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NFS1 (NFS1, cysteine desulfurase)

Identity

Other aliasHUSSY-08
IscS
NIFS
HGNC (Hugo) NFS1
LocusID (NCBI) 9054
Atlas_Id 57449
Location 20q11.22  [Link to chromosome band 20q11]
Location_base_pair Starts at 35668688 and ends at 35699365 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
BCAS3 (17q23.2) / NFS1 (20q11.22)NFS1 (20q11.22) / HGD (3q13.33)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(17;20)(q23;q11) BCAS3/NFS1


External links

Nomenclature
HGNC (Hugo)NFS1   15910
Cards
Entrez_Gene (NCBI)NFS1  9054  NFS1, cysteine desulfurase
AliasesHUSSY-08; IscS; NIFS
GeneCards (Weizmann)NFS1
Ensembl hg19 (Hinxton)ENSG00000244005 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000244005 [Gene_View]  ENSG00000244005 [Sequence]  chr20:35668688-35699365 [Contig_View]  NFS1 [Vega]
ICGC DataPortalENSG00000244005
TCGA cBioPortalNFS1
AceView (NCBI)NFS1
Genatlas (Paris)NFS1
WikiGenes9054
SOURCE (Princeton)NFS1
Genetics Home Reference (NIH)NFS1
Genomic and cartography
GoldenPath hg38 (UCSC)NFS1  -     chr20:35668688-35699365 -  20q11.22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NFS1  -     20q11.22   [Description]    (hg19-Feb_2009)
EnsemblNFS1 - 20q11.22 [CytoView hg19]  NFS1 - 20q11.22 [CytoView hg38]
Mapping of homologs : NCBINFS1 [Mapview hg19]  NFS1 [Mapview hg38]
OMIM603485   
Gene and transcription
Genbank (Entrez)AF097025 AJ010952 AK001265 AK001470 AK056242
RefSeq transcript (Entrez)NM_001198989 NM_021100 NM_181679
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NFS1
Cluster EST : UnigeneHs.194692 [ NCBI ]
CGAP (NCI)Hs.194692
Alternative Splicing GalleryENSG00000244005
Gene ExpressionNFS1 [ NCBI-GEO ]   NFS1 [ EBI - ARRAY_EXPRESS ]   NFS1 [ SEEK ]   NFS1 [ MEM ]
Gene Expression Viewer (FireBrowse)NFS1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9054
GTEX Portal (Tissue expression)NFS1
Human Protein AtlasENSG00000244005-NFS1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y697   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y697  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y697
Splice isoforms : SwissVarQ9Y697
Catalytic activity : Enzyme2.8.1.7 [ Enzyme-Expasy ]   2.8.1.72.8.1.7 [ IntEnz-EBI ]   2.8.1.7 [ BRENDA ]   2.8.1.7 [ KEGG ]   
PhosPhoSitePlusQ9Y697
Domaine pattern : Prosite (Expaxy)AA_TRANSFER_CLASS_5 (PS00595)   
Domains : Interpro (EBI)Aminotrans_V_dom    Aminotrans_V_PyrdxlP_BS    Cys_deSase_IscS    Cysteine_dSase    PyrdxlP-dep_Trfase    PyrdxlP-dep_Trfase_dom1    PyrdxlP-dep_Trfase_major   
Domain families : Pfam (Sanger)Aminotran_5 (PF00266)   
Domain families : Pfam (NCBI)pfam00266   
Conserved Domain (NCBI)NFS1
DMDM Disease mutations9054
Blocks (Seattle)NFS1
PDB (SRS)5KZ5    5USR    5WGB    5WKP    5WLW   
PDB (PDBSum)5KZ5    5USR    5WGB    5WKP    5WLW   
PDB (IMB)5KZ5    5USR    5WGB    5WKP    5WLW   
PDB (RSDB)5KZ5    5USR    5WGB    5WKP    5WLW   
Structural Biology KnowledgeBase5KZ5    5USR    5WGB    5WKP    5WLW   
SCOP (Structural Classification of Proteins)5KZ5    5USR    5WGB    5WKP    5WLW   
CATH (Classification of proteins structures)5KZ5    5USR    5WGB    5WKP    5WLW   
SuperfamilyQ9Y697
Human Protein Atlas [tissue]ENSG00000244005-NFS1 [tissue]
Peptide AtlasQ9Y697
IPIIPI00295240   IPI00643101   IPI01009114   IPI01011487   IPI01010855   IPI01010391   IPI00103063   IPI00795961   IPI00853465   IPI00894203   IPI00894115   IPI00894007   IPI00892641   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y697
IntAct (EBI)Q9Y697
FunCoupENSG00000244005
BioGRIDNFS1
STRING (EMBL)NFS1
ZODIACNFS1
Ontologies - Pathways
QuickGOQ9Y697
Ontology : AmiGOsulfur amino acid metabolic process  protein binding  nucleus  nucleoplasm  mitochondrion  mitochondrial matrix  mitochondrial matrix  cytosol  cytosol  Mo-molybdopterin cofactor biosynthetic process  iron incorporation into metallo-sulfur cluster  pyridoxal phosphate binding  cysteine desulfurase activity  cysteine desulfurase activity  cysteine desulfurase activity  molybdopterin cofactor biosynthetic process  protein homodimerization activity  small molecule metabolic process  [2Fe-2S] cluster assembly  metal ion binding  iron-sulfur cluster binding  protein-containing complex assembly  
Ontology : EGO-EBIsulfur amino acid metabolic process  protein binding  nucleus  nucleoplasm  mitochondrion  mitochondrial matrix  mitochondrial matrix  cytosol  cytosol  Mo-molybdopterin cofactor biosynthetic process  iron incorporation into metallo-sulfur cluster  pyridoxal phosphate binding  cysteine desulfurase activity  cysteine desulfurase activity  cysteine desulfurase activity  molybdopterin cofactor biosynthetic process  protein homodimerization activity  small molecule metabolic process  [2Fe-2S] cluster assembly  metal ion binding  iron-sulfur cluster binding  protein-containing complex assembly  
Pathways : KEGGThiamine metabolism    Sulfur relay system   
NDEx NetworkNFS1
Atlas of Cancer Signalling NetworkNFS1
Wikipedia pathwaysNFS1
Orthology - Evolution
OrthoDB9054
GeneTree (enSembl)ENSG00000244005
Phylogenetic Trees/Animal Genes : TreeFamNFS1
HOVERGENQ9Y697
HOGENOMQ9Y697
Homologs : HomoloGeneNFS1
Homology/Alignments : Family Browser (UCSC)NFS1
Gene fusions - Rearrangements
Fusion : QuiverNFS1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNFS1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NFS1
dbVarNFS1
ClinVarNFS1
1000_GenomesNFS1 
Exome Variant ServerNFS1
ExAC (Exome Aggregation Consortium)ENSG00000244005
GNOMAD BrowserENSG00000244005
Varsome BrowserNFS1
Genetic variants : HAPMAP9054
Genomic Variants (DGV)NFS1 [DGVbeta]
DECIPHERNFS1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNFS1 
Mutations
ICGC Data PortalNFS1 
TCGA Data PortalNFS1 
Broad Tumor PortalNFS1
OASIS PortalNFS1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNFS1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNFS1
BioMutasearch NFS1
DgiDB (Drug Gene Interaction Database)NFS1
DoCM (Curated mutations)NFS1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NFS1 (select a term)
intoGenNFS1
Cancer3DNFS1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603485   
Orphanet
DisGeNETNFS1
MedgenNFS1
Genetic Testing Registry NFS1
NextProtQ9Y697 [Medical]
TSGene9054
GENETestsNFS1
Target ValidationNFS1
Huge Navigator NFS1 [HugePedia]
snp3D : Map Gene to Disease9054
BioCentury BCIQNFS1
ClinGenNFS1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9054
Chemical/Pharm GKB GenePA31607
Clinical trialNFS1
Miscellaneous
canSAR (ICR)NFS1 (select the gene name)
Probes
Litterature
PubMed38 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNFS1
EVEXNFS1
GoPubMedNFS1
iHOPNFS1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:26:06 CET 2018

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