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NFIA (nuclear factor I A)

Identity

Alias_namesnuclear factor I/A
Alias_symbol (synonym)NFI-L
KIAA1439
Other aliasCTF
NF-I/A
NF1-A
NFI-A
HGNC (Hugo) NFIA
LocusID (NCBI) 4774
Atlas_Id 53987
Location 1p31.3  [Link to chromosome band 1p31]
Location_base_pair Starts at 61547980 and ends at 61928460 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ATG4C (1p31.3) / NFIA (1p31.3)FAF1 (1p32.3) / NFIA (1p31.3)HYI (1p34.2) / NFIA (1p31.3)
NFIA (1p31.3) / CBFA2T3 (16q24.3)NFIA (1p31.3) / CYP2J2 (1p32.1)NFIA (1p31.3) / DCLK1 (13q13.3)
NFIA (1p31.3) / EHF (11p13)NFIA (1p31.3) / FGGY (1p32.1)NFIA (1p31.3) / GNPAT (1q42.2)
NFIA (1p31.3) / LTV1 (6q24.2)NFIA (1p31.3) / NFIA (1p31.3)NFIA (1p31.3) / PIK3R1 (5q13.1)
NFIA (1p31.3) / RNLS (10q23.31)NFIA (1p31.3) / RYR2 (1q43)NFIA (1p31.3) / SCP2 (1p32.3)
NFIA (1p31.3) / ST6GALNAC3 (1p31.1)PATJ (1p31.3) / NFIA (1p31.3)SEC11A (15q25.3) / NFIA (1p31.3)
UTRN (6q24.2) / NFIA (1p31.3)ZNF566 (19q13.12) / NFIA (1p31.3)NFIA 1p31.3 / EHF 11p13
ATG4C 1p31.3 / NFIA 1p31.3FAF1 1p32.3 / NFIA 1p31.3HYI 1p34.2 / NFIA 1p31.3
INADL 1p31.3 / NFIA 1p31.3NFIA 1p31.3 / CYP2J2 1p32.1NFIA 1p31.3 / DCLK1 13q13.3
NFIA 1p31.3 / FGGY 1p32.1NFIA 1p31.3 / LTV1 6q24.2NFIA 1p31.3 / ST6GALNAC3 1p31.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NFIA   7784
Cards
Entrez_Gene (NCBI)NFIA  4774  nuclear factor I A
AliasesCTF; NF-I/A; NF1-A; NFI-A; 
NFI-L
GeneCards (Weizmann)NFIA
Ensembl hg19 (Hinxton)ENSG00000162599 [Gene_View]  chr1:61547980-61928460 [Contig_View]  NFIA [Vega]
Ensembl hg38 (Hinxton)ENSG00000162599 [Gene_View]  chr1:61547980-61928460 [Contig_View]  NFIA [Vega]
ICGC DataPortalENSG00000162599
TCGA cBioPortalNFIA
AceView (NCBI)NFIA
Genatlas (Paris)NFIA
WikiGenes4774
SOURCE (Princeton)NFIA
Genetics Home Reference (NIH)NFIA
Genomic and cartography
GoldenPath hg19 (UCSC)NFIA  -     chr1:61547980-61928460 +  1p31.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)NFIA  -     1p31.3   [Description]    (hg38-Dec_2013)
EnsemblNFIA - 1p31.3 [CytoView hg19]  NFIA - 1p31.3 [CytoView hg38]
Mapping of homologs : NCBINFIA [Mapview hg19]  NFIA [Mapview hg38]
OMIM600727   
Gene and transcription
Genbank (Entrez)AA974652 AB037860 AF086381 AI799785 AK024964
RefSeq transcript (Entrez)NM_001134673 NM_001145511 NM_001145512 NM_005595
RefSeq genomic (Entrez)NC_000001 NC_018912 NG_011787 NT_032977 NW_004929290
Consensus coding sequences : CCDS (NCBI)NFIA
Cluster EST : UnigeneHs.744898 [ NCBI ]
CGAP (NCI)Hs.744898
Alternative Splicing GalleryENSG00000162599
Gene ExpressionNFIA [ NCBI-GEO ]   NFIA [ EBI - ARRAY_EXPRESS ]   NFIA [ SEEK ]   NFIA [ MEM ]
Gene Expression Viewer (FireBrowse)NFIA [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4774
GTEX Portal (Tissue expression)NFIA
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ12857   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ12857  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ12857
Splice isoforms : SwissVarQ12857
PhosPhoSitePlusQ12857
Domaine pattern : Prosite (Expaxy)CTF_NFI_1 (PS00349)    CTF_NFI_2 (PS51080)   
Domains : Interpro (EBI)CTF/NFI    CTF/NFI_DNA-bd-dom    CTF/NFI_DNA-bd_CS    CTF/NFI_DNA-bd_N    MAD_homology1_Dwarfin-type   
Domain families : Pfam (Sanger)CTF_NFI (PF00859)    MH1 (PF03165)    NfI_DNAbd_pre-N (PF10524)   
Domain families : Pfam (NCBI)pfam00859    pfam03165    pfam10524   
Domain families : Smart (EMBL)DWA (SM00523)  
Conserved Domain (NCBI)NFIA
DMDM Disease mutations4774
Blocks (Seattle)NFIA
SuperfamilyQ12857
Human Protein AtlasENSG00000162599
Peptide AtlasQ12857
HPRD09007
IPIIPI00029745   IPI00923394   IPI00815925   IPI00163319   IPI00641645   IPI00646660   IPI00513825   IPI00514434   
Protein Interaction databases
DIP (DOE-UCLA)Q12857
IntAct (EBI)Q12857
FunCoupENSG00000162599
BioGRIDNFIA
STRING (EMBL)NFIA
ZODIACNFIA
Ontologies - Pathways
QuickGOQ12857
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II core promoter proximal region sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  chromatin binding  transcription factor activity, sequence-specific DNA binding  nucleus  nucleus  nucleoplasm  DNA replication  regulation of transcription, DNA-templated  transcription from RNA polymerase II promoter  transcription factor binding  viral genome replication  cell junction  positive regulation of transcription from RNA polymerase II promoter  synapse maturation  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II core promoter proximal region sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  chromatin binding  transcription factor activity, sequence-specific DNA binding  nucleus  nucleus  nucleoplasm  DNA replication  regulation of transcription, DNA-templated  transcription from RNA polymerase II promoter  transcription factor binding  viral genome replication  cell junction  positive regulation of transcription from RNA polymerase II promoter  synapse maturation  
NDEx NetworkNFIA
Atlas of Cancer Signalling NetworkNFIA
Wikipedia pathwaysNFIA
Orthology - Evolution
OrthoDB4774
GeneTree (enSembl)ENSG00000162599
Phylogenetic Trees/Animal Genes : TreeFamNFIA
HOVERGENQ12857
HOGENOMQ12857
Homologs : HomoloGeneNFIA
Homology/Alignments : Family Browser (UCSC)NFIA
Gene fusions - Rearrangements
Fusion : MitelmanATG4C/NFIA [1p31.3/1p31.3]  [t(1;1)(p31;p31)]  
Fusion : MitelmanFAF1/NFIA [1p32.3/1p31.3]  [t(1;1)(p31;p32)]  
Fusion : MitelmanHYI/NFIA [1p34.2/1p31.3]  [t(1;1)(p31;p34)]  
Fusion : MitelmanINADL/NFIA [1p31.3/1p31.3]  [t(1;1)(p31;p31)]  
Fusion : MitelmanNFIA/CBFA2T3 [1p31.3/16q24.3]  [t(1;16)(p31;q24)]  
Fusion : MitelmanNFIA/CYP2J2 [1p31.3/1p32.1]  [t(1;1)(p31;p32)]  
Fusion : MitelmanNFIA/DCLK1 [1p31.3/13q13.3]  [t(1;13)(p31;q13)]  
Fusion : MitelmanNFIA/EHF [1p31.3/11p13]  [t(1;11)(p31;p13)]  
Fusion : MitelmanNFIA/FGGY [1p31.3/1p32.1]  [t(1;1)(p31;p32)]  
Fusion : MitelmanNFIA/LTV1 [1p31.3/6q24.2]  [t(1;6)(p31;q24)]  
Fusion : MitelmanNFIA/RNLS [1p31.3/10q23.31]  [t(1;10)(p31;q23)]  
Fusion : MitelmanNFIA/ST6GALNAC3 [1p31.3/1p31.1]  [t(1;1)(p31;p31)]  
Fusion: TCGAATG4C 1p31.3 NFIA 1p31.3 OV
Fusion: TCGAFAF1 1p32.3 NFIA 1p31.3 BRCA
Fusion: TCGAHYI 1p34.2 NFIA 1p31.3 BRCA
Fusion: TCGAINADL 1p31.3 NFIA 1p31.3 OV
Fusion: TCGANFIA 1p31.3 CYP2J2 1p32.1 PRAD
Fusion: TCGANFIA 1p31.3 DCLK1 13q13.3 BRCA
Fusion: TCGANFIA 1p31.3 FGGY 1p32.1 BRCA
Fusion: TCGANFIA 1p31.3 LTV1 6q24.2 BRCA
Fusion: TCGANFIA 1p31.3 ST6GALNAC3 1p31.1 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNFIA [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NFIA
dbVarNFIA
ClinVarNFIA
1000_GenomesNFIA 
Exome Variant ServerNFIA
ExAC (Exome Aggregation Consortium)NFIA (select the gene name)
Genetic variants : HAPMAP4774
Genomic Variants (DGV)NFIA [DGVbeta]
DECIPHER (Syndromes)1:61547980-61928460  ENSG00000162599
CONAN: Copy Number AnalysisNFIA 
Mutations
ICGC Data PortalNFIA 
TCGA Data PortalNFIA 
Broad Tumor PortalNFIA
OASIS PortalNFIA [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNFIA  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNFIA
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NFIA
DgiDB (Drug Gene Interaction Database)NFIA
DoCM (Curated mutations)NFIA (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NFIA (select a term)
intoGenNFIA
Cancer3DNFIA(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600727   
Orphanet22863   
MedgenNFIA
Genetic Testing Registry NFIA
NextProtQ12857 [Medical]
TSGene4774
GENETestsNFIA
Huge Navigator NFIA [HugePedia]
snp3D : Map Gene to Disease4774
BioCentury BCIQNFIA
ClinGenNFIA (curated)
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4774
Chemical/Pharm GKB GenePA31590
Clinical trialNFIA
Miscellaneous
canSAR (ICR)NFIA (select the gene name)
Probes
Litterature
PubMed45 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNFIA
EVEXNFIA
GoPubMedNFIA
iHOPNFIA
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:18:44 CET 2017

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