Atlas of Genetics and Cytogenetics in Oncology and Haematology

Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   
X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

NFKBIA (NFKB inhibitor alpha)

Identity

Other namesIKBA
MAD-3
NFKBI
HGNC (Hugo) NFKBIA
LocusID (NCBI) 4792
Atlas_Id 41530
Location 14q13.2  [Link to chromosome band 14q13]
Location_base_pair Starts at 35870716 and ends at 35873960 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)		NFKBIA (14q13.2) / NFKBIA (14q13.2)NFKBIA (14q13.2) / RFC5 (12q24.23)PPP2R3C (14q13.2) / NFKBIA (14q13.2)
TCF3 (19p13.3) / NFKBIA (14q13.2)PPP2R3C 14q13.2 / NFKBIA 14q13.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 3 ]
  Classical Hodgkin lymphoma
Hodgkin lymphoma
t(8;17)(q24;q22) ???BCL3/MYC

External links

Nomenclature
HGNC (Hugo)NFKBIA   7797
Cards
Entrez_Gene (NCBI)NFKBIA  4792  NFKB inhibitor alpha
AliasesIKBA; MAD-3; NFKBI
GeneCards (Weizmann)NFKBIA
Ensembl hg19 (Hinxton)ENSG00000100906 [Gene_View]  chr14:35870716-35873960 [Contig_View]  NFKBIA [Vega]
Ensembl hg38 (Hinxton)ENSG00000100906 [Gene_View]  chr14:35870716-35873960 [Contig_View]  NFKBIA [Vega]
ICGC DataPortalENSG00000100906
TCGA cBioPortalNFKBIA
AceView (NCBI)NFKBIA
Genatlas (Paris)NFKBIA
WikiGenes4792
SOURCE (Princeton)NFKBIA
Genomic and cartography
GoldenPath hg19 (UCSC)NFKBIA  -     chr14:35870716-35873960 -  14q13.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)NFKBIA  -     14q13.2   [Description]    (hg38-Dec_2013)
EnsemblNFKBIA - 14q13.2 [CytoView hg19]  NFKBIA - 14q13.2 [CytoView hg38]
Mapping of homologs : NCBINFKBIA [Mapview hg19]  NFKBIA [Mapview hg38]
OMIM164008   612132   
Gene and transcription
Genbank (Entrez)AK311515 AK313421 AY033600 BC002601 BC004983
RefSeq transcript (Entrez)NM_020529
RefSeq genomic (Entrez)NC_000014 NC_018925 NG_007571 NT_026437 NW_004929393
Consensus coding sequences : CCDS (NCBI)NFKBIA
Cluster EST : UnigeneHs.81328 [ NCBI ]
CGAP (NCI)Hs.81328
Alternative Splicing GalleryENSG00000100906
Gene ExpressionNFKBIA [ NCBI-GEO ]   NFKBIA [ EBI - ARRAY_EXPRESS ]   NFKBIA [ SEEK ]   NFKBIA [ MEM ]
Gene Expression Viewer (FireBrowse)NFKBIA [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4792
GTEX Portal (Tissue expression)NFKBIA
Protein : pattern, domain, 3D structure
UniProt/SwissProtP25963 (Uniprot)
NextProtP25963  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP25963
Splice isoforms : SwissVarP25963 (Swissvar)
PhosPhoSitePlusP25963
Domaine pattern : Prosite (Expaxy)ANK_REP_REGION (PS50297)    ANK_REPEAT (PS50088)   
Domains : Interpro (EBI)Ankyrin_rpt    Ankyrin_rpt-contain_dom   
Domain families : Pfam (Sanger)Ank_2 (PF12796)    Ank_3 (PF13606)   
Domain families : Pfam (NCBI)pfam12796    pfam13606   
Domain families : Smart (EMBL)ANK (SM00248)  
DMDM Disease mutations4792
Blocks (Seattle)NFKBIA
PDB (SRS)1IKN    1NFI   
PDB (PDBSum)1IKN    1NFI   
PDB (IMB)1IKN    1NFI   
PDB (RSDB)1IKN    1NFI   
Structural Biology KnowledgeBase1IKN    1NFI   
SCOP (Structural Classification of Proteins)1IKN    1NFI   
CATH (Classification of proteins structures)1IKN    1NFI   
SuperfamilyP25963
Human Protein AtlasENSG00000100906
Peptide AtlasP25963
HPRD01235
IPIIPI00018330   IPI01025114   IPI01024985   IPI01026284   IPI01026140   
Protein Interaction databases
DIP (DOE-UCLA)P25963
IntAct (EBI)P25963
FunCoupENSG00000100906
BioGRIDNFKBIA
STRING (EMBL)NFKBIA
ZODIACNFKBIA
Ontologies - Pathways
QuickGOP25963
Ontology : AmiGOprotein import into nucleus, translocation  stimulatory C-type lectin receptor signaling pathway  protein binding  nucleus  cytoplasm  cytosol  plasma membrane  apoptotic process  cytoplasmic sequestering of NF-kappaB  transcription factor binding  nuclear localization sequence binding  negative regulation of macrophage derived foam cell differentiation  positive regulation of cholesterol efflux  negative regulation of lipid storage  viral process  enzyme binding  heat shock protein binding  ubiquitin protein ligase binding  lipopolysaccharide-mediated signaling pathway  negative regulation of NF-kappaB transcription factor activity  positive regulation of cellular protein metabolic process  protein complex binding  response to muramyl dipeptide  I-kappaB/NF-kappaB complex  toll-like receptor 4 signaling pathway  response to muscle stretch  Fc-epsilon receptor signaling pathway  regulation of cell proliferation  regulation of NF-kappaB import into nucleus  identical protein binding  cytoplasmic sequestering of transcription factor  negative regulation of apoptotic process  response to exogenous dsRNA  negative regulation of DNA binding  negative regulation of myeloid cell differentiation  negative regulation of Notch signaling pathway  positive regulation of transcription from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  T cell receptor signaling pathway  NF-kappaB binding  NF-kappaB binding  positive regulation of NF-kappaB transcription factor activity  cellular response to cold  nucleotide-binding oligomerization domain containing 1 signaling pathway  nucleotide-binding oligomerization domain containing 2 signaling pathway  cellular response to cytokine stimulus  cellular response to organic cyclic compound  
Ontology : EGO-EBIprotein import into nucleus, translocation  stimulatory C-type lectin receptor signaling pathway  protein binding  nucleus  cytoplasm  cytosol  plasma membrane  apoptotic process  cytoplasmic sequestering of NF-kappaB  transcription factor binding  nuclear localization sequence binding  negative regulation of macrophage derived foam cell differentiation  positive regulation of cholesterol efflux  negative regulation of lipid storage  viral process  enzyme binding  heat shock protein binding  ubiquitin protein ligase binding  lipopolysaccharide-mediated signaling pathway  negative regulation of NF-kappaB transcription factor activity  positive regulation of cellular protein metabolic process  protein complex binding  response to muramyl dipeptide  I-kappaB/NF-kappaB complex  toll-like receptor 4 signaling pathway  response to muscle stretch  Fc-epsilon receptor signaling pathway  regulation of cell proliferation  regulation of NF-kappaB import into nucleus  identical protein binding  cytoplasmic sequestering of transcription factor  negative regulation of apoptotic process  response to exogenous dsRNA  negative regulation of DNA binding  negative regulation of myeloid cell differentiation  negative regulation of Notch signaling pathway  positive regulation of transcription from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  T cell receptor signaling pathway  NF-kappaB binding  NF-kappaB binding  positive regulation of NF-kappaB transcription factor activity  cellular response to cold  nucleotide-binding oligomerization domain containing 1 signaling pathway  nucleotide-binding oligomerization domain containing 2 signaling pathway  cellular response to cytokine stimulus  cellular response to organic cyclic compound  
Pathways : BIOCARTAThe 4-1BB-dependent immune response [Genes]    CD40L Signaling Pathway [Genes]    NF-kB Signaling Pathway [Genes]    AKT Signaling Pathway [Genes]    ATM Signaling Pathway [Genes]    Cadmium induces DNA synthesis and proliferation in macrophages [Genes]    TNF/Stress Related Signaling [Genes]    T Cell Receptor Signaling Pathway [Genes]    Chaperones modulate interferon Signaling Pathway [Genes]    Induction of apoptosis through DR3 and DR4/5 Death Receptors [Genes]    Erythropoietin mediated neuroprotection through NF-kB [Genes]    MAPKinase Signaling Pathway [Genes]    Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha) [Genes]    TNFR2 Signaling Pathway [Genes]    Toll-Like Receptor Pathway [Genes]    HIV-I Nef: negative effector of Fas and TNF [Genes]    Signal transduction through IL1R [Genes]    Acetylation and Deacetylation of RelA in The Nucleus [Genes]    Keratinocyte Differentiation [Genes]    Activation of PKC through G protein coupled receptor [Genes]    fMLP induced chemokine gene expression in HMC-1 cells [Genes]    Influence of Ras and Rho proteins on G1 to S Transition [Genes]    NFkB activation by Nontypeable Hemophilus influenzae [Genes]    Double Stranded RNA Induced Gene Expression [Genes]    Neuropeptides VIP and PACAP inhibit the apoptosis of activated T cells [Genes]   
Pathways : KEGGChemokine signaling pathway    NF-kappa B signaling pathway    Apoptosis    Osteoclast differentiation    Toll-like receptor signaling pathway    NOD-like receptor signaling pathway    RIG-I-like receptor signaling pathway    Cytosolic DNA-sensing pathway    T cell receptor signaling pathway    B cell receptor signaling pathway    TNF signaling pathway    Neurotrophin signaling pathway    Adipocytokine signaling pathway    Epithelial cell signaling in Helicobacter pylori infection    Shigellosis    Legionellosis    Leishmaniasis    Chagas disease (American trypanosomiasis)    Toxoplasmosis    Hepatitis C    Hepatitis B    Measles    Influenza A    HTLV-I infection    Herpes simplex infection    Epstein-Barr virus infection    Pathways in cancer    Viral carcinogenesis    Prostate cancer    Chronic myeloid leukemia    Small cell lung cancer   
NDEx NetworkNFKBIA
Atlas of Cancer Signalling NetworkNFKBIA
Wikipedia pathwaysNFKBIA
Orthology - Evolution
OrthoDB4792
GeneTree (enSembl)ENSG00000100906
Phylogenetic Trees/Animal Genes : TreeFamNFKBIA
Homologs : HomoloGeneNFKBIA
Homology/Alignments : Family Browser (UCSC)NFKBIA
Gene fusions - Rearrangements
Fusion: TCGAPPP2R3C 14q13.2 NFKBIA 14q13.2 BRCA
Polymorphisms : SNP, variants
NCBI Variation ViewerNFKBIA [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NFKBIA
dbVarNFKBIA
ClinVarNFKBIA
1000_GenomesNFKBIA 
Exome Variant ServerNFKBIA
ExAC (Exome Aggregation Consortium)NFKBIA (select the gene name)
Genetic variants : HAPMAP4792
Genomic Variants (DGV)NFKBIA [DGVbeta]
Mutations
ICGC Data PortalNFKBIA 
TCGA Data PortalNFKBIA 
Broad Tumor PortalNFKBIA
OASIS PortalNFKBIA [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNFKBIA 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)**PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database
BioMutasearch NFKBIA
DgiDB (Drug Gene Interaction Database)NFKBIA
DoCM (Curated mutations)NFKBIA (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NFKBIA (select a term)
intoGenNFKBIA
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)14:35870716-35873960  ENSG00000100906
CONAN: Copy Number AnalysisNFKBIA 
Mutations and Diseases : HGMDNFKBIA
OMIM164008    612132   
MedgenNFKBIA
Genetic Testing Registry NFKBIA
NextProtP25963 [Medical]
TSGene4792
GENETestsNFKBIA
Huge Navigator NFKBIA [HugePedia]
snp3D : Map Gene to Disease4792
BioCentury BCIQNFKBIA
ClinGenNFKBIA
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4792
Chemical/Pharm GKB GenePA31601
Clinical trialNFKBIA
Miscellaneous
canSAR (ICR)NFKBIA (select the gene name)
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNFKBIA
EVEXNFKBIA
GoPubMedNFKBIA
iHOPNFKBIA
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 19 19:04:37 CEST 2016
Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.