NFIL3 (nuclear factor, interleukin 3 regulated)

2013-07-01  

Identity

HGNC
NFIL3
LOCATION
9q22.31
LOCUSID
4783
ALIAS
E4BP4,IL3BP1,NF-IL3A,NFIL3A
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4783
MIM: 605327
HGNC: 7787
Ensembl: ENSG00000165030

Variants:

dbSNP: 4783
ClinVar: 4783
TCGA: ENSG00000165030
COSMIC: NFIL3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000165030ENST00000297689Q16649
ENSG00000165030ENST00000297689A0A024R241

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Circadian ClockREACTOMER-HSA-400253
BMAL1:CLOCK,NPAS2 activates circadian gene expressionREACTOMER-HSA-1368108

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
198399952009Association study of 21 circadian genes with bipolar I disorder, schizoaffective disorder, and schizophrenia.49
189372942008Genome-wide association scan of the time to onset of attention deficit hyperactivity disorder.41
196938012010PER2 variantion is associated with depression vulnerability.31
201746232010Systematic analysis of circadian genes in a population-based sample reveals association of TIMELESS with depression and sleep disturbance.27
190587892009A common variant in DRD3 receptor is associated with autism spectrum disorder.19
236300762013Survival factor NFIL3 restricts FOXO-induced gene expression in cancer.18
188294862008Negative regulation of the osteoblast function in multiple myeloma through the repressor gene E4BP4 activated by malignant plasma cells.13
292157402018The STAT3/NFIL3 signaling axis-mediated chemotherapy resistance is reversed by Raddeanin A via inducing apoptosis in choriocarcinoma cells.12
201864622010E4BP4 is a cardiac survival factor and essential for embryonic heart development.11

Citation

Dessen P

NFIL3 (nuclear factor, interleukin 3 regulated)

Atlas Genet Cytogenet Oncol Haematol. 2013-07-01

Online version: http://atlasgeneticsoncology.org/gene/53422/nfil3