pattern : Prosite (Expaxy)BZIP (PS50217)    BZIP_BASIC (PS00036)   
Domains : Interpro (EBI)bZIP    bZIP_Maf    NFE2L1    TF_DNA-bd_sf   
Domain families : Pfam (Sanger)bZIP_Maf (PF03131)   
Domain families : Pfam (NCBI)pfam03131   
Domain families : Smart (EMBL)BRLZ (SM00338)  
Conserved Domain (NCBI)NFE2L1
SuperfamilyQ14494
AlphaFold pdb e-kbQ14494   
Human Protein Atlas [tissue]ENSG00000082641-NFE2L1 [tissue]
HPRD01223
Protein Interaction databases
DIP (DOE-UCLA)Q14494
IntAct (EBI)Q14494
BioGRIDNFE2L1
STRING (EMBL)NFE2L1
ZODIACNFE2L1
Ontologies - Pathways
QuickGOQ14494
Ontology : AmiGOchromatin  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity  protein binding  nucleus  nucleoplasm  endoplasmic reticulum membrane  cytosol  regulation of transcription by RNA polymerase II  regulation of transcription by RNA polymerase II  heme biosynthetic process  cholesterol metabolic process  lipid binding  anatomical structure morphogenesis  integral component of membrane  cellular response to oxidative stress  identical protein binding  
Ontology : EGO-EBIchromatin  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity  protein binding  nucleus  nucleoplasm  endoplasmic reticulum membrane  cytosol  regulation of transcription by RNA polymerase II  regulation of transcription by RNA polymerase II  heme biosynthetic process  cholesterol metabolic process  lipid binding  anatomical structure morphogenesis  integral component of membrane  cellular response to oxidative stress  identical protein binding  
NDEx NetworkNFE2L1
Atlas of Cancer Signalling NetworkNFE2L1
Wikipedia pathwaysNFE2L1
Orthology - Evolution
OrthoDB4779
GeneTree (enSembl)ENSG00000082641
Phylogenetic Trees/Animal Genes : TreeFamNFE2L1
Homologs : HomoloGeneNFE2L1
Homology/Alignments : Family Browser (UCSC)NFE2L1
Gene fusions - Rearrangements
Fusion : MitelmanNFE2L1/SLC39A11 [17q21.32/17q24.3]  
Fusion : QuiverNFE2L1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNFE2L1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NFE2L1
dbVarNFE2L1
ClinVarNFE2L1
MonarchNFE2L1
1000_GenomesNFE2L1 
Exome Variant ServerNFE2L1
GNOMAD BrowserENSG00000082641
Varsome BrowserNFE2L1
ACMGNFE2L1 variants
VarityQ14494
Genomic Variants (DGV)NFE2L1 [DGVbeta]
DECIPHERNFE2L1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNFE2L1 
Mutations
ICGC Data PortalNFE2L1 
TCGA Data PortalNFE2L1 
Broad Tumor PortalNFE2L1
OASIS PortalNFE2L1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNFE2L1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DNFE2L1
Mutations and Diseases : HGMDNFE2L1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaNFE2L1
DgiDB (Drug Gene Interaction Database)NFE2L1
DoCM (Curated mutations)NFE2L1
CIViC (Clinical Interpretations of Variants in Cancer)NFE2L1
Cancer3DNFE2L1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM163260   
Orphanet
DisGeNETNFE2L1
MedgenNFE2L1
Genetic Testing Registry NFE2L1
NextProtQ14494 [Medical]
GENETestsNFE2L1
Target ValidationNFE2L1
Huge Navigator NFE2L1 [HugePedia]
ClinGenNFE2L1
Clinical trials, drugs, therapy
MyCancerGenomeNFE2L1
Protein Interactions : CTDNFE2L1
Pharm GKB GenePA31587
PharosQ14494
Clinical trialNFE2L1
Miscellaneous
canSAR (ICR)NFE2L1
HarmonizomeNFE2L1
DataMed IndexNFE2L1
Probes
Litterature
PubMed83 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXNFE2L1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:22:38 CEST 2021

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