Atlas of Genetics and Cytogenetics in Oncology and Haematology


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NFS1 (NFS1 cysteine desulfurase)

Identity

Alias_namesnitrogen fixation 1 (S. cerevisiae, homolog)
NFS1 nitrogen fixation 1 homolog (S. cerevisiae)
Alias_symbol (synonym)NifS
IscS
Other aliasHUSSY-08
NIFS
HGNC (Hugo) NFS1
LocusID (NCBI) 9054
Atlas_Id 70817
Location 20q11.22  [Link to chromosome band 20q11]
Location_base_pair Starts at 34256610 and ends at 34287287 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
BCAS3 (17q23.2) / NFS1 (20q11.22)NFS1 (20q11.22) / HGD (3q13.33)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NFS1   15910
Cards
Entrez_Gene (NCBI)NFS1  9054  NFS1 cysteine desulfurase
AliasesHUSSY-08; IscS; NIFS
GeneCards (Weizmann)NFS1
Ensembl hg19 (Hinxton)ENSG00000244005 [Gene_View]  chr20:34256610-34287287 [Contig_View]  NFS1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000244005 [Gene_View]  chr20:34256610-34287287 [Contig_View]  NFS1 [Vega]
ICGC DataPortalENSG00000244005
TCGA cBioPortalNFS1
AceView (NCBI)NFS1
Genatlas (Paris)NFS1
WikiGenes9054
SOURCE (Princeton)NFS1
Genetics Home Reference (NIH)NFS1
Genomic and cartography
GoldenPath hg19 (UCSC)NFS1  -     chr20:34256610-34287287 -  20q11.22   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)NFS1  -     20q11.22   [Description]    (hg38-Dec_2013)
EnsemblNFS1 - 20q11.22 [CytoView hg19]  NFS1 - 20q11.22 [CytoView hg38]
Mapping of homologs : NCBINFS1 [Mapview hg19]  NFS1 [Mapview hg38]
OMIM603485   
Gene and transcription
Genbank (Entrez)AF097025 AJ010952 AK001265 AK001470 AK056242
RefSeq transcript (Entrez)NM_001198989 NM_021100 NM_181679
RefSeq genomic (Entrez)NC_000020 NC_018931 NG_033237 NT_011362 NW_004929418
Consensus coding sequences : CCDS (NCBI)NFS1
Cluster EST : UnigeneHs.194692 [ NCBI ]
CGAP (NCI)Hs.194692
Alternative Splicing GalleryENSG00000244005
Gene ExpressionNFS1 [ NCBI-GEO ]   NFS1 [ EBI - ARRAY_EXPRESS ]   NFS1 [ SEEK ]   NFS1 [ MEM ]
Gene Expression Viewer (FireBrowse)NFS1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9054
GTEX Portal (Tissue expression)NFS1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y697   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y697  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y697
Splice isoforms : SwissVarQ9Y697
Catalytic activity : Enzyme2.8.1.7 [ Enzyme-Expasy ]   2.8.1.72.8.1.7 [ IntEnz-EBI ]   2.8.1.7 [ BRENDA ]   2.8.1.7 [ KEGG ]   
PhosPhoSitePlusQ9Y697
Domaine pattern : Prosite (Expaxy)AA_TRANSFER_CLASS_5 (PS00595)   
Domains : Interpro (EBI)Aminotrans_V_dom    Aminotrans_V_PyrdxlP_BS    Cys_deSase_IscS    Cysteine_dSase    PyrdxlP-dep_Trfase    PyrdxlP-dep_Trfase_major_sub1    PyrdxlP-dep_Trfase_major_sub2   
Domain families : Pfam (Sanger)Aminotran_5 (PF00266)   
Domain families : Pfam (NCBI)pfam00266   
Conserved Domain (NCBI)NFS1
DMDM Disease mutations9054
Blocks (Seattle)NFS1
SuperfamilyQ9Y697
Human Protein AtlasENSG00000244005
Peptide AtlasQ9Y697
HPRD04597
IPIIPI00295240   IPI00643101   IPI01009114   IPI01011487   IPI01010855   IPI01010391   IPI00103063   IPI00795961   IPI00853465   IPI00894203   IPI00894115   IPI00894007   IPI00892641   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y697
IntAct (EBI)Q9Y697
FunCoupENSG00000244005
BioGRIDNFS1
STRING (EMBL)NFS1
ZODIACNFS1
Ontologies - Pathways
QuickGOQ9Y697
Ontology : AmiGOsulfur amino acid metabolic process  protein binding  nucleus  nucleoplasm  nucleolus  cytoplasm  mitochondrion  mitochondrial matrix  mitochondrial matrix  cytosol  cytosol  protein complex assembly  cysteine metabolic process  vitamin metabolic process  water-soluble vitamin metabolic process  Mo-molybdopterin cofactor biosynthetic process  iron incorporation into metallo-sulfur cluster  pyridoxal phosphate binding  cysteine desulfurase activity  cysteine desulfurase activity  cysteine desulfurase activity  molybdopterin cofactor biosynthetic process  protein homodimerization activity  intracellular membrane-bounded organelle  small molecule metabolic process  metal ion binding  iron-sulfur cluster binding  
Ontology : EGO-EBIsulfur amino acid metabolic process  protein binding  nucleus  nucleoplasm  nucleolus  cytoplasm  mitochondrion  mitochondrial matrix  mitochondrial matrix  cytosol  cytosol  protein complex assembly  cysteine metabolic process  vitamin metabolic process  water-soluble vitamin metabolic process  Mo-molybdopterin cofactor biosynthetic process  iron incorporation into metallo-sulfur cluster  pyridoxal phosphate binding  cysteine desulfurase activity  cysteine desulfurase activity  cysteine desulfurase activity  molybdopterin cofactor biosynthetic process  protein homodimerization activity  intracellular membrane-bounded organelle  small molecule metabolic process  metal ion binding  iron-sulfur cluster binding  
Pathways : KEGGThiamine metabolism    Sulfur relay system   
NDEx NetworkNFS1
Atlas of Cancer Signalling NetworkNFS1
Wikipedia pathwaysNFS1
Orthology - Evolution
OrthoDB9054
GeneTree (enSembl)ENSG00000244005
Phylogenetic Trees/Animal Genes : TreeFamNFS1
HOVERGENQ9Y697
HOGENOMQ9Y697
Homologs : HomoloGeneNFS1
Homology/Alignments : Family Browser (UCSC)NFS1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNFS1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NFS1
dbVarNFS1
ClinVarNFS1
1000_GenomesNFS1 
Exome Variant ServerNFS1
ExAC (Exome Aggregation Consortium)NFS1 (select the gene name)
Genetic variants : HAPMAP9054
Genomic Variants (DGV)NFS1 [DGVbeta]
DECIPHER (Syndromes)20:34256610-34287287  ENSG00000244005
CONAN: Copy Number AnalysisNFS1 
Mutations
ICGC Data PortalNFS1 
TCGA Data PortalNFS1 
Broad Tumor PortalNFS1
OASIS PortalNFS1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNFS1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNFS1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch NFS1
DgiDB (Drug Gene Interaction Database)NFS1
DoCM (Curated mutations)NFS1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NFS1 (select a term)
intoGenNFS1
Cancer3DNFS1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603485   
Orphanet22684   
MedgenNFS1
Genetic Testing Registry NFS1
NextProtQ9Y697 [Medical]
TSGene9054
GENETestsNFS1
Huge Navigator NFS1 [HugePedia]
snp3D : Map Gene to Disease9054
BioCentury BCIQNFS1
ClinGenNFS1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9054
Chemical/Pharm GKB GenePA31607
Clinical trialNFS1
Miscellaneous
canSAR (ICR)NFS1 (select the gene name)
Probes
Litterature
PubMed25 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNFS1
EVEXNFS1
GoPubMedNFS1
iHOPNFS1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Mar 14 12:34:53 CET 2017

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