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NFIX (nuclear factor I X)

Identity

Alias_namesnuclear factor I/X (CCAAT-binding transcription factor)
Alias_symbol (synonym)NF1A
Other aliasCTF
MRSHSS
NF-I/X
NF1-X
SOTOS2
HGNC (Hugo) NFIX
LocusID (NCBI) 4784
Atlas_Id 50885
Location 19p13.13  [Link to chromosome band 19p13]
Location_base_pair Starts at 12995770 and ends at 13098796 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
BSG (19p13.3) / NFIX (19p13.2)MCU (10q22.1) / NFIX (19p13.2)NFIX (19p13.2) / CHCHD3 (7q32.3)
NFIX (19p13.2) / DAND5 (19p13.2)NFIX (19p13.2) / GATAD2A (19p13.11)NFIX (19p13.2) / GCDH (19p13.2)
NFIX (19p13.2) / MAST1 (19p13.2)NFIX (19p13.2) / NFIX (19p13.2)NFIX (19p13.2) / RALGPS1 (9q33.3)
NFIX (19p13.2) / RBM5 (3p21.31)TBCD (17q25.3) / NFIX (19p13.2)NFIX 19p13.13 / MAST1 19p13.13
MCU 10q22.1 / NFIX 19p13.2NFIX 19p13.2 / DAND5 19p13.2NFIX 19p13.2 / GATAD2A 19p13.11
NFIX 19p13.2 / GCDH 19p13.2NFIX 19p13.2 / RALGPS1 9q33.3TBCD 17q25.3 / NFIX 19p13.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 9 ]
  Lung: Translocations in Small Cell Carcinoma
t(9;19)(q33;p13) NFIX/RALGPS1
t(10;19)(q22;p13) MCU/NFIX
t(17;19)(q25;p13) TBCD/NFIX
BSG/NFIX (19p13)
NFIX/DAND5 (19p13)
NFIX/GCDH (19p13)
NFIX/MAST1 (19p13)
NFIX/GATAD2A (19p13)

Other Cancer prone implicated (Data extracted from papers in the Atlas) [ 1 ]
  Sotos syndrome (SOS)

External links

Nomenclature
HGNC (Hugo)NFIX   7788
Cards
Entrez_Gene (NCBI)NFIX  4784  nuclear factor I X
AliasesCTF; MRSHSS; NF-I/X; NF1-X; 
NF1A; SOTOS2
GeneCards (Weizmann)NFIX
Ensembl hg19 (Hinxton)ENSG00000008441 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000008441 [Gene_View]  ENSG00000008441 [Sequence]  chr19:12995770-13098796 [Contig_View]  NFIX [Vega]
ICGC DataPortalENSG00000008441
TCGA cBioPortalNFIX
AceView (NCBI)NFIX
Genatlas (Paris)NFIX
WikiGenes4784
SOURCE (Princeton)NFIX
Genetics Home Reference (NIH)NFIX
Genomic and cartography
GoldenPath hg38 (UCSC)NFIX  -     chr19:12995770-13098796 +  19p13.13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NFIX  -     19p13.13   [Description]    (hg19-Feb_2009)
GoldenPathNFIX - 19p13.13 [CytoView hg19]  NFIX - 19p13.13 [CytoView hg38]
ImmunoBaseENSG00000008441
Mapping of homologs : NCBINFIX [Mapview hg19]  NFIX [Mapview hg38]
OMIM164005   602535   614753   
Gene and transcription
Genbank (Entrez)AK295290 AK297261 BC036885 BC117113 BC117115
RefSeq transcript (Entrez)NM_001271043 NM_001271044 NM_001365902 NM_001365982 NM_001365983 NM_001365984 NM_001365985 NM_002501
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NFIX
Cluster EST : UnigeneHs.257970 [ NCBI ]
CGAP (NCI)Hs.257970
Alternative Splicing GalleryENSG00000008441
Gene ExpressionNFIX [ NCBI-GEO ]   NFIX [ EBI - ARRAY_EXPRESS ]   NFIX [ SEEK ]   NFIX [ MEM ]
Gene Expression Viewer (FireBrowse)NFIX [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4784
GTEX Portal (Tissue expression)NFIX
Human Protein AtlasENSG00000008441-NFIX [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14938   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ14938  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ14938
Splice isoforms : SwissVarQ14938
PhosPhoSitePlusQ14938
Domaine pattern : Prosite (Expaxy)CTF_NFI_1 (PS00349)    CTF_NFI_2 (PS51080)   
Domains : Interpro (EBI)CTF/NFI    CTF/NFI_DNA-bd-dom    CTF/NFI_DNA-bd_CS    CTF/NFI_DNA-bd_N    MAD_homology1_Dwarfin-type   
Domain families : Pfam (Sanger)CTF_NFI (PF00859)    MH1 (PF03165)    NfI_DNAbd_pre-N (PF10524)   
Domain families : Pfam (NCBI)pfam00859    pfam03165    pfam10524   
Domain families : Smart (EMBL)DWA (SM00523)  
Conserved Domain (NCBI)NFIX
DMDM Disease mutations4784
Blocks (Seattle)NFIX
SuperfamilyQ14938
Human Protein Atlas [tissue]ENSG00000008441-NFIX [tissue]
Peptide AtlasQ14938
HPRD01234
IPIIPI00221071   IPI00306473   IPI00221073   IPI00395691   IPI00218260   IPI00953207   IPI00011507   IPI00747331   
Protein Interaction databases
DIP (DOE-UCLA)Q14938
IntAct (EBI)Q14938
FunCoupENSG00000008441
BioGRIDNFIX
STRING (EMBL)NFIX
ZODIACNFIX
Ontologies - Pathways
QuickGOQ14938
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  negative regulation of transcription by RNA polymerase II  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA binding  DNA-binding transcription factor activity  protein binding  nucleus  DNA replication  transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  negative regulation of transcription by RNA polymerase II  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA binding  DNA-binding transcription factor activity  protein binding  nucleus  DNA replication  transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  
NDEx NetworkNFIX
Atlas of Cancer Signalling NetworkNFIX
Wikipedia pathwaysNFIX
Orthology - Evolution
OrthoDB4784
GeneTree (enSembl)ENSG00000008441
Phylogenetic Trees/Animal Genes : TreeFamNFIX
HOGENOMQ14938
Homologs : HomoloGeneNFIX
Homology/Alignments : Family Browser (UCSC)NFIX
Gene fusions - Rearrangements
Fusion : MitelmanBSG/NFIX [19p13.3/19p13.2]  [t(19;19)(p13;p13)]  
Fusion : MitelmanMCU/NFIX [10q22.1/19p13.2]  [t(10;19)(q22;p13)]  
Fusion : MitelmanNFIX/DAND5 [19p13.2/19p13.2]  [t(19;19)(p13;p13)]  
Fusion : MitelmanNFIX/GATAD2A [19p13.2/19p13.11]  [t(19;19)(p13;p13)]  
Fusion : MitelmanNFIX/GCDH [19p13.2/19p13.2]  [t(19;19)(p13;p13)]  
Fusion : MitelmanNFIX/MAST1 [19p13.2/19p13.2]  [t(19;19)(p13;p13)]  
Fusion : MitelmanNFIX/RALGPS1 [19p13.2/9q33.3]  [t(9;19)(q33;p13)]  
Fusion : MitelmanTBCD/NFIX [17q25.3/19p13.2]  [t(17;19)(q25;p13)]  
Fusion PortalMCU 10q22.1 NFIX 19p13.2 BRCA
Fusion PortalNFIX 19p13.2 DAND5 19p13.2 BRCA LUAD
Fusion PortalNFIX 19p13.2 GATAD2A 19p13.11 THCA
Fusion PortalNFIX 19p13.2 GCDH 19p13.2 LUAD
Fusion PortalNFIX 19p13.2 RALGPS1 9q33.3 HNSC
Fusion PortalTBCD 17q25.3 NFIX 19p13.2 BRCA
Fusion : QuiverNFIX
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNFIX [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NFIX
dbVarNFIX
ClinVarNFIX
1000_GenomesNFIX 
Exome Variant ServerNFIX
ExAC (Exome Aggregation Consortium)ENSG00000008441
GNOMAD BrowserENSG00000008441
Varsome BrowserNFIX
Genetic variants : HAPMAP4784
Genomic Variants (DGV)NFIX [DGVbeta]
DECIPHERNFIX [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNFIX 
Mutations
ICGC Data PortalNFIX 
TCGA Data PortalNFIX 
Broad Tumor PortalNFIX
OASIS PortalNFIX [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNFIX  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DNFIX
Mutations and Diseases : HGMDNFIX
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NFIX
DgiDB (Drug Gene Interaction Database)NFIX
DoCM (Curated mutations)NFIX (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NFIX (select a term)
intoGenNFIX
Cancer3DNFIX(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM164005    602535    614753   
Orphanet2279    23101   
DisGeNETNFIX
MedgenNFIX
Genetic Testing Registry NFIX
NextProtQ14938 [Medical]
TSGene4784
GENETestsNFIX
Target ValidationNFIX
Huge Navigator NFIX [HugePedia]
snp3D : Map Gene to Disease4784
BioCentury BCIQNFIX
ClinGenNFIX (curated)
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4784
Chemical/Pharm GKB GenePA31594
Clinical trialNFIX
Miscellaneous
canSAR (ICR)NFIX (select the gene name)
DataMed IndexNFIX
Probes
Litterature
PubMed53 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNFIX
EVEXNFIX
GoPubMedNFIX
iHOPNFIX
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Nov 13 17:57:55 CET 2019
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