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NFIL3 (nuclear factor, interleukin 3 regulated)

Identity

Alias (NCBI)E4BP4
IL3BP1
NF-IL3A
NFIL3A
HGNC (Hugo) NFIL3
HGNC Alias symbE4BP4
NFIL3A
NF-IL3A
HGNC Alias nameE4 promoter-binding protein
 adenovirus E4 promoter region binding protein
HGNC Previous nameIL3BP1
HGNC Previous nameinterleukin-3 binding protein 1
LocusID (NCBI) 4783
Atlas_Id 53422
Location 9q22.31  [Link to chromosome band 9q22]
Location_base_pair Starts at 91409045 and ends at 91423832 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
LARP4 (12q13.12) / NFIL3 (9q22.31)NAIP (5q13.2) / NFIL3 (9q22.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

 

Nomenclature
HGNC (Hugo)NFIL3   7787
Cards
Entrez_Gene (NCBI)NFIL3    nuclear factor, interleukin 3 regulated
AliasesE4BP4; IL3BP1; NF-IL3A; NFIL3A
GeneCards (Weizmann)NFIL3
Ensembl hg19 (Hinxton)ENSG00000165030 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000165030 [Gene_View]  ENSG00000165030 [Sequence]  chr9:91409045-91423832 [Contig_View]  NFIL3 [Vega]
ICGC DataPortalENSG00000165030
TCGA cBioPortalNFIL3
AceView (NCBI)NFIL3
Genatlas (Paris)NFIL3
SOURCE (Princeton)NFIL3
Genetics Home Reference (NIH)NFIL3
Genomic and cartography
GoldenPath hg38 (UCSC)NFIL3  -     chr9:91409045-91423832 -  9q22.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NFIL3  -     9q22.31   [Description]    (hg19-Feb_2009)
GoldenPathNFIL3 - 9q22.31 [CytoView hg19]  NFIL3 - 9q22.31 [CytoView hg38]
ImmunoBaseENSG00000165030
Genome Data Viewer NCBINFIL3 [Mapview hg19]  
OMIM605327   
Gene and transcription
Genbank (Entrez)AK313970 AW163045 BC008197 BQ937243 CR542049
RefSeq transcript (Entrez)NM_001289999 NM_001290000 NM_005384
Consensus coding sequences : CCDS (NCBI)NFIL3
Gene ExpressionNFIL3 [ NCBI-GEO ]   NFIL3 [ EBI - ARRAY_EXPRESS ]   NFIL3 [ SEEK ]   NFIL3 [ MEM ]
Gene Expression Viewer (FireBrowse)NFIL3 [ Firebrowse - Broad ]
GenevisibleExpression of NFIL3 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4783
GTEX Portal (Tissue expression)NFIL3
Human Protein AtlasENSG00000165030-NFIL3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ16649   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ16649  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ16649
PhosPhoSitePlusQ16649
Domaine pattern : Prosite (Expaxy)BZIP (PS50217)    BZIP_BASIC (PS00036)   
Domains : Interpro (EBI)bZIP    NFIL3/E4BP4    Vert_IL3-reg_TF   
Domain families : Pfam (Sanger)bZIP_2 (PF07716)    Vert_IL3-reg_TF (PF06529)   
Domain families : Pfam (NCBI)pfam07716    pfam06529   
Domain families : Smart (EMBL)BRLZ (SM00338)  
Conserved Domain (NCBI)NFIL3
SuperfamilyQ16649
AlphaFold pdb e-kbQ16649   
Human Protein Atlas [tissue]ENSG00000165030-NFIL3 [tissue]
HPRD05619
Protein Interaction databases
DIP (DOE-UCLA)Q16649
IntAct (EBI)Q16649
BioGRIDNFIL3
STRING (EMBL)NFIL3
ZODIACNFIL3
Ontologies - Pathways
QuickGOQ16649
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  chromatin  RNA polymerase II transcription regulatory region sequence-specific DNA binding  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription repressor activity, RNA polymerase II-specific  natural killer cell differentiation  DNA-binding transcription factor activity  protein binding  nucleus  regulation of transcription, DNA-templated  transcription by RNA polymerase II  immune response  circadian rhythm  positive regulation of gene expression  identical protein binding  negative regulation of transcription, DNA-templated  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  cellular response to interleukin-4  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  chromatin  RNA polymerase II transcription regulatory region sequence-specific DNA binding  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription repressor activity, RNA polymerase II-specific  natural killer cell differentiation  DNA-binding transcription factor activity  protein binding  nucleus  regulation of transcription, DNA-templated  transcription by RNA polymerase II  immune response  circadian rhythm  positive regulation of gene expression  identical protein binding  negative regulation of transcription, DNA-templated  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  cellular response to interleukin-4  
NDEx NetworkNFIL3
Atlas of Cancer Signalling NetworkNFIL3
Wikipedia pathwaysNFIL3
Orthology - Evolution
OrthoDB4783
GeneTree (enSembl)ENSG00000165030
Phylogenetic Trees/Animal Genes : TreeFamNFIL3
Homologs : HomoloGeneNFIL3
Homology/Alignments : Family Browser (UCSC)NFIL3
Gene fusions - Rearrangements
Fusion : QuiverNFIL3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNFIL3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NFIL3
dbVarNFIL3
ClinVarNFIL3
MonarchNFIL3
1000_GenomesNFIL3 
Exome Variant ServerNFIL3
GNOMAD BrowserENSG00000165030
Varsome BrowserNFIL3
ACMGNFIL3 variants
VarityQ16649
Genomic Variants (DGV)NFIL3 [DGVbeta]
DECIPHERNFIL3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNFIL3 
Mutations
ICGC Data PortalNFIL3 
TCGA Data PortalNFIL3 
Broad Tumor PortalNFIL3
OASIS PortalNFIL3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNFIL3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DNFIL3
Mutations and Diseases : HGMDNFIL3
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaNFIL3
DgiDB (Drug Gene Interaction Database)NFIL3
DoCM (Curated mutations)NFIL3
CIViC (Clinical Interpretations of Variants in Cancer)NFIL3
Cancer3DNFIL3
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605327   
Orphanet
DisGeNETNFIL3
MedgenNFIL3
Genetic Testing Registry NFIL3
NextProtQ16649 [Medical]
GENETestsNFIL3
Target ValidationNFIL3
Huge Navigator NFIL3 [HugePedia]
ClinGenNFIL3
Clinical trials, drugs, therapy
MyCancerGenomeNFIL3
Protein Interactions : CTDNFIL3
Pharm GKB GenePA31593
PharosQ16649
Clinical trialNFIL3
Miscellaneous
canSAR (ICR)NFIL3
HarmonizomeNFIL3
DataMed IndexNFIL3
Probes
Litterature
PubMed63 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXNFIL3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:22:39 CEST 2021
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