NFS1 (NFS1 cysteine desulfurase)

2018-07-01  

Identity

HGNC
LOCATION
20q11.22
LOCUSID
ALIAS
HUSSY-08,IscS,NIFS
FUSION GENES

Other Information

Locus ID:

NCBI: 9054
MIM: 603485
HGNC: 15910
Ensembl: ENSG00000244005

Variants:

dbSNP: 9054
ClinVar: 9054
TCGA: ENSG00000244005
COSMIC: NFS1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000244005ENST00000306750Q8WV90
ENSG00000244005ENST00000374085Q9Y697
ENSG00000244005ENST00000374085Q5QP19
ENSG00000244005ENST00000374092Q9Y697
ENSG00000244005ENST00000397425Q9Y697
ENSG00000244005ENST00000397425Q5QP19
ENSG00000244005ENST00000413203F8WER8
ENSG00000244005ENST00000419569A2A2M1
ENSG00000244005ENST00000440385F2Z2E7
ENSG00000244005ENST00000456462F8WB23
ENSG00000244005ENST00000541387Q9Y697

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Pathways

PathwaySourceExternal ID
Thiamine metabolismKEGGko00730
Thiamine metabolismKEGGhsa00730
Metabolic pathwaysKEGGhsa01100
Sulfur relay systemKEGGko04122
Sulfur relay systemKEGGhsa04122
MetabolismREACTOMER-HSA-1430728
Metabolism of vitamins and cofactorsREACTOMER-HSA-196854
Metabolism of water-soluble vitamins and cofactorsREACTOMER-HSA-196849
Molybdenum cofactor biosynthesisREACTOMER-HSA-947581
Mitochondrial iron-sulfur cluster biogenesisREACTOMER-HSA-1362409

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
168473222006Role of human mitochondrial Nfs1 in cytosolic iron-sulfur protein biogenesis and iron regulation.62
186504372008A novel role for human Nfs1 in the cytoplasm: Nfs1 acts as a sulfur donor for MOCS3, a protein involved in molybdenum cofactor biosynthesis.55
291685062017NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis.46
286343022017Structure of human Fe-S assembly subcomplex reveals unexpected cysteine desulfurase architecture and acyl-ACP-ISD11 interactions.43
242172462013Frataxin directly stimulates mitochondrial cysteine desulfurase by exposing substrate-binding sites, and a mutant Fe-S cluster scaffold protein with frataxin-bypassing ability acts similarly.38
197208322009Dual targeting of Nfs1 and discovery of its novel processing enzyme, Icp55.29
165278102006Roles of the mammalian cytosolic cysteine desulfurase, ISCS, and scaffold protein, ISCU, in iron-sulfur cluster assembly.27
239400312013Human mitochondrial chaperone (mtHSP70) and cysteine desulfurase (NFS1) bind preferentially to the disordered conformation, whereas co-chaperone (HSC20) binds to the structured conformation of the iron-sulfur cluster scaffold protein (ISCU).22
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.17
226899952012Cysteine desulfurase Nfs1 and Pim1 protease control levels of Isu, the Fe-S cluster biogenesis scaffold.16

Citation

Dessen P

NFS1 (NFS1 cysteine desulfurase)

Atlas Genet Cytogenet Oncol Haematol. 2018-07-01

Online version: http://atlasgeneticsoncology.org/gene/57449/nfs1