NFX1 (nuclear transcription factor, X-box binding 1)

2014-08-01  

Identity

HGNC
LOCATION
9p13.3
LOCUSID
ALIAS
NFX2,TEG-42,Tex42
FUSION GENES

Other Information

Locus ID:

NCBI: 4799
MIM: 603255
HGNC: 7803
Ensembl: ENSG00000086102

Variants:

dbSNP: 4799
ClinVar: 4799
TCGA: ENSG00000086102
COSMIC: NFX1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000086102ENST00000318524Q12986
ENSG00000086102ENST00000379540Q12986

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
153713412004Identification of a novel telomerase repressor that interacts with the human papillomavirus type-16 E6/E6-AP complex.82
166874062006Nrf1 is targeted to the endoplasmic reticulum membrane by an N-terminal transmembrane domain. Inhibition of nuclear translocation and transacting function.75
185058292008NFX1 interacts with mSin3A/histone deacetylase to repress hTERT transcription in keratinocytes.29
193693362009NFX1-123 increases hTERT expression and telomerase activity posttranscriptionally in human papillomavirus type 16 E6 keratinocytes.25
172674992007NFX1-123 and poly(A) binding proteins synergistically augment activation of telomerase in human papillomavirus type 16 E6-expressing cells.24
207395282010NFX1 plays a role in human papillomavirus type 16 E6 activation of NFkappaB activity.17
153581742004TAP/NXF1, the primary mRNA export receptor, specifically interacts with a neuronal RNA-binding protein HuD.9
241092362013NFX1-123 and human papillomavirus 16E6 increase Notch expression in keratinocytes.8
257230532015Human papillomavirus 16E6 and NFX1-123 potentiate Notch signaling and differentiation without activating cellular arrest.5
310592662019Identification of a USP9X Substrate NFX1-123 by SILAC-Based Quantitative Proteomics.3

Citation

Dessen P

NFX1 (nuclear transcription factor, X-box binding 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54500/nfx1