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NFKBIE (NFKB inhibitor epsilon)

Identity

Alias_namesnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor
Alias_symbol (synonym)IKBE
Other alias
HGNC (Hugo) NFKBIE
LocusID (NCBI) 4794
Atlas_Id 41532
Location 6p21.1  [Link to chromosome band 6p21]
Location_base_pair Starts at 44258166 and ends at 44265788 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CD2AP (6p12.3) / NFKBIE (6p21.1)NFKBIE (6p21.1) / SLC29A1 (6p21.1)CD2AP 6p12.3 / NFKBIE 6p21.1
NFKBIE 6p21.1 / SLC29A1 6p21.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 3 ]
  Classical Hodgkin lymphoma
Hodgkin lymphoma
t(8;17)(q24;q22) ???BCL3/MYC


External links

Nomenclature
HGNC (Hugo)NFKBIE   7799
Cards
Entrez_Gene (NCBI)NFKBIE  4794  NFKB inhibitor epsilon
AliasesIKBE
GeneCards (Weizmann)NFKBIE
Ensembl hg19 (Hinxton)ENSG00000146232 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000146232 [Gene_View]  chr6:44258166-44265788 [Contig_View]  NFKBIE [Vega]
ICGC DataPortalENSG00000146232
TCGA cBioPortalNFKBIE
AceView (NCBI)NFKBIE
Genatlas (Paris)NFKBIE
WikiGenes4794
SOURCE (Princeton)NFKBIE
Genetics Home Reference (NIH)NFKBIE
Genomic and cartography
GoldenPath hg38 (UCSC)NFKBIE  -     chr6:44258166-44265788 -  6p21.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NFKBIE  -     6p21.1   [Description]    (hg19-Feb_2009)
EnsemblNFKBIE - 6p21.1 [CytoView hg19]  NFKBIE - 6p21.1 [CytoView hg38]
Mapping of homologs : NCBINFKBIE [Mapview hg19]  NFKBIE [Mapview hg38]
OMIM604548   
Gene and transcription
Genbank (Entrez)AK130739 AK301360 BC011676 BC063609 BC166665
RefSeq transcript (Entrez)NM_004556
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NFKBIE
Cluster EST : UnigeneHs.458276 [ NCBI ]
CGAP (NCI)Hs.458276
Alternative Splicing GalleryENSG00000146232
Gene ExpressionNFKBIE [ NCBI-GEO ]   NFKBIE [ EBI - ARRAY_EXPRESS ]   NFKBIE [ SEEK ]   NFKBIE [ MEM ]
Gene Expression Viewer (FireBrowse)NFKBIE [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4794
GTEX Portal (Tissue expression)NFKBIE
Protein : pattern, domain, 3D structure
UniProt/SwissProtO00221   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO00221  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO00221
Splice isoforms : SwissVarO00221
PhosPhoSitePlusO00221
Domaine pattern : Prosite (Expaxy)ANK_REP_REGION (PS50297)    ANK_REPEAT (PS50088)   
Domains : Interpro (EBI)Ankyrin_rpt    Ankyrin_rpt-contain_dom   
Domain families : Pfam (Sanger)Ank_2 (PF12796)   
Domain families : Pfam (NCBI)pfam12796   
Domain families : Smart (EMBL)ANK (SM00248)  
Conserved Domain (NCBI)NFKBIE
DMDM Disease mutations4794
Blocks (Seattle)NFKBIE
SuperfamilyO00221
Human Protein AtlasENSG00000146232
Peptide AtlasO00221
HPRD05181
IPIIPI00414656   IPI00442458   IPI00646324   
Protein Interaction databases
DIP (DOE-UCLA)O00221
IntAct (EBI)O00221
FunCoupENSG00000146232
BioGRIDNFKBIE
STRING (EMBL)NFKBIE
ZODIACNFKBIE
Ontologies - Pathways
QuickGOO00221
Ontology : AmiGOfibrillar center  protein binding  nucleus  cytoplasm  Golgi apparatus  cytosol  cytosol  D-serine transport  cytoplasmic sequestering of transcription factor  perinuclear region of cytoplasm  
Ontology : EGO-EBIfibrillar center  protein binding  nucleus  cytoplasm  Golgi apparatus  cytosol  cytosol  D-serine transport  cytoplasmic sequestering of transcription factor  perinuclear region of cytoplasm  
Pathways : KEGGT cell receptor signaling pathway    B cell receptor signaling pathway    Neurotrophin signaling pathway    Adipocytokine signaling pathway    Epstein-Barr virus infection   
NDEx NetworkNFKBIE
Atlas of Cancer Signalling NetworkNFKBIE
Wikipedia pathwaysNFKBIE
Orthology - Evolution
OrthoDB4794
GeneTree (enSembl)ENSG00000146232
Phylogenetic Trees/Animal Genes : TreeFamNFKBIE
HOVERGENO00221
HOGENOMO00221
Homologs : HomoloGeneNFKBIE
Homology/Alignments : Family Browser (UCSC)NFKBIE
Gene fusions - Rearrangements
Fusion : MitelmanCD2AP/NFKBIE [6p12.3/6p21.1]  [t(6;6)(p12;p21)]  
Fusion : MitelmanNFKBIE/SLC29A1 [6p21.1/6p21.1]  [t(6;6)(p21;p21)]  
Fusion: TCGACD2AP 6p12.3 NFKBIE 6p21.1 LUAD
Fusion: TCGANFKBIE 6p21.1 SLC29A1 6p21.1 KIRC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNFKBIE [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NFKBIE
dbVarNFKBIE
ClinVarNFKBIE
1000_GenomesNFKBIE 
Exome Variant ServerNFKBIE
ExAC (Exome Aggregation Consortium)NFKBIE (select the gene name)
Genetic variants : HAPMAP4794
Genomic Variants (DGV)NFKBIE [DGVbeta]
DECIPHERNFKBIE [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNFKBIE 
Mutations
ICGC Data PortalNFKBIE 
TCGA Data PortalNFKBIE 
Broad Tumor PortalNFKBIE
OASIS PortalNFKBIE [ Somatic mutations - Copy number]
Cancer Gene: CensusNFKBIE 
Somatic Mutations in Cancer : COSMICNFKBIE  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNFKBIE
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NFKBIE
DgiDB (Drug Gene Interaction Database)NFKBIE
DoCM (Curated mutations)NFKBIE (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NFKBIE (select a term)
intoGenNFKBIE
Cancer3DNFKBIE(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604548   
Orphanet
MedgenNFKBIE
Genetic Testing Registry NFKBIE
NextProtO00221 [Medical]
TSGene4794
GENETestsNFKBIE
Target ValidationNFKBIE
Huge Navigator NFKBIE [HugePedia]
snp3D : Map Gene to Disease4794
BioCentury BCIQNFKBIE
ClinGenNFKBIE
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4794
Chemical/Pharm GKB GenePA31603
Clinical trialNFKBIE
Miscellaneous
canSAR (ICR)NFKBIE (select the gene name)
Probes
Litterature
PubMed51 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNFKBIE
EVEXNFKBIE
GoPubMedNFKBIE
iHOPNFKBIE
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 25 19:22:04 CEST 2017

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