Atlas of Genetics and Cytogenetics in Oncology and Haematology

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NGF (nerve growth factor)

Identity

Alias_namesNGFB
nerve growth factor (beta polypeptide)
Other aliasBeta-NGF
HSAN5
HGNC (Hugo) NGF
LocusID (NCBI) 4803
Atlas_Id 41534
Location 1p13.2  [Link to chromosome band 1p13]
Location_base_pair Starts at 115285916 and ends at 115338236 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)NGF   7808
LRG (Locus Reference Genomic)LRG_260
Cards
Entrez_Gene (NCBI)NGF  4803  nerve growth factor
AliasesBeta-NGF; HSAN5; NGFB
GeneCards (Weizmann)NGF
Ensembl hg19 (Hinxton)ENSG00000134259 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000134259 [Gene_View]  ENSG00000134259 [Sequence]  chr1:115285916-115338236 [Contig_View]  NGF [Vega]
ICGC DataPortalENSG00000134259
TCGA cBioPortalNGF
AceView (NCBI)NGF
Genatlas (Paris)NGF
WikiGenes4803
SOURCE (Princeton)NGF
Genetics Home Reference (NIH)NGF
Genomic and cartography
GoldenPath hg38 (UCSC)NGF  -     chr1:115285916-115338236 -  1p13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NGF  -     1p13.2   [Description]    (hg19-Feb_2009)
GoldenPathNGF - 1p13.2 [CytoView hg19]  NGF - 1p13.2 [CytoView hg38]
ImmunoBaseENSG00000134259
Mapping of homologs : NCBINGF [Mapview hg19]  NGF [Mapview hg38]
OMIM162030   608654   
Gene and transcription
Genbank (Entrez)AF411526 BC032517 BC126148 BC126150 BE045524
RefSeq transcript (Entrez)NM_002506
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NGF
Alternative Splicing GalleryENSG00000134259
Gene ExpressionNGF [ NCBI-GEO ]   NGF [ EBI - ARRAY_EXPRESS ]   NGF [ SEEK ]   NGF [ MEM ]
Gene Expression Viewer (FireBrowse)NGF [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4803
GTEX Portal (Tissue expression)NGF
Human Protein AtlasENSG00000134259-NGF [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP01138   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP01138  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP01138
Splice isoforms : SwissVarP01138
PhosPhoSitePlusP01138
Domaine pattern : Prosite (Expaxy)NGF_1 (PS00248)    NGF_2 (PS50270)   
Domains : Interpro (EBI)Cystine-knot_cytokine    Nerve_growth_factor-like    Nerve_growth_factor-rel    Nerve_growth_factor_bsu    Nerve_growth_factor_bsu_mml    Nerve_growth_factor_CS   
Domain families : Pfam (Sanger)NGF (PF00243)   
Domain families : Pfam (NCBI)pfam00243   
Domain families : Smart (EMBL)NGF (SM00140)  
Conserved Domain (NCBI)NGF
DMDM Disease mutations4803
Blocks (Seattle)NGF
PDB (RSDB)1SG1    1WWW    2IFG    4EDW    4EDX    4ZBN    5JZ7   
PDB Europe1SG1    1WWW    2IFG    4EDW    4EDX    4ZBN    5JZ7   
PDB (PDBSum)1SG1    1WWW    2IFG    4EDW    4EDX    4ZBN    5JZ7   
PDB (IMB)1SG1    1WWW    2IFG    4EDW    4EDX    4ZBN    5JZ7   
Structural Biology KnowledgeBase1SG1    1WWW    2IFG    4EDW    4EDX    4ZBN    5JZ7   
SCOP (Structural Classification of Proteins)1SG1    1WWW    2IFG    4EDW    4EDX    4ZBN    5JZ7   
CATH (Classification of proteins structures)1SG1    1WWW    2IFG    4EDW    4EDX    4ZBN    5JZ7   
SuperfamilyP01138
Human Protein Atlas [tissue]ENSG00000134259-NGF [tissue]
Peptide AtlasP01138
HPRD08874
IPIIPI00000076   IPI00930156   
Protein Interaction databases
DIP (DOE-UCLA)P01138
IntAct (EBI)P01138
FunCoupENSG00000134259
BioGRIDNGF
STRING (EMBL)NGF
ZODIACNGF
Ontologies - Pathways
QuickGOP01138
Ontology : AmiGOactivation of MAPKK activity  nerve growth factor receptor binding  nerve growth factor receptor binding  protein binding  extracellular region  extracellular space  Golgi lumen  cytosol  activation of cysteine-type endopeptidase activity involved in apoptotic process  transmembrane receptor protein tyrosine kinase signaling pathway  peripheral nervous system development  memory  synaptic vesicle  growth factor activity  metalloendopeptidase inhibitor activity  negative regulation of cell proliferation  lipid binding  extrinsic apoptotic signaling pathway via death domain receptors  positive regulation of gene expression  positive regulation of gene expression  nerve development  axon  dendrite  cytoplasmic vesicle  endosome lumen  nerve growth factor processing  nerve growth factor signaling pathway  positive regulation of apoptotic process  negative regulation of apoptotic process  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  regulation of cysteine-type endopeptidase activity involved in apoptotic process  positive regulation of DNA binding  negative regulation of neuron apoptotic process  regulation of neuron differentiation  positive regulation of neuron differentiation  positive regulation of Ras protein signal transduction  neurotrophin TRK receptor signaling pathway  phosphatidylinositol-mediated signaling  positive regulation of collateral sprouting  neuron projection morphogenesis  neuron projection morphogenesis  positive regulation of axonogenesis  modulation of chemical synaptic transmission  
Ontology : EGO-EBIactivation of MAPKK activity  nerve growth factor receptor binding  nerve growth factor receptor binding  protein binding  extracellular region  extracellular space  Golgi lumen  cytosol  activation of cysteine-type endopeptidase activity involved in apoptotic process  transmembrane receptor protein tyrosine kinase signaling pathway  peripheral nervous system development  memory  synaptic vesicle  growth factor activity  metalloendopeptidase inhibitor activity  negative regulation of cell proliferation  lipid binding  extrinsic apoptotic signaling pathway via death domain receptors  positive regulation of gene expression  positive regulation of gene expression  nerve development  axon  dendrite  cytoplasmic vesicle  endosome lumen  nerve growth factor processing  nerve growth factor signaling pathway  positive regulation of apoptotic process  negative regulation of apoptotic process  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  regulation of cysteine-type endopeptidase activity involved in apoptotic process  positive regulation of DNA binding  negative regulation of neuron apoptotic process  regulation of neuron differentiation  positive regulation of neuron differentiation  positive regulation of Ras protein signal transduction  neurotrophin TRK receptor signaling pathway  phosphatidylinositol-mediated signaling  positive regulation of collateral sprouting  neuron projection morphogenesis  neuron projection morphogenesis  positive regulation of axonogenesis  modulation of chemical synaptic transmission  
Pathways : KEGGMAPK signaling pathway    Ras signaling pathway    Rap1 signaling pathway    PI3K-Akt signaling pathway    Apoptosis    Neurotrophin signaling pathway   
NDEx NetworkNGF
Atlas of Cancer Signalling NetworkNGF
Wikipedia pathwaysNGF
Orthology - Evolution
OrthoDB4803
GeneTree (enSembl)ENSG00000134259
Phylogenetic Trees/Animal Genes : TreeFamNGF
HOGENOMP01138
Homologs : HomoloGeneNGF
Homology/Alignments : Family Browser (UCSC)NGF
Gene fusions - Rearrangements
Fusion : QuiverNGF
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNGF [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NGF
dbVarNGF
ClinVarNGF
1000_GenomesNGF 
Exome Variant ServerNGF
ExAC (Exome Aggregation Consortium)ENSG00000134259
GNOMAD BrowserENSG00000134259
Varsome BrowserNGF
Genetic variants : HAPMAP4803
Genomic Variants (DGV)NGF [DGVbeta]
DECIPHERNGF [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNGF 
Mutations
ICGC Data PortalNGF 
TCGA Data PortalNGF 
Broad Tumor PortalNGF
OASIS PortalNGF [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNGF  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DNGF
Mutations and Diseases : HGMDNGF
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)Leiden Muscular Dystrophy pages
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NGF
DgiDB (Drug Gene Interaction Database)NGF
DoCM (Curated mutations)NGF (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NGF (select a term)
intoGenNGF
Cancer3DNGF(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM162030    608654   
Orphanet10856   
DisGeNETNGF
MedgenNGF
Genetic Testing Registry NGF
NextProtP01138 [Medical]
TSGene4803
GENETestsNGF
Target ValidationNGF
Huge Navigator NGF [HugePedia]
snp3D : Map Gene to Disease4803
BioCentury BCIQNGF
ClinGenNGF
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4803
Chemical/Pharm GKB GenePA162397475
Clinical trialNGF
Miscellaneous
canSAR (ICR)NGF (select the gene name)
DataMed IndexNGF
Probes
Litterature
PubMed345 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNGF
EVEXNGF
GoPubMedNGF
iHOPNGF
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Feb 19 16:59:00 CET 2020
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