NGF (nerve growth factor)

2003-05-01  

Identity

HGNC
LOCATION
1p13.2
LOCUSID
ALIAS
Beta-NGF,HSAN5,NGFB

Other Information

Locus ID:

NCBI: 4803
MIM: 162030
HGNC: 7808
Ensembl: ENSG00000134259

Variants:

dbSNP: 4803
ClinVar: 4803
TCGA: ENSG00000134259
COSMIC: NGF

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000134259ENST00000369512P01138

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
ApoptosisKEGGko04210
MAPK signaling pathwayKEGGhsa04010
ApoptosisKEGGhsa04210
Neurotrophin signaling pathwayKEGGko04722
Neurotrophin signaling pathwayKEGGhsa04722
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Ras signaling pathwayKEGGhsa04014
Rap1 signaling pathwayKEGGhsa04015
Rap1 signaling pathwayKEGGko04015
Inflammatory mediator regulation of TRP channelsKEGGhsa04750
Inflammatory mediator regulation of TRP channelsKEGGko04750
Signal TransductionREACTOMER-HSA-162582
Signalling by NGFREACTOMER-HSA-166520
NGF processingREACTOMER-HSA-167060
p75 NTR receptor-mediated signallingREACTOMER-HSA-193704
NFG and proNGF binds to p75NTRREACTOMER-HSA-205017
Cell death signalling via NRAGE, NRIF and NADEREACTOMER-HSA-204998
NRAGE signals death through JNKREACTOMER-HSA-193648
NRIF signals cell death from the nucleusREACTOMER-HSA-205043
NADE modulates death signallingREACTOMER-HSA-205025
p75NTR negatively regulates cell cycle via SC1REACTOMER-HSA-193670
p75NTR signals via NF-kBREACTOMER-HSA-193639
p75NTR recruits signalling complexesREACTOMER-HSA-209543
NF-kB is activated and signals survivalREACTOMER-HSA-209560
Ceramide signallingREACTOMER-HSA-193681
p75NTR regulates axonogenesisREACTOMER-HSA-193697
Axonal growth stimulationREACTOMER-HSA-209563
NGF signalling via TRKA from the plasma membraneREACTOMER-HSA-187037
Activation of TRKA receptorsREACTOMER-HSA-187015
TRKA activation by NGFREACTOMER-HSA-187042
Signalling to ERKsREACTOMER-HSA-187687
Signalling to RASREACTOMER-HSA-167044
Signalling to p38 via RIT and RINREACTOMER-HSA-187706
Prolonged ERK activation eventsREACTOMER-HSA-169893
Frs2-mediated activationREACTOMER-HSA-170968
ARMS-mediated activationREACTOMER-HSA-170984
PLC-gamma1 signallingREACTOMER-HSA-167021
PI3K/AKT activationREACTOMER-HSA-198203
Signalling to STAT3REACTOMER-HSA-198745
Retrograde neurotrophin signallingREACTOMER-HSA-177504

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA444460Heroin DependenceDiseaseClinicalAnnotationassociatedPD21358750, 23651024
PA445043Opioid-Related DisordersDiseaseClinicalAnnotationassociatedPD21358750, 23651024
PA450401methadoneChemicalClinicalAnnotationassociatedPD21358750, 23651024

References

Pubmed IDYearTitleCitations
149857632004Sortilin is essential for proNGF-induced neuronal cell death.289
163199262005NGF rapidly increases membrane expression of TRPV1 heat-gated ion channels.238
177034122007Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.100
198745742009Genetical genomic determinants of alcohol consumption in rats and humans.93
195982352009Genes related to sex steroids, neural growth, and social-emotional behavior are associated with autistic traits, empathy, and Asperger syndrome.92
160791482005The p62 scaffold regulates nerve growth factor-induced NF-kappaB activation by influencing TRAF6 polyubiquitination.87
151313062004Structure of nerve growth factor complexed with the shared neurotrophin receptor p75.67
149761602004A mutation in the nerve growth factor beta gene (NGFB) causes loss of pain perception.65
187278392008Expression and regulation of neurotrophins in the nondegenerate and degenerate human intervertebral disc.63
203602452010Nerve growth factor promotes cardiac repair following myocardial infarction.62

Citation

Dessen P

NGF (nerve growth factor)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/41534/ngf