Atlas of Genetics and Cytogenetics in Oncology and Haematology


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NFYC (nuclear transcription factor Y subunit gamma)

Identity

Alias_namesnuclear transcription factor Y
Alias_symbol (synonym)CBF-C
NF-YC
Other aliasCBFC
H1TF2A
HAP5
HSM
HGNC (Hugo) NFYC
LocusID (NCBI) 4802
Atlas_Id 46637
Location 1p34.2  [Link to chromosome band 1p34]
Location_base_pair Starts at 40691570 and ends at 40771606 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
FSTL5 (4q32.2) / NFYC (1p34.2)LOC389831 () / NFYC (1p34.2)NFYC (1p34.2) / NDE1 (16p13.11)
NFYC (1p34.2) / RPLP2 (11p15.5)NFYC (1p34.2) / STK25 (2q37.3)SRRM1 (1p36.11) / NFYC (1p34.2)
WARS (14q32.2) / NFYC (1p34.2)SRRM1 1p36.11 / NFYC 1p34.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(1;1)(p34;p36) SRRM1/NFYC


External links

Nomenclature
HGNC (Hugo)NFYC   7806
Cards
Entrez_Gene (NCBI)NFYC  4802  nuclear transcription factor Y subunit gamma
AliasesCBF-C; CBFC; H1TF2A; HAP5; 
HSM; NF-YC
GeneCards (Weizmann)NFYC
Ensembl hg19 (Hinxton)ENSG00000066136 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000066136 [Gene_View]  ENSG00000066136 [Sequence]  chr1:40691570-40771606 [Contig_View]  NFYC [Vega]
ICGC DataPortalENSG00000066136
TCGA cBioPortalNFYC
AceView (NCBI)NFYC
Genatlas (Paris)NFYC
WikiGenes4802
SOURCE (Princeton)NFYC
Genetics Home Reference (NIH)NFYC
Genomic and cartography
GoldenPath hg38 (UCSC)NFYC  -     chr1:40691570-40771606 +  1p34.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NFYC  -     1p34.2   [Description]    (hg19-Feb_2009)
EnsemblNFYC - 1p34.2 [CytoView hg19]  NFYC - 1p34.2 [CytoView hg38]
Mapping of homologs : NCBINFYC [Mapview hg19]  NFYC [Mapview hg38]
OMIM605344   
Gene and transcription
Genbank (Entrez)AB208975 AF191744 AK000346 AK093786 AK126386
RefSeq transcript (Entrez)NM_001142587 NM_001142588 NM_001142589 NM_001142590 NM_001308114 NM_001308115 NM_014223
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NFYC
Cluster EST : UnigeneHs.713051 [ NCBI ]
CGAP (NCI)Hs.713051
Alternative Splicing GalleryENSG00000066136
Gene ExpressionNFYC [ NCBI-GEO ]   NFYC [ EBI - ARRAY_EXPRESS ]   NFYC [ SEEK ]   NFYC [ MEM ]
Gene Expression Viewer (FireBrowse)NFYC [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4802
GTEX Portal (Tissue expression)NFYC
Human Protein AtlasENSG00000066136-NFYC [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13952   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13952  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13952
Splice isoforms : SwissVarQ13952
PhosPhoSitePlusQ13952
Domains : Interpro (EBI)CBFA_NFYB_domain    Histone-fold    NFYC/HAP5_su   
Domain families : Pfam (Sanger)CBFD_NFYB_HMF (PF00808)   
Domain families : Pfam (NCBI)pfam00808   
Conserved Domain (NCBI)NFYC
DMDM Disease mutations4802
Blocks (Seattle)NFYC
PDB (SRS)1N1J    4AWL    4CSR   
PDB (PDBSum)1N1J    4AWL    4CSR   
PDB (IMB)1N1J    4AWL    4CSR   
PDB (RSDB)1N1J    4AWL    4CSR   
Structural Biology KnowledgeBase1N1J    4AWL    4CSR   
SCOP (Structural Classification of Proteins)1N1J    4AWL    4CSR   
CATH (Classification of proteins structures)1N1J    4AWL    4CSR   
SuperfamilyQ13952
Human Protein Atlas [tissue]ENSG00000066136-NFYC [tissue]
Peptide AtlasQ13952
IPIIPI00071697   IPI00911001   IPI00216407   IPI00973748   IPI00745424   IPI00513906   IPI01012229   IPI00003341   IPI00943050   IPI00646320   IPI00979585   IPI00514289   IPI00645066   IPI00977185   IPI00984271   IPI01015480   IPI00977877   IPI00644539   
Protein Interaction databases
DIP (DOE-UCLA)Q13952
IntAct (EBI)Q13952
FunCoupENSG00000066136
BioGRIDNFYC
STRING (EMBL)NFYC
ZODIACNFYC
Ontologies - Pathways
QuickGOQ13952
Ontology : AmiGORNA polymerase II proximal promoter sequence-specific DNA binding  RNA polymerase II proximal promoter sequence-specific DNA binding  RNA polymerase II distal enhancer sequence-specific DNA binding  RNA polymerase II transcription factor activity, sequence-specific DNA binding  RNA polymerase II transcription factor activity, sequence-specific DNA binding  RNA polymerase II transcription factor activity, sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding  DNA binding  DNA-binding transcription factor activity  transcription coactivator activity  protein binding  nucleus  nucleus  nucleoplasm  nucleoplasm  nucleoplasm  regulation of transcription, DNA-templated  regulation of transcription by RNA polymerase II  transcription by RNA polymerase II  protein folding  transcription factor binding  transcription factor binding  CCAAT-binding factor complex  CCAAT-binding factor complex  protein-DNA complex  protein-DNA complex  sequence-specific DNA binding  transcription regulatory region DNA binding  regulation of cholesterol biosynthetic process  negative regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  protein heterodimerization activity  RNA polymerase II transcription factor complex  
Ontology : EGO-EBIRNA polymerase II proximal promoter sequence-specific DNA binding  RNA polymerase II proximal promoter sequence-specific DNA binding  RNA polymerase II distal enhancer sequence-specific DNA binding  RNA polymerase II transcription factor activity, sequence-specific DNA binding  RNA polymerase II transcription factor activity, sequence-specific DNA binding  RNA polymerase II transcription factor activity, sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding  DNA binding  DNA-binding transcription factor activity  transcription coactivator activity  protein binding  nucleus  nucleus  nucleoplasm  nucleoplasm  nucleoplasm  regulation of transcription, DNA-templated  regulation of transcription by RNA polymerase II  transcription by RNA polymerase II  protein folding  transcription factor binding  transcription factor binding  CCAAT-binding factor complex  CCAAT-binding factor complex  protein-DNA complex  protein-DNA complex  sequence-specific DNA binding  transcription regulatory region DNA binding  regulation of cholesterol biosynthetic process  negative regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  protein heterodimerization activity  RNA polymerase II transcription factor complex  
Pathways : KEGGAntigen processing and presentation    Tuberculosis   
NDEx NetworkNFYC
Atlas of Cancer Signalling NetworkNFYC
Wikipedia pathwaysNFYC
Orthology - Evolution
OrthoDB4802
GeneTree (enSembl)ENSG00000066136
Phylogenetic Trees/Animal Genes : TreeFamNFYC
HOVERGENQ13952
HOGENOMQ13952
Homologs : HomoloGeneNFYC
Homology/Alignments : Family Browser (UCSC)NFYC
Gene fusions - Rearrangements
Fusion : MitelmanSRRM1/NFYC [1p36.11/1p34.2]  [t(1;1)(p34;p36)]  
Fusion PortalSRRM1 1p36.11 NFYC 1p34.2 PRAD
Fusion : QuiverNFYC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNFYC [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NFYC
dbVarNFYC
ClinVarNFYC
1000_GenomesNFYC 
Exome Variant ServerNFYC
ExAC (Exome Aggregation Consortium)ENSG00000066136
GNOMAD BrowserENSG00000066136
Varsome BrowserNFYC
Genetic variants : HAPMAP4802
Genomic Variants (DGV)NFYC [DGVbeta]
DECIPHERNFYC [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNFYC 
Mutations
ICGC Data PortalNFYC 
TCGA Data PortalNFYC 
Broad Tumor PortalNFYC
OASIS PortalNFYC [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNFYC  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNFYC
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NFYC
DgiDB (Drug Gene Interaction Database)NFYC
DoCM (Curated mutations)NFYC (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NFYC (select a term)
intoGenNFYC
Cancer3DNFYC(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605344   
Orphanet
DisGeNETNFYC
MedgenNFYC
Genetic Testing Registry NFYC
NextProtQ13952 [Medical]
TSGene4802
GENETestsNFYC
Target ValidationNFYC
Huge Navigator NFYC [HugePedia]
snp3D : Map Gene to Disease4802
BioCentury BCIQNFYC
ClinGenNFYC
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4802
Chemical/Pharm GKB GenePA31611
Clinical trialNFYC
Miscellaneous
canSAR (ICR)NFYC (select the gene name)
Probes
Litterature
PubMed57 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNFYC
EVEXNFYC
GoPubMedNFYC
iHOPNFYC
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Aug 27 11:40:40 CEST 2018

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