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NFKBIB (NFKB inhibitor beta)

Identity

Alias (NCBI)IKBB
TRIP9
HGNC (Hugo) NFKBIB
HGNC Alias symbIKBB
TRIP9
HGNC Alias nameNF-kappa-B inhibitor beta
HGNC Previous namenuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
LocusID (NCBI) 4793
Atlas_Id 41531
Location 19q13.2  [Link to chromosome band 19q13]
Location_base_pair Starts at 38899969 and ends at 38908889 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
EEF1D (8q24.3) / NFKBIB (19q13.2)NFKBIB (19q13.2) / BGN (Xq28)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(8;17)(q24;q22) ???BCL3/MYC
t(14;19)(q32;q13) IGH/Various Partners

External links

Nomenclature
HGNC (Hugo)NFKBIB   7798
Cards
Entrez_Gene (NCBI)NFKBIB  4793  NFKB inhibitor beta
AliasesIKBB; TRIP9
GeneCards (Weizmann)NFKBIB
Ensembl hg19 (Hinxton)ENSG00000104825 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000104825 [Gene_View]  ENSG00000104825 [Sequence]  chr19:38899969-38908889 [Contig_View]  NFKBIB [Vega]
ICGC DataPortalENSG00000104825
TCGA cBioPortalNFKBIB
AceView (NCBI)NFKBIB
Genatlas (Paris)NFKBIB
WikiGenes4793
SOURCE (Princeton)NFKBIB
Genetics Home Reference (NIH)NFKBIB
Genomic and cartography
GoldenPath hg38 (UCSC)NFKBIB  -     chr19:38899969-38908889 +  19q13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NFKBIB  -     19q13.2   [Description]    (hg19-Feb_2009)
GoldenPathNFKBIB - 19q13.2 [CytoView hg19]  NFKBIB - 19q13.2 [CytoView hg38]
ImmunoBaseENSG00000104825
genome Data Viewer NCBINFKBIB [Mapview hg19]  
OMIM604495   
Gene and transcription
Genbank (Entrez)AA044256 AB209784 AB362577 AI684894 AK057862
RefSeq transcript (Entrez)NM_001001716 NM_001243116 NM_001369699 NM_001369700 NM_002503
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NFKBIB
Alternative Splicing GalleryENSG00000104825
Gene ExpressionNFKBIB [ NCBI-GEO ]   NFKBIB [ EBI - ARRAY_EXPRESS ]   NFKBIB [ SEEK ]   NFKBIB [ MEM ]
Gene Expression Viewer (FireBrowse)NFKBIB [ Firebrowse - Broad ]
GenevisibleExpression of NFKBIB in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4793
GTEX Portal (Tissue expression)NFKBIB
Human Protein AtlasENSG00000104825-NFKBIB [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15653   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ15653  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ15653
Splice isoforms : SwissVarQ15653
PhosPhoSitePlusQ15653
Domaine pattern : Prosite (Expaxy)ANK_REP_REGION (PS50297)    ANK_REPEAT (PS50088)   
Domains : Interpro (EBI)Ankyrin_rpt    Ankyrin_rpt-contain_dom    Ankyrin_rpt-contain_sf   
Domain families : Pfam (Sanger)Ank_2 (PF12796)   
Domain families : Pfam (NCBI)pfam12796   
Domain families : Smart (EMBL)ANK (SM00248)  
Conserved Domain (NCBI)NFKBIB
DMDM Disease mutations4793
Blocks (Seattle)NFKBIB
SuperfamilyQ15653
Human Protein Atlas [tissue]ENSG00000104825-NFKBIB [tissue]
Peptide AtlasQ15653
HPRD07260
IPIIPI00161119   IPI00514744   IPI00387046   
Protein Interaction databases
DIP (DOE-UCLA)Q15653
IntAct (EBI)Q15653
FunCoupENSG00000104825
BioGRIDNFKBIB
STRING (EMBL)NFKBIB
ZODIACNFKBIB
Ontologies - Pathways
QuickGOQ15653
Ontology : AmiGOtranscription coactivator activity  protein binding  nucleus  cytosol  cytosol  transcription, DNA-templated  signal transduction  cytoplasmic sequestering of NF-kappaB  cellular response to lipopolysaccharide  positive regulation of nucleic acid-templated transcription  
Ontology : EGO-EBItranscription coactivator activity  protein binding  nucleus  cytosol  cytosol  transcription, DNA-templated  signal transduction  cytoplasmic sequestering of NF-kappaB  cellular response to lipopolysaccharide  positive regulation of nucleic acid-templated transcription  
Pathways : KEGGChemokine signaling pathway    NOD-like receptor signaling pathway    RIG-I-like receptor signaling pathway    Cytosolic DNA-sensing pathway    T cell receptor signaling pathway    B cell receptor signaling pathway    Neurotrophin signaling pathway    Adipocytokine signaling pathway    Shigellosis    Leishmaniasis    Toxoplasmosis    Measles    Influenza A    Herpes simplex infection    Epstein-Barr virus infection   
NDEx NetworkNFKBIB
Atlas of Cancer Signalling NetworkNFKBIB
Wikipedia pathwaysNFKBIB
Orthology - Evolution
OrthoDB4793
GeneTree (enSembl)ENSG00000104825
Phylogenetic Trees/Animal Genes : TreeFamNFKBIB
HOGENOMQ15653
Homologs : HomoloGeneNFKBIB
Homology/Alignments : Family Browser (UCSC)NFKBIB
Gene fusions - Rearrangements
Fusion : QuiverNFKBIB
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNFKBIB [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NFKBIB
dbVarNFKBIB
ClinVarNFKBIB
MonarchNFKBIB
1000_GenomesNFKBIB 
Exome Variant ServerNFKBIB
GNOMAD BrowserENSG00000104825
Varsome BrowserNFKBIB
Genetic variants : HAPMAP4793
Genomic Variants (DGV)NFKBIB [DGVbeta]
DECIPHERNFKBIB [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNFKBIB 
Mutations
ICGC Data PortalNFKBIB 
TCGA Data PortalNFKBIB 
Broad Tumor PortalNFKBIB
OASIS PortalNFKBIB [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNFKBIB  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DNFKBIB
Mutations and Diseases : HGMDNFKBIB
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NFKBIB
DgiDB (Drug Gene Interaction Database)NFKBIB
DoCM (Curated mutations)NFKBIB (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NFKBIB (select a term)
intoGenNFKBIB
Cancer3DNFKBIB(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604495   
Orphanet
DisGeNETNFKBIB
MedgenNFKBIB
Genetic Testing Registry NFKBIB
NextProtQ15653 [Medical]
TSGene4793
GENETestsNFKBIB
Target ValidationNFKBIB
Huge Navigator NFKBIB [HugePedia]
snp3D : Map Gene to Disease4793
BioCentury BCIQNFKBIB
ClinGenNFKBIB
Clinical trials, drugs, therapy
Protein Interactions : CTD4793
Pharm GKB GenePA31602
Clinical trialNFKBIB
Miscellaneous
canSAR (ICR)NFKBIB (select the gene name)
HarmonizomeNFKBIB
DataMed IndexNFKBIB
Probes
Litterature
PubMed89 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNFKBIB
EVEXNFKBIB
GoPubMedNFKBIB
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 14 14:24:12 CEST 2020
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