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NFE2L3 (nuclear factor, erythroid 2 like 3)

Identity

Alias_namesnuclear factor (erythroid-derived 2)-like 3
nuclear factor, erythroid 2-like 3
Alias_symbol (synonym)Nrf3
Other aliasNRF3
HGNC (Hugo) NFE2L3
LocusID (NCBI) 9603
Atlas_Id 70813
Location 7p15.2  [Link to chromosome band 7p15]
Location_base_pair Starts at 26152227 and ends at 26187136 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NFE2L3   7783
Cards
Entrez_Gene (NCBI)NFE2L3  9603  nuclear factor, erythroid 2 like 3
AliasesNRF3
GeneCards (Weizmann)NFE2L3
Ensembl hg19 (Hinxton)ENSG00000050344 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000050344 [Gene_View]  chr7:26152227-26187136 [Contig_View]  NFE2L3 [Vega]
ICGC DataPortalENSG00000050344
TCGA cBioPortalNFE2L3
AceView (NCBI)NFE2L3
Genatlas (Paris)NFE2L3
WikiGenes9603
SOURCE (Princeton)NFE2L3
Genetics Home Reference (NIH)NFE2L3
Genomic and cartography
GoldenPath hg38 (UCSC)NFE2L3  -     chr7:26152227-26187136 +  7p15.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NFE2L3  -     7p15.2   [Description]    (hg19-Feb_2009)
EnsemblNFE2L3 - 7p15.2 [CytoView hg19]  NFE2L3 - 7p15.2 [CytoView hg38]
Mapping of homologs : NCBINFE2L3 [Mapview hg19]  NFE2L3 [Mapview hg38]
OMIM604135   
Gene and transcription
Genbank (Entrez)AA603252 AB010812 AF125534 AF133059 AF134891
RefSeq transcript (Entrez)NM_004289
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NFE2L3
Cluster EST : UnigeneHs.712898 [ NCBI ]
CGAP (NCI)Hs.712898
Alternative Splicing GalleryENSG00000050344
Gene ExpressionNFE2L3 [ NCBI-GEO ]   NFE2L3 [ EBI - ARRAY_EXPRESS ]   NFE2L3 [ SEEK ]   NFE2L3 [ MEM ]
Gene Expression Viewer (FireBrowse)NFE2L3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9603
GTEX Portal (Tissue expression)NFE2L3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y4A8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y4A8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y4A8
Splice isoforms : SwissVarQ9Y4A8
PhosPhoSitePlusQ9Y4A8
Domaine pattern : Prosite (Expaxy)BZIP (PS50217)    BZIP_BASIC (PS00036)   
Domains : Interpro (EBI)bZIP    bZIP_Maf    NF2L3    TF_DNA-bd   
Domain families : Pfam (Sanger)bZIP_Maf (PF03131)   
Domain families : Pfam (NCBI)pfam03131   
Domain families : Smart (EMBL)BRLZ (SM00338)  
Conserved Domain (NCBI)NFE2L3
DMDM Disease mutations9603
Blocks (Seattle)NFE2L3
SuperfamilyQ9Y4A8
Human Protein AtlasENSG00000050344
Peptide AtlasQ9Y4A8
HPRD09162
IPIIPI00009207   IPI01010723   IPI00816018   IPI00748600   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y4A8
IntAct (EBI)Q9Y4A8
FunCoupENSG00000050344
BioGRIDNFE2L3
STRING (EMBL)NFE2L3
ZODIACNFE2L3
Ontologies - Pathways
QuickGOQ9Y4A8
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  transcription regulatory region sequence-specific DNA binding  RNA polymerase II core promoter proximal region sequence-specific DNA binding  transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding  transcription factor activity, sequence-specific DNA binding  transcription coactivator activity  protein binding  nucleus  cytoplasm  regulation of transcription from RNA polymerase II promoter  transcription from RNA polymerase II promoter  positive regulation of transcription, DNA-templated  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  transcription regulatory region sequence-specific DNA binding  RNA polymerase II core promoter proximal region sequence-specific DNA binding  transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding  transcription factor activity, sequence-specific DNA binding  transcription coactivator activity  protein binding  nucleus  cytoplasm  regulation of transcription from RNA polymerase II promoter  transcription from RNA polymerase II promoter  positive regulation of transcription, DNA-templated  
NDEx NetworkNFE2L3
Atlas of Cancer Signalling NetworkNFE2L3
Wikipedia pathwaysNFE2L3
Orthology - Evolution
OrthoDB9603
GeneTree (enSembl)ENSG00000050344
Phylogenetic Trees/Animal Genes : TreeFamNFE2L3
HOVERGENQ9Y4A8
HOGENOMQ9Y4A8
Homologs : HomoloGeneNFE2L3
Homology/Alignments : Family Browser (UCSC)NFE2L3
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNFE2L3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NFE2L3
dbVarNFE2L3
ClinVarNFE2L3
1000_GenomesNFE2L3 
Exome Variant ServerNFE2L3
ExAC (Exome Aggregation Consortium)NFE2L3 (select the gene name)
Genetic variants : HAPMAP9603
Genomic Variants (DGV)NFE2L3 [DGVbeta]
DECIPHERNFE2L3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNFE2L3 
Mutations
ICGC Data PortalNFE2L3 
TCGA Data PortalNFE2L3 
Broad Tumor PortalNFE2L3
OASIS PortalNFE2L3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNFE2L3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNFE2L3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NFE2L3
DgiDB (Drug Gene Interaction Database)NFE2L3
DoCM (Curated mutations)NFE2L3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NFE2L3 (select a term)
intoGenNFE2L3
Cancer3DNFE2L3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604135   
Orphanet
MedgenNFE2L3
Genetic Testing Registry NFE2L3
NextProtQ9Y4A8 [Medical]
TSGene9603
GENETestsNFE2L3
Target ValidationNFE2L3
Huge Navigator NFE2L3 [HugePedia]
snp3D : Map Gene to Disease9603
BioCentury BCIQNFE2L3
ClinGenNFE2L3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9603
Chemical/Pharm GKB GenePA31589
Clinical trialNFE2L3
Miscellaneous
canSAR (ICR)NFE2L3 (select the gene name)
Probes
Litterature
PubMed25 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNFE2L3
EVEXNFE2L3
GoPubMedNFE2L3
iHOPNFE2L3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed May 31 15:32:36 CEST 2017

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