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NFXL1 (nuclear transcription factor, X-box binding like 1)

Identity

Alias_symbol (synonym)HOZFP
Other aliasCDZFP
OZFP
URCC5
HGNC (Hugo) NFXL1
LocusID (NCBI) 152518
Atlas_Id 70819
Location 4p12  [Link to chromosome band 4p12]
Location_base_pair Starts at 47847233 and ends at 47914667 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
DTX3L (3q21.1) / NFXL1 (4p12)NFXL1 (4p12) / RACK1 (5q35.3)OCIAD2 (4p11) / NFXL1 (4p12)
RACK1 (5q35.3) / NFXL1 (4p12)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NFXL1   18726
Cards
Entrez_Gene (NCBI)NFXL1  152518  nuclear transcription factor, X-box binding like 1
AliasesCDZFP; HOZFP; OZFP; URCC5
GeneCards (Weizmann)NFXL1
Ensembl hg19 (Hinxton)ENSG00000170448 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000170448 [Gene_View]  chr4:47847233-47914667 [Contig_View]  NFXL1 [Vega]
ICGC DataPortalENSG00000170448
TCGA cBioPortalNFXL1
AceView (NCBI)NFXL1
Genatlas (Paris)NFXL1
WikiGenes152518
SOURCE (Princeton)NFXL1
Genetics Home Reference (NIH)NFXL1
Genomic and cartography
GoldenPath hg38 (UCSC)NFXL1  -     chr4:47847233-47914667 -  4p12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NFXL1  -     4p12   [Description]    (hg19-Feb_2009)
EnsemblNFXL1 - 4p12 [CytoView hg19]  NFXL1 - 4p12 [CytoView hg38]
Mapping of homologs : NCBINFXL1 [Mapview hg19]  NFXL1 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AB085695 AB181916 AK131285 AK302440 AY134856
RefSeq transcript (Entrez)NM_001278623 NM_001278624 NM_152995
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NFXL1
Cluster EST : UnigeneHs.646325 [ NCBI ]
CGAP (NCI)Hs.646325
Alternative Splicing GalleryENSG00000170448
Gene ExpressionNFXL1 [ NCBI-GEO ]   NFXL1 [ EBI - ARRAY_EXPRESS ]   NFXL1 [ SEEK ]   NFXL1 [ MEM ]
Gene Expression Viewer (FireBrowse)NFXL1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)152518
GTEX Portal (Tissue expression)NFXL1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6ZNB6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6ZNB6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6ZNB6
Splice isoforms : SwissVarQ6ZNB6
PhosPhoSitePlusQ6ZNB6
Domaine pattern : Prosite (Expaxy)ZF_RING_2 (PS50089)   
Domains : Interpro (EBI)NFX1_fam    Zinc_finger_PHD-type_CS    Znf_NFX1    Znf_RING   
Domain families : Pfam (Sanger)zf-NF-X1 (PF01422)   
Domain families : Pfam (NCBI)pfam01422   
Domain families : Smart (EMBL)ZnF_NFX (SM00438)  
Conserved Domain (NCBI)NFXL1
DMDM Disease mutations152518
Blocks (Seattle)NFXL1
SuperfamilyQ6ZNB6
Human Protein AtlasENSG00000170448
Peptide AtlasQ6ZNB6
HPRD11025
IPIIPI00442274   IPI00745540   
Protein Interaction databases
DIP (DOE-UCLA)Q6ZNB6
IntAct (EBI)Q6ZNB6
FunCoupENSG00000170448
BioGRIDNFXL1
STRING (EMBL)NFXL1
ZODIACNFXL1
Ontologies - Pathways
QuickGOQ6ZNB6
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II regulatory region sequence-specific DNA binding  transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding  nucleus  transcription from RNA polymerase II promoter  zinc ion binding  membrane  integral component of membrane  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II regulatory region sequence-specific DNA binding  transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding  nucleus  transcription from RNA polymerase II promoter  zinc ion binding  membrane  integral component of membrane  
NDEx NetworkNFXL1
Atlas of Cancer Signalling NetworkNFXL1
Wikipedia pathwaysNFXL1
Orthology - Evolution
OrthoDB152518
GeneTree (enSembl)ENSG00000170448
Phylogenetic Trees/Animal Genes : TreeFamNFXL1
HOVERGENQ6ZNB6
HOGENOMQ6ZNB6
Homologs : HomoloGeneNFXL1
Homology/Alignments : Family Browser (UCSC)NFXL1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNFXL1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NFXL1
dbVarNFXL1
ClinVarNFXL1
1000_GenomesNFXL1 
Exome Variant ServerNFXL1
ExAC (Exome Aggregation Consortium)NFXL1 (select the gene name)
Genetic variants : HAPMAP152518
Genomic Variants (DGV)NFXL1 [DGVbeta]
DECIPHERNFXL1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNFXL1 
Mutations
ICGC Data PortalNFXL1 
TCGA Data PortalNFXL1 
Broad Tumor PortalNFXL1
OASIS PortalNFXL1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNFXL1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNFXL1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch NFXL1
DgiDB (Drug Gene Interaction Database)NFXL1
DoCM (Curated mutations)NFXL1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NFXL1 (select a term)
intoGenNFXL1
Cancer3DNFXL1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
MedgenNFXL1
Genetic Testing Registry NFXL1
NextProtQ6ZNB6 [Medical]
TSGene152518
GENETestsNFXL1
Target ValidationNFXL1
Huge Navigator NFXL1 [HugePedia]
snp3D : Map Gene to Disease152518
BioCentury BCIQNFXL1
ClinGenNFXL1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD152518
Chemical/Pharm GKB GenePA38661
Clinical trialNFXL1
Miscellaneous
canSAR (ICR)NFXL1 (select the gene name)
Probes
Litterature
PubMed17 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNFXL1
EVEXNFXL1
GoPubMedNFXL1
iHOPNFXL1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:32:00 CEST 2017

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