Atlas of Genetics and Cytogenetics in Oncology and Haematology

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NFX1 (nuclear transcription factor, X-box binding 1)

Identity

Alias_symbol (synonym)NFX2
MGC20369
Tex42
TEG-42
Other alias
HGNC (Hugo) NFX1
LocusID (NCBI) 4799
Atlas_Id 54500
Location 9p13.3  [Link to chromosome band 9p13]
Location_base_pair Starts at 33290417 and ends at 33348723 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ABHD2 (15q26.1) / NFX1 (9p13.3)B4GALT1 (9p21.1) / NFX1 (9p13.3)CRLS1 (20p12.3) / NFX1 (9p13.3)
FN1 (2q35) / NFX1 (9p13.3)GALNT1 (18q12.2) / NFX1 (9p13.3)NFX1 (9p13.3) / ACO1 (9p21.1)
NFX1 (9p13.3) / ARHGEF39 (9p13.3)NFX1 (9p13.3) / BAG1 (9p13.3)NFX1 (9p13.3) / C11orf80 (11q13.2)
NFX1 (9p13.3) / C9orf24 (9p13.3)NFX1 (9p13.3) / DAAM1 (14q23.1)NFX1 (9p13.3) / NFX1 (9p13.3)
NFX1 (9p13.3) / SPINK4 (9p13.3)NFX1 (9p13.3) / TMEM8B (9p13.3)NFX1 (9p13.3) / ZNF616 (19q13.41)
ZNF600 (19q13.41) / NFX1 (9p13.3)B4GALT1 9p21.1 / NFX1 9p13.3CRLS1 20p12.3 / NFX1 9p13.3
NFX1 9p13.3 / ACO1 9p21.1NFX1 9p13.3 C9orf100NFX1 9p13.3 / C9orf24 9p13.3
NFX1 9p13.3 / SPINK4 9p13.3NFX1 9p13.3 / TMEM8B 9p13.3NFX1 9p13.3 / ZNF616 19q13.41
ZNF600 19q13.41 / NFX1 9p13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 8 ]
  NFX1/ARHGEF39 (9p13)
NFX1/SPINK4 (9p13)
NFX1/TMEM8B (9p13)
t(9;9)(p13;p21) B4GALT1/NFX1
t(9;9)(p13;p21) NFX1/ACO1
t(9;19)(p13;q13) NFX1/ZNF616
t(9;19)(p13;q13) ZNF600/NFX1
t(9;20)(p13;p12) CRLS1/NFX1

External links

Nomenclature
HGNC (Hugo)NFX1   7803
Cards
Entrez_Gene (NCBI)NFX1  4799  nuclear transcription factor, X-box binding 1
AliasesNFX2; TEG-42; Tex42
GeneCards (Weizmann)NFX1
Ensembl hg19 (Hinxton)ENSG00000086102 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000086102 [Gene_View]  ENSG00000086102 [Sequence]  chr9:33290417-33348723 [Contig_View]  NFX1 [Vega]
ICGC DataPortalENSG00000086102
TCGA cBioPortalNFX1
AceView (NCBI)NFX1
Genatlas (Paris)NFX1
WikiGenes4799
SOURCE (Princeton)NFX1
Genetics Home Reference (NIH)NFX1
Genomic and cartography
GoldenPath hg38 (UCSC)NFX1  -     chr9:33290417-33348723 +  9p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NFX1  -     9p13.3   [Description]    (hg19-Feb_2009)
EnsemblNFX1 - 9p13.3 [CytoView hg19]  NFX1 - 9p13.3 [CytoView hg38]
Mapping of homologs : NCBINFX1 [Mapview hg19]  NFX1 [Mapview hg38]
OMIM603255   
Gene and transcription
Genbank (Entrez)AF332009 AI679589 AI884552 AK055847 AK225750
RefSeq transcript (Entrez)NM_001318758 NM_002504 NM_147133 NM_147134
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NFX1
Cluster EST : UnigeneHs.413074 [ NCBI ]
CGAP (NCI)Hs.413074
Alternative Splicing GalleryENSG00000086102
Gene ExpressionNFX1 [ NCBI-GEO ]   NFX1 [ EBI - ARRAY_EXPRESS ]   NFX1 [ SEEK ]   NFX1 [ MEM ]
Gene Expression Viewer (FireBrowse)NFX1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4799
GTEX Portal (Tissue expression)NFX1
Human Protein AtlasENSG00000086102-NFX1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ12986   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ12986  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ12986
Splice isoforms : SwissVarQ12986
Catalytic activity : Enzyme2.3.2.- [ Enzyme-Expasy ]   2.3.2.-2.3.2.- [ IntEnz-EBI ]   2.3.2.- [ BRENDA ]   2.3.2.- [ KEGG ]   
PhosPhoSitePlusQ12986
Domaine pattern : Prosite (Expaxy)R3H (PS51061)    ZF_RING_2 (PS50089)   
Domains : Interpro (EBI)NFX1_fam    R3H_dom    R3H_dom_sf    R3H_NF-X1    Zinc_finger_PHD-type_CS    Znf_NFX1    Znf_PHD-finger    Znf_RING   
Domain families : Pfam (Sanger)R3H (PF01424)    zf-NF-X1 (PF01422)   
Domain families : Pfam (NCBI)pfam01424    pfam01422   
Domain families : Smart (EMBL)R3H (SM00393)  RING (SM00184)  ZnF_NFX (SM00438)  
Conserved Domain (NCBI)NFX1
DMDM Disease mutations4799
Blocks (Seattle)NFX1
SuperfamilyQ12986
Human Protein Atlas [tissue]ENSG00000086102-NFX1 [tissue]
Peptide AtlasQ12986
HPRD11936
IPIIPI00843917   IPI00158157   IPI00158159   IPI00030404   IPI01010052   
Protein Interaction databases
DIP (DOE-UCLA)Q12986
IntAct (EBI)Q12986
FunCoupENSG00000086102
BioGRIDNFX1
STRING (EMBL)NFX1
ZODIACNFX1
Ontologies - Pathways
QuickGOQ12986
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  negative regulation of transcription by RNA polymerase II  RNA polymerase II regulatory region sequence-specific DNA binding  RNA polymerase II regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription repressor activity, RNA polymerase II-specific  DNA-binding transcription factor activity  RNA binding  nucleus  nucleus  nucleolus  cytosol  plasma membrane  transcription by RNA polymerase II  inflammatory response  zinc ion binding  viral process  transferase activity  negative regulation of MHC class II biosynthetic process  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  negative regulation of transcription by RNA polymerase II  RNA polymerase II regulatory region sequence-specific DNA binding  RNA polymerase II regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription repressor activity, RNA polymerase II-specific  DNA-binding transcription factor activity  RNA binding  nucleus  nucleus  nucleolus  cytosol  plasma membrane  transcription by RNA polymerase II  inflammatory response  zinc ion binding  viral process  transferase activity  negative regulation of MHC class II biosynthetic process  
NDEx NetworkNFX1
Atlas of Cancer Signalling NetworkNFX1
Wikipedia pathwaysNFX1
Orthology - Evolution
OrthoDB4799
GeneTree (enSembl)ENSG00000086102
Phylogenetic Trees/Animal Genes : TreeFamNFX1
HOGENOMQ12986
Homologs : HomoloGeneNFX1
Homology/Alignments : Family Browser (UCSC)NFX1
Gene fusions - Rearrangements
Fusion : MitelmanB4GALT1/NFX1 [9p21.1/9p13.3]  [t(9;9)(p13;p21)]  
Fusion : MitelmanCRLS1/NFX1 [20p12.3/9p13.3]  [t(9;20)(p13;p12)]  
Fusion : MitelmanNFX1/ACO1 [9p13.3/9p21.1]  [t(9;9)(p13;p21)]  
Fusion : MitelmanNFX1/ARHGEF39 [9p13.3/9p13.3]  [t(9;9)(p13;p13)]  
Fusion : MitelmanNFX1/C9orf24 [9p13.3/9p13.3]  [t(9;9)(p13;p13)]  
Fusion : MitelmanNFX1/SPINK4 [9p13.3/9p13.3]  [t(9;9)(p13;p13)]  
Fusion : MitelmanNFX1/TMEM8B [9p13.3/9p13.3]  [t(9;9)(p13;p13)]  
Fusion : MitelmanNFX1/ZNF616 [9p13.3/19q13.41]  [t(9;19)(p13;q13)]  
Fusion : MitelmanZNF600/NFX1 [19q13.41/9p13.3]  [t(9;19)(p13;q13)]  
Fusion PortalB4GALT1 9p21.1 NFX1 9p13.3 BRCA
Fusion PortalCRLS1 20p12.3 NFX1 9p13.3 KIRC
Fusion PortalNFX1 9p13.3 ACO1 9p21.1 LUSC
Fusion PortalNFX1 9p13.3 C9orf100 HNSC
Fusion PortalNFX1 9p13.3 C9orf24 9p13.3 GBM
Fusion PortalNFX1 9p13.3 SPINK4 9p13.3 BRCA
Fusion PortalNFX1 9p13.3 TMEM8B 9p13.3 LUSC
Fusion PortalNFX1 9p13.3 ZNF616 19q13.41 BRCA
Fusion PortalZNF600 19q13.41 NFX1 9p13.3 BRCA
Fusion Cancer (Beijing)FN1 [2q35]  -  NFX1 [9p13.3]  [FUSC003438]
Fusion : QuiverNFX1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNFX1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NFX1
dbVarNFX1
ClinVarNFX1
1000_GenomesNFX1 
Exome Variant ServerNFX1
ExAC (Exome Aggregation Consortium)ENSG00000086102
GNOMAD BrowserENSG00000086102
Varsome BrowserNFX1
Genetic variants : HAPMAP4799
Genomic Variants (DGV)NFX1 [DGVbeta]
DECIPHERNFX1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNFX1 
Mutations
ICGC Data PortalNFX1 
TCGA Data PortalNFX1 
Broad Tumor PortalNFX1
OASIS PortalNFX1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNFX1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNFX1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NFX1
DgiDB (Drug Gene Interaction Database)NFX1
DoCM (Curated mutations)NFX1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NFX1 (select a term)
intoGenNFX1
Cancer3DNFX1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603255   
Orphanet
DisGeNETNFX1
MedgenNFX1
Genetic Testing Registry NFX1
NextProtQ12986 [Medical]
TSGene4799
GENETestsNFX1
Target ValidationNFX1
Huge Navigator NFX1 [HugePedia]
snp3D : Map Gene to Disease4799
BioCentury BCIQNFX1
ClinGenNFX1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4799
Chemical/Pharm GKB GenePA31608
Clinical trialNFX1
Miscellaneous
canSAR (ICR)NFX1 (select the gene name)
Probes
Litterature
PubMed34 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNFX1
EVEXNFX1
GoPubMedNFX1
iHOPNFX1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Dec 21 15:38:53 CET 2018
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