Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

NHEJ1 (non-homologous end joining factor 1)

Identity

Alias_namesnonhomologous end-joining factor 1
Alias_symbol (synonym)Cernunnos
XLF
FLJ12610
Other alias
HGNC (Hugo) NHEJ1
LocusID (NCBI) 79840
Atlas_Id 45953
Location 2q35  [Link to chromosome band 2q35]
Location_base_pair Starts at 219075324 and ends at 219160865 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
NHEJ1 (2q35) / CNPPD1 (2q35)TAF1B (2p25.1) / NHEJ1 (2q35)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)NHEJ1   25737
LRG (Locus Reference Genomic)LRG_90
Cards
Entrez_Gene (NCBI)NHEJ1  79840  non-homologous end joining factor 1
AliasesXLF
GeneCards (Weizmann)NHEJ1
Ensembl hg19 (Hinxton)ENSG00000187736 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000187736 [Gene_View]  chr2:219075324-219160865 [Contig_View]  NHEJ1 [Vega]
ICGC DataPortalENSG00000187736
TCGA cBioPortalNHEJ1
AceView (NCBI)NHEJ1
Genatlas (Paris)NHEJ1
WikiGenes79840
SOURCE (Princeton)NHEJ1
Genetics Home Reference (NIH)NHEJ1
Genomic and cartography
GoldenPath hg38 (UCSC)NHEJ1  -     chr2:219075324-219160865 -  2q35   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NHEJ1  -     2q35   [Description]    (hg19-Feb_2009)
EnsemblNHEJ1 - 2q35 [CytoView hg19]  NHEJ1 - 2q35 [CytoView hg38]
Mapping of homologs : NCBINHEJ1 [Mapview hg19]  NHEJ1 [Mapview hg38]
OMIM611290   611291   
Gene and transcription
Genbank (Entrez)AJ972687 AK022672 BC008210 BC012732 BC030986
RefSeq transcript (Entrez)NM_024782
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NHEJ1
Cluster EST : UnigeneHs.225988 [ NCBI ]
CGAP (NCI)Hs.225988
Alternative Splicing GalleryENSG00000187736
Gene ExpressionNHEJ1 [ NCBI-GEO ]   NHEJ1 [ EBI - ARRAY_EXPRESS ]   NHEJ1 [ SEEK ]   NHEJ1 [ MEM ]
Gene Expression Viewer (FireBrowse)NHEJ1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)79840
GTEX Portal (Tissue expression)NHEJ1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H9Q4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H9Q4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H9Q4
Splice isoforms : SwissVarQ9H9Q4
PhosPhoSitePlusQ9H9Q4
Domains : Interpro (EBI)XLF_fam    XRCC4_N   
Domain families : Pfam (Sanger)XLF (PF09302)   
Domain families : Pfam (NCBI)pfam09302   
Conserved Domain (NCBI)NHEJ1
DMDM Disease mutations79840
Blocks (Seattle)NHEJ1
PDB (SRS)2QM4    2R9A    3Q4F    3RWR    3SR2    3W03   
PDB (PDBSum)2QM4    2R9A    3Q4F    3RWR    3SR2    3W03   
PDB (IMB)2QM4    2R9A    3Q4F    3RWR    3SR2    3W03   
PDB (RSDB)2QM4    2R9A    3Q4F    3RWR    3SR2    3W03   
Structural Biology KnowledgeBase2QM4    2R9A    3Q4F    3RWR    3SR2    3W03   
SCOP (Structural Classification of Proteins)2QM4    2R9A    3Q4F    3RWR    3SR2    3W03   
CATH (Classification of proteins structures)2QM4    2R9A    3Q4F    3RWR    3SR2    3W03   
SuperfamilyQ9H9Q4
Human Protein AtlasENSG00000187736
Peptide AtlasQ9H9Q4
HPRD07784
IPIIPI00549762   IPI00735288   IPI00917378   IPI00916935   IPI00917068   IPI00916609   
Protein Interaction databases
DIP (DOE-UCLA)Q9H9Q4
IntAct (EBI)Q9H9Q4
FunCoupENSG00000187736
BioGRIDNHEJ1
STRING (EMBL)NHEJ1
ZODIACNHEJ1
Ontologies - Pathways
QuickGOQ9H9Q4
Ontology : AmiGOfibrillar center  protein binding  nucleus  nucleoplasm  double-strand break repair via nonhomologous end joining  double-strand break repair via nonhomologous end joining  central nervous system development  response to ionizing radiation  B cell differentiation  T cell differentiation  DNA ligase IV complex  DNA end binding  positive regulation of ligase activity  nonhomologous end joining complex  
Ontology : EGO-EBIfibrillar center  protein binding  nucleus  nucleoplasm  double-strand break repair via nonhomologous end joining  double-strand break repair via nonhomologous end joining  central nervous system development  response to ionizing radiation  B cell differentiation  T cell differentiation  DNA ligase IV complex  DNA end binding  positive regulation of ligase activity  nonhomologous end joining complex  
Pathways : KEGGNon-homologous end-joining   
NDEx NetworkNHEJ1
Atlas of Cancer Signalling NetworkNHEJ1
Wikipedia pathwaysNHEJ1
Orthology - Evolution
OrthoDB79840
GeneTree (enSembl)ENSG00000187736
Phylogenetic Trees/Animal Genes : TreeFamNHEJ1
HOVERGENQ9H9Q4
HOGENOMQ9H9Q4
Homologs : HomoloGeneNHEJ1
Homology/Alignments : Family Browser (UCSC)NHEJ1
Gene fusions - Rearrangements
Fusion : MitelmanTAF1B/NHEJ1 [2p25.1/2q35]  [t(2;2)(p25;q35)]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNHEJ1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NHEJ1
dbVarNHEJ1
ClinVarNHEJ1
1000_GenomesNHEJ1 
Exome Variant ServerNHEJ1
ExAC (Exome Aggregation Consortium)NHEJ1 (select the gene name)
Genetic variants : HAPMAP79840
Genomic Variants (DGV)NHEJ1 [DGVbeta]
DECIPHERNHEJ1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNHEJ1 
Mutations
ICGC Data PortalNHEJ1 
TCGA Data PortalNHEJ1 
Broad Tumor PortalNHEJ1
OASIS PortalNHEJ1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNHEJ1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNHEJ1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)**PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database
BioMutasearch NHEJ1
DgiDB (Drug Gene Interaction Database)NHEJ1
DoCM (Curated mutations)NHEJ1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NHEJ1 (select a term)
intoGenNHEJ1
Cancer3DNHEJ1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611290    611291   
Orphanet17815   
MedgenNHEJ1
Genetic Testing Registry NHEJ1
NextProtQ9H9Q4 [Medical]
TSGene79840
GENETestsNHEJ1
Huge Navigator NHEJ1 [HugePedia]
snp3D : Map Gene to Disease79840
BioCentury BCIQNHEJ1
ClinGenNHEJ1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD79840
Chemical/Pharm GKB GenePA144596401
Clinical trialNHEJ1
Miscellaneous
canSAR (ICR)NHEJ1 (select the gene name)
Probes
Litterature
PubMed61 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNHEJ1
EVEXNHEJ1
GoPubMedNHEJ1
iHOPNHEJ1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri May 19 12:28:39 CEST 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.